The 44th Annual Meeting of ISSLS took place in Athens, Greece from May 29th to June 2nd, 2017. Dr. Iatridis moderated 1 session (Disc Regeneration) and provided 2 podium presentations: “Hyperosmolar overloading induces notochordal cell differentiation with osmosensitive aquaporin3 upregulation and altered N-cadherin and connexin-43 expression” and “Bioactive dietary polyphenol preparation for preventing painful behavior associated with lumbar disc degeneration: an in-vivo rat model”.
Tag Archives: leadership
Mount Sinai Spine Research Day – May 18
The Sinai Spine Research Day on May 18th highlights the latest clinical and basic science spine research and demonstrates the strong commitment to promote research that answers critical scientific questions while also improving clinical care. This year, four members of the spine lab will be giving presentations:
Alon Lai: “Bioactive dietary polyphenol preparation for preventing painful behavior associated with lumbar disc degeneration”
Thomas Evashwick-Rogler: “Hyperosmolar overloading induces notochordal cell differentiation with osmosensitive Aquaporin3 upregulation and altered Ncadherin and Connexin43 expression”
Rose Long: “Repair of annular injury using a fibrin based sealant in ovine after one year”
Olivia Torre: “Development of an in vivo model of neonatal intervertebral disc injury and regeneration”
5/18/2017
ORS 2017 Recap
The Spine Lab and collaborators successfully presented 10 abstracts this year at ORS in San Diego
- Rolfe RA, Oyen ML, Iatridis JC, Nowlan NC: Short Periods of Fetal Immobility Lead to Dramatic Effects on Spine and Rib Development, Paper #: 212.
- Long RG, Nakai T, Sakai D, Iatridis JC, Alini M, Grad S, Li Z: TGFβ1 induces a contractile CD146+ phenotype of human annulus fibrosus cells and may be delivered in a carrier for annulus fibrosus repair, Poster #: 1793.
- Torre OM, Das R, Mosley GE, Huang AH, Iatridis JC: Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration, Poster #: 1829.
- Cruz MA, Hom WW, Merril R, Torre OM, Nasser P, Hecht AC, Illien-Junger S, Iatridis JC: Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1800, 2017.
- Lin HA, Varma DM, Hom WW, Cruz MA, Nasser PR, Iatridis JC, Nicoll SB: Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1799, 2017.
- Lai A, Evashwick-Rogler TW, Salandra JM, Ho L, Laudier DM, Cho SK, Hecht AC, Winkelstein BA, Pasinetti GM Iatridis JC: A Potential Safe and Novel Drink For Preventing Pain Associated With Disc Degeneration – An In-Vivo Rat Model, Transactions of the Orthopaedic Research Society, Poster session: PS2-121, Poster # 1839, 2017.
- Evashwick-Rogler TW, Lai A, Salandra JM, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, Hecht Ac, Iatridis JC: Disc height loss, but not Pro-inflammatory cytokine or Substance P expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model, Transactions of the Orthopaedic Research Society, Poster Session: PS1-044, Spine – Disc Biology, Poster #: 854, 2017.
- Palacio-Mancheno P, Evashwick-Rogler TW, Laudier DM, Purmessur D, Iatridis JC: Hyperosmolar Overloading in a Mouse Organ Culture Model Induces Notochordal Cell Differentiation with Osmoregulatory Aquaporin3 Upregulation and Altered N-Cad and Connexin-43 Mechanotransduction Expression, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster # 1817, 2017.
- Palacio-Mancheno P, Kindschuh WF, Chen X, Harned AA, Iatridis JC: Illien-Jünger S: Age- and Sex-Dependent Effects of Advanced Glycation Endproducts Ingestion on Vertebral Bone Quality and Function, Transactions of the Orthopaedic Research Society, Poster Session: PS1-029, Bone – Musculoskeletal Development and Aging, Poster #: 0672, 2017.
