Scientific Computing and Data

Partnering with researchers to advance scientific discovery

BODE2 Publications

Year 1 (7/15/2020-7/15/2021): 64

  1. Basak S, Kumar A, Ramsey S, Gibbs E, Kapoor A, et al. 2020. High-resolution structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition. eLife 9:e57870
  2. Breen MS, Garg P, Tang L, Mendonca D, Levy T, et al. 2020. Episignatures Stratifying Helsmoortel-Van Der Aa Syndrome Show Modest Correlation with Phenotype. The American Journal of Human Genetics 107:555-63
  3. Breen MS, Garg P, Tang L, Mendonca D, Levy T, et al. 2020. Episignatures stratifying ADNP syndrome show modest correlation with phenotype. bioRxiv:2020.04.01.014902
  4. Britton GJ, Contijoch EJ, Spindler MP, Aggarwala V, Dogan B, et al. 2020. Defined microbiota transplant restores Th17/RORγt<sup>+</sup> regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas. Proceedings of the National Academy of Sciences 117:21536-45
  5. Cravedi P, Fribourg M, Zhang W, Yi Z, Zaslavsky E, et al. 2020. Distinct peripheral blood molecular signature emerges with successful tacrolimus withdrawal in kidney transplant recipients. American Journal of Transplantation 20:3477-85
  6. Diaz JEL, Ahsen ME, Schaffter T, Chen X, Realubit RB, et al. 2020. The transcriptomic response of cells to a drug combination is more than the sum of the responses to the monotherapies. eLife 9:e52707
  7. Esai Selvan M, Zauderer MG, Rudin CM, Jones S, Mukherjee S, et al. 2020. Inherited Rare, Deleterious Variants in <em>ATM</em> Increase Lung Adenocarcinoma Risk. Journal of Thoracic Oncology 15:1871-9
  8. Hammerstad SS, Blackard JT, Lombardi A, Owen RP, Concepcion E, et al. 2020. Hepatitis C Virus Infection of Human Thyrocytes: Metabolic, Hormonal, and Immunological Implications. J Clin Endocrinol Metab 105:1157-68
  9. Hartzell S, Bin S, Cantarelli C, Haverly M, Manrique J, et al. 2020. Kidney Failure Associates With T Cell Exhaustion and Imbalanced Follicular Helper T Cells. Front Immunol 11:583702-
  10. Lavin KM, Ge Y, Sealfon SC, Nair VD, Wilk K, et al. 2020. Rehabilitative Impact of Exercise Training on Human Skeletal Muscle Transcriptional Programs in Parkinson’s Disease. Front Physiol 11:653-
  11. Lavin KM, Sealfon SC, McDonald M-LN, Roberts BM, Wilk K, et al. 2020. Skeletal muscle transcriptional networks linked to type I myofiber grouping in Parkinson’s disease. J Appl Physiol (1985) 128:229-40
  12. Letizia AG, Ramos I, Obla A, Goforth C, Weir DL, et al. 2020. SARS-CoV-2 Transmission among Marine Recruits during Quarantine. N Engl J Med 383:2407-16
  13. Li W, Bicak M, Sjoberg DD, Vertosick E, Dahlin A, et al. 2020. Genome-wide association study identifies novel single nucleotide polymorphisms having age-specific effect on prostate-specific antigen levels. The Prostate 80:1405-12
  14. Martin-Trujillo A, Patel N, Richter F, Jadhav B, Garg P, et al. 2020. Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles. PLoS Genet 16:e1009189-e
  15. Miner GH, Renton AE, Taubenfeld E, Tadros RO, Marcora E, et al. 2020. Whole genome sequencing identifies loci specifically associated with thoracic aortic wall defects and abdominal aortic aneurysms in patients with European ancestry. JVS: Vascular Science 1:233-45
  16. Nair VD, Ge Y, Li S, Pincas H, Jain N, et al. 2020. Sedentary and Trained Older Men Have Distinct Circulating Exosomal microRNA Profiles at Baseline and in Response to Acute Exercise. Front Physiol 11:605-
