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Accepted abstracts for ORS 2017

Spine Group Abstracts
1. Rolfe RA, Oyen ML, Iatridis JC, Nowlan NC: Short Periods of Fetal Immobility Lead to Dramatic Effects on Spine and Rib Development, Transactions of the Orthopaedic Research Society, Podium Session: 31,
Spine Pathogenesis and Therapeutics, 11:00 AM – 11:10 AM, Paper #: 212, 2017.
2. Long RG, Nakai T, Sakai D, Iatridis JC, Alini M, Grad S, Li Z: TGFβ1 induces a contractile CD146+ phenotype of human annulus fibrosus cells and may be delivered in a carrier for annulus fibrosus repair, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Poster #: 1793, 2017.
3. Torre OM, Das R, Mosley GE, Huang AH, Iatridis JC: Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster #: 1829, 2017.
4. Cruz MA, Hom WW, Merril R, Torre OM, Nasser P, Hecht AC, Illien-Junger S, Iatridis JC: Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1800, 2017.
5. Lin HA, Varma DM, Hom WW, Nasser PR, Iatridis JC, Nicoll SB: Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1799, 2017.
6. Lai A, Evashwick-Rogler TW, Salandra JM, Ho L, Laudier DM, Cho SK, Hecht AC, Winkelstein BA, Pasinetti GM Iatridis JC: A Potential Safe and Novel Drink For Preventing Pain Associated With Disc Degeneration – An In-Vivo Rat Model, Transactions of the Orthopaedic Research Society, Poster session: PS2-121, Poster # 1839, 2017.
7. Evashwick-Rogler TW, Lai A, Salandra JM, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, Hecht Ac, Iatridis JC: Disc height loss, but not Pro-inflammatory cytokine or Substance P expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model, Transactions of the Orthopaedic Research Society, Poster Session: PS1-044, Spine – Disc Biology, Poster #: 854, 2017.
8. Palacio-Mancheno P, Evashwick-Rogler TW, Laudier DM, Purmessur D, Iatridis JC: Hyperosmolar Overloading in a Mouse Organ Culture Model Induces Notochordal Cell Differentiation with Osmoregulatory Aquaporin3 Upregulation and Altered N-Cad and Connexin-43 Mechanotransduction Expression, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster # 1817, 2017.
9. Palacio-Mancheno P, Kindschuh WF, Chen X, Harned AA, Iatridis JC: Illien-Jünger S: Age- and Sex-Dependent Effects of Advanced Glycation Endproducts Ingestion on Vertebral Bone Quality and Function, Transactions of the Orthopaedic Research Society, Poster Session: PS1-029, Bone – Musculoskeletal Development and Aging, Poster #: 0672, 2017.

Hand Group Abstract
10. Gluck MJ, Beck CM, Vijayaraghavan S, Iatridis JC, Hausman MR: In Situ Imaging of Rat Median Nerve Damage Using Second Harmonic Generation Microscopy: Advancing Towards an In Vivo Application, Transactions of the Orthopaedic Research Society, Poster Session: PS2-152, Diagnostic Imaging, Poster #: 2241, 2017.
11. Beck CM, Nasser P, Gluck MJ, Hausman MR, Koehler SM: Optimizing the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters, Transactions of the Orthopaedic Research Society, Poster Teaser Session: PS2-042, Poster #: 0328, 2017
12. Gluck MJ, Beck CM, Golan EJ, Nasser PR, Shukla DR, Hausman MR: pMUCL Reconstruction Recovers Elbow Stability In The Presence Of Posteromedial Rotatory Instability: A Cadaveric Study, Transactions of the Orthopaedic Research Society, Late Breaking Poster Session: LB- 156, Late Breaking PS2, Poster #: 2428, 2017

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PSRS 2016 meeting – November 4, 2016

PSRS 2016 - Iatridis Lab
Spine Research Lab at Philadelphia Spine Research Symposium (PSRS) in Philadelphia, PA held November 4, 2016.

PSRS 2016 - Olivia and Rose
Olivia Torre (left) and Rose Long (right) after winning first and third prize in podium presentations at the Philadelphia Spine Research Symposium (PSRS) in Philadelphia, PA held November 4, 2016.

On November 4, 2016, the Iatridis Lab attended the 2016 Philadelphia Spine Research Symposium (PSRS) held at Drexel University in Philadelphia.  The meeting aimed to “cover all areas of spine research spanning from basic to clinical, and encompass the broad areas of development, pathophysiology, aging, pain, therapeutics and diagnostics.”

Dr. James Iatridis served as one of the organizers of the upcoming symposium while 4 podium presentations and 1 poster was presented from Mount Sinai.  Rose Long present her podium presentation entitled,  “TGF-β1 Induces a Contractile CD146+ Phenotype of Human Annulus Fibrosus Cells with Affinity to Collagen Scaffold for Annulus Fibrosus Repair and won 3rd prize in podium presentations while Olivia Torre presented her podium presentation entitled, “Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration” and won first prize in podium presentations.  In addition, Tom Evashwick-Rogler presented his podium presentation entitled,  “Disc Height Loss, But Not Pro-Inflammatory Cytokine or Substance P Expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model” and Huizi Anna Lin presented her podium presentation entitiled,  “Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility”.   Finally, Warren Hom presented his poster entitled, Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs”.