- Gluck MJ, Beck CM, Vijayaraghavan S, Iatridis JC, Hausman MR: In Situ Imaging of Rat Median Nerve Damage Using Second Harmonic Generation Microscopy: Advancing Towards an In Vivo Application, Transactions of the Orthopaedic Research Society, Poster Session: PS2-152, Diagnostic Imaging, Poster #: 2241, 2017.
James Iatridis also Chaired the ORS Spine Section Meeting and became 2nd Vice President of the ORS. We enjoyed being part of the Van Mow academic tree during his Shands Award Presentation #VanMow #ORS2017.
In addition to research activities, most of the Orthopaedic Research Lab attendees met at Tom Evashwick-Rogler’s family home for a great barbeque in celebration of a very successful meeting.
James Iatridis Elected as 2nd Vice President of ORS
Dr. Iatridis was elected as the 2nd Vice President of the Orthopaedic Research Society. His 4 year term in the presidential lineage on the ORS Board of Directors will begin after the ORS annual meeting in San Diego in March 2017. During his 20 years as a member of the ORS, Dr. Iatridis has served as a program topic chair, regularly organized workshops and judged award competitions, and reviewed abstracts. He has also been the Chair of the ORS/OREF/AAOS New Investigator Research Funding Workshop and the inaugural Chair of the ORS Spine Section. Dr. Iatridis has a strong vision to balancing the growth opportunities offered by the new ORS Sections with focus and efficiency, while also nurturing the broad orthopaedic mission and the cohesive orthopaedic research community. He is committed to building innovative partnerships with diverse involvement across disciplines and geographies.
Source: ORS Election Results
James Iatridis Elected as 2nd Vice President of ORS
Dr. Iatridis was elected as the 2nd Vice President of the Orthopaedic Research Society. His 4 year term in the presidential lineage on the ORS Board of Directors will begin after the ORS annual meeting in San Diego in March 2017. During his 20 years as a member of the ORS, Dr. Iatridis has served as a program topic chair, regularly organized workshops and judged award competitions, and reviewed abstracts. He has also been the Chair of the ORS/OREF/AAOS New Investigator Research Funding Workshop and the inaugural Chair of the ORS Spine Section. Dr. Iatridis has a strong vision to balancing the growth opportunities offered by the new ORS Sections with focus and efficiency, while also nurturing the broad orthopaedic mission and the cohesive orthopaedic research community. He is committed to building innovative partnerships with diverse involvement across disciplines and geographies.
Source: ORS Election Results
Accepted abstracts for ORS 2017
Spine Group Abstracts
1. Rolfe RA, Oyen ML, Iatridis JC, Nowlan NC: Short Periods of Fetal Immobility Lead to Dramatic Effects on Spine and Rib Development, Transactions of the Orthopaedic Research Society, Podium Session: 31,
Spine Pathogenesis and Therapeutics, 11:00 AM – 11:10 AM, Paper #: 212, 2017.
2. Long RG, Nakai T, Sakai D, Iatridis JC, Alini M, Grad S, Li Z: TGFβ1 induces a contractile CD146+ phenotype of human annulus fibrosus cells and may be delivered in a carrier for annulus fibrosus repair, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Poster #: 1793, 2017.
3. Torre OM, Das R, Mosley GE, Huang AH, Iatridis JC: Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster #: 1829, 2017.
4. Cruz MA, Hom WW, Merril R, Torre OM, Nasser P, Hecht AC, Illien-Junger S, Iatridis JC: Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1800, 2017.
5. Lin HA, Varma DM, Hom WW, Nasser PR, Iatridis JC, Nicoll SB: Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1799, 2017.
6. Lai A, Evashwick-Rogler TW, Salandra JM, Ho L, Laudier DM, Cho SK, Hecht AC, Winkelstein BA, Pasinetti GM Iatridis JC: A Potential Safe and Novel Drink For Preventing Pain Associated With Disc Degeneration – An In-Vivo Rat Model, Transactions of the Orthopaedic Research Society, Poster session: PS2-121, Poster # 1839, 2017.
