Category Archives: Presentation

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ORS Acceptances!

Congratulations to the team on the excellent ORS abstract acceptances! We are proud of the diverse and exciting work submitted and accepted this year!

  1. Torre OM, Das R, Berenblum RE, Huang AH, Iatridis JC: Neonatal mice intervertebral discs restore function following herniation injury, Transactions of the Orthopaedic Research Society, Session 013, Podium Presentation #: 0068, 2018.
  2. Torre OM, Evashwick-Rogler TW, Iatridis JC: Optimizing Biomechanical Loading Protocols Ex Vivo to Improve Detection of Mild Intervertebral Disc Injuries, Transactions of the Orthopaedic Research Society, PS1-054, Poster #: 0771, 2018.
  3. Krishnamoorthy D, Liu X, Lin L, Xue P, Zhang E, Zhang F, Linhardt RJ, Iatridis JC: Characterization of human lumbar intervertebral disc glycosaminoglycan sulfation patterns using multiple reaction monitoring with liquid chromatography- mass spectrometry, Transactions of the Orthopaedic Research Society, PS1-053, Poster #: 0748, 2018.
  4. Krishnamoorthy D, Torre OM, Natelson D, Smith M, Iatridis JC, Illien-Jünger S: Dietary advanced glycation end product consumption leads to mechanical stiffening of murine intervertebral discs, Transactions of the Orthopaedic Research Society, PS2-152, Poster #: 1630, 2018.
  5. Mui B, DiStefano T, Hecht AC, Iatridis JC: Hydrogel formulation and culture conditions influence TGF- β3 release kinetics and extracellular matrix elaboration in genipin-crosslinked fibrin for annulus fibrosus repair, Transactions of the Orthopaedic Research Society, PS2-154, Poster #: 1666, 2018.
  6. Hom WW, Lin HA, Korda N, Desai JS, Nasser P, Hecht AC, Nicoll SB, Iatridis JC: Ex vivo biomechanical evaluation of a combined annulus fibrosus and nucleus pulposus hydrogel repair in a large animal model of severe intervertebral disc herniation injury, Transactions of the Orthopaedic Research Society, Spine: Modeling and Mechanics, Session 38, Podium Presentation #: 0216, 2018.
  7. Mosley GE, Evashwick-Rogler TW, Kaseta T, Lai A, Iatridis JC: Sex differences in rat lumbar intervertebral discs following annular puncture injury, Transactions of the Orthopaedic Research Society, PS2-152, Poster #: 1641, 2018.
  8. Zhou GK, Bradley EW, Westendorf JJ, Iatridis JC, Illien-Junger S: Role of Phlpp1 in Cell Proliferation and Apoptosis in Intervertebral Discs, Transactions of the Orthopaedic Research Society, PS1-053, Poster #:  0750, 2018.
  9. Real A, Ukogu C, Hecht AC, Iatridis JC: Elevated Glycohemoglobin HbA1c is Associated with Low Back Pain Independent of BMI, Transactions of the Orthopaedic Research Society, PS1-058, Poster #: 0802, 2018.
  10. Gluck MJ, Beck CM, Skodras A, Laudier D, Fowkes ME, Iatridis JC, Cagle PJ, Hausman MR: In Vivo Monitoring of Nerve Structure and Function Following Neural Stretch Injury via SHG Microscopy and Intra-Operative Nerve Stimulation, Transactions of the Orthopaedic Research Society, Session 056, Podium Presentation #: 0308, 2018.
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ORS PSRS 2017

The Iatridis & Illien-Junger Labs had a great time at the ORS PSRS 4th International Spine Research Symposium in Lake Harmony PA! Chaired by Makarand Risbud, PSRS is a unique meeting in which prominent investigators and trainees in the spine research community come together to share their latest findings, trends, and ideas.

Congratulations to our PhD Candidate, Olivia Torre, on being a recipient of the “ORS PSRS Trainee Podium Award for Outstanding Scientific Research”! Her presentation, “Functional Restoration of Intervertebral Disc Biomechanics Following Neonatal Herniation Injury,” was delivered during the ‘Disc Biomechanics and Imaging’ session on October 26th, 2017.

