Avi Ma’ayan’s Publications on PubMed  | Google Scholar | ResearchGate

Featured Publication

ChEA3: transcription factor enrichment analysis by orthogonal omics integration


Evangelista JE, Clarke DJB, Xie Z, Marino GB, Utti V, Jenkins SL, Ahooyi TM, Bologa CG, Yang JJ, Binder JL, Kumar P, Lambert CG, Grethe JS, Wenger E, Taylor D, Oprea TI, de Bono B, Ma’ayan AToxicology knowledge graph for structural birth defectsCommunications Medicine 3(1):98 (2023) PMID: 37460679

Evangelista JE, Xie Z, Marino GB, Nguyen N, Clarke DJB, Ma’ayan AEnrichr-KG: bridging enrichment analysis across multiple librariesNucleic Acids Research 51(W1):W168-W179 (2023) PMID: 37166973

Marino GB, Ngai M, Clarke DJB, Fleishman RH, Deng EZ, Xie Z, Ahmed N, Ma’ayan AGeneRanger and TargetRanger: processed gene and protein expression levels across cells and tissues for target discoveryNucleic Acids Research 51(W1):W213-W224 (2023) PMID: 37166966

Deng EZ, Fleishman RH, Xie Z, Marino GB, Clarke DJB, Ma’ayan AComputational screen to identify potential targets for immunotherapeutic identification and removal of senescence cellsAging Cell 22(6):e13809 (2023) PMID: 37082798

Marino GB, Wojciechowicz ML, Clarke DJB, Kuleshov MV, Xie Z, Jeon M, Lachmann A, Ma’ayan AlncHUB2: aggregated and inferred knowledge about human and mouse lncRNAsDatabase (Oxford) 2023:baad009 (2023) PMID: 36869839

Lachmann A, Rizzo KA, Bartal A, Jeon M, Clarke DJB, Ma’ayan APrismEXP: gene annotation prediction from stratified gene-gene co-expression matricesPeerJ 11:e14927 (2023) PMID: 36874981


Charbonneau AL, Brady A, Czajkowski K, Aluvathingal J, Canchi S, Carter R, Chard K, Clarke DJB, Crabtree J, Creasy HH, D’Arcy M, Felix V, Giglio M, Gingrich A, Harris RM, Hodges TK, Ifeonu O, Jeon M, Kropiwnicki E, Lim MCW, Liming RL, Lumian J, Mahurkar AA, Mandal M, Munro JB, Nadendla S, Richter R, Romano C, Rocca-Serra P, Schor M, Schuler RE, Tangmunarunkit H, Waldrop A, Williams C, Word K, Sansone SA, Ma’ayan A , Wagner R, Foster I, Kesselman C, Brown CT, White O. Making Common Fund data more findable: catalyzing a data ecosystemGigascience 11:giac105 (2022) PMID: 36409836

Clarke DJB, Rebman AW, Fan J, Soloski MJ, Aucott JN, Ma’ayan AGene set predictor for post-treatment Lyme diseaseCell Reports Medicine 3(11):100816 (2022) PMID: 36384094

Gross SM, Dane MA, Smith RL, Devlin KL, McLean IC, Derrick DS, Mills CE, Subramanian K, London AB, Torre D, Evangelista JE, Clarke DJB, Xie Z, Erdem C, Lyons N, Natoli T, Pessa S, Lu X, Mullahoo J, Li J, Adam M, Wassie B, Liu M, Kilburn DF, Liby TA, Bucher E, Sanchez-Aguila C, Daily K, Omberg L, Wang Y, Jacobson C, Yapp C, Chung M, Vidovic D, Lu Y, Schurer S, Lee A, Pillai A, Subramanian A, Papanastasiou M, Fraenkel E, Feiler HS, Mills GB, Jaffe JD, Ma’ayan A, Birtwistle MR, Sorger PK, Korkola JE, Gray JW, Heiser LM. A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responsesCommunications Biology 5(1):1066 (2022) PMID: 36207580

Jenkins EC, Chattopadhyay M, Gomez M, Torre D, Ma’ayan A, Torres-Martin M, Sia D, Germain D. Age alters the oncogenic trajectory toward luminal mammary tumors that activate unfolded proteins responsesCell Aging 21(10):e13665 (2022) PMID: 36111352

Jeon M, Xie Z, Evangelista JE, Wojciechowicz ML, Clarke DJB, Ma’ayan ATransforming L1000 profiles to RNA-seq-like profiles with deep learningBMC Bioinformatics 23(1):74 (2022) PMID: 36100892

Pilarczyk M, Fazel-Najafabadi M, Kouril M, Shamsaei B, Vasiliauskas J, Niu W, Mahi N, Zhang L, Clark NA, Ren Y, White S, Karim R, Xu H, Biesiada J, Bennett MF, Davidson SE, Reichard JF, Roberts K, Stathias V, Koleti A, Vidovic D, Clarke DJB, Schürer SC, Ma’ayan A, Meller J, Medvedovic M. Connecting omics signatures and revealing biological mechanisms with iLINCSNature Communications 13(1):4678 (2022) PMID: 35945222