7. Evashwick-Rogler TW, Lai A, Salandra JM, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, Hecht Ac, Iatridis JC: Disc height loss, but not Pro-inflammatory cytokine or Substance P expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model, Transactions of the Orthopaedic Research Society, Poster Session: PS1-044, Spine – Disc Biology, Poster #: 854, 2017.
8. Palacio-Mancheno P, Evashwick-Rogler TW, Laudier DM, Purmessur D, Iatridis JC: Hyperosmolar Overloading in a Mouse Organ Culture Model Induces Notochordal Cell Differentiation with Osmoregulatory Aquaporin3 Upregulation and Altered N-Cad and Connexin-43 Mechanotransduction Expression, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster # 1817, 2017.
9. Palacio-Mancheno P, Kindschuh WF, Chen X, Harned AA, Iatridis JC: Illien-Jünger S: Age- and Sex-Dependent Effects of Advanced Glycation Endproducts Ingestion on Vertebral Bone Quality and Function, Transactions of the Orthopaedic Research Society, Poster Session: PS1-029, Bone – Musculoskeletal Development and Aging, Poster #: 0672, 2017.
Hand Group Abstract
10. Gluck MJ, Beck CM, Vijayaraghavan S, Iatridis JC, Hausman MR: In Situ Imaging of Rat Median Nerve Damage Using Second Harmonic Generation Microscopy: Advancing Towards an In Vivo Application, Transactions of the Orthopaedic Research Society, Poster Session: PS2-152, Diagnostic Imaging, Poster #: 2241, 2017.
11. Beck CM, Nasser P, Gluck MJ, Hausman MR, Koehler SM: Optimizing the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters, Transactions of the Orthopaedic Research Society, Poster Teaser Session: PS2-042, Poster #: 0328, 2017
12. Gluck MJ, Beck CM, Golan EJ, Nasser PR, Shukla DR, Hausman MR: pMUCL Reconstruction Recovers Elbow Stability In The Presence Of Posteromedial Rotatory Instability: A Cadaveric Study, Transactions of the Orthopaedic Research Society, Late Breaking Poster Session: LB- 156, Late Breaking PS2, Poster #: 2428, 2017
PSRS 2016 meeting – November 4, 2016
Spine Research Lab at Philadelphia Spine Research Symposium (PSRS) in Philadelphia, PA held November 4, 2016.
Olivia Torre (left) and Rose Long (right) after winning first and third prize in podium presentations at the Philadelphia Spine Research Symposium (PSRS) in Philadelphia, PA held November 4, 2016.
On November 4, 2016, the Iatridis Lab attended the 2016 Philadelphia Spine Research Symposium (PSRS) held at Drexel University in Philadelphia. The meeting aimed to “cover all areas of spine research spanning from basic to clinical, and encompass the broad areas of development, pathophysiology, aging, pain, therapeutics and diagnostics.”
Dr. James Iatridis served as one of the organizers of the upcoming symposium while 4 podium presentations and 1 poster was presented from Mount Sinai. Rose Long present her podium presentation entitled, “TGF-β1 Induces a Contractile CD146+ Phenotype of Human Annulus Fibrosus Cells with Affinity to Collagen Scaffold for Annulus Fibrosus Repair and won 3rd prize in podium presentations while Olivia Torre presented her podium presentation entitled, “Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration” and won first prize in podium presentations. In addition, Tom Evashwick-Rogler presented his podium presentation entitled, “Disc Height Loss, But Not Pro-Inflammatory Cytokine or Substance P Expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model” and Huizi Anna Lin presented her podium presentation entitiled, “Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility”. Finally, Warren Hom presented his poster entitled, Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs”.