  17. Papa L, Djedaini M, Martin TC, Zangui M, Beaumont KG, et al. 2020. Limited Mitochondrial Activity Coupled With Strong Expression of CD34, CD90 and EPCR Determines the Functional Fitness of ex vivo Expanded Human Hematopoietic Stem Cells. Front Cell Dev Biol 8:592348-
  18. Roudko V, Bozkus CC, Orfanelli T, McClain CB, Carr C, et al. 2020. Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable Tumors. Cell 183:1634-49.e17
  19. Sieh W, Rothstein JH, Klein RJ, Alexeeff SE, Sakoda LC, et al. 2020. Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk. Nature Communications 11:5116
  20. Wang L, Timsina P, Pandey G. Computational performance of heterogeneous ensemble frameworks on high-performance computing platforms. Proc. 2020 IEEE International Conference on Big Data (Big Data), 2020:2843-50:
  21. Wang X, Liu R, Zhang W, Hyink DP, Das GC, et al. 2020. Role of SIRT1 in HIV-associated kidney disease. American Journal of Physiology-Renal Physiology 319:F335-F44
  22. Wu H, Wei M, Jiang X, Tan J, Xu W, et al. 2020. lncRNA PVT1 Promotes Tumorigenesis of Colorectal Cancer by Stabilizing miR-16-5p and Interacting with the VEGFA/VEGFR1/AKT Axis. Molecular Therapy – Nucleic Acids 20:438-50
  23. Yi Z, Keung KL, Li L, Hu M, Lu B, et al. 2020. Key driver genes as potential therapeutic targets in renal allograft rejection. JCI Insight 5:e136220
  24. Zhang Z, Menon MC, Zhang W, Stahl E, Loza B-L, et al. 2020. Genome-wide non-HLA donor-recipient genetic differences influence renal allograft survival via early allograft fibrosis. Kidney International 98:758-68
  25. Bao R, Ng A, Sasaki M, Esai Selvan M, Katti A, et al. 2021. Functional Common and Rare <em>ERBB2</em> Germline Variants Cooperate in Familial and Sporadic Cancer Susceptibility. Cancer Prevention Research 14:441-54
  26. Belbin GM, Cullina S, Wenric S, Soper ER, Glicksberg BS, et al. 2021. Toward a fine-scale population health monitoring system. Cell 184:2068-83.e11
  27. Bendl J, Hauberg ME, Girdhar K, Im E, Vicari JM, et al. 2021. The three-dimensional landscape of chromatin accessibility in Alzheimer’s disease. bioRxiv:2021.01.11.426303
  28. Britton GJ, Chen-Liaw A, Cossarini F, Livanos AE, Spindler MP, et al. 2021. Limited intestinal inflammation despite diarrhea, fecal viral RNA and SARS-CoV-2-specific IgA in patients with acute COVID-19. Scientific Reports 11:13308
  29. Cao A, Li J, Asadi M, Basgen JM, Zhu B, et al. 2021. DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity. The Journal of Clinical Investigation 131
  30. Crawford AA, Bankier S, Altmaier E, Barnes CLK, Clark DW, et al. 2021. Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease. Journal of Human Genetics 66:625-36
  31. da Cruz HF, Pfahringer B, Martensen T, Schneider F, Meyer A, et al. 2021. Using interpretability approaches to update “black-box” clinical prediction models: an external validation study in nephrology. Artificial Intelligence in Medicine 111:101982
  32. Estill M, Ribeiro E, Francoeur NJ, Smith ML, Sebra R, et al. 2021. Long read, isoform aware sequencing of mouse nucleus accumbens after chronic cocaine treatment. Scientific Reports 11:6729
  33. Forrest IS, Chaudhary K, Vy HMT, Bafna S, Jordan DM, et al. 2021. Ancestrally and Temporally Diverse Analysis of Penetrance of Clinical Variants in 72,434 Individuals. medRxiv:2021.03.11.21253430