Congratulations to Assistant Professor, Dr. Svenja Illien-Junger, on being a recipient of the Young Investigator Award. Dr. Illien-Junger advises ORL’s MS student, George Zhao, who presented the poster, “Phlpp1 in Cell Proliferation and Apoptosis During IVD Growth and Degeneration,” during the second poster session on October 25th, 2017.

In addition to these awards, Dr. Iatridis gave a fantastic talk titled, “Annulus Fibrosus Injury, Repair, and Regeneration” and Dr. Krishnamoorthy presented her poster, “Characterization of Human Lumbar Intervertebral Disc Glycosaminoglycan Sulfation Patterns using Multiple Reaction Monitoring with Liquid Chromatography-mass Spectrometry”.

We are very proud of these achievements and we look forward to ORL’s future research successes!

In addition to presenting our research and networking within the community, the Spine Lab enjoyed the time away from NYC in the Poconos.

Team learns about disc pathobiology:

Dr. James Iatridis giving his talk:

 Olivia receiving her award:

Svenja receiving her award:

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Einstein Meeting 2017

Thursday, October 19th marked the 6th annual Musculoskeletal Repair and Regeneration Symposium hosted by the Albert Einstein College of Medicine. Orthopaedic research at Mount Sinai was well represented at the meeting with multiple posters and a talk from Dr. James Iatridis on annulus fibrosis repair in a large animal model. Most excitingly, Olivia Torre was named one of three winners of the Young Investigator Award for graduate students and postdoctoral fellows for her work on injury and regeneration in the neonatal mouse intervertebral disc.

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Take a look at the Huang Laboratory Page for a Related Post!

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Sun Valley Invited Presentation

James attended the ORS Musculoskeletal Biology Workshop at Sun Valley!  He participated in the panel discussion “Grant Writing Advice for Junior Investigators”. He also chaired and presented at the session entitled “Problems in Orthopaedics: Degenerative Disk Disease” with Drs. Mak Risbud and James Kang.

Hiking in Sawtooth National Forest with Dr. Jim Kang and also with conference organizers Drs. David Burr and Teresita Bellido.

 

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ISSLS Annual Meeting – May 29-June 2

The 44th Annual Meeting of ISSLS took place in Athens, Greece from May 29th to June 2nd, 2017. Dr. Iatridis moderated 1 session (Disc Regeneration) and provided 2 podium presentations: “Hyperosmolar overloading induces notochordal cell differentiation with osmosensitive aquaporin3 upregulation and altered N-cadherin and connexin-43 expression” and “Bioactive dietary polyphenol preparation for preventing painful behavior associated with lumbar disc degeneration: an in-vivo rat model”.

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ORS 2017 Recap

The Spine Lab and collaborators successfully presented 10 abstracts this year at ORS in San Diego

  1. Rolfe RA, Oyen ML, Iatridis JC, Nowlan NC: Short Periods of Fetal Immobility Lead to Dramatic Effects on Spine and Rib Development, Paper #: 212.
  2. Long RG, Nakai T, Sakai D, Iatridis JC, Alini M, Grad S, Li Z: TGFβ1 induces a contractile CD146+ phenotype of human annulus fibrosus cells and may be delivered in a carrier for annulus fibrosus repair, Poster #: 1793.
  3. Torre OM, Das R, Mosley GE, Huang AH, Iatridis JC: Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration, Poster #: 1829.
  4. Cruz MA, Hom WW, Merril R, Torre OM, Nasser P, Hecht AC, Illien-Junger S, Iatridis JC: Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1800, 2017.
  5. Lin HA, Varma DM, Hom WW, Cruz MA, Nasser PR, Iatridis JC, Nicoll SB: Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1799, 2017.
  6. Lai A, Evashwick-Rogler TW, Salandra JM, Ho L, Laudier DM, Cho SK, Hecht AC, Winkelstein BA,  Pasinetti GM Iatridis JC: A Potential Safe and Novel Drink For Preventing Pain Associated With Disc Degeneration – An In-Vivo Rat Model, Transactions of the Orthopaedic Research Society, Poster session: PS2-121, Poster # 1839, 2017.
  7. Evashwick-Rogler TW, Lai A, Salandra JM, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, Hecht Ac, Iatridis JC: Disc height loss, but not Pro-inflammatory cytokine or Substance P expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model, Transactions of the Orthopaedic Research Society, Poster Session: PS1-044, Spine – Disc Biology, Poster #: 854, 2017.
  8. Palacio-Mancheno P, Evashwick-Rogler TW, Laudier DM, Purmessur D, Iatridis JC: Hyperosmolar Overloading in a Mouse Organ Culture Model Induces Notochordal Cell Differentiation with Osmoregulatory Aquaporin3 Upregulation and Altered N-Cad and Connexin-43 Mechanotransduction Expression, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster # 1817, 2017.
  9. Palacio-Mancheno P, Kindschuh WF, Chen X, Harned AA, Iatridis JC: Illien-Jünger S: Age- and Sex-Dependent Effects of Advanced Glycation Endproducts Ingestion on Vertebral Bone Quality and Function, Transactions of the Orthopaedic Research Society, Poster Session: PS1-029, Bone – Musculoskeletal Development and Aging,  Poster #: 0672, 2017.
  10. Gluck MJ, Beck CM, Vijayaraghavan S, Iatridis JC, Hausman MR: In Situ Imaging of Rat Median Nerve Damage Using Second Harmonic Generation Microscopy: Advancing Towards an In Vivo Application, Transactions of the Orthopaedic Research Society, Poster Session: PS2-152, Diagnostic Imaging, Poster #: 2241, 2017.

