Mount Sinai-Cooper Union Collaborative Symposium

Chris Panebianco along with Drs. Iatridis and Jennifer Weiser were highlighted at the annual Cooper Union-Mount Sinai “Research-Pitch Symposium” on September 24, 2021.

Shown here, Sanjna Rao, undergraduate BME student from Cooper Union, whose primary mentor is Dr. Jennifer Weiser from Cooper Union. Sanja worked with Chris Panebianco, PhD student at Mount Sinai and Cooper Union Alumnus, to make great progress on our cell-delivery projects for annulus fibrosus repair. Sanjna is in the cell culture suite with Chris, Brian Bueno and Dr. Jennifer Gansau.

Mount Sinai SURP and Summer Students 2021

The Spine Lab was delighted to welcome on-site summer students back to the ORL in 2021.

We were exceedingly impressed at the excellence and ambition of all 3 summer students. The SURP students presented excellent posters at Mount Sinai in Guggenheim Pavilion on August

  • Kelsey Goune, pursuing a Biology Major at Lehman College, worked on our neonatal regeneration project with Danielle D’Erminio as main mentor.
  • Kashaf Zaheer, pursuing a Biochemistry Major at Vassar College, worked on our discogenic pain project with Alon Lai as main mentor.
  • Sanjna Rao, pursuing a Biomedical Engineering Major at Cooper Union, worked on our annulus repair projects with Chris Panebianco as main mentor.

ORL Field Days 2021 returns

Team building could not be more fun than during ORL Field Days where Chris Panebianco is an exceptional organizer!

We were happy to have the return of ORL Field Days on June 4, 2021 to celebrate collaboration, fun and 100% vaccination compliance.

Congratulations Keti Vaso on your successful MEng degree from Cooper Union

Congratulations Keti Vaso on your excellent MEng thesis titled ‘Evaluation of the Regenerative Potential of Mesenchymal Stem Cell-derived Exosomes for Annulus Fibrosus Repair and Controlled Delivery Using Hydrogel-embedded Poly(lactic-co-glycolic) Acid Microspheres’ and on your successful defense on April 29, 2021. You were an outstanding contributor with Tyler and our team advancing several ambitious projects. We wish you much continued success in your current position as R&D Scientist at Henkel.

Dr. Weiser from Cooper Union, Keti’s primary mentor, has been an outstanding collaborator with our lab in biomaterials and educational research.

ORS Acceptances!

Congratulations to the team on the excellent ORS abstract acceptances! We are proud of the diverse and exciting work submitted and accepted this year!

  1. Torre OM, Das R, Berenblum RE, Huang AH, Iatridis JC: Neonatal mice intervertebral discs restore function following herniation injury, Transactions of the Orthopaedic Research Society, Session 013, Podium Presentation #: 0068, 2018.
  2. Torre OM, Evashwick-Rogler TW, Iatridis JC: Optimizing Biomechanical Loading Protocols Ex Vivo to Improve Detection of Mild Intervertebral Disc Injuries, Transactions of the Orthopaedic Research Society, PS1-054, Poster #: 0771, 2018.
  3. Krishnamoorthy D, Liu X, Lin L, Xue P, Zhang E, Zhang F, Linhardt RJ, Iatridis JC: Characterization of human lumbar intervertebral disc glycosaminoglycan sulfation patterns using multiple reaction monitoring with liquid chromatography- mass spectrometry, Transactions of the Orthopaedic Research Society, PS1-053, Poster #: 0748, 2018.
  4. Krishnamoorthy D, Torre OM, Natelson D, Smith M, Iatridis JC, Illien-Jünger S: Dietary advanced glycation end product consumption leads to mechanical stiffening of murine intervertebral discs, Transactions of the Orthopaedic Research Society, PS2-152, Poster #: 1630, 2018.
  5. Mui B, DiStefano T, Hecht AC, Iatridis JC: Hydrogel formulation and culture conditions influence TGF- β3 release kinetics and extracellular matrix elaboration in genipin-crosslinked fibrin for annulus fibrosus repair, Transactions of the Orthopaedic Research Society, PS2-154, Poster #: 1666, 2018.
  6. Hom WW, Lin HA, Korda N, Desai JS, Nasser P, Hecht AC, Nicoll SB, Iatridis JC: Ex vivo biomechanical evaluation of a combined annulus fibrosus and nucleus pulposus hydrogel repair in a large animal model of severe intervertebral disc herniation injury, Transactions of the Orthopaedic Research Society, Spine: Modeling and Mechanics, Session 38, Podium Presentation #: 0216, 2018.
  7. Mosley GE, Evashwick-Rogler TW, Kaseta T, Lai A, Iatridis JC: Sex differences in rat lumbar intervertebral discs following annular puncture injury, Transactions of the Orthopaedic Research Society, PS2-152, Poster #: 1641, 2018.
  8. Zhou GK, Bradley EW, Westendorf JJ, Iatridis JC, Illien-Junger S: Role of Phlpp1 in Cell Proliferation and Apoptosis in Intervertebral Discs, Transactions of the Orthopaedic Research Society, PS1-053, Poster #:  0750, 2018.
  9. Real A, Ukogu C, Hecht AC, Iatridis JC: Elevated Glycohemoglobin HbA1c is Associated with Low Back Pain Independent of BMI, Transactions of the Orthopaedic Research Society, PS1-058, Poster #: 0802, 2018.
  10. Gluck MJ, Beck CM, Skodras A, Laudier D, Fowkes ME, Iatridis JC, Cagle PJ, Hausman MR: In Vivo Monitoring of Nerve Structure and Function Following Neural Stretch Injury via SHG Microscopy and Intra-Operative Nerve Stimulation, Transactions of the Orthopaedic Research Society, Session 056, Podium Presentation #: 0308, 2018.

Publication in the Journal of Bone and Mineral Research!

Congratulations to the team on the publication of “Dietary Advanced Glycation End Products Have Sex- and Age-Dependent Effects on Vertebral Bone Microstructure and Mechanical Function in Mice.”!

The recently published manuscript in the Journal of Bone and Mineral Research demonstrated that a poor diet, high in advanced glycation end products can, independent of diabetic or overweight conditions, diminish vertebral microstructure, mechanical behaviors and fracture resistance in young female mice. This work suggests poor diet as a potential cause of accelerated spinal aging, especially in females

Publication in the Spine Journal!

Congratulations to the team on the publication of “Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration.” in the Spine Journal!

This paper is one of the first to identify and localize multiple macrophage phenotypic markers in human IVDs. The most important findings identified CCR7+ and CD163+ macrophages increased with IVD degeneration grade and were significantly more present in IVD regions with structural irregularities and defects. These results improve our understanding of the important role macrophages and macrophage-like cells play in the complex inflammatory processes involved in IVD degeneration.