Tag Archives: research

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ORS Acceptances!

Congratulations to the team on the excellent ORS abstract acceptances! We are proud of the diverse and exciting work submitted and accepted this year!

  1. Torre OM, Das R, Berenblum RE, Huang AH, Iatridis JC: Neonatal mice intervertebral discs restore function following herniation injury, Transactions of the Orthopaedic Research Society, Session 013, Podium Presentation #: 0068, 2018.
  2. Torre OM, Evashwick-Rogler TW, Iatridis JC: Optimizing Biomechanical Loading Protocols Ex Vivo to Improve Detection of Mild Intervertebral Disc Injuries, Transactions of the Orthopaedic Research Society, PS1-054, Poster #: 0771, 2018.
  3. Krishnamoorthy D, Liu X, Lin L, Xue P, Zhang E, Zhang F, Linhardt RJ, Iatridis JC: Characterization of human lumbar intervertebral disc glycosaminoglycan sulfation patterns using multiple reaction monitoring with liquid chromatography- mass spectrometry, Transactions of the Orthopaedic Research Society, PS1-053, Poster #: 0748, 2018.
  4. Krishnamoorthy D, Torre OM, Natelson D, Smith M, Iatridis JC, Illien-Jünger S: Dietary advanced glycation end product consumption leads to mechanical stiffening of murine intervertebral discs, Transactions of the Orthopaedic Research Society, PS2-152, Poster #: 1630, 2018.
  5. Mui B, DiStefano T, Hecht AC, Iatridis JC: Hydrogel formulation and culture conditions influence TGF- β3 release kinetics and extracellular matrix elaboration in genipin-crosslinked fibrin for annulus fibrosus repair, Transactions of the Orthopaedic Research Society, PS2-154, Poster #: 1666, 2018.
  6. Hom WW, Lin HA, Korda N, Desai JS, Nasser P, Hecht AC, Nicoll SB, Iatridis JC: Ex vivo biomechanical evaluation of a combined annulus fibrosus and nucleus pulposus hydrogel repair in a large animal model of severe intervertebral disc herniation injury, Transactions of the Orthopaedic Research Society, Spine: Modeling and Mechanics, Session 38, Podium Presentation #: 0216, 2018.
  7. Mosley GE, Evashwick-Rogler TW, Kaseta T, Lai A, Iatridis JC: Sex differences in rat lumbar intervertebral discs following annular puncture injury, Transactions of the Orthopaedic Research Society, PS2-152, Poster #: 1641, 2018.
  8. Zhou GK, Bradley EW, Westendorf JJ, Iatridis JC, Illien-Junger S: Role of Phlpp1 in Cell Proliferation and Apoptosis in Intervertebral Discs, Transactions of the Orthopaedic Research Society, PS1-053, Poster #:  0750, 2018.
  9. Real A, Ukogu C, Hecht AC, Iatridis JC: Elevated Glycohemoglobin HbA1c is Associated with Low Back Pain Independent of BMI, Transactions of the Orthopaedic Research Society, PS1-058, Poster #: 0802, 2018.
  10. Gluck MJ, Beck CM, Skodras A, Laudier D, Fowkes ME, Iatridis JC, Cagle PJ, Hausman MR: In Vivo Monitoring of Nerve Structure and Function Following Neural Stretch Injury via SHG Microscopy and Intra-Operative Nerve Stimulation, Transactions of the Orthopaedic Research Society, Session 056, Podium Presentation #: 0308, 2018.
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Publication in the Journal of Bone and Mineral Research!

Congratulations to the team on the publication of “Dietary Advanced Glycation End Products Have Sex- and Age-Dependent Effects on Vertebral Bone Microstructure and Mechanical Function in Mice.”!

The recently published manuscript in the Journal of Bone and Mineral Research demonstrated that a poor diet, high in advanced glycation end products can, independent of diabetic or overweight conditions, diminish vertebral microstructure, mechanical behaviors and fracture resistance in young female mice. This work suggests poor diet as a potential cause of accelerated spinal aging, especially in females

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Publication in the Spine Journal!

Congratulations to the team on the publication of “Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration.” in the Spine Journal!

This paper is one of the first to identify and localize multiple macrophage phenotypic markers in human IVDs. The most important findings identified CCR7+ and CD163+ macrophages increased with IVD degeneration grade and were significantly more present in IVD regions with structural irregularities and defects. These results improve our understanding of the important role macrophages and macrophage-like cells play in the complex inflammatory processes involved in IVD degeneration.

