Welcome to Divya Krishnamoorthy who joined the spine lab as a Post-doctoral Fellow who recently graduated with her PhD in Biomedical Engineering in the lab of Dr. Clinton Rubin from the State University of New York, Stony Brook. Divya will work with James Iatridis and Svenja Illien-Junger to identify effects of diabetes and diet on spinal pathologies including investigating interactions between the intervertebral disc and vertebrae.
Tag Archives: spine
Congratulations and Farewell to Paolo Palacio-Mancheno
Congratulations to Paolo Palacio-Mancheno, PhD for his new job at Procter & Gamble as a Research Scientist! In the 2 years that Paolo has been a Postdoctoral Fellow, he has made many contributions toward advancing intervertebral disc research. In addition to his research and leadership skills, Paolo has been a great friend, colleague, and mentor to everyone in the lab. While we are sad to see him leave, we wish him the best in his new position at P&G.
James Iatridis Elected as 2nd Vice President of ORS
Dr. Iatridis was elected as the 2nd Vice President of the Orthopaedic Research Society. His 4 year term in the presidential lineage on the ORS Board of Directors will begin after the ORS annual meeting in San Diego in March 2017. During his 20 years as a member of the ORS, Dr. Iatridis has served as a program topic chair, regularly organized workshops and judged award competitions, and reviewed abstracts. He has also been the Chair of the ORS/OREF/AAOS New Investigator Research Funding Workshop and the inaugural Chair of the ORS Spine Section. Dr. Iatridis has a strong vision to balancing the growth opportunities offered by the new ORS Sections with focus and efficiency, while also nurturing the broad orthopaedic mission and the cohesive orthopaedic research community. He is committed to building innovative partnerships with diverse involvement across disciplines and geographies.
Source: ORS Election Results
James Iatridis Elected as 2nd Vice President of ORS
Dr. Iatridis was elected as the 2nd Vice President of the Orthopaedic Research Society. His 4 year term in the presidential lineage on the ORS Board of Directors will begin after the ORS annual meeting in San Diego in March 2017. During his 20 years as a member of the ORS, Dr. Iatridis has served as a program topic chair, regularly organized workshops and judged award competitions, and reviewed abstracts. He has also been the Chair of the ORS/OREF/AAOS New Investigator Research Funding Workshop and the inaugural Chair of the ORS Spine Section. Dr. Iatridis has a strong vision to balancing the growth opportunities offered by the new ORS Sections with focus and efficiency, while also nurturing the broad orthopaedic mission and the cohesive orthopaedic research community. He is committed to building innovative partnerships with diverse involvement across disciplines and geographies.
Source: ORS Election Results
ORL Accepted Abstracts for ORS 2017
Spine Group Abstracts
1. Rolfe RA, Oyen ML, Iatridis JC, Nowlan NC: Short Periods of Fetal Immobility Lead to Dramatic Effects on Spine and Rib Development, Transactions of the Orthopaedic Research Society, Podium Session: 31,
Spine Pathogenesis and Therapeutics, 11:00 AM – 11:10 AM, Paper #: 212, 2017.
2. Long RG, Nakai T, Sakai D, Iatridis JC, Alini M, Grad S, Li Z: TGFβ1 induces a contractile CD146+ phenotype of human annulus fibrosus cells and may be delivered in a carrier for annulus fibrosus repair, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Poster #: 1793, 2017.
3. Torre OM, Das R, Mosley GE, Huang AH, Iatridis JC: Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster #: 1829, 2017.
4. Cruz MA, Hom WW, Merril R, Torre OM, Nasser P, Hecht AC, Illien-Junger S, Iatridis JC: Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1800, 2017.
5. Lin HA, Varma DM, Hom WW, Nasser PR, Iatridis JC, Nicoll SB: Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1799, 2017.
6. Lai A, Evashwick-Rogler TW, Salandra JM, Ho L, Laudier DM, Cho SK, Hecht AC, Winkelstein BA, Pasinetti GM Iatridis JC: A Potential Safe and Novel Drink For Preventing Pain Associated With Disc Degeneration – An In-Vivo Rat Model, Transactions of the Orthopaedic Research Society, Poster session: PS2-121, Poster # 1839, 2017.