More information about the symposium can be found here:  http://www.philaspinemeeting.org/index.html

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5th Annual Musculoskeletal Repair and Regeneration Symposium – October 13, 2016

Einstein Symposium 2016_resized
Organizers and speakers of the 5th Annual Musculoskeletal Repair and Regeneration Symposium

The Mount Sinai ORL attended the 5th Annual Musculoskeletal Repair and Regeneration Symposium at Albert Einstein College of Medicine on October 13, 2016. The symposium mission is “to expand the knowledge base within the field, and to foster creativity, collaboration and networking between researchers throughout the region.”

During the symposium, Dr. Alice Huang gave a presentation entitled “Regulation of tendon regeneration” and Dr. James Iatridis presented his talk entitled “Injury, inflammation, and altered mechanotransduction in the intervertebral disc” while also serving as the Steering Chair for the “Novel views into musculoskeletal degenerative diseases” session. In addition, Rose Long presented her poster, “CD146+ phenotype of human annulus fibrosus cells induced by TGFβ1 has affinity to collagen scaffold aimed for annulus fibrosus repair” and together Matthew Gluck and Christina Beck presented their posters “In Situ Imaging of Rat Median Nerve Damage Using SHG Microscopy: Advancing Towards an In Vivo Application” and “Biomechanical Analysis of the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters”.

More information about the symposium can be found here:https://www.einstein.yu.edu/departments/orthopaedic-surgery/symposium/

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5th Annual Musculoskeletal Repair and Regeneration Symposium – October 13, 2016

Einstein Symposium 2016_resized
Organizers and speakers of the 5th Annual Musculoskeletal Repair and Regeneration Symposium

The Mount Sinai ORL attended the 5th Annual Musculoskeletal Repair and Regeneration Symposium at Albert Einstein College of Medicine on October 13, 2016. The symposium mission is “to expand the knowledge base within the field, and to foster creativity, collaboration and networking between researchers throughout the region.”

During the symposium, Dr. Alice Huang gave a presentation entitled “Regulation of tendon regeneration” and Dr. James Iatridis presented his talk entitled “Injury, inflammation, and altered mechanotransduction in the intervertebral disc” while also serving as the Steering Chair for the “Novel views into musculoskeletal degenerative diseases” session. In addition, Rose Long presented her poster, “CD146+ phenotype of human annulus fibrosus cells induced by TGFβ1 has affinity to collagen scaffold aimed for annulus fibrosus repair” and together Matthew Gluck and Christina Beck presented their posters “In Situ Imaging of Rat Median Nerve Damage Using SHG Microscopy: Advancing Towards an In Vivo Application” and “Biomechanical Analysis of the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters”.

More information about the symposium can be found here: https://www.einstein.yu.edu/departments/orthopaedic-surgery/symposium/

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Gordon Research Conference and Seminar – August 7-12, 2016

Paolo Palacio-Mancheno, Rose Long and Olivia Torre of the Iatridis lab attended the Musculoskeletal Biology & Bioengineering Gordon Research Conference and Seminar at the Proctor Academy in Andover, NH August 7-12, 2016. The theme of the 2016 GRC was “Stepping Across Disciplines to Spur Innovation in Musculoskeletal Biology and Bioengineering” as the goal of the conference was to bring together leaders in the field of musculoskeletal biology and bioengineering to foster new scientific interactions across the field.

During the week long conference, Dr. James Iatridis presented a keynote lecture entitled “Injury, Inflammation, and Altered Mechanotransduction in the Intervertebral Disc” and Rose Long presented a seminar entitled “Induction of Cd146+ Phenotype by Tgfb1 from Human Annulus Fibrosis Cells for Annulus Repair”.  In addition, both Paolo Palacio-Mencheno and Olivia Torre presented their posters “Hyperosmolar Conditions Induce Notochordal Cell Maturation and Matrix Production with Aquaporin3 Upregulation in Nucleus Pulposus” and “Hyperosmolar Conditions Induce Notochordal Cell Maturation and Matrix Production with Aquaporin3 Upregulation in Nucleus Pulposus”, respectively.

Read more about the conference here: https://www.grc.org/programs.aspx?id=10990

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Orthopaedic Research Society Spine Section 2016 Annual Meeting

Spine-Section-Awards-1024x684ORS Spine Section 2016 Poster and Podium award winners with ORS Spine Section leadership.

The ORS Spine Section held its first section meeting on Friday, March 4 as part of the ORS 2016 Annual Meeting programming at Disney’s Coronado Springs Resort in Orlando, Florida.

The theme for the 2016 meeting was Spine Research for Functional Translation with scientific symposia on animal models and imaging. Invited speakers included spine researchers and clinicians representing academics, government, and industry.