Xie Z, Kropiwnicki E, Wojciechowicz ML, Jagodnik KM, Shu I, Bailey A, Clarke DJB, Jeon M, Evangelista JE, V Kuleshov M, Lachmann A, Parigi AA, Sanchez JM, Jenkins SL, Ma’ayan AGetting started with LINCS datasets and toolsCurrent Protocols 2(7):e487 (2022) PMID: 35876555

Evangelista JE, Clarke DJB, Xie Z, Lachmann A, Jeon M, Chen K, Jagodnik KM, Jenkins SL, Kuleshov MV, Wojciechowicz ML, Schurer SC, Medvedovic M, Ma’ayan ASigCom LINCS: data and metadata search engine for a million gene expression signaturesNucleic Acids Research 50(W1):W697-709 (2022) PMID: 35524556

Clarke DJB, Kuleshov MV, Xie Z, Evangelista JE, Meyers MR, Kropiwnicki E, Jenkins SL, Ma’ayan AGene and drug landing page aggregatorBioinformatics Advances 2(1):vbac013 (2022) PMID: 35368424

Wickramasinghe NM, Sachs D, Shewale B, Gonzalez DM, Dhanan-Krishnan P, Torre D, LaMarca E, Raimo S, Dariolli R, Serasinghe MN, Mayourian J, Sebra R, Beaumont K, Iyengar S, French DL, Hansen A, Eschenhagen T, Chipuk JE, Sobie EA, Jacobs A, Akbarian S, Ischiropoulos H, Ma’ayan A, Houten SM, Costa K, Dubois NC. PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytesCell Stem Cell 29(4):559-576.e7 (2022) PMID: 35325615

Kropiwnicki E, Lachmann A, Clarke DJB, Xie Z, Jagodnik KM, Ma’ayan ADrugShot: querying biomedical search terms to retrieve prioritized lists of small moleculesBMC Bioinformatics 23(1):76 (2022) PMID: 35183110

Lachmann A, Xie Z, Ma’ayan AblitzGSEA: Efficient computation of Gene Set Enrichment Analysis through Gamma distribution approximationBioinformatics btac076 (2022) PMID: 35143610

Kropiwnicki E, Binder JL, Yang JJ, Holmes J, Lachmann A, Clarke DJB, Sheils T, Kelleher KJ, Metzger VT, Bologa CG, Oprea TI, Ma’ayan A. Getting started with the IDG KMC datasets and toolsCurrent Protocols 2(1):e355 (2022) PMID: 35085427


Onoufriadis A, Proudfoot LE, Ainali C, Torre D, Papanikolaou M, Rayinda T, Rashidghamat E, Danarti R, Mellerio JE, Ma’ayan A, McGrath JA. Transcriptomic profiling of recessive dystrophic epidermolysis bullosa wounded skin highlights drug repurposing opportunities to improve wound healingExperimental Dermatology (2021) PMID: 34694680

Piret SE, Attallah AA, Gu X, Guo Y, Gujarati NA, Henein J, Zollman A, Hato T, Ma’ayan A, Revelo MP, Dickman KG, Chen CH, Shun CT, Rosenquist TA, He JC, Mallipattu SK. Loss of proximal tubular transcription factor Krüppel-like factor 15 exacerbates kidney injury through loss of fatty acid oxidationKidney International (2021) PMID: 34634362

Bobe JR, Jutras BL, Horn EJ, Embers ME, Bailey A, Moritz RL, Zhang Y, Soloski MJ, Ostfeld RS, Marconi RT, Aucott J, Ma’ayan A, Keesing F, Lewis K, Ben Mamoun C, Rebman AW, McClune ME, Breitschwerdt EB, Reddy PJ, Maggi R, Yang F, Nemser B, Ozcan A, Garner O, Di Carlo D, Ballard Z, Joung HA, Garcia-Romeu A, Griffiths RR, Baumgarth N, Fallon BA. Recent progress in Lyme disease and remaining challengesFrontiers in Medicine (2021) PMID: 34485323

Kuleshov MV, Xie Z, London ABK, Yang J, Evangelista JE, Lachmann A, Shu I, Torre D, Ma’ayan AKEA3: improved kinase enrichment analysis via data integrationNucleic Acids Research 49(W1):W304-W316 (2021) PMID: 34019655

Piret SE, Guo Y, Attallah AA, Horne SJ, Zollman A, Owusu D, Henein J, Sidorenko VS, Revelo MP, Hato T, Ma’ayan A, He JC, Mallipattu SK. Krüppel-like factor 6-mediated loss of BCAA catabolism contributes to kidney injury in mice and humansProc Natl Acad Sci USA 118(23) (2021) PMID: 34074766

Sevilla A, Papatsenko D, Mazloom AR, Xu H, Vasileva A, Unwin RD, LeRoy G, Chen EY, Garrett-Bakelman FE, Lee DF, Trinite B, Webb RL, Wang Z, Su J, Gingold J, Melnick A, Garcia BA, Whetton AD, MacArthur BD, Ma’ayan A, Lemischka IR. An Esrrb and Nanog cell fate regulatory module controlled by feed forward loop interactionsFrontiers in Cell and Developmental Biology 9:630067 (2021) PMID: 33816475