James Iatridis also Chaired the ORS Spine Section Meeting and became 2nd Vice President of the ORS. We enjoyed being part of the Van Mow academic tree during his Shands Award Presentation #VanMow #ORS2017.

In addition to research activities, most of the Orthopaedic Research Lab attendees met at Tom Evashwick-Rogler’s family home for a great barbeque in celebration of a very successful meeting.

 

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ORL Accepted Abstracts for ORS 2017

Spine Group Abstracts
1. Rolfe RA, Oyen ML, Iatridis JC, Nowlan NC: Short Periods of Fetal Immobility Lead to Dramatic Effects on Spine and Rib Development, Transactions of the Orthopaedic Research Society, Podium Session: 31,
Spine Pathogenesis and Therapeutics, 11:00 AM – 11:10 AM, Paper #: 212, 2017.
2. Long RG, Nakai T, Sakai D, Iatridis JC, Alini M, Grad S, Li Z: TGFβ1 induces a contractile CD146+ phenotype of human annulus fibrosus cells and may be delivered in a carrier for annulus fibrosus repair, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Poster #: 1793, 2017.
3. Torre OM, Das R, Mosley GE, Huang AH, Iatridis JC: Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster #: 1829, 2017.
4. Cruz MA, Hom WW, Merril R, Torre OM, Nasser P, Hecht AC, Illien-Junger S, Iatridis JC: Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1800, 2017.
5. Lin HA, Varma DM, Hom WW, Nasser PR, Iatridis JC, Nicoll SB: Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1799, 2017.
6. Lai A, Evashwick-Rogler TW, Salandra JM, Ho L, Laudier DM, Cho SK, Hecht AC, Winkelstein BA, Pasinetti GM Iatridis JC: A Potential Safe and Novel Drink For Preventing Pain Associated With Disc Degeneration – An In-Vivo Rat Model, Transactions of the Orthopaedic Research Society, Poster session: PS2-121, Poster # 1839, 2017.
7. Evashwick-Rogler TW, Lai A, Salandra JM, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, Hecht Ac, Iatridis JC: Disc height loss, but not Pro-inflammatory cytokine or Substance P expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model, Transactions of the Orthopaedic Research Society, Poster Session: PS1-044, Spine – Disc Biology, Poster #: 854, 2017.
8. Palacio-Mancheno P, Evashwick-Rogler TW, Laudier DM, Purmessur D, Iatridis JC: Hyperosmolar Overloading in a Mouse Organ Culture Model Induces Notochordal Cell Differentiation with Osmoregulatory Aquaporin3 Upregulation and Altered N-Cad and Connexin-43 Mechanotransduction Expression, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster # 1817, 2017.
9. Palacio-Mancheno P, Kindschuh WF, Chen X, Harned AA, Iatridis JC: Illien-Jünger S: Age- and Sex-Dependent Effects of Advanced Glycation Endproducts Ingestion on Vertebral Bone Quality and Function, Transactions of the Orthopaedic Research Society, Poster Session: PS1-029, Bone – Musculoskeletal Development and Aging, Poster #: 0672, 2017.