The ORS Spine Section meeting aimed to disseminate cutting edge information on focus topics of interest, to develop & strengthen collaborative research networks, to support young investigators, and to engage clinicians & industry experts.  Dr. James Iatridis (shown sixth from left) served as the Chair of the newly created ORS Spine section for 2015 and 2016.  Svenja Illien-Junger, PhD (shown third from left) received a Podium Award at for her presentation at this year’s meeting.  In all, Dr. Iatridis’ Spine Bioengineer Lab had nine podium presentations at the ORS.

In addition, Mount Sinai alums Dr. Devina Purmessur and Dr. Nelly Andarawis-Puri organized two popular New Investigator mentoring sessions: I) Successfully competing for a faculty position and II) How to lead and motivate a successful team.  As one of the leaders of Orthopaedic Research, Dr. James Iatridis was invited to give a lecture on “Choosing the right people” for the second session.

The tendon research program was well represented at the ORS this year with three podium presentations given by Dr. Alice Huang, Kristen Howell, and David Shiovitz.  Dr. Huang also served as a moderator for the New Investigator mentoring sessions I and II, as well as Tendon and Ligament: Cell Biology and Development.

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ORS PSRS 3rd International Spine Research Symposium

PSRS-Awards-2015

Mount Sinai Spine was an important sponsor of the ORS PSRS Spine Research Symposium. Many members of the Spine Lab participated in this meeting. Dr. Iatridis was an invited faculty who gave a talk entitled ‘Annulus Fibrosus Repair Strategies in the Intervertebral Disc’. Alumnus, Dr. Devina Purmessur, was an invited speaker on the Special Rising Star Session organized by the ORS Spine Section, and gave a talk on ‘The Role of the IVD Microenvironment on Neurovascular Ingrowth’. Dr. Alon Lai and Visiting Professor, Dr. Hironobu Watanabe (Keiyu Spine Center, Keiyu Orthopedic Hospital, Tatebayashi, Gunma), received a 1st Place Poster Award in the ‘Preclinical, Animal Models, and Clinical’ session (http://www.ors.org/ors-psrs-award-recipients/).

http://www.ors.org/philaspinemeeting/

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Accepted abstracts for ORS 2016

 

  1. Rolfe RA, Oyen ML, Iatridis JC, Nowlan NC: Mechanical Stimulation is required for normal spinal curvature and vertebral segmentation in the developing chick, Transactions of the Orthopaedic Research Society, 2016, Poster # 0852.
  2. Watanabe H, Lai A, Schuchman M, Cho SK, Hecht AC, Iatridis JC: Can Intradiscal Injection with TNF-α Inhibitor Reduce Pain and Disc Degeneration in a Rat Model?, Can Intradiscal Injection with TNF-α Inhibitor Reduce Pain and Disc Degeneration in a Rat Model?, Transactions of the Orthopaedic Research Society, 2016, Poster # 0875.
  3. Nakazawa KR, Walter BA, Laudier DM, Spiller KL, Iatridis JC: Exogenous and Endogenous Macrophage Phenotypes and Localization in Human Intervertebral Disc Degeneration, Transactions of the Orthopaedic Research Society, 2016, Poster # 0891.
  4. Lai A, Watanabe H, Ho L, Cho SK, Hecht AC, Pasinetti GM, Iatridis JC: Polyphenol Metabolites Potentially Alleviate Painful Behavior Induced by Annular Injury – An In-vivo Rat Model, Transactions of the Orthopaedic Research Society, 2016, Poster # 1735.
  5. Cruz MA, Torre OM, Merrill RK, Illien-Junger S, Hecht AC, Iatridis JC: Genipin-crosslinked Fibrin has Potential for Use as a Cell Carrier for Annulus Fibrosus Repair, Transactions of the Orthopaedic Research Society, 2016, Poster # 0867.
  6. Kindschuh WF, Palacio-Mancheno P, Chen X, Iatridis JC, Illien-Jünger S: Sex-Dependent Effects of Dietary Advanced Glycation Endproducts on Vertebral Bone, Transactions of the Orthopaedic Research Society, 2016, Poster #  0908.
  7. Aly N, Palacio-Mancheno P, Ahmed F, Tadros M, Purmessur D, Iatridis: JC: Effects of Osmolarity on Nucleus Pulposus Matrix and Cellular Phenotype in a Mouse Whole IVD Organ Culture Model: Contributions of TRPV4 and Aquaporins, Transactions of the Orthopaedic Research Society, 2016, Poster.
  8. Tadros M, Palacio-Mancheno P, Ahmed F, Aly N, Purmessur D, Iatridis JC: Injury-related Changes to the Intervertebral Disc Phenotype are associated with Aquaporin Expression, Independent of TRPV4 in the Inner Annulus Fibrosus, Transactions of the Orthopaedic Research Society, 2016, Poster # 1749.
  9. Varma DM, Lin HA, Long RG, Hecht AC, Iatridis JC, Nicoll SB: In Situ Gelling Cellulosic Copolymer Hydrogels Restore Intervertebral Disc Height and Biomechanical Properties Post Nucleotomy, Transactions of the Orthopaedic Research Society, 2016, Poster # 0869.