  34. Hernandez MM, Gonzalez-Reiche AS, Alshammary H, Fabre S, Khan Z, et al. 2021. Before the Surge: Molecular Evidence of SARS-CoV-2 in New York City Prior to the First Report. medRxiv:2021.02.08.21251303
  35. Ho JSY, Mok BW-Y, Campisi L, Jordan T, Yildiz S, et al. 2021. TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation. Cell 184:2618-32.e17
  36. Jatiani SS, Christie S, Leshchenko VV, Jain R, Kapoor A, et al. 2021. SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma. Clinical Cancer Research
  37. Johnson JS, Cote AC, Dobbyn A, Sloofman LG, Xu J, et al. 2021. The Phenome-wide Consequences of Anorexia Nervosa Genes. medRxiv:2021.02.12.21250941
  38. Khalil BD, Sanchez R, Rahman T, Rodriguez-Tirado C, Moritsch S, et al. 2021. A specific agonist of the orphan nuclear receptor NR2F1 suppresses metastasis through the induction of cancer cell dormancy. bioRxiv:2021.01.30.428967
  39. Kirkpatrick Roubidoux E, McMahon M, Carreño JM, Capuano C, Jiang K, et al. 2021. Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase. mSphere 6:e00958-20
  40. Kontorovich AR, Tang Y, Patel N, Georgievskaya Z, Shadrina M, et al. 2021. Burden of Cardiomyopathic Genetic Variation in Lethal Pediatric Myocarditis. Circulation: Genomic and Precision Medicine 0
  41. Kulkarni KR, Schafer M, Berner L, Fiore VG, Heflin M, et al. 2021. An interpretable connectivity-based decoding model for classification of chronic marijuana use. bioRxiv:2021.05.04.442433
  42. LEHRER S, RHEINSTEIN PH. 2021. Homozygosity for rs17775810 Minor Allele Associated With Reduced Mortality of COVID-19 in the UK Biobank Cohort. In Vivo 35:965-8
  43. Lehrer S, Rheinstein PH. 2021. BIN1 rs744373 SNP and COVID‑19 mortality. World Acad Sci J 3:13
  44. Li W, Klein RJ. 2021. Genome-wide association study identifies a role for the progesterone receptor in benign prostatic hyperplasia risk. Prostate Cancer and Prostatic Diseases 24:492-8
  45. Linderman MD, Paudyal C, Shakeel M, Kelley W, Bashir A, Gelb BD. 2021. NPSV: A simulation-driven approach to genotyping structural variants in whole-genome sequencing data. GigaScience 10
  46. Livanos AE, Jha D, Cossarini F, Gonzalez-Reiche AS, Tokuyama M, et al. 2021. Intestinal Host Response to SARS-CoV-2 Infection and COVID-19 Outcomes in Patients With Gastrointestinal Symptoms. Gastroenterology
  47. Mahadevan NR, Knelson EH, Wolff JO, Vajdi A, Saigi M, et al. 2021. Intrinsic immunogenicity of small cell lung carcinoma revealed by its cellular plasticity. Cancer Discovery:candisc.0913.2020
  48. Meliambro K, Li X, Salem F, Yi Z, Sun Z, et al. 2021. Molecular Analysis of the Kidney From a Patient With COVID-19-Associated Collapsing Glomerulopathy. Kidney Med:10.1016/j.xkme.2021.02.012
  49. Neira V, Brito B, Agüero B, Berrios F, Valdés V, et al. 2021. A household case evidences shorter shedding of SARS-CoV-2 in naturally infected cats compared to their human owners. Emerging Microbes & Infections 10:376-83
  50. Nešić D, Bush M, Spasic A, Li J, Kamata T, et al. 2021. Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin αIIbβ3 for ligand binding. Blood Advances 5:1781-90
  51. Patel RS, Tomlinson JE, Divers TJ, Van de Walle GR, Rosenberg BR. 2021. Single-cell resolution landscape of equine peripheral blood mononuclear cells reveals diverse cell types including T-bet+ B cells. BMC Biology 19:13