Hand and Elbow Group Abstracts
1. Gluck MJ, Beck CM, Vijayaraghavan S, Iatridis JC, Hausman MR: In Situ Imaging of Rat Median Nerve Damage Using Second Harmonic Generation Microscopy: Advancing Towards an In Vivo Application, Transactions of the Orthopaedic Research Society, Poster Session: PS2-152, Diagnostic Imaging, Poster #: 2241, 2017.
2. Beck CM, Nasser P, Gluck MJ, Hausman MR, Koehler SM: Optimizing the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters, Transactions of the Orthopaedic Research Society, Poster Teaser Session: PS2-042, Poster #: 0328, 2017
3. Gluck MJ, Beck CM, Golan EJ, Nasser PR, Shukla DR, Hausman MR: pMUCL Reconstruction Recovers Elbow Stability In The Presence Of Posteromedial Rotatory Instability: A Cadaveric Study, Transactions of the Orthopaedic Research Society, Late Breaking Poster Session: LB- 156, Late Breaking PS2, Poster #: 2428, 2017

Tendon Group Abstracts
1.“The role of innate and adaptive immunity in regenerative and non-regenerative tendon healing” by Kristen Howell and Alice Huang will be presented in the Tendon and Ligament Biology Session, March 21, 2017 (11:00 am).
2. “Targeted Smad4 Deletion in Tenocytes Enables Tendon Cell Recruitment After Adult Tendon Injury” by Chun (Jerry) Chien, Kristen Howell, and Alice Huang will be presented in the Tendon and Ligament: Cell Biology Poster Session One, March 20-21, 2017.
3. “Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration” by Olivia Torre, Grace Mosley, Rohit Das, Alice Huang, and James Iatridis will be presented in the Spine: Disc Biology Poster Session Two, March 21-22, 2017.
4. “Scleraxis is Essential for Tenocyte Recruitment to Enable Tendon Growth” by Deepanwita Pal, Alice Huang, Lingyan Wang, John Brigande, and Ronen Schweitzer will be presented in the Tendon and Ligament Biology Session, March 21, 2017 (10:30am).
5. “Smad4 Regulation of Tendon Elongation” by Saundra Schlesinger, Seong Seo, Alice Huang, Brian Pryce, Ronen Schweitzer will be presented in the Tendon and Ligament: Cell Biology Poster Session Two, March 21-22, 2017.

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PSRS 2016 meeting – November 4, 2016

PSRS 2016 - Iatridis Lab
Spine Research Lab at Philadelphia Spine Research Symposium (PSRS) in Philadelphia, PA held November 4, 2016.

PSRS 2016 - Olivia and Rose
Olivia Torre (left) and Rose Long (right) after winning first and third prize in podium presentations at the Philadelphia Spine Research Symposium (PSRS) in Philadelphia, PA held November 4, 2016.

On November 4, 2016, the Iatridis Lab attended the 2016 Philadelphia Spine Research Symposium (PSRS) held at Drexel University in Philadelphia.  The meeting aimed to “cover all areas of spine research spanning from basic to clinical, and encompass the broad areas of development, pathophysiology, aging, pain, therapeutics and diagnostics.”

Dr. James Iatridis served as one of the organizers of the upcoming symposium while 4 podium presentations and 1 poster was presented from Mount Sinai.  Rose Long present her podium presentation entitled,  “TGF-β1 Induces a Contractile CD146+ Phenotype of Human Annulus Fibrosus Cells with Affinity to Collagen Scaffold for Annulus Fibrosus Repair and won 3rd prize in podium presentations while Olivia Torre presented her podium presentation entitled, “Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration” and won first prize in podium presentations.  In addition, Tom Evashwick-Rogler presented his podium presentation entitled,  “Disc Height Loss, But Not Pro-Inflammatory Cytokine or Substance P Expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model” and Huizi Anna Lin presented her podium presentation entitiled,  “Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility”.   Finally, Warren Hom presented his poster entitled, Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs”.

More information about the symposium can be found here:  http://www.philaspinemeeting.org/index.html