7. Evashwick-Rogler TW, Lai A, Salandra JM, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, Hecht Ac, Iatridis JC: Disc height loss, but not Pro-inflammatory cytokine or Substance P expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model, Transactions of the Orthopaedic Research Society, Poster Session: PS1-044, Spine – Disc Biology, Poster #: 854, 2017.
8. Palacio-Mancheno P, Evashwick-Rogler TW, Laudier DM, Purmessur D, Iatridis JC: Hyperosmolar Overloading in a Mouse Organ Culture Model Induces Notochordal Cell Differentiation with Osmoregulatory Aquaporin3 Upregulation and Altered N-Cad and Connexin-43 Mechanotransduction Expression, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster # 1817, 2017.
9. Palacio-Mancheno P, Kindschuh WF, Chen X, Harned AA, Iatridis JC: Illien-Jünger S: Age- and Sex-Dependent Effects of Advanced Glycation Endproducts Ingestion on Vertebral Bone Quality and Function, Transactions of the Orthopaedic Research Society, Poster Session: PS1-029, Bone – Musculoskeletal Development and Aging, Poster #: 0672, 2017.
Hand and Elbow Group Abstracts
1. Gluck MJ, Beck CM, Vijayaraghavan S, Iatridis JC, Hausman MR: In Situ Imaging of Rat Median Nerve Damage Using Second Harmonic Generation Microscopy: Advancing Towards an In Vivo Application, Transactions of the Orthopaedic Research Society, Poster Session: PS2-152, Diagnostic Imaging, Poster #: 2241, 2017.
2. Beck CM, Nasser P, Gluck MJ, Hausman MR, Koehler SM: Optimizing the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters, Transactions of the Orthopaedic Research Society, Poster Teaser Session: PS2-042, Poster #: 0328, 2017
3. Gluck MJ, Beck CM, Golan EJ, Nasser PR, Shukla DR, Hausman MR: pMUCL Reconstruction Recovers Elbow Stability In The Presence Of Posteromedial Rotatory Instability: A Cadaveric Study, Transactions of the Orthopaedic Research Society, Late Breaking Poster Session: LB- 156, Late Breaking PS2, Poster #: 2428, 2017
Tendon Group Abstracts
1.“The role of innate and adaptive immunity in regenerative and non-regenerative tendon healing” by Kristen Howell and Alice Huang will be presented in the Tendon and Ligament Biology Session, March 21, 2017 (11:00 am).
2. “Targeted Smad4 Deletion in Tenocytes Enables Tendon Cell Recruitment After Adult Tendon Injury” by Chun (Jerry) Chien, Kristen Howell, and Alice Huang will be presented in the Tendon and Ligament: Cell Biology Poster Session One, March 20-21, 2017.
3. “Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration” by Olivia Torre, Grace Mosley, Rohit Das, Alice Huang, and James Iatridis will be presented in the Spine: Disc Biology Poster Session Two, March 21-22, 2017.
4. “Scleraxis is Essential for Tenocyte Recruitment to Enable Tendon Growth” by Deepanwita Pal, Alice Huang, Lingyan Wang, John Brigande, and Ronen Schweitzer will be presented in the Tendon and Ligament Biology Session, March 21, 2017 (10:30am).
5. “Smad4 Regulation of Tendon Elongation” by Saundra Schlesinger, Seong Seo, Alice Huang, Brian Pryce, Ronen Schweitzer will be presented in the Tendon and Ligament: Cell Biology Poster Session Two, March 21-22, 2017.
Accepted abstracts for ORS 2017
Spine Group Abstracts
1. Rolfe RA, Oyen ML, Iatridis JC, Nowlan NC: Short Periods of Fetal Immobility Lead to Dramatic Effects on Spine and Rib Development, Transactions of the Orthopaedic Research Society, Podium Session: 31,
Spine Pathogenesis and Therapeutics, 11:00 AM – 11:10 AM, Paper #: 212, 2017.
2. Long RG, Nakai T, Sakai D, Iatridis JC, Alini M, Grad S, Li Z: TGFβ1 induces a contractile CD146+ phenotype of human annulus fibrosus cells and may be delivered in a carrier for annulus fibrosus repair, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Poster #: 1793, 2017.
3. Torre OM, Das R, Mosley GE, Huang AH, Iatridis JC: Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster #: 1829, 2017.
