Category Archives: Diet, Diabetes, and Spine Health

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ORS Acceptances!

Congratulations to the team on the excellent ORS abstract acceptances! We are proud of the diverse and exciting work submitted and accepted this year!

  1. Torre OM, Das R, Berenblum RE, Huang AH, Iatridis JC: Neonatal mice intervertebral discs restore function following herniation injury, Transactions of the Orthopaedic Research Society, Session 013, Podium Presentation #: 0068, 2018.
  2. Torre OM, Evashwick-Rogler TW, Iatridis JC: Optimizing Biomechanical Loading Protocols Ex Vivo to Improve Detection of Mild Intervertebral Disc Injuries, Transactions of the Orthopaedic Research Society, PS1-054, Poster #: 0771, 2018.
  3. Krishnamoorthy D, Liu X, Lin L, Xue P, Zhang E, Zhang F, Linhardt RJ, Iatridis JC: Characterization of human lumbar intervertebral disc glycosaminoglycan sulfation patterns using multiple reaction monitoring with liquid chromatography- mass spectrometry, Transactions of the Orthopaedic Research Society, PS1-053, Poster #: 0748, 2018.
  4. Krishnamoorthy D, Torre OM, Natelson D, Smith M, Iatridis JC, Illien-Jünger S: Dietary advanced glycation end product consumption leads to mechanical stiffening of murine intervertebral discs, Transactions of the Orthopaedic Research Society, PS2-152, Poster #: 1630, 2018.
  5. Mui B, DiStefano T, Hecht AC, Iatridis JC: Hydrogel formulation and culture conditions influence TGF- β3 release kinetics and extracellular matrix elaboration in genipin-crosslinked fibrin for annulus fibrosus repair, Transactions of the Orthopaedic Research Society, PS2-154, Poster #: 1666, 2018.
  6. Hom WW, Lin HA, Korda N, Desai JS, Nasser P, Hecht AC, Nicoll SB, Iatridis JC: Ex vivo biomechanical evaluation of a combined annulus fibrosus and nucleus pulposus hydrogel repair in a large animal model of severe intervertebral disc herniation injury, Transactions of the Orthopaedic Research Society, Spine: Modeling and Mechanics, Session 38, Podium Presentation #: 0216, 2018.
  7. Mosley GE, Evashwick-Rogler TW, Kaseta T, Lai A, Iatridis JC: Sex differences in rat lumbar intervertebral discs following annular puncture injury, Transactions of the Orthopaedic Research Society, PS2-152, Poster #: 1641, 2018.
  8. Zhou GK, Bradley EW, Westendorf JJ, Iatridis JC, Illien-Junger S: Role of Phlpp1 in Cell Proliferation and Apoptosis in Intervertebral Discs, Transactions of the Orthopaedic Research Society, PS1-053, Poster #:  0750, 2018.
  9. Real A, Ukogu C, Hecht AC, Iatridis JC: Elevated Glycohemoglobin HbA1c is Associated with Low Back Pain Independent of BMI, Transactions of the Orthopaedic Research Society, PS1-058, Poster #: 0802, 2018.
  10. Gluck MJ, Beck CM, Skodras A, Laudier D, Fowkes ME, Iatridis JC, Cagle PJ, Hausman MR: In Vivo Monitoring of Nerve Structure and Function Following Neural Stretch Injury via SHG Microscopy and Intra-Operative Nerve Stimulation, Transactions of the Orthopaedic Research Society, Session 056, Podium Presentation #: 0308, 2018.
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Publication in the Journal of Bone and Mineral Research!

Congratulations to the team on the publication of “Dietary Advanced Glycation End Products Have Sex- and Age-Dependent Effects on Vertebral Bone Microstructure and Mechanical Function in Mice.”!

The recently published manuscript in the Journal of Bone and Mineral Research demonstrated that a poor diet, high in advanced glycation end products can, independent of diabetic or overweight conditions, diminish vertebral microstructure, mechanical behaviors and fracture resistance in young female mice. This work suggests poor diet as a potential cause of accelerated spinal aging, especially in females

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ORS PSRS 2017

The Iatridis & Illien-Junger Labs had a great time at the ORS PSRS 4th International Spine Research Symposium in Lake Harmony PA! Chaired by Makarand Risbud, PSRS is a unique meeting in which prominent investigators and trainees in the spine research community come together to share their latest findings, trends, and ideas.

Congratulations to our PhD Candidate, Olivia Torre, on being a recipient of the “ORS PSRS Trainee Podium Award for Outstanding Scientific Research”! Her presentation, “Functional Restoration of Intervertebral Disc Biomechanics Following Neonatal Herniation Injury,” was delivered during the ‘Disc Biomechanics and Imaging’ session on October 26th, 2017.

