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Mount Sinai Spine Research Day – May 18

The Sinai Spine Research Day on May 18th highlights the latest clinical and basic science spine research and demonstrates the strong commitment to promote research that answers critical scientific questions while also improving clinical care. This year, four members of the spine lab will be giving presentations:

Alon Lai: “Bioactive dietary polyphenol preparation for preventing painful behavior associated with lumbar disc degeneration”

Thomas Evashwick-Rogler: “Hyperosmolar overloading induces notochordal cell differentiation with osmosensitive Aquaporin3 upregulation and altered Ncadherin and Connexin43 expression”

Rose Long: “Repair of annular injury using a fibrin based sealant in ovine after one year”

Olivia Torre: “Development of an in vivo model of neonatal intervertebral disc injury and regeneration”

  5/18/2017
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Welcome to Nimrod Korda!

Welcome to Nimrod Korda who joins the lab as our student intern.  Nimrod will receive his BS from the ORT Braude College of Engineering in Israel where he was a part of Dr. Sarit Sivan’s lab.  For his research, Nimrod will be working on characterizing a GAG-mimetic hydrogel for nucleus pulposus replacement.

 

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Welcome to Kengo Fujii!

Welcome to Dr. Kengo Fujii who joins the lab for a research year as a postdoctoral fellow.  Dr. Fujii is a visiting orthopaedic surgeon from the University of Tsukuba in Japan. For his postdoctoral research, Dr. Fujii will apply his expertise to intervertebral disc biomechanics and mechanisms of discogenic pain.

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ORS 2017 Recap

The Spine Lab and collaborators successfully presented 10 abstracts this year at ORS in San Diego

  1. Rolfe RA, Oyen ML, Iatridis JC, Nowlan NC: Short Periods of Fetal Immobility Lead to Dramatic Effects on Spine and Rib Development, Paper #: 212.
  2. Long RG, Nakai T, Sakai D, Iatridis JC, Alini M, Grad S, Li Z: TGFβ1 induces a contractile CD146+ phenotype of human annulus fibrosus cells and may be delivered in a carrier for annulus fibrosus repair, Poster #: 1793.
  3. Torre OM, Das R, Mosley GE, Huang AH, Iatridis JC: Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration, Poster #: 1829.
  4. Cruz MA, Hom WW, Merril R, Torre OM, Nasser P, Hecht AC, Illien-Junger S, Iatridis JC: Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1800, 2017.
  5. Lin HA, Varma DM, Hom WW, Cruz MA, Nasser PR, Iatridis JC, Nicoll SB: Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1799, 2017.
  6. Lai A, Evashwick-Rogler TW, Salandra JM, Ho L, Laudier DM, Cho SK, Hecht AC, Winkelstein BA,  Pasinetti GM Iatridis JC: A Potential Safe and Novel Drink For Preventing Pain Associated With Disc Degeneration – An In-Vivo Rat Model, Transactions of the Orthopaedic Research Society, Poster session: PS2-121, Poster # 1839, 2017.
  7. Evashwick-Rogler TW, Lai A, Salandra JM, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, Hecht Ac, Iatridis JC: Disc height loss, but not Pro-inflammatory cytokine or Substance P expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model, Transactions of the Orthopaedic Research Society, Poster Session: PS1-044, Spine – Disc Biology, Poster #: 854, 2017.
  8. Palacio-Mancheno P, Evashwick-Rogler TW, Laudier DM, Purmessur D, Iatridis JC: Hyperosmolar Overloading in a Mouse Organ Culture Model Induces Notochordal Cell Differentiation with Osmoregulatory Aquaporin3 Upregulation and Altered N-Cad and Connexin-43 Mechanotransduction Expression, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster # 1817, 2017.
  9. Palacio-Mancheno P, Kindschuh WF, Chen X, Harned AA, Iatridis JC: Illien-Jünger S: Age- and Sex-Dependent Effects of Advanced Glycation Endproducts Ingestion on Vertebral Bone Quality and Function, Transactions of the Orthopaedic Research Society, Poster Session: PS1-029, Bone – Musculoskeletal Development and Aging,  Poster #: 0672, 2017.
  10. Gluck MJ, Beck CM, Vijayaraghavan S, Iatridis JC, Hausman MR: In Situ Imaging of Rat Median Nerve Damage Using Second Harmonic Generation Microscopy: Advancing Towards an In Vivo Application, Transactions of the Orthopaedic Research Society, Poster Session: PS2-152, Diagnostic Imaging, Poster #: 2241, 2017.

