ORS Acceptances!

Congratulations to the team on the excellent ORS abstract acceptances! We are proud of the diverse and exciting work submitted and accepted this year!

  1. Torre OM, Das R, Berenblum RE, Huang AH, Iatridis JC: Neonatal mice intervertebral discs restore function following herniation injury, Transactions of the Orthopaedic Research Society, Session 013, Podium Presentation #: 0068, 2018.
  2. Torre OM, Evashwick-Rogler TW, Iatridis JC: Optimizing Biomechanical Loading Protocols Ex Vivo to Improve Detection of Mild Intervertebral Disc Injuries, Transactions of the Orthopaedic Research Society, PS1-054, Poster #: 0771, 2018.
  3. Krishnamoorthy D, Liu X, Lin L, Xue P, Zhang E, Zhang F, Linhardt RJ, Iatridis JC: Characterization of human lumbar intervertebral disc glycosaminoglycan sulfation patterns using multiple reaction monitoring with liquid chromatography- mass spectrometry, Transactions of the Orthopaedic Research Society, PS1-053, Poster #: 0748, 2018.
  4. Krishnamoorthy D, Torre OM, Natelson D, Smith M, Iatridis JC, Illien-Jünger S: Dietary advanced glycation end product consumption leads to mechanical stiffening of murine intervertebral discs, Transactions of the Orthopaedic Research Society, PS2-152, Poster #: 1630, 2018.
  5. Mui B, DiStefano T, Hecht AC, Iatridis JC: Hydrogel formulation and culture conditions influence TGF- β3 release kinetics and extracellular matrix elaboration in genipin-crosslinked fibrin for annulus fibrosus repair, Transactions of the Orthopaedic Research Society, PS2-154, Poster #: 1666, 2018.
  6. Hom WW, Lin HA, Korda N, Desai JS, Nasser P, Hecht AC, Nicoll SB, Iatridis JC: Ex vivo biomechanical evaluation of a combined annulus fibrosus and nucleus pulposus hydrogel repair in a large animal model of severe intervertebral disc herniation injury, Transactions of the Orthopaedic Research Society, Spine: Modeling and Mechanics, Session 38, Podium Presentation #: 0216, 2018.
  7. Mosley GE, Evashwick-Rogler TW, Kaseta T, Lai A, Iatridis JC: Sex differences in rat lumbar intervertebral discs following annular puncture injury, Transactions of the Orthopaedic Research Society, PS2-152, Poster #: 1641, 2018.
  8. Zhou GK, Bradley EW, Westendorf JJ, Iatridis JC, Illien-Junger S: Role of Phlpp1 in Cell Proliferation and Apoptosis in Intervertebral Discs, Transactions of the Orthopaedic Research Society, PS1-053, Poster #:  0750, 2018.
  9. Real A, Ukogu C, Hecht AC, Iatridis JC: Elevated Glycohemoglobin HbA1c is Associated with Low Back Pain Independent of BMI, Transactions of the Orthopaedic Research Society, PS1-058, Poster #: 0802, 2018.
  10. Gluck MJ, Beck CM, Skodras A, Laudier D, Fowkes ME, Iatridis JC, Cagle PJ, Hausman MR: In Vivo Monitoring of Nerve Structure and Function Following Neural Stretch Injury via SHG Microscopy and Intra-Operative Nerve Stimulation, Transactions of the Orthopaedic Research Society, Session 056, Podium Presentation #: 0308, 2018.

5th Annual Musculoskeletal Repair and Regeneration Symposium – October 13, 2016

Einstein Symposium 2016_resized
Organizers and speakers of the 5th Annual Musculoskeletal Repair and Regeneration Symposium

The Mount Sinai ORL attended the 5th Annual Musculoskeletal Repair and Regeneration Symposium at Albert Einstein College of Medicine on October 13, 2016. The symposium mission is “to expand the knowledge base within the field, and to foster creativity, collaboration and networking between researchers throughout the region.”

During the symposium, Dr. Alice Huang gave a presentation entitled “Regulation of tendon regeneration” and Dr. James Iatridis presented his talk entitled “Injury, inflammation, and altered mechanotransduction in the intervertebral disc” while also serving as the Steering Chair for the “Novel views into musculoskeletal degenerative diseases” session. In addition, Rose Long presented her poster, “CD146+ phenotype of human annulus fibrosus cells induced by TGFβ1 has affinity to collagen scaffold aimed for annulus fibrosus repair” and together Matthew Gluck and Christina Beck presented their posters “In Situ Imaging of Rat Median Nerve Damage Using SHG Microscopy: Advancing Towards an In Vivo Application” and “Biomechanical Analysis of the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters”.