  52. Pryce KD, Kang HJ, Sakloth F, Liu Y, Khan S, et al. 2021. A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects. Neuropharmacology 195:108673
  53. Roubidoux EK, Carreño JM, McMahon M, Jiang K, van Bakel H, et al. 2021. Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model. mBio 12:e03617-20
  54. Ruf-Zamojski F, Zhang Z, Zamojski M, Smith GR, Mendelev N, et al. 2021. Single nucleus multi-omics regulatory landscape of the murine pituitary. Nature Communications 12:2677
  55. Saxena M, van der Burg SH, Melief CJM, Bhardwaj N. 2021. Therapeutic cancer vaccines. Nature Reviews Cancer 21:360-78
  56. Smith RHB, Khan ZM, Ung PM-U, Scopton AP, Silber L, et al. 2021. Type II Binders Targeting the “GLR-Out” Conformation of the Pseudokinase STRADα. Biochemistry 60:289-302
  57. Thibado JK, Tano J-Y, Lee J, Salas-Estrada L, Provasi D, et al. 2021. Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors. eLife 10:e67027
  58. Vangeepuram N, Liu B, Chiu P-h, Wang L, Pandey G. 2021. Predicting youth diabetes risk using NHANES data and machine learning. Scientific Reports 11:11212
  59. Vialle RA, de Paiva Lopes K, Bennett DA, Crary JF, Raj T. 2021. The impact of genomic structural variation on the transcriptome, chromatin, and proteome in the human brain. medRxiv:2021.02.25.21252245
  60. Waller RG, Klein RJ, Vijai J, McKay JD, Clay-Gilmour A, et al. 2021. Sequencing at lymphoid neoplasm susceptibility loci maps six myeloma risk genes. Human Molecular Genetics 30:1142-53
  61. Webb BD, Hotchkiss H, Prasun P, Gelb BD, Satlin L. 2021. Biallelic loss-of-function variants in KCNJ16 presenting with hypokalemic metabolic acidosis. European Journal of Human Genetics
  62. Yi Z, Salem F, Menon MC, Keung K, Xi C, et al. 2021. Deep learning identifies pathological abnormalities predictive of graft loss in kidney transplant biopsies. bioRxiv:2021.04.18.440166
  63. Zeng B, Bendl J, Kosoy R, Fullard JF, Hoffman GE, Roussos P. 2021. Trans-ethnic eQTL meta-analysis of human brain reveals regulatory architecture and candidate causal variants for brain-related traits. medRxiv:2021.01.25.21250099
  64. Zhou Y, Ramsey S, Provasi D, El Daibani A, Appourchaux K, et al. 2021. Predicted Mode of Binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom’s Alkaloids with Reported Antinociception In Vivo. Biochemistry 60:1420-9

 

 

Deployment(7/15/2019-7/15/2020): 58

  1. Andrews SJ, Goate A. 2019. Mendelian randomization indicates that TNF is not causally associated with Alzheimer’s disease. Neurobiology of aging 84:241 e1- e3
  2. Andrews SJ, Fulton-Howard B, Goate A. 2020. Interpretation of risk loci from genome-wide association studies of Alzheimer’s disease. The Lancet. Neurology 19:326-35
  3. Andrews SJ, Fulton-Howard B, O’Reilly P, Marcora E, Goate AM, collaborators of the Alzheimer’s Disease Genetics C. 2020. Causal associations between modifiable risk factors and the Alzheimer’s phenome. Annals of Neurology n/a
  4. Andrews SJ, Fulton-Howard B, Patterson C, McFall GP, Gross A, et al. 2020. Mitonuclear interactions influence Alzheimer’s disease risk. Neurobiology of aging 87:138 e7- e14
  5. Andrews SJ, Goate A, Anstey KJ. 2020. Association between alcohol consumption and Alzheimer’s disease: A Mendelian randomization study. Alzheimer’s & dementia : the journal of the Alzheimer’s Association 16:345-53