James Iatridis also Chaired the ORS Spine Section Meeting and became 2nd Vice President of the ORS. We enjoyed being part of the Van Mow academic tree during his Shands Award Presentation #VanMow #ORS2017.

In addition to research activities, most of the Orthopaedic Research Lab attendees met at Tom Evashwick-Rogler’s family home for a great barbeque in celebration of a very successful meeting.

 

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Welcome to Divya Krishnamoorthy!

Welcome to Divya Krishnamoorthy who joined the spine lab as a Post-doctoral Fellow who recently graduated with her PhD in Biomedical Engineering in the lab of Dr. Clinton Rubin from the State University of New York, Stony Brook.  Divya will work with James Iatridis and Svenja Illien-Junger to identify effects of diabetes and diet on spinal pathologies including investigating interactions between the intervertebral disc and vertebrae.

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Congratulations and Farewell to Paolo Palacio-Mancheno

Paolo Farewell smallerCongratulations to Paolo Palacio-Mancheno, PhD for his new job at Procter & Gamble as a Research Scientist!  In the 2 years that Paolo has been a Postdoctoral Fellow, he has made many contributions toward advancing intervertebral disc research.  In addition to his research and leadership skills, Paolo has been a great friend, colleague, and mentor to everyone in the lab.  While we are sad to see him leave, we wish him the best in his new position at P&G.

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James Iatridis Elected as 2nd Vice President of ORS

james Iatridis

Dr. Iatridis was elected as the 2nd Vice President of the Orthopaedic Research Society.  His 4 year term in the presidential lineage on the ORS Board of Directors will begin after the ORS annual meeting in San Diego in March 2017.  During his 20 years as a member of the ORS, Dr. Iatridis has served as a program topic chair, regularly organized workshops and judged award competitions, and reviewed abstracts.  He has also been the Chair of the ORS/OREF/AAOS New Investigator Research Funding Workshop and the inaugural Chair of the ORS Spine Section.  Dr. Iatridis has a strong vision to balancing the growth opportunities offered by the new ORS Sections with focus and efficiency, while also nurturing the broad orthopaedic mission and the cohesive orthopaedic research community.  He is committed to building innovative partnerships with diverse involvement across disciplines and geographies.

 

Source: ORS Election Results

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James Iatridis Elected as 2nd Vice President of ORS

james Iatridis (3)Dr. Iatridis was elected as the 2nd Vice President of the Orthopaedic Research Society.  His 4 year term in the presidential lineage on the ORS Board of Directors will begin after the ORS annual meeting in San Diego in March 2017.  During his 20 years as a member of the ORS, Dr. Iatridis has served as a program topic chair, regularly organized workshops and judged award competitions, and reviewed abstracts.  He has also been the Chair of the ORS/OREF/AAOS New Investigator Research Funding Workshop and the inaugural Chair of the ORS Spine Section.  Dr. Iatridis has a strong vision to balancing the growth opportunities offered by the new ORS Sections with focus and efficiency, while also nurturing the broad orthopaedic mission and the cohesive orthopaedic research community.  He is committed to building innovative partnerships with diverse involvement across disciplines and geographies.