4. Cruz MA, Hom WW, Merril R, Torre OM, Nasser P, Hecht AC, Illien-Junger S, Iatridis JC: Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1800, 2017.
5. Lin HA, Varma DM, Hom WW, Nasser PR, Iatridis JC, Nicoll SB: Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1799, 2017.
6. Lai A, Evashwick-Rogler TW, Salandra JM, Ho L, Laudier DM, Cho SK, Hecht AC, Winkelstein BA, Pasinetti GM Iatridis JC: A Potential Safe and Novel Drink For Preventing Pain Associated With Disc Degeneration – An In-Vivo Rat Model, Transactions of the Orthopaedic Research Society, Poster session: PS2-121, Poster # 1839, 2017.
7. Evashwick-Rogler TW, Lai A, Salandra JM, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, Hecht Ac, Iatridis JC: Disc height loss, but not Pro-inflammatory cytokine or Substance P expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model, Transactions of the Orthopaedic Research Society, Poster Session: PS1-044, Spine – Disc Biology, Poster #: 854, 2017.
8. Palacio-Mancheno P, Evashwick-Rogler TW, Laudier DM, Purmessur D, Iatridis JC: Hyperosmolar Overloading in a Mouse Organ Culture Model Induces Notochordal Cell Differentiation with Osmoregulatory Aquaporin3 Upregulation and Altered N-Cad and Connexin-43 Mechanotransduction Expression, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster # 1817, 2017.
9. Palacio-Mancheno P, Kindschuh WF, Chen X, Harned AA, Iatridis JC: Illien-Jünger S: Age- and Sex-Dependent Effects of Advanced Glycation Endproducts Ingestion on Vertebral Bone Quality and Function, Transactions of the Orthopaedic Research Society, Poster Session: PS1-029, Bone – Musculoskeletal Development and Aging, Poster #: 0672, 2017.
Hand Group Abstract
10. Gluck MJ, Beck CM, Vijayaraghavan S, Iatridis JC, Hausman MR: In Situ Imaging of Rat Median Nerve Damage Using Second Harmonic Generation Microscopy: Advancing Towards an In Vivo Application, Transactions of the Orthopaedic Research Society, Poster Session: PS2-152, Diagnostic Imaging, Poster #: 2241, 2017.
11. Beck CM, Nasser P, Gluck MJ, Hausman MR, Koehler SM: Optimizing the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters, Transactions of the Orthopaedic Research Society, Poster Teaser Session: PS2-042, Poster #: 0328, 2017
12. Gluck MJ, Beck CM, Golan EJ, Nasser PR, Shukla DR, Hausman MR: pMUCL Reconstruction Recovers Elbow Stability In The Presence Of Posteromedial Rotatory Instability: A Cadaveric Study, Transactions of the Orthopaedic Research Society, Late Breaking Poster Session: LB- 156, Late Breaking PS2, Poster #: 2428, 2017
PSRS 2016 meeting – November 4, 2016
Spine Research Lab at Philadelphia Spine Research Symposium (PSRS) in Philadelphia, PA held November 4, 2016.
Olivia Torre (left) and Rose Long (right) after winning first and third prize in podium presentations at the Philadelphia Spine Research Symposium (PSRS) in Philadelphia, PA held November 4, 2016.
On November 4, 2016, the Iatridis Lab attended the 2016 Philadelphia Spine Research Symposium (PSRS) held at Drexel University in Philadelphia. The meeting aimed to “cover all areas of spine research spanning from basic to clinical, and encompass the broad areas of development, pathophysiology, aging, pain, therapeutics and diagnostics.”
Dr. James Iatridis served as one of the organizers of the upcoming symposium while 4 podium presentations and 1 poster was presented from Mount Sinai. Rose Long present her podium presentation entitled, “TGF-β1 Induces a Contractile CD146+ Phenotype of Human Annulus Fibrosus Cells with Affinity to Collagen Scaffold for Annulus Fibrosus Repair and won 3rd prize in podium presentations while Olivia Torre presented her podium presentation entitled, “Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration” and won first prize in podium presentations. In addition, Tom Evashwick-Rogler presented his podium presentation entitled, “Disc Height Loss, But Not Pro-Inflammatory Cytokine or Substance P Expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model” and Huizi Anna Lin presented her podium presentation entitiled, “Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility”. Finally, Warren Hom presented his poster entitled, Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs”.