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ORS PSRS 2017

The Iatridis & Illien-Junger Labs had a great time at the ORS PSRS 4th International Spine Research Symposium in Lake Harmony PA! Chaired by Makarand Risbud, PSRS is a unique meeting in which prominent investigators and trainees in the spine research community come together to share their latest findings, trends, and ideas.

Congratulations to our PhD Candidate, Olivia Torre, on being a recipient of the “ORS PSRS Trainee Podium Award for Outstanding Scientific Research”! Her presentation, “Functional Restoration of Intervertebral Disc Biomechanics Following Neonatal Herniation Injury,” was delivered during the ‘Disc Biomechanics and Imaging’ session on October 26th, 2017.

Congratulations to Assistant Professor, Dr. Svenja Illien-Junger, on being a recipient of the Young Investigator Award. Dr. Illien-Junger advises ORL’s MS student, George Zhao, who presented the poster, “Phlpp1 in Cell Proliferation and Apoptosis During IVD Growth and Degeneration,” during the second poster session on October 25th, 2017.

In addition to these awards, Dr. Iatridis gave a fantastic talk titled, “Annulus Fibrosus Injury, Repair, and Regeneration” and Dr. Krishnamoorthy presented her poster, “Characterization of Human Lumbar Intervertebral Disc Glycosaminoglycan Sulfation Patterns using Multiple Reaction Monitoring with Liquid Chromatography-mass Spectrometry”.

We are very proud of these achievements and we look forward to ORL’s future research successes!

In addition to presenting our research and networking within the community, the Spine Lab enjoyed the time away from NYC in the Poconos.

Team learns about disc pathobiology:

Dr. James Iatridis giving his talk:

 Olivia receiving her award:

Svenja receiving her award:

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Publication in the Journal of Orthopaedic Research!

Congratulations to the team on the publication of “Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N-cadherin expression.”!

The recently published paper in the Journal of Orthopaedic Research identifies extracellular osmolarity as a triggering mechanism for nucleus pulposus maturation and identifies a compensatory shift in osmosensitive and mechanotransductive proteins from notochoral cells to small nucleus pulposus cells. This work furthers our understanding of the processes underlying IVD aging and mechanotransduction.

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PSRS Acceptances

Congratulations to our team for the acceptances for a podium presentation and poster presentations in the ORS PSRS 4th International Spine Research Symposium!

Torre OM, Das R, Berenblum RE, Huang AH, Iatridis JC: Functional restoration of intervertebral disc biomechanics following neonatal herniation injury, ORS PSRS 4th International Spine Research Symposium, Podium, 2017.

Zhou GK, Bradley EW, Westendorf JJ, Iatridis JC, Illien-Junger S: Phlpp1 in Cell Proliferation and Apoptosis During IVD Growth and Degeneration, ORS PSRS 4th International Spine Research Symposium, Poster, 2017.

Krishnamoorthy D, Liu X, Lin L , Xue  P, Zhang E, Zhang F, Linhardt RJ, Iatridis JC: Characterization of human lumbar intervertebral disc glycosaminoglycan sulfation patterns using multiple reaction monitoring with liquid chromatography- mass spectrometry, ORS PSRS 4th International Spine Research Symposium, Poster, 2017.

Dr. Iatridis was also invited to talk at the ORS PSRS Spine Research Symposium on the topic “Annulus fibrosus injury, repair, and regeneration”.

We look forward to attending and presenting at the ORS PSRS 4th International Spine Research Symposium at Split Rock Resort in Lake Harmony, Pennsylvania on October 27th.

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ORS Submissions 2017

Congratulations to the Orthopaedics Research Lab for a wonderfully productive ORS deadline! We are proud of the 10 diverse and exciting abstracts we submitted this year.

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Sun Valley Invited Presentation

James attended the ORS Musculoskeletal Biology Workshop at Sun Valley!  He participated in the panel discussion “Grant Writing Advice for Junior Investigators”. He also chaired and presented at the session entitled “Problems in Orthopaedics: Degenerative Disk Disease” with Drs. Mak Risbud and James Kang.

Hiking in Sawtooth National Forest with Dr. Jim Kang and also with conference organizers Drs. David Burr and Teresita Bellido.