Source: ORS Election Results

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ORL Accepted Abstracts for ORS 2017

Spine Group Abstracts
1. Rolfe RA, Oyen ML, Iatridis JC, Nowlan NC: Short Periods of Fetal Immobility Lead to Dramatic Effects on Spine and Rib Development, Transactions of the Orthopaedic Research Society, Podium Session: 31,
Spine Pathogenesis and Therapeutics, 11:00 AM – 11:10 AM, Paper #: 212, 2017.
2. Long RG, Nakai T, Sakai D, Iatridis JC, Alini M, Grad S, Li Z: TGFβ1 induces a contractile CD146+ phenotype of human annulus fibrosus cells and may be delivered in a carrier for annulus fibrosus repair, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Poster #: 1793, 2017.
3. Torre OM, Das R, Mosley GE, Huang AH, Iatridis JC: Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster #: 1829, 2017.
4. Cruz MA, Hom WW, Merril R, Torre OM, Nasser P, Hecht AC, Illien-Junger S, Iatridis JC: Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1800, 2017.
5. Lin HA, Varma DM, Hom WW, Nasser PR, Iatridis JC, Nicoll SB: Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1799, 2017.
6. Lai A, Evashwick-Rogler TW, Salandra JM, Ho L, Laudier DM, Cho SK, Hecht AC, Winkelstein BA, Pasinetti GM Iatridis JC: A Potential Safe and Novel Drink For Preventing Pain Associated With Disc Degeneration – An In-Vivo Rat Model, Transactions of the Orthopaedic Research Society, Poster session: PS2-121, Poster # 1839, 2017.
7. Evashwick-Rogler TW, Lai A, Salandra JM, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, Hecht Ac, Iatridis JC: Disc height loss, but not Pro-inflammatory cytokine or Substance P expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model, Transactions of the Orthopaedic Research Society, Poster Session: PS1-044, Spine – Disc Biology, Poster #: 854, 2017.
8. Palacio-Mancheno P, Evashwick-Rogler TW, Laudier DM, Purmessur D, Iatridis JC: Hyperosmolar Overloading in a Mouse Organ Culture Model Induces Notochordal Cell Differentiation with Osmoregulatory Aquaporin3 Upregulation and Altered N-Cad and Connexin-43 Mechanotransduction Expression, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster # 1817, 2017.
9. Palacio-Mancheno P, Kindschuh WF, Chen X, Harned AA, Iatridis JC: Illien-Jünger S: Age- and Sex-Dependent Effects of Advanced Glycation Endproducts Ingestion on Vertebral Bone Quality and Function, Transactions of the Orthopaedic Research Society, Poster Session: PS1-029, Bone – Musculoskeletal Development and Aging, Poster #: 0672, 2017.

Hand and Elbow Group Abstracts
1. Gluck MJ, Beck CM, Vijayaraghavan S, Iatridis JC, Hausman MR: In Situ Imaging of Rat Median Nerve Damage Using Second Harmonic Generation Microscopy: Advancing Towards an In Vivo Application, Transactions of the Orthopaedic Research Society, Poster Session: PS2-152, Diagnostic Imaging, Poster #: 2241, 2017.
2. Beck CM, Nasser P, Gluck MJ, Hausman MR, Koehler SM: Optimizing the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters, Transactions of the Orthopaedic Research Society, Poster Teaser Session: PS2-042, Poster #: 0328, 2017
3. Gluck MJ, Beck CM, Golan EJ, Nasser PR, Shukla DR, Hausman MR: pMUCL Reconstruction Recovers Elbow Stability In The Presence Of Posteromedial Rotatory Instability: A Cadaveric Study, Transactions of the Orthopaedic Research Society, Late Breaking Poster Session: LB- 156, Late Breaking PS2, Poster #: 2428, 2017

Tendon Group Abstracts
1.“The role of innate and adaptive immunity in regenerative and non-regenerative tendon healing” by Kristen Howell and Alice Huang will be presented in the Tendon and Ligament Biology Session, March 21, 2017 (11:00 am).
2. “Targeted Smad4 Deletion in Tenocytes Enables Tendon Cell Recruitment After Adult Tendon Injury” by Chun (Jerry) Chien, Kristen Howell, and Alice Huang will be presented in the Tendon and Ligament: Cell Biology Poster Session One, March 20-21, 2017.
3. “Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration” by Olivia Torre, Grace Mosley, Rohit Das, Alice Huang, and James Iatridis will be presented in the Spine: Disc Biology Poster Session Two, March 21-22, 2017.
4. “Scleraxis is Essential for Tenocyte Recruitment to Enable Tendon Growth” by Deepanwita Pal, Alice Huang, Lingyan Wang, John Brigande, and Ronen Schweitzer will be presented in the Tendon and Ligament Biology Session, March 21, 2017 (10:30am).
5. “Smad4 Regulation of Tendon Elongation” by Saundra Schlesinger, Seong Seo, Alice Huang, Brian Pryce, Ronen Schweitzer will be presented in the Tendon and Ligament: Cell Biology Poster Session Two, March 21-22, 2017.

