Publication in the Journal of Orthopaedic Research!

Congratulations to the team on the publication of “Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N-cadherin expression.”!

The recently published paper in the Journal of Orthopaedic Research identifies extracellular osmolarity as a triggering mechanism for nucleus pulposus maturation and identifies a compensatory shift in osmosensitive and mechanotransductive proteins from notochoral cells to small nucleus pulposus cells. This work furthers our understanding of the processes underlying IVD aging and mechanotransduction.