Publication in the Journal of Bone and Mineral Research!

Congratulations to the team on the publication of “Dietary Advanced Glycation End Products Have Sex- and Age-Dependent Effects on Vertebral Bone Microstructure and Mechanical Function in Mice.”!

The recently published manuscript in the Journal of Bone and Mineral Research demonstrated that a poor diet, high in advanced glycation end products can, independent of diabetic or overweight conditions, diminish vertebral microstructure, mechanical behaviors and fracture resistance in young female mice. This work suggests poor diet as a potential cause of accelerated spinal aging, especially in females

Publication in the Spine Journal!

Congratulations to the team on the publication of “Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration.” in the Spine Journal!

This paper is one of the first to identify and localize multiple macrophage phenotypic markers in human IVDs. The most important findings identified CCR7+ and CD163+ macrophages increased with IVD degeneration grade and were significantly more present in IVD regions with structural irregularities and defects. These results improve our understanding of the important role macrophages and macrophage-like cells play in the complex inflammatory processes involved in IVD degeneration.

Publication in the Journal of Orthopaedic Research!

Congratulations to the team on the publication of “Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N-cadherin expression.”!

The recently published paper in the Journal of Orthopaedic Research identifies extracellular osmolarity as a triggering mechanism for nucleus pulposus maturation and identifies a compensatory shift in osmosensitive and mechanotransductive proteins from notochoral cells to small nucleus pulposus cells. This work furthers our understanding of the processes underlying IVD aging and mechanotransduction.

PSRS Acceptances

Congratulations to our team for the acceptances for a podium presentation and poster presentations in the ORS PSRS 4th International Spine Research Symposium!

Torre OM, Das R, Berenblum RE, Huang AH, Iatridis JC: Functional restoration of intervertebral disc biomechanics following neonatal herniation injury, ORS PSRS 4th International Spine Research Symposium, Podium, 2017.

Zhou GK, Bradley EW, Westendorf JJ, Iatridis JC, Illien-Junger S: Phlpp1 in Cell Proliferation and Apoptosis During IVD Growth and Degeneration, ORS PSRS 4th International Spine Research Symposium, Poster, 2017.

Krishnamoorthy D, Liu X, Lin L , Xue  P, Zhang E, Zhang F, Linhardt RJ, Iatridis JC: Characterization of human lumbar intervertebral disc glycosaminoglycan sulfation patterns using multiple reaction monitoring with liquid chromatography- mass spectrometry, ORS PSRS 4th International Spine Research Symposium, Poster, 2017.

Dr. Iatridis was also invited to talk at the ORS PSRS Spine Research Symposium on the topic “Annulus fibrosus injury, repair, and regeneration”.

We look forward to attending and presenting at the ORS PSRS 4th International Spine Research Symposium at Split Rock Resort in Lake Harmony, Pennsylvania on October 27th.

5th Annual Musculoskeletal Repair and Regeneration Symposium – October 13, 2016

Einstein Symposium 2016_resized
Organizers and speakers of the 5th Annual Musculoskeletal Repair and Regeneration Symposium

The Mount Sinai ORL attended the 5th Annual Musculoskeletal Repair and Regeneration Symposium at Albert Einstein College of Medicine on October 13, 2016. The symposium mission is “to expand the knowledge base within the field, and to foster creativity, collaboration and networking between researchers throughout the region.”

During the symposium, Dr. Alice Huang gave a presentation entitled “Regulation of tendon regeneration” and Dr. James Iatridis presented his talk entitled “Injury, inflammation, and altered mechanotransduction in the intervertebral disc” while also serving as the Steering Chair for the “Novel views into musculoskeletal degenerative diseases” session. In addition, Rose Long presented her poster, “CD146+ phenotype of human annulus fibrosus cells induced by TGFβ1 has affinity to collagen scaffold aimed for annulus fibrosus repair” and together Matthew Gluck and Christina Beck presented their posters “In Situ Imaging of Rat Median Nerve Damage Using SHG Microscopy: Advancing Towards an In Vivo Application” and “Biomechanical Analysis of the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters”.

More information about the symposium can be found here:

JOR: New Horizons in Spine Research

JOR - New Horizons in Spine ResearchSpecial Issue: New Horizons in Spine Research – Part 1: Disc Biology, Spine Biomechanics, and Pathomechanisms of Back Pain

August 2016

Volume 34, Issue 8

Pages 1283–1491

Issue edited by: James C. Iatridis, James Kang, Rita Kandel, Makarand V. Risbud

To advance novel spine science and collaborations, the 3rd International Spine Research Symposium, co-sponsored by the Philadelphia Spine Research Society (PSRS), NIAMS/NIH and the Orthopaedic Research Society (ORS), was held to enhance understanding of the clinical problems associated with degenerative disc disease, and to highlight cutting-edge scientific research in areas of basic biology, epidemiology, disease mechanisms, biomechanics, tissue engineering and imaging of the intervertebral disc (IVD).[4] This special issue on ‘New Horizons in Spine Research’ and a second issue to follow at a later date are outcomes from that meeting, with articles selected from the strong response to the ‘call for papers’. This issue focuses on the fundamental topics of disc ageing and cell biology, spine biomechanics, anatomy and imaging, and pathomechanisms of spine pain. A second special issue will focus on repair and regeneration. This growing passion for advancing spine research and improving spinal health has ignited the spine research community to coalesce within the Orthopaedic Research Society as the newly formed Spine Section ( in order to enhance communication and collaboration. Read the issue.

Orthopaedic Research Society Spine Section 2016 Annual Meeting

Spine-Section-Awards-1024x684ORS Spine Section 2016 Poster and Podium award winners with ORS Spine Section leadership.

The ORS Spine Section held its first section meeting on Friday, March 4 as part of the ORS 2016 Annual Meeting programming at Disney’s Coronado Springs Resort in Orlando, Florida.

The theme for the 2016 meeting was Spine Research for Functional Translation with scientific symposia on animal models and imaging. Invited speakers included spine researchers and clinicians representing academics, government, and industry.

The ORS Spine Section meeting aimed to disseminate cutting edge information on focus topics of interest, to develop & strengthen collaborative research networks, to support young investigators, and to engage clinicians & industry experts.  Dr. James Iatridis (shown sixth from left) served as the Chair of the newly created ORS Spine section for 2015 and 2016.  Svenja Illien-Junger, PhD (shown third from left) received a Podium Award at for her presentation at this year’s meeting.  In all, Dr. Iatridis’ Spine Bioengineer Lab had nine podium presentations at the ORS.

In addition, Mount Sinai alums Dr. Devina Purmessur and Dr. Nelly Andarawis-Puri organized two popular New Investigator mentoring sessions: I) Successfully competing for a faculty position and II) How to lead and motivate a successful team.  As one of the leaders of Orthopaedic Research, Dr. James Iatridis was invited to give a lecture on “Choosing the right people” for the second session.

The tendon research program was well represented at the ORS this year with three podium presentations given by Dr. Alice Huang, Kristen Howell, and David Shiovitz.  Dr. Huang also served as a moderator for the New Investigator mentoring sessions I and II, as well as Tendon and Ligament: Cell Biology and Development.