Congratulations to Assistant Professor, Dr. Svenja Illien-Junger, on being a recipient of the Young Investigator Award. Dr. Illien-Junger advises ORL’s MS student, George Zhao, who presented the poster, “Phlpp1 in Cell Proliferation and Apoptosis During IVD Growth and Degeneration,” during the second poster session on October 25th, 2017.

In addition to these awards, Dr. Iatridis gave a fantastic talk titled, “Annulus Fibrosus Injury, Repair, and Regeneration” and Dr. Krishnamoorthy presented her poster, “Characterization of Human Lumbar Intervertebral Disc Glycosaminoglycan Sulfation Patterns using Multiple Reaction Monitoring with Liquid Chromatography-mass Spectrometry”.

We are very proud of these achievements and we look forward to ORL’s future research successes!

In addition to presenting our research and networking within the community, the Spine Lab enjoyed the time away from NYC in the Poconos.

Team learns about disc pathobiology:

Dr. James Iatridis giving his talk:

 Olivia receiving her award:

Svenja receiving her award:

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Einstein Meeting 2017

Thursday, October 19th marked the 6th annual Musculoskeletal Repair and Regeneration Symposium hosted by the Albert Einstein College of Medicine. Orthopaedic research at Mount Sinai was well represented at the meeting with multiple posters and a talk from Dr. James Iatridis on annulus fibrosis repair in a large animal model. Most excitingly, Olivia Torre was named one of three winners of the Young Investigator Award for graduate students and postdoctoral fellows for her work on injury and regeneration in the neonatal mouse intervertebral disc.

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Take a look at the Huang Laboratory Page for a Related Post!

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ORS 2017 Recap

The Spine Lab and collaborators successfully presented 10 abstracts this year at ORS in San Diego

  1. Rolfe RA, Oyen ML, Iatridis JC, Nowlan NC: Short Periods of Fetal Immobility Lead to Dramatic Effects on Spine and Rib Development, Paper #: 212.
  2. Long RG, Nakai T, Sakai D, Iatridis JC, Alini M, Grad S, Li Z: TGFβ1 induces a contractile CD146+ phenotype of human annulus fibrosus cells and may be delivered in a carrier for annulus fibrosus repair, Poster #: 1793.
  3. Torre OM, Das R, Mosley GE, Huang AH, Iatridis JC: Development of an In Vivo Model of Neonatal Intervertebral Disc Injury and Regeneration, Poster #: 1829.
  4. Cruz MA, Hom WW, Merril R, Torre OM, Nasser P, Hecht AC, Illien-Junger S, Iatridis JC: Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1800, 2017.
  5. Lin HA, Varma DM, Hom WW, Cruz MA, Nasser PR, Iatridis JC, Nicoll SB: Injectable Cellulosic Hydrogels as Nucleus Pulposus Replacements: Assessment of Herniation Risk, Fatigue Behavior, and In Vivo Biocompatibility, Transactions of the Orthopaedic Research Society, Poster Session: PS2-120, Spine – Disc, Tissue Engineering and Repair, Poster #: 1799, 2017.
  6. Lai A, Evashwick-Rogler TW, Salandra JM, Ho L, Laudier DM, Cho SK, Hecht AC, Winkelstein BA,  Pasinetti GM Iatridis JC: A Potential Safe and Novel Drink For Preventing Pain Associated With Disc Degeneration – An In-Vivo Rat Model, Transactions of the Orthopaedic Research Society, Poster session: PS2-121, Poster # 1839, 2017.
  7. Evashwick-Rogler TW, Lai A, Salandra JM, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, Hecht Ac, Iatridis JC: Disc height loss, but not Pro-inflammatory cytokine or Substance P expression, Predicts Intervertebral Disc Degeneration-Related Pain in a Rat Model, Transactions of the Orthopaedic Research Society, Poster Session: PS1-044, Spine – Disc Biology, Poster #: 854, 2017.
  8. Palacio-Mancheno P, Evashwick-Rogler TW, Laudier DM, Purmessur D, Iatridis JC: Hyperosmolar Overloading in a Mouse Organ Culture Model Induces Notochordal Cell Differentiation with Osmoregulatory Aquaporin3 Upregulation and Altered N-Cad and Connexin-43 Mechanotransduction Expression, Transactions of the Orthopaedic Research Society, Poster Session: PS2-121, Spine – Disc Biology, Poster # 1817, 2017.
  9. Palacio-Mancheno P, Kindschuh WF, Chen X, Harned AA, Iatridis JC: Illien-Jünger S: Age- and Sex-Dependent Effects of Advanced Glycation Endproducts Ingestion on Vertebral Bone Quality and Function, Transactions of the Orthopaedic Research Society, Poster Session: PS1-029, Bone – Musculoskeletal Development and Aging,  Poster #: 0672, 2017.
  10. Gluck MJ, Beck CM, Vijayaraghavan S, Iatridis JC, Hausman MR: In Situ Imaging of Rat Median Nerve Damage Using Second Harmonic Generation Microscopy: Advancing Towards an In Vivo Application, Transactions of the Orthopaedic Research Society, Poster Session: PS2-152, Diagnostic Imaging, Poster #: 2241, 2017.

