Category Archives: Team

Posted on by

ORS 2017 Recap

The Spine Lab and collaborators successfully presented 10 abstracts this year at ORS in San Diego

  1. Rolfe RA, Oyen ML, Iatridis JC, Nowlan NC: Short Periods of Fetal Immobility Lead to Dramatic Effects on Spine and Rib Development, Paper #: 212.
  2. Long RG, Nakai T, Sakai D, Iatridis JC, Alini M, Grad S, Li Z: TGFβ1 induces a contractile CD146+ phenotype of human annulus fibrosus cells and may be delivered in a carrier for annulus fibrosus repair, Poster #: 1793.
  3. Torre OM, Das R, Mosley GE, Huang AH, Iatridis JC: Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration, Poster #: 1829.
  4. Cruz MA, Hom WW, Merril R, Torre OM, Nasser P, Hecht AC, Illien-Junger S, Iatridis JC: Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1800, 2017.
  5. Lin HA, Varma DM, Hom WW, Cruz MA, Nasser PR, Iatridis JC, Nicoll SB: Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1799, 2017.
  6. Lai A, Evashwick-Rogler TW, Salandra JM, Ho L, Laudier DM, Cho SK, Hecht AC, Winkelstein BA,  Pasinetti GM Iatridis JC: A Potential Safe and Novel Drink For Preventing Pain Associated With Disc Degeneration – An In-Vivo Rat Model, Transactions of the Orthopaedic Research Society, Poster session: PS2-121, Poster # 1839, 2017.
  7. Evashwick-Rogler TW, Lai A, Salandra JM, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, Hecht Ac, Iatridis JC: Disc height loss, but not Pro-inflammatory cytokine or Substance P expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model, Transactions of the Orthopaedic Research Society, Poster Session: PS1-044, Spine – Disc Biology, Poster #: 854, 2017.
  8. Palacio-Mancheno P, Evashwick-Rogler TW, Laudier DM, Purmessur D, Iatridis JC: Hyperosmolar Overloading in a Mouse Organ Culture Model Induces Notochordal Cell Differentiation with Osmoregulatory Aquaporin3 Upregulation and Altered N-Cad and Connexin-43 Mechanotransduction Expression, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster # 1817, 2017.
  9. Palacio-Mancheno P, Kindschuh WF, Chen X, Harned AA, Iatridis JC: Illien-Jünger S: Age- and Sex-Dependent Effects of Advanced Glycation Endproducts Ingestion on Vertebral Bone Quality and Function, Transactions of the Orthopaedic Research Society, Poster Session: PS1-029, Bone – Musculoskeletal Development and Aging,  Poster #: 0672, 2017.
  10. Gluck MJ, Beck CM, Vijayaraghavan S, Iatridis JC, Hausman MR: In Situ Imaging of Rat Median Nerve Damage Using Second Harmonic Generation Microscopy: Advancing Towards an In Vivo Application, Transactions of the Orthopaedic Research Society, Poster Session: PS2-152, Diagnostic Imaging, Poster #: 2241, 2017.

James Iatridis also Chaired the ORS Spine Section Meeting and became 2nd Vice President of the ORS. We enjoyed being part of the Van Mow academic tree during his Shands Award Presentation #VanMow #ORS2017.

In addition to research activities, most of the Orthopaedic Research Lab attendees met at Tom Evashwick-Rogler’s family home for a great barbeque in celebration of a very successful meeting.

 

Posted on by

Welcome to Divya Krishnamoorthy!

Welcome to Divya Krishnamoorthy who joined the spine lab as a Post-doctoral Fellow who recently graduated with her PhD in Biomedical Engineering in the lab of Dr. Clinton Rubin from the State University of New York, Stony Brook.  Divya will work with James Iatridis and Svenja Illien-Junger to identify effects of diabetes and diet on spinal pathologies including investigating interactions between the intervertebral disc and vertebrae.

Posted on by

Congratulations and Farewell to Paolo Palacio-Mancheno

Paolo Farewell smallerCongratulations to Paolo Palacio-Mancheno, PhD for his new job at Procter & Gamble as a Research Scientist!  In the 2 years that Paolo has been a Postdoctoral Fellow, he has made many contributions toward advancing intervertebral disc research.  In addition to his research and leadership skills, Paolo has been a great friend, colleague, and mentor to everyone in the lab.  While we are sad to see him leave, we wish him the best in his new position at P&G.

Posted on by

James Iatridis Elected as 2nd Vice President of ORS

james Iatridis

Dr. Iatridis was elected as the 2nd Vice President of the Orthopaedic Research Society.  His 4 year term in the presidential lineage on the ORS Board of Directors will begin after the ORS annual meeting in San Diego in March 2017.  During his 20 years as a member of the ORS, Dr. Iatridis has served as a program topic chair, regularly organized workshops and judged award competitions, and reviewed abstracts.  He has also been the Chair of the ORS/OREF/AAOS New Investigator Research Funding Workshop and the inaugural Chair of the ORS Spine Section.  Dr. Iatridis has a strong vision to balancing the growth opportunities offered by the new ORS Sections with focus and efficiency, while also nurturing the broad orthopaedic mission and the cohesive orthopaedic research community.  He is committed to building innovative partnerships with diverse involvement across disciplines and geographies.

 

Source: ORS Election Results

Posted on by

James Iatridis Elected as 2nd Vice President of ORS

james Iatridis (3)Dr. Iatridis was elected as the 2nd Vice President of the Orthopaedic Research Society.  His 4 year term in the presidential lineage on the ORS Board of Directors will begin after the ORS annual meeting in San Diego in March 2017.  During his 20 years as a member of the ORS, Dr. Iatridis has served as a program topic chair, regularly organized workshops and judged award competitions, and reviewed abstracts.  He has also been the Chair of the ORS/OREF/AAOS New Investigator Research Funding Workshop and the inaugural Chair of the ORS Spine Section.  Dr. Iatridis has a strong vision to balancing the growth opportunities offered by the new ORS Sections with focus and efficiency, while also nurturing the broad orthopaedic mission and the cohesive orthopaedic research community.  He is committed to building innovative partnerships with diverse involvement across disciplines and geographies.