  6. Bicak M, Wang X, Gao X, Xu X, Vaananen R-M, et al. 2020. Prostate cancer risk SNP rs10993994 is a trans-eQTL for SNHG11 mediated through MSMB. Human Molecular Genetics
  7. Britton GJ, Chen-Liaw A, Cossarini F, Livanos AE, Spindler MP, et al. 2020. SARS-CoV-2-specific IgA and limited inflammatory cytokines are present in the stool of select patients with acute COVID-19. medRxiv:2020.09.03.20183947
  8. Caban AB, Pak TR, Obla A, Dupper A, Chacko KI, et al. 2020. PathoSPOT genomic epidemiology reveals under-the-radar nosocomial outbreaks. medRxiv:2020.05.11.20098103
  9. Do AN, Watson CT, Cohain AT, Griffin RS, Grishin A, et al. 2020. Dual transcriptomic and epigenomic study of reaction severity in peanut-allergic children. The Journal of allergy and clinical immunology 145:1219-30
  10. Egervari G, Akpoyibo D, Rahman T, Fullard JF, Callens JE, et al. 2020. Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder. Nat Commun 11:4634-
  11. Espeso-Gil S, Halene T, Bendl J, Kassim B, Ben Hutta G, et al. 2020. A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons. Genome medicine 12:19-
  12. Fulton-Howard B, Goate AM, Adelson RP, Koppel J, Gordon ML, et al. 2020. Greater Effect of Polygenic Risk Score for Alzheimer’s Disease Among Younger Cases who are Apolipoprotein E-ε4 Carriers. Neurobiology of Aging
  13. Garg P, Jadhav B, Rodriguez OL, Patel N, Martin-Trujillo A, et al. 2020. A Survey of Rare Epigenetic Variation in 23,116 Human Genomes Identifies Disease-Relevant Epivariations and CGG Expansions. The American Journal of Human Genetics 107:654-69
  14. Gonzalez-Reiche AS, Hernandez MM, Sullivan MJ, Ciferri B, Alshammary H, et al. 2020. Introductions and early spread of SARS-CoV-2 in the New York City area. Science:eabc1917
  15. Gordon DE, Watson A, Roguev A, Zheng S, Jang GM, et al. 2020. A Quantitative Genetic Interaction Map of HIV Infection. Molecular cell 78:197-209 e7
  16. Han L, Zhao X, Benton ML, Perumal T, Collins RL, et al. 2020. Functional annotation of rare structural variation in the human brain. Nat Commun 11:2990-
  17. Hoffman GE, Bendl J, Girdhar K, Roussos P. 2020. decorate: differential epigenetic correlation test. Bioinformatics 36:2856-61
  18. Hoffman GE, Roussos P. 2020. dream: Powerful differential expression analysis for repeated measures designs. Bioinformatics
  19. Holmes G, Gonzalez-Reiche AS, Lu N, Zhou X, Rivera J, et al. 2020. Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis. Cell Reports 32:107871
  20. Hu X, Provasi D, Ramsey S, Filizola M. 2020. Mechanism of μ-Opioid Receptor-Magnesium Interaction and Positive Allosteric Modulation. Biophysical Journal 118:909-21
  21. Hur JY, Frost GR, Wu X, Crump C, Pan SJ, et al. 2020. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease. Nature
  22. Imai M, Yamashita M, Sakai-Tagawa Y, Iwatsuki-Horimoto K, Kiso M, et al. 2020. Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets. Nature Microbiology 5:27-33
  23. Janiri D, Doucet GE, Pompili M, Sani G, Luna B, et al. 2020. Risk and protective factors for childhood suicidality: a US population-based study. The lancet. Psychiatry 7:317-26
  24. Javaid W, Ehni J, Gonzalez-Reiche AS, Carreno JM, Hirsch E, et al. 2020. Real Time Investigation of a large Nosocomial Influenza A Outbreak Informed by Genomic Epidemiology. medRxiv:2020.05.10.20096693