James Iatridis also Chaired the ORS Spine Section Meeting and became 2nd Vice President of the ORS. We enjoyed being part of the Van Mow academic tree during his Shands Award Presentation #VanMow #ORS2017.

In addition to research activities, most of the Orthopaedic Research Lab attendees met at Tom Evashwick-Rogler’s family home for a great barbeque in celebration of a very successful meeting.

 

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James Iatridis Elected as 2nd Vice President of ORS

james Iatridis

Dr. Iatridis was elected as the 2nd Vice President of the Orthopaedic Research Society.  His 4 year term in the presidential lineage on the ORS Board of Directors will begin after the ORS annual meeting in San Diego in March 2017.  During his 20 years as a member of the ORS, Dr. Iatridis has served as a program topic chair, regularly organized workshops and judged award competitions, and reviewed abstracts.  He has also been the Chair of the ORS/OREF/AAOS New Investigator Research Funding Workshop and the inaugural Chair of the ORS Spine Section.  Dr. Iatridis has a strong vision to balancing the growth opportunities offered by the new ORS Sections with focus and efficiency, while also nurturing the broad orthopaedic mission and the cohesive orthopaedic research community.  He is committed to building innovative partnerships with diverse involvement across disciplines and geographies.

 

Source: ORS Election Results

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Accepted abstracts for ORS 2016

 

  1. Rolfe RA, Oyen ML, Iatridis JC, Nowlan NC: Mechanical Stimulation is required for normal spinal curvature and vertebral segmentation in the developing chick, Transactions of the Orthopaedic Research Society, 2016, Poster # 0852.
  2. Watanabe H, Lai A, Schuchman M, Cho SK, Hecht AC, Iatridis JC: Can Intradiscal Injection with TNF-α Inhibitor Reduce Pain and Disc Degeneration in a Rat Model?, Can Intradiscal Injection with TNF-α Inhibitor Reduce Pain and Disc Degeneration in a Rat Model?, Transactions of the Orthopaedic Research Society, 2016, Poster # 0875.
  3. Nakazawa KR, Walter BA, Laudier DM, Spiller KL, Iatridis JC: Exogenous and Endogenous Macrophage Phenotypes and Localization in Human Intervertebral Disc Degeneration, Transactions of the Orthopaedic Research Society, 2016, Poster # 0891.
  4. Lai A, Watanabe H, Ho L, Cho SK, Hecht AC, Pasinetti GM, Iatridis JC: Polyphenol Metabolites Potentially Alleviate Painful Behavior Induced by Annular Injury – An In-vivo Rat Model, Transactions of the Orthopaedic Research Society, 2016, Poster # 1735.
  5. Cruz MA, Torre OM, Merrill RK, Illien-Junger S, Hecht AC, Iatridis JC: Genipin-crosslinked Fibrin has Potential for Use as a Cell Carrier for Annulus Fibrosus Repair, Transactions of the Orthopaedic Research Society, 2016, Poster # 0867.
  6. Kindschuh WF, Palacio-Mancheno P, Chen X, Iatridis JC, Illien-Jünger S: Sex-Dependent Effects of Dietary Advanced Glycation Endproducts on Vertebral Bone, Transactions of the Orthopaedic Research Society, 2016, Poster #  0908.
  7. Aly N, Palacio-Mancheno P, Ahmed F, Tadros M, Purmessur D, Iatridis: JC: Effects of Osmolarity on Nucleus Pulposus Matrix and Cellular Phenotype in a Mouse Whole IVD Organ Culture Model: Contributions of TRPV4 and Aquaporins, Transactions of the Orthopaedic Research Society, 2016, Poster.
  8. Tadros M, Palacio-Mancheno P, Ahmed F, Aly N, Purmessur D, Iatridis JC: Injury-related Changes to the Intervertebral Disc Phenotype are associated with Aquaporin Expression, Independent of TRPV4 in the Inner Annulus Fibrosus, Transactions of the Orthopaedic Research Society, 2016, Poster # 1749.
  9. Varma DM, Lin HA, Long RG, Hecht AC, Iatridis JC, Nicoll SB: In Situ Gelling Cellulosic Copolymer Hydrogels Restore Intervertebral Disc Height and Biomechanical Properties Post Nucleotomy, Transactions of the Orthopaedic Research Society, 2016, Poster # 0869.