More information about the symposium can be found here:https://www.einstein.yu.edu/departments/orthopaedic-surgery/symposium/

Gordon Research Conference and Seminar – August 7-12, 2016

Paolo Palacio-Mancheno, Rose Long and Olivia Torre of the Iatridis lab attended the Musculoskeletal Biology & Bioengineering Gordon Research Conference and Seminar at the Proctor Academy in Andover, NH August 7-12, 2016. The theme of the 2016 GRC was “Stepping Across Disciplines to Spur Innovation in Musculoskeletal Biology and Bioengineering” as the goal of the conference was to bring together leaders in the field of musculoskeletal biology and bioengineering to foster new scientific interactions across the field.

During the week long conference, Dr. James Iatridis presented a keynote lecture entitled “Injury, Inflammation, and Altered Mechanotransduction in the Intervertebral Disc” and Rose Long presented a seminar entitled “Induction of Cd146+ Phenotype by Tgfb1 from Human Annulus Fibrosis Cells for Annulus Repair”.  In addition, both Paolo Palacio-Mencheno and Olivia Torre presented their posters “Hyperosmolar Conditions Induce Notochordal Cell Maturation and Matrix Production with Aquaporin3 Upregulation in Nucleus Pulposus” and “Hyperosmolar Conditions Induce Notochordal Cell Maturation and Matrix Production with Aquaporin3 Upregulation in Nucleus Pulposus”, respectively.

Read more about the conference here: https://www.grc.org/programs.aspx?id=10990

Orthopaedic Research Society Spine Section 2016 Annual Meeting

Spine-Section-Awards-1024x684ORS Spine Section 2016 Poster and Podium award winners with ORS Spine Section leadership.

The ORS Spine Section held its first section meeting on Friday, March 4 as part of the ORS 2016 Annual Meeting programming at Disney’s Coronado Springs Resort in Orlando, Florida.

The theme for the 2016 meeting was Spine Research for Functional Translation with scientific symposia on animal models and imaging. Invited speakers included spine researchers and clinicians representing academics, government, and industry.

The ORS Spine Section meeting aimed to disseminate cutting edge information on focus topics of interest, to develop & strengthen collaborative research networks, to support young investigators, and to engage clinicians & industry experts.  Dr. James Iatridis (shown sixth from left) served as the Chair of the newly created ORS Spine section for 2015 and 2016.  Svenja Illien-Junger, PhD (shown third from left) received a Podium Award at for her presentation at this year’s meeting.  In all, Dr. Iatridis’ Spine Bioengineer Lab had nine podium presentations at the ORS.

In addition, Mount Sinai alums Dr. Devina Purmessur and Dr. Nelly Andarawis-Puri organized two popular New Investigator mentoring sessions: I) Successfully competing for a faculty position and II) How to lead and motivate a successful team.  As one of the leaders of Orthopaedic Research, Dr. James Iatridis was invited to give a lecture on “Choosing the right people” for the second session.

The tendon research program was well represented at the ORS this year with three podium presentations given by Dr. Alice Huang, Kristen Howell, and David Shiovitz.  Dr. Huang also served as a moderator for the New Investigator mentoring sessions I and II, as well as Tendon and Ligament: Cell Biology and Development.

ORS PSRS 3rd International Spine Research Symposium


Mount Sinai Spine was an important sponsor of the ORS PSRS Spine Research Symposium. Many members of the Spine Lab participated in this meeting. Dr. Iatridis was an invited faculty who gave a talk entitled ‘Annulus Fibrosus Repair Strategies in the Intervertebral Disc’. Alumnus, Dr. Devina Purmessur, was an invited speaker on the Special Rising Star Session organized by the ORS Spine Section, and gave a talk on ‘The Role of the IVD Microenvironment on Neurovascular Ingrowth’. Dr. Alon Lai and Visiting Professor, Dr. Hironobu Watanabe (Keiyu Spine Center, Keiyu Orthopedic Hospital, Tatebayashi, Gunma), received a 1st Place Poster Award in the ‘Preclinical, Animal Models, and Clinical’ session (http://www.ors.org/ors-psrs-award-recipients/).


AO Visit to Mount Sinai

AO FAll 2015 visit_1

The Annulus Fibrosus Rupture (AFR) Consortium of the AO Foundation visited the ORL on September 16, 2015. The AFR consortium participated in research collaboration discussions and finished the day with a visit to the Cooper Hewitt, Smithsonian Design Museum.  The AFR is an international consortium with its epicenter at the AO Research Institute in Davos, Switzerland. The AFR consortium is committed to developing novel treatments to promote annulus re pair.