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Accepted abstracts for ORS 2017

Spine Group Abstracts
1. Rolfe RA, Oyen ML, Iatridis JC, Nowlan NC: Short Periods of Fetal Immobility Lead to Dramatic Effects on Spine and Rib Development, Transactions of the Orthopaedic Research Society, Podium Session: 31,
Spine Pathogenesis and Therapeutics, 11:00 AM – 11:10 AM, Paper #: 212, 2017.
2. Long RG, Nakai T, Sakai D, Iatridis JC, Alini M, Grad S, Li Z: TGFβ1 induces a contractile CD146+ phenotype of human annulus fibrosus cells and may be delivered in a carrier for annulus fibrosus repair, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Poster #: 1793, 2017.
3. Torre OM, Das R, Mosley GE, Huang AH, Iatridis JC: Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster #: 1829, 2017.
4. Cruz MA, Hom WW, Merril R, Torre OM, Nasser P, Hecht AC, Illien-Junger S, Iatridis JC: Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1800, 2017.
5. Lin HA, Varma DM, Hom WW, Nasser PR, Iatridis JC, Nicoll SB: Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1799, 2017.
6. Lai A, Evashwick-Rogler TW, Salandra JM, Ho L, Laudier DM, Cho SK, Hecht AC, Winkelstein BA, Pasinetti GM Iatridis JC: A Potential Safe and Novel Drink For Preventing Pain Associated With Disc Degeneration – An In-Vivo Rat Model, Transactions of the Orthopaedic Research Society, Poster session: PS2-121, Poster # 1839, 2017.
7. Evashwick-Rogler TW, Lai A, Salandra JM, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, Hecht Ac, Iatridis JC: Disc height loss, but not Pro-inflammatory cytokine or Substance P expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model, Transactions of the Orthopaedic Research Society, Poster Session: PS1-044, Spine – Disc Biology, Poster #: 854, 2017.
8. Palacio-Mancheno P, Evashwick-Rogler TW, Laudier DM, Purmessur D, Iatridis JC: Hyperosmolar Overloading in a Mouse Organ Culture Model Induces Notochordal Cell Differentiation with Osmoregulatory Aquaporin3 Upregulation and Altered N-Cad and Connexin-43 Mechanotransduction Expression, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster # 1817, 2017.
9. Palacio-Mancheno P, Kindschuh WF, Chen X, Harned AA, Iatridis JC: Illien-Jünger S: Age- and Sex-Dependent Effects of Advanced Glycation Endproducts Ingestion on Vertebral Bone Quality and Function, Transactions of the Orthopaedic Research Society, Poster Session: PS1-029, Bone – Musculoskeletal Development and Aging, Poster #: 0672, 2017.

Hand Group Abstract
10. Gluck MJ, Beck CM, Vijayaraghavan S, Iatridis JC, Hausman MR: In Situ Imaging of Rat Median Nerve Damage Using Second Harmonic Generation Microscopy: Advancing Towards an In Vivo Application, Transactions of the Orthopaedic Research Society, Poster Session: PS2-152, Diagnostic Imaging, Poster #: 2241, 2017.
11. Beck CM, Nasser P, Gluck MJ, Hausman MR, Koehler SM: Optimizing the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters, Transactions of the Orthopaedic Research Society, Poster Teaser Session: PS2-042, Poster #: 0328, 2017
12. Gluck MJ, Beck CM, Golan EJ, Nasser PR, Shukla DR, Hausman MR: pMUCL Reconstruction Recovers Elbow Stability In The Presence Of Posteromedial Rotatory Instability: A Cadaveric Study, Transactions of the Orthopaedic Research Society, Late Breaking Poster Session: LB- 156, Late Breaking PS2, Poster #: 2428, 2017