Source: ORS Election Results

Posted on by

5th Annual Musculoskeletal Repair and Regeneration Symposium – October 13, 2016

Einstein Symposium 2016_resized
Organizers and speakers of the 5th Annual Musculoskeletal Repair and Regeneration Symposium

The Mount Sinai ORL attended the 5th Annual Musculoskeletal Repair and Regeneration Symposium at Albert Einstein College of Medicine on October 13, 2016. The symposium mission is “to expand the knowledge base within the field, and to foster creativity, collaboration and networking between researchers throughout the region.”

During the symposium, Dr. Alice Huang gave a presentation entitled “Regulation of tendon regeneration” and Dr. James Iatridis presented his talk entitled “Injury, inflammation, and altered mechanotransduction in the intervertebral disc” while also serving as the Steering Chair for the “Novel views into musculoskeletal degenerative diseases” session. In addition, Rose Long presented her poster, “CD146+ phenotype of human annulus fibrosus cells induced by TGFβ1 has affinity to collagen scaffold aimed for annulus fibrosus repair” and together Matthew Gluck and Christina Beck presented their posters “In Situ Imaging of Rat Median Nerve Damage Using SHG Microscopy: Advancing Towards an In Vivo Application” and “Biomechanical Analysis of the Reduction and Association of the Scaphoid and Lunate (RASL) Technique: Screw Trajectory Matters”.

More information about the symposium can be found here: https://www.einstein.yu.edu/departments/orthopaedic-surgery/symposium/

Posted on by

Post-doctoral Fellow – Job Postings

There are immediate openings for two Post-doctoral Fellowships in the Spine Bioengineering Unit of the Orthopaedics Research Labs at Mount Sinai under the guidance of Dr. James Iatridis. The lab focuses on spine research combining bioengineering and biology to investigate pathophysiology of back pain and disc degeneration and to develop regenerative treatments. In support of NIH funded R01 grants. The projects focus on tissue engineering of the intervertebral disc and on mechanisms for diabetes induced disc degeneration. The ideal candidates will have a background in biology or bioengineering with relevant experience on animal models, biological assays, histological methods, mechanical testing and/or computational analyses. This position offers a tremendous learning experience to highly motivated and independent individuals.  A minimum two year commitment is required.  To apply, please submit your CV, a very short description of your research interests and goals, and the names of three references to james.iatridis@mssm.edu.  For more information about the lab, please see our lab web page: https://labs.icahn.mssm.edu/iatridislab/

Job Qualifications

Education and Experience:
PhD in bioengineering, biology or related field.

Posted on by

Associate Researcher – Job Posting

This posting describes a Research Technician position in the Spine Research of the Orthopaedics Research Labs at Mount Sinai under the guidance of Dr. James Iatridis and Svenja Illien-Jünger.  The lab focuses on spine research combining bioengineering and biology to investigate pathophysiology of back pain and disc degeneration and to develop regenerative treatments. In support of a newly funded NIH R01 grant on mechanisms for diabetes induced disc degeneration. The ideal candidate will have a background in biology or bioengineering with relevant experience on animal models, biological assays and histological methods. The candidate will support most aspects of this project and will also have some responsibilities associated with lab maintenance.  This position offers a tremendous learning experience to highly motivated and independent individuals.  A two year commitment is required.  To apply, please submit your CV, a very short description of your research interests and goals, and three references to svenja.illien-junger@mssm.edu.  For more information about the lab, please see our lab web page: https://labs.icahn.mssm.edu/iatridislab/

Duties and Responsibilities:
1. Mouse experiments, surgeries and genotyping.
2. Basic molecular biology assays.
3. Immunohistochemistry and histology.
4. Biomechanical testing.
5. Basic tissue culture, tissue engineered constructs, explant cultures.

Job Qualifications

Education:
Bachelor’s Degree in biology, bioengineering or related field.

Experience:
Previous experience in any of the above techniques is not necessary, however preference will be given to those with prior research experience.

Posted on by

ORL hosts Girls Inc Eureka! Summer Program

018Alice Huang presents background on tendon research in the Huang Lab to Girls Inc students (Photo credit: Nomi Ellenson)

On August 2, the Orthopaedic Research Labs hosted 20 students from the Girls Inc Eureka! Summer Program.  Girls Inc. Eureka! Is a STEM-based approach to engaging and empowering 8th-12th grade girls for future success.  The ORL visit kicked off with scientific presentations by Dr. Alice Huang on tendon research and Dr. James Iatridis on spine research.  Didactic presentations were followed by hands-on rotations through six modules led by our trainees and staff: mouse gait analysis, fluorescence microscopy, tendon tissue engineering, cryosectioning, orthopaedic biomechanics, and spine organ culture.  The event capped with an inspiring Q&A discussion with Dr. Leesa Galatz on what it means to be a clinician-scientist.  Special thanks to Kristen Howell, Jerry Chien, Varun Arvind, Anton Doe, Phil Nasser, Christina Beck, Olivia Torre, and Rose Long for leading the lab modules, LifeSci Advisors for providing lab coats to the students, and all of the Girls Inc students for allowing us to share our love of science with you!

Read more about Girls, Inc. Eureka!’s visit to the ORL:

https://www.theguardian.com/money/2016/aug/13/science-tech-engineering-math-stem-jobs-gender-gap-new-york

Lab tour with Girls, Inc. Eureka!