  25. Kapoor A, Provasi D, Filizola M. 2020. Atomic-Level Characterization of the Methadone-Stabilized Active Conformation of &lt;em&gt;µ&lt;/em&gt;-Opioid Receptor. Molecular Pharmacology 98:475
  26. Kerns SL, Fachal L, Dorling L, Barnett GC, Baran A, et al. 2020. Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy. J Natl Cancer Inst 112:179-90
  27. Kovatch P, Gai L, Cho HM, Fluder E, Jiang D. Optimizing High-Performance Computing Systems for Biomedical Workloads. Proc. 2020 IEEE International Parallel and Distributed Processing Symposium Workshops (IPDPSW), 2020:183-92:
  28. Lamim Ribeiro JM, Provasi D, Filizola M. 2020. A combination of machine learning and infrequent metadynamics to efficiently predict kinetic rates, transition states, and molecular determinants of drug dissociation from G protein-coupled receptors. J Chem Phys 153:124105-
  29. Leader AM, Grout JA, Chang C, Maier B, Tabachnikova A, et al. 2020. CITEseq analysis of non-small-cell lung cancer lesions reveals an axis of immune cell activation associated with tumor antigen load and <em>TP53</em> mutations. bioRxiv:2020.07.16.207605
  30. Lee WH, Rodrigue A, Glahn DC, Bassett DS, Frangou S. 2020. Heritability and Cognitive Relevance of Structural Brain Controllability. Cerebral cortex (New York, N.Y. : 1991) 30:3044-54
  31. Livanos AE, Jha D, Cossarini F, Gonzalez-Reiche AS, Tokuyama M, et al. 2020. Gastrointestinal involvement attenuates COVID-19 severity and mortality. medRxiv:2020.09.07.20187666
  32. Ma A, Stratikopoulos E, Park K-S, Wei J, Martin TC, et al. 2020. Discovery of a first-in-class EZH2 selective degrader. Nature Chemical Biology 16:214-22
  33. Mei AH-C, Tung K, Han J, Perumal D, Laganà A, et al. 2020. MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21(Cip1). Oncotarget 11:727-39
  34. Navarro E, Udine E, de Paiva Lopes K, Parks M, Riboldi G, et al. 2020. Discordant transcriptional signatures of mitochondrial genes in Parkinson’s disease human myeloid cells. bioRxiv:2020.07.20.212407
  35. Nešić D, Zhang Y, Spasic A, Li J, Provasi D, et al. 2020. Cryo-Electron Microscopy Structure of the αIIbβ3-Abciximab Complex. Arteriosclerosis, Thrombosis, and Vascular Biology 40:624-37
  36. O’Donnell T, Rubinsteyn A, Laserson U. 2020. A model of antigen processing improves prediction of MHC I-presented peptides. bioRxiv:2020.03.28.013714
  37. Patel RS, Tomlinson JE, Divers TJ, Van de Walle GR, Rosenberg BR. 2020. Single cell resolution landscape of equine peripheral blood mononuclear cells reveals diverse immune cell subtypes including T-bet<sup>+</sup> B cells. bioRxiv:2020.05.05.077362
  38. Perumal D, Imai N, Laganà A, Finnigan J, Melnekoff D, et al. 2020. Mutation-derived Neoantigen-specific T-cell Responses in Multiple Myeloma. Clin Cancer Res 26:450-64
  39. Ramdhani S, Navarro E, Udine E, Efthymiou AG, Schilder BM, et al. 2020. Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs. PLoS genetics 16:e1008549
  40. Richter F, Morton SU, Kim SW, Kitaygorodsky A, Wasson LK, et al. 2020. Genomic analyses implicate noncoding de novo variants in congenital heart disease. Nature Genetics 52:769-77
  41. Rodriguez OL, Gibson WS, Parks T, Emery M, Powell J, et al. 2020. A Novel Framework for Characterizing Genomic Haplotype Diversity in the Human Immunoglobulin Heavy Chain Locus. Frontiers in Immunology 11