More information about the symposium can be found here: http://www.philaspinemeeting.org/index.html
5th Annual Musculoskeletal Repair and Regeneration Symposium – October 13, 2016
Organizers and speakers of the 5th Annual Musculoskeletal Repair and Regeneration Symposium
The Mount Sinai ORL attended the 5th Annual Musculoskeletal Repair and Regeneration Symposium at Albert Einstein College of Medicine on October 13, 2016. The symposium mission is “to expand the knowledge base within the field, and to foster creativity, collaboration and networking between researchers throughout the region.”
During the symposium, Dr. Alice Huang gave a presentation entitled “Regulation of tendon regeneration” and Dr. James Iatridis presented his talk entitled “Injury, inflammation, and altered mechanotransduction in the intervertebral disc” while also serving as the Steering Chair for the “Novel views into musculoskeletal degenerative diseases” session. In addition, Rose Long presented her poster, “CD146+ phenotype of human annulus fibrosus cells induced by TGFβ1 has affinity to collagen scaffold aimed for annulus fibrosus repair” and together Matthew Gluck and Christina Beck presented their posters “In Situ Imaging of Rat Median Nerve Damage Using SHG Microscopy: Advancing Towards an In Vivo Application” and “Biomechanical Analysis of the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters”.
More information about the symposium can be found here:https://www.einstein.yu.edu/departments/orthopaedic-surgery/symposium/
5th Annual Musculoskeletal Repair and Regeneration Symposium – October 13, 2016
Organizers and speakers of the 5th Annual Musculoskeletal Repair and Regeneration Symposium
The Mount Sinai ORL attended the 5th Annual Musculoskeletal Repair and Regeneration Symposium at Albert Einstein College of Medicine on October 13, 2016. The symposium mission is “to expand the knowledge base within the field, and to foster creativity, collaboration and networking between researchers throughout the region.”
During the symposium, Dr. Alice Huang gave a presentation entitled “Regulation of tendon regeneration” and Dr. James Iatridis presented his talk entitled “Injury, inflammation, and altered mechanotransduction in the intervertebral disc” while also serving as the Steering Chair for the “Novel views into musculoskeletal degenerative diseases” session. In addition, Rose Long presented her poster, “CD146+ phenotype of human annulus fibrosus cells induced by TGFβ1 has affinity to collagen scaffold aimed for annulus fibrosus repair” and together Matthew Gluck and Christina Beck presented their posters “In Situ Imaging of Rat Median Nerve Damage Using SHG Microscopy: Advancing Towards an In Vivo Application” and “Biomechanical Analysis of the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters”.
More information about the symposium can be found here: https://www.einstein.yu.edu/departments/orthopaedic-surgery/symposium/
JOR: New Horizons in Spine Research
Special Issue: New Horizons in Spine Research – Part 1: Disc Biology, Spine Biomechanics, and Pathomechanisms of Back Pain
August 2016
Volume 34, Issue 8
Pages 1283–1491
Issue edited by: James C. Iatridis, James Kang, Rita Kandel, Makarand V. Risbud
To advance novel spine science and collaborations, the 3rd International Spine Research Symposium, co-sponsored by the Philadelphia Spine Research Society (PSRS), NIAMS/NIH and the Orthopaedic Research Society (ORS), was held to enhance understanding of the clinical problems associated with degenerative disc disease, and to highlight cutting-edge scientific research in areas of basic biology, epidemiology, disease mechanisms, biomechanics, tissue engineering and imaging of the intervertebral disc (IVD).[4] This special issue on ‘New Horizons in Spine Research’ and a second issue to follow at a later date are outcomes from that meeting, with articles selected from the strong response to the ‘call for papers’. This issue focuses on the fundamental topics of disc ageing and cell biology, spine biomechanics, anatomy and imaging, and pathomechanisms of spine pain. A second special issue will focus on repair and regeneration. This growing passion for advancing spine research and improving spinal health has ignited the spine research community to coalesce within the Orthopaedic Research Society as the newly formed Spine Section (http://www.ors.org/spinesection/) in order to enhance communication and collaboration. Read the issue.