More information about the symposium can be found here: http://www.philaspinemeeting.org/index.html
5th Annual Musculoskeletal Repair and Regeneration Symposium – October 13, 2016
Organizers and speakers of the 5th Annual Musculoskeletal Repair and Regeneration Symposium
The Mount Sinai ORL attended the 5th Annual Musculoskeletal Repair and Regeneration Symposium at Albert Einstein College of Medicine on October 13, 2016. The symposium mission is “to expand the knowledge base within the field, and to foster creativity, collaboration and networking between researchers throughout the region.”
During the symposium, Dr. Alice Huang gave a presentation entitled “Regulation of tendon regeneration” and Dr. James Iatridis presented his talk entitled “Injury, inflammation, and altered mechanotransduction in the intervertebral disc” while also serving as the Steering Chair for the “Novel views into musculoskeletal degenerative diseases” session. In addition, Rose Long presented her poster, “CD146+ phenotype of human annulus fibrosus cells induced by TGFβ1 has affinity to collagen scaffold aimed for annulus fibrosus repair” and together Matthew Gluck and Christina Beck presented their posters “In Situ Imaging of Rat Median Nerve Damage Using SHG Microscopy: Advancing Towards an In Vivo Application” and “Biomechanical Analysis of the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters”.
More information about the symposium can be found here:https://www.einstein.yu.edu/departments/orthopaedic-surgery/symposium/
5th Annual Musculoskeletal Repair and Regeneration Symposium – October 13, 2016
Organizers and speakers of the 5th Annual Musculoskeletal Repair and Regeneration Symposium
The Mount Sinai ORL attended the 5th Annual Musculoskeletal Repair and Regeneration Symposium at Albert Einstein College of Medicine on October 13, 2016. The symposium mission is “to expand the knowledge base within the field, and to foster creativity, collaboration and networking between researchers throughout the region.”
During the symposium, Dr. Alice Huang gave a presentation entitled “Regulation of tendon regeneration” and Dr. James Iatridis presented his talk entitled “Injury, inflammation, and altered mechanotransduction in the intervertebral disc” while also serving as the Steering Chair for the “Novel views into musculoskeletal degenerative diseases” session. In addition, Rose Long presented her poster, “CD146+ phenotype of human annulus fibrosus cells induced by TGFβ1 has affinity to collagen scaffold aimed for annulus fibrosus repair” and together Matthew Gluck and Christina Beck presented their posters “In Situ Imaging of Rat Median Nerve Damage Using SHG Microscopy: Advancing Towards an In Vivo Application” and “Biomechanical Analysis of the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters”.
More information about the symposium can be found here: https://www.einstein.yu.edu/departments/orthopaedic-surgery/symposium/
JOR: New Horizons in Spine Research
Special Issue: New Horizons in Spine Research – Part 1: Disc Biology, Spine Biomechanics, and Pathomechanisms of Back Pain
August 2016
Volume 34, Issue 8
Pages 1283–1491
Issue edited by: James C. Iatridis, James Kang, Rita Kandel, Makarand V. Risbud
To advance novel spine science and collaborations, the 3rd International Spine Research Symposium, co-sponsored by the Philadelphia Spine Research Society (PSRS), NIAMS/NIH and the Orthopaedic Research Society (ORS), was held to enhance understanding of the clinical problems associated with degenerative disc disease, and to highlight cutting-edge scientific research in areas of basic biology, epidemiology, disease mechanisms, biomechanics, tissue engineering and imaging of the intervertebral disc (IVD).[4] This special issue on ‘New Horizons in Spine Research’ and a second issue to follow at a later date are outcomes from that meeting, with articles selected from the strong response to the ‘call for papers’. This issue focuses on the fundamental topics of disc ageing and cell biology, spine biomechanics, anatomy and imaging, and pathomechanisms of spine pain. A second special issue will focus on repair and regeneration. This growing passion for advancing spine research and improving spinal health has ignited the spine research community to coalesce within the Orthopaedic Research Society as the newly formed Spine Section (http://www.ors.org/spinesection/) in order to enhance communication and collaboration. Read the issue.