  42. Rodríguez Y, Gerona-Navarro G, Osman R, Zhou MM. 2020. In silico design and molecular basis for the selectivity of Olinone toward the first over the second bromodomain of BRD4. Proteins 88:414-30
  43. Rodríguez-Espigares I, Torrens-Fontanals M, Tiemann JKS, Aranda-García D, Ramírez-Anguita JM, et al. 2020. GPCRmd uncovers the dynamics of the 3D-GPCRome. Nature Methods 17:777-87
  44. Schneeberger PE, Kortüm F, Korenke GC, Alawi M, Santer R, et al. 2020. Biallelic MADD variants cause a phenotypic spectrum ranging from developmental delay to a multisystem disorder. Brain : a journal of neurology 143:2437-53
  45. Seiden AH, Richter F, Patel N, Rodriguez OL, Deikus G, et al. 2020. Elucidation of de novo small insertion/deletion biology with parent-of-origin phasing. Human Mutation 41:800-6
  46. Sevim Bayrak C, Zhang P, Tristani-Firouzi M, Gelb BD, Itan Y. 2020. De novo variants in exomes of congenital heart disease patients identify risk genes and pathways. Genome Medicine 12:9
  47. Song WM, Lin X, Liao X, Hu D, Lin J, et al. 2020. Multiscale network analysis reveals molecular mechanisms and key regulators of the tumor microenvironment in gastric cancer. International journal of cancer 146:1268-80
  48. Walker RW, Belbin GM, Sorokin EP, Van Vleck T, Wojcik GL, et al. 2020. A common variant in PNPLA3 is associated with age at diagnosis of NAFLD in patients from a multi-ethnic biobank. Journal of hepatology 72:1070-81
  49. Wang C, Forst CV, Chou TW, Geber A, Wang M, et al. 2020. Cell-to-Cell Variation in Defective Virus Expression and Effects on Host Responses during Influenza Virus Infection. mBio 11
  50. Wang H-Y, MacDonald ML, Borgmann-Winter KE, Banerjee A, Sleiman P, et al. 2020. mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia. Mol Psychiatry 25:750-60
  51. Wang L, Sebra RP, Sfakianos JP, Allette K, Wang W, et al. 2020. A reference profile-free deconvolution method to infer cancer cell-intrinsic subtypes and tumor-type-specific stromal profiles. Genome medicine 12:24-
  52. Weiss K, Lazar HP, Kurolap A, Martinez AF, Paperna T, et al. 2020. The CHD4-related syndrome: a comprehensive investigation of theclinical spectrum, genotype–phenotype correlations, and molecular basis. Genetics in Medicine 22:389-97
  53. Wenger BM, Patel N, Lui M, Moscati A, Do R, et al. 2020. A genotype-first approach to exploring Mendelian cardiovascular traits with clear external manifestations. Genetics in Medicine
  54. Woo YJ, Roussos P, Haroutunian V, Katsel P, Gandy S, et al. 2020. Comparison of brain connectomes by MRI and genomics and its implication in Alzheimer’s disease. BMC medicine 18:23-
  55. Xie J, Liu L, Mladkova N, Li Y, Ren H, et al. 2020. The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis. Nat Commun 11:1600
  56. Yang C, Mogno I, Contijoch EJ, Borgerding JN, Aggarwala V, et al. 2020. Fecal IgA Levels Are Determined by Strain-Level Differences in Bacteroides ovatus and Are Modifiable by Gut Microbiota Manipulation. Cell host & microbe 27:467-75 e6
  57. Yang J, Peng S, Zhang B, Houten S, Schadt E, et al. 2020. Human geroprotector discovery by targeting the converging subnetworks of aging and age-related diseases. GeroScience 42:353-72
  58. Zhang Q, Sidorenko J, Couvy-Duchesne B, Marioni RE, Wright MJ, et al. 2020. Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture. Nat Commun 11:4799