Peer-Reviewed Articles

2018

Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs. Cruz MA, Hom WW, DiStefano TJ, Merrill R, Torre OM, Lin HA, Hecht AC, Illien-Junger S, Iatridis JCTissue Eng Part A. 2018 Feb;24(3-4):187-198. doi: 10.1089/ten.TEA.2017.0334. Epub 2018 Jan 11. PMID: 29214889

2017

Looking beyond the intervertebral disc: the need for behavioral assays in models of discogenic pain. Mosley GE, Evashwick-Rogler TW, Lai A, Iatridis JC. Ann N Y Acad Sci. 2017 Dec;1409(1):51-66. doi: 10.1111/nyas.13429. Epub 2017 Aug 10. Review. PMID: 28797134

Dietary Advanced Glycation End Products have Sex-and Age Dependent Effects on Vertebral Bone Microstructure and Mechanical Function in Mice. Illien-Jünger S, Palacio-Mancheno P, Kindschuh WF, Chen X, Sroga GE, Vashishth D, Iatridis JC. J Bone Miner Res. 2017 Nov 21. doi: 10.1002/jbmr.3321. [Epub ahead of print] PMID: 29160901

Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration. Nakazawa KR, Walter BA, Laudier DM, Krishnamoorthy D, Mosley GE, Spiller KL, Iatridis JC. Spine J. 2017 Oct 11. pii: S1529-9430(17)31048-3. doi: 10.1016/j.spinee.2017.09.018. [Epub ahead of print] PMID:29031872

Abnormal fetal muscle forces result in defects in spinal curvature and alterations in vertebral segmentation and shape. Rolfe RA, Bezer JH, Kim T, Zaidon AZ, Oyen ML, Iatridis JC, Nowlan NC. J Orthop Res. 2017 Oct;35(10):2135-2144. doi: 10.1002/jor.23518. Epub 2017 May 12. PMID: 28079273 Free PMC Article

Animal models for studying the etiology and treatment of low back pain. Shi C, Qiu S, Riester SM, Das V, Zhu B, Wallace AA, van Wijnen AJ, Mwale F, Iatridis JC, Sakai D, Votta-Velis G, Yuan W, Im HJ. J Orthop Res. 2017 Sep 18. doi: 10.1002/jor.23741. [Epub ahead of print] Review. PMID:28921656

Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N-cadherin expression. Palacio-Mancheno PE, Evashwick-Rogler TW, Laudier DM, Purmessur D, Iatridis JC. J Orthop Res. 2017 Aug 29. doi: 10.1002/jor.23715. [Epub ahead of print] PMID:28853179

Looking beyond the intervertebral disc: the need for behavioral assays in models of discogenic pain. Mosley GE, Evashwick-Rogler TW, Lai A, Iatridis JC. Ann N Y Acad Sci. 2017 Aug 10. doi: 10.1111/nyas.13429. [Epub ahead of print] Review. PMID:28797134

Structural and Chemical Modification to Improve Adhesive and Material Properties of Fibrin-Genipin for Repair of Annulus Fibrosus Defects in Intervertebral Disks. Cruz MA, McAnany S, Gupta N, Long RG, Nasser P, Eglin D, Hecht AC, Illien-Junger S, Iatridis JC. J Biomech Eng. 2017 Aug 1;139(8). doi: 10.1115/1.4036623. PMID: 28464119

Intervertebral Disk Degeneration and Repair. Dowdell J, Erwin M, Choma T, Vaccaro A, Iatridis J, Cho SK. Neurosurgery. 2017 Mar 1;80(3S):S46-S54. doi: 10.1093/neuros/nyw078. Review. PMID:28350945

New horizons in spine research: Intervertebral disc repair and regeneration. Iatridis JC, Kang J, Kandel R, Risbud MV. J Orthop Res. 2017 Jan;35(1):5-7. doi: 10.1002/jor.23499. No abstract available. PMID: 28114734

2016

AGEs induce ectopic endochondral ossification in intervertebral discs Illien-Jünger S, Torre OM, Kindschuh WF, Chen X, Laudier DM, Iatridis JC. Eur Cell Mater. 2016 Nov 18;32:257-270. PMID: 27858401 Free PMC Article

In vitro and biomechanical screening of polyethylene glycol and poly(trimethylene carbonate) block copolymers for annulus fibrosus repair. Long RG, Rotman SG, Hom WW, Assael DJ, Illien-Jünger S, Grijpma DW, Iatridis JC. J Tissue Eng Regen Med. 2016 Nov 12. doi: 10.1002/term.2356. [Epub ahead of print] PMID: 27860368

Does type 2 diabetes mellitus promote intervertebral disc degeneration? Fabiane SM, Ward KJ, Iatridis JC, Williams FM. Eur Spine J. 2016 Sep;25(9):2716-20. doi: 10.1007/s00586-016 4612-3. Epub 2016 Jun 6. PMID: 27272275 Free PMC Article

New Horizons in Spine Research: Disc biology, spine biomechanics and pathomechanisms of back pain. Iatridis JC, Kang J, Kandel R, Risbud MV. J Orthop Res. 2016 Aug;34(8):1287-8. doi: 10.1002/jor.23375. No abstract available. PMID: 27571441 Free PMC Article

Molecular mechanisms of biological aging in intervertebral discs. Vo NV, Hartman RA, Patil PR, Risbud MV, Kletsas D, Iatridis JC, Hoyland JA, Le Maitre CL, Sowa GA, Kang JD. J Orthop Res. 2016 Aug;34(8):1289-306. doi: 10.1002/jor.23195. Epub 2016 Aug 12. Review. PMID: 26890203 Free PMC Article

Reduced tissue osmolarity increases TRPV4 expression and pro-inflammatory cytokines in intervertebral disc cells. Walter BA, Purmessur D, Moon A, Occhiogrosso J, Laudier DM, Hecht AC, Iatridis JC. Eur Cell Mater. 2016 Jul 19;32:123-36. PMID: 27434269 Free PMC Article

Do mechanical strain and TNF-α interact to amplify pro-inflammatory cytokine production in human annulus fibrosus cells? Likhitpanichkul M, Torre OM, Gruen J, Walter BA, Hecht AC, Iatridis JC. J Biomech. 2016 May 3;49(7):1214-1220. doi: 10.1016/j.jbiomech.2016.02.029. Epub 2016 Feb 18.PMID: 26924657 Free PMC Article

Development of a bovine decellularized extracellular matrix-biomaterial for nucleus pulposus regeneration. Illien-Jünger S, Sedaghatpour DD, Laudier DM, Hecht AC, Qureshi SA, Iatridis JC. J Orthop Res. 2016 May;34(5):876-88. doi: 10.1002/jor.23088. Epub 2015 Dec 1. PMID: 26509556 Free PMC Article

Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo. Lai A, Moon A, Purmessur D, Skovrlj B, Laudier DM, Winkelstein BA, Cho SK, Hecht AC, Iatridis JC. Spine J. 2016 Mar;16(3):420-31. doi: 10.1016/j.spinee.2015.11.019. Epub 2015 Dec 2. PMID: 26610672 Free PMC Article

Mechanical restoration and failure analyses of a hydrogel and scaffold composite strategy for annulus fibrosus repair. Long RG, Bürki A, Zysset P, Eglin D, Grijpma DW, Blanquer SBG, Hecht AC, Iatridis JC. Acta Biomater. 2016 Jan;30:116-125. doi: 10.1016/j.actbio.2015.11.015. Epub 2015 Nov 11. PMID: 26577987 Free PMC Article

2015

Form and function of the intervertebral disc in health and disease: a morphological and stain comparison study. Walter BA, Torre OM, Laudier D, Naidich TP, Hecht AC, Iatridis JC. J Anat. 2015 Dec;227(6):707-16. doi: 10.1111/joa.12258. Epub 2014 Nov 25. PMID: 25424497 Free PMC Article

Association Between BMP-2 and Carcinogenicity. Skovrlj B, Koehler SM, Anderson PA, Qureshi SA, Hecht AC, Iatridis JC, Cho SK. Spine (Phila Pa 1976). 2015 Dec;40(23):1862-71. doi: 10.1097/BRS.0000000000001126. Review. PMID: 26274524

Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNFα drug. Likhitpanichkul M, Kim Y, Torre OM, See E, Kazezian Z, Pandit A, Hecht AC, Iatridis JC. Spine J. 2015 Sep 1;15(9):2045-54. doi: 10.1016/j.spinee.2015.04.026. Epub 2015 Apr 23. PMID: 25912501 Free PMC Article

Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells. Walter BA, Purmessur D, Likhitpanichkul M, Weinberg A, Cho SK, Qureshi SA, Hecht AC, Iatridis JC. Spine (Phila Pa 1976). 2015 Jul 1;40(13):955-63. doi: 10.1097/BRS.0000000000000932. PMID: 25893355 Free PMC Article

Assessment of functional and behavioral changes sensitive to painful disc degeneration. Lai A, Moon A, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, Hecht AC, Iatridis JC. J Orthop Res. 2015 May;33(5):755-64. doi: 10.1002/jor.22833. Epub 2015 Mar 31. PMID: 25731955 Free PMC Article

Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability. Purmessur D, Cornejo MC, Cho SK, Roughley PJ, Linhardt RJ, Hecht AC, Iatridis JC. Spine J. 2015 May 1;15(5):1060-9. doi: 10.1016/j.spinee.2015.02.003. Epub 2015 Feb 7. PMID: 25661435 Free PMC Article

TNFα transport induced by dynamic loading alters biomechanics of intact intervertebral discs. Walter BA, Likhitpanichkul M, Illien-Junger S, Roughley PJ, Hecht AC, Iatridis JC. PLoS One. 2015 Mar 3;10(3):e0118358. doi: 10.1371/journal.pone.0118358. eCollection 2015. PMID: 25734788 Free PMC Article

Defining the phenotype of young healthy nucleus pulposus cells: recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting. Risbud MV, Schoepflin ZR, Mwale F, Kandel RA, Grad S, Iatridis JC, Sakai D, Hoyland JA. J Orthop Res. 2015 Mar;33(3):283-93. doi: 10.1002/jor.22789. Epub 2015 Jan 21. PMID: 25411088 Free PMC Article

Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines. Cornejo MC, Cho SK, Giannarelli C, Iatridis JC, Purmessur D. Osteoarthritis Cartilage. 2015 Mar;23(3):487-96. doi: 10.1016/j.joca.2014.12.010. Epub 2014 Dec 19. PMID: 25534363 Free PMC Article

Chronic ingestion of advanced glycation end products induces degenerative spinal changes and hypertrophy in aging pre-diabetic mice. Illien-Jünger S, Lu Y, Qureshi SA, Hecht AC, Cai W, Vlassara H, Striker GE, Iatridis JC. PLoS One. 2015 Feb 10;10(2):e0116625. doi: 10.1371/journal.pone.0116625. eCollection 2015. PMID: 25668621 Free PMC Article

Organ culture bioreactors–platforms to study human intervertebral disc degeneration and regenerative therapy. Gantenbein B, Illien-Jünger S, Chan SC, Walser J, Haglund L, Ferguson SJ, Iatridis JC, Grad S. Curr Stem Cell Res Ther. 2015;10(4):339-52. Review. PMID: 25764196 Free PMC Article