Kropiwnicki E, Evangelista JE, Stein DJ, Clarke DJB, Lachmann A, Kuleshov MV, Jeon M, Jagodnik KM, Ma’ayan ADrugmonizome and Drugmonizome-ML: integration and abstraction of small molecule attributes for drug enrichment analysis and machine learningDatabase baab017 (2021) PMID: 33787872

Xie Z, Bailey A, Kuleshov MV, Clarke DJB, Evangelista JE, Jenkins SL, Lachmann A, Wojciechowicz ML, Kropiwnicki E, Jagodnik KM, Jeon M, Ma’ayan AGene set knowledge discovery with EnrichrCurrent Protocols 1(3):e90 (2021) PMID: 33780170

Clarke DJB, Rebman AW, Bailey A, Wojciechowicz ML, Jenkins SL, Evangelista JE, Danieletto M, Fan J, Eshoo MW, Mosel MR, Robinson W, Ramadoss N, Bobe J, Soloski MJ, Aucott JN, Ma’ayan APredicting Lyme Disease from patients’ peripheral blood mononuclear cells profiled with RNA-sequencingFrontiers in Immunology 12:636289 (2021) PMID: 33763080

Austin E, Koo E, Merleev A, Torre D, Marusina A, Luxardi G, Mamalis A, Isseroff RR, Ma’ayan A, Maverakis E, Jagdeo J. Transcriptome analysis of human dermal fibroblasts following red light phototherapyScientific Reports 11(1):7315 (2021) PMID: 33795767

Clarke DJB, Jeon M, Stein DJ, Moiseyev N, Kropiwnicki E, Dai C, Xie Z, Wojciechowicz ML, Litz S, Hom J, Evangelista JE, Goldman L, Zhang S, Yoon C, Ahamed T, Bhuiyan S, Cheng M, Karam J, Jagodnik KM, Shu I, Lachmann A, Ayling S, Jenkins SL, Ma’ayan AAppyters: Turning Jupyter notebooks into data-driven web appsPatterns 2(3):100213 (2021) PMID: 33748796

Jeon M, Jagodnik KM, Kropiwnicki E, Stein DJ, Ma’ayan APrioritizing pain-associated targets with machine learningBiochemistry (2021) PMID: 33606503

Zhang L, Wang Z, Liu R, Li Z, Lin J, Wojciechowicz ML, Huang J, Lee K, Ma’ayan A, He JC. Connectivity mapping identifies BI-2536 as a potential drug to treat diabetic kidney diseaseDiabetes 70(2):589-602 (2021) PMID: 33067313


Eberlein J, Davenport B, Nguyen TT, Victorino F, Jhun K, van der Heide V, Kuleshov M, Ma’ayan A, Kedl R, Homann D. Chemokine signatures of pathogen-specific T cells I: Effector T cellsJournal of Immunology 205(8):2169-2187 (2020) PMID: 32948687

Davenport B, Eberlein J, Nguyen TT, Victorino F, van der Heide V, Kuleshov M, Ma’ayan A, Kedl R, Homann D. Chemokine signatures of pathogen-specific T cells II: Memory T cells in acute and chronic infection. Journal of Immunology 205(8):2188-2206 (2020) PMID: 32948682

Kuleshov MV, Stein DJ, Clarke DJB, Kropiwnicki E, Jagodnik KM, Bartal A, Evangelista JE, Hom J, Cheng M, Bailey A, Zhou A, Ferguson LB, Lachmann A, Ma’ayan A. The COVID-19 gene and drug set library. Patterns 1(6):100090 (2020) PMID: 32838343

Chen Z, Herting CJ, Ross JL, Gabanic B, Vallcorba MP, Szulzewsky F, Wojciechowicz ML, Cimino PJ, Ezhilarasan R, Sulman EP, Ying M, Ma’ayan A, Read RD, Hambardzumyan D. Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade. Glia 68(10):2148-2166 (2020) PMID: 32639068

Borziak K, Qi T, Evangelista JE, Clarke DJB, Ma’ayan A, Finkelstein J. Towards intelligent integration and sharing of stem cell research data. Studies in Health Technologies and Informatics 272:334-337 (2020) PMID: 32604670

Wojciechowicz ML, Ma’ayan A. GPR84: an immune response dial? Nature Reviews Drug Discovery 19(6):374 (2020) PMID: 32494048

Bartal A, Lachmann A, Clarke DJB, Seiden AH, Jagodnik KM, Ma’ayan A. EnrichrBot: Twitter bot tracking tweets about human genes. Bioinformatics 36(12):3932-3934 (2020) PMID: 32277816

Bernitz JM, Rapp K, Daniel MG, Shcherbinin D, Yuan Y, Gomes A, Waghray A, Brosh R, Lachmann A, Ma’ayan A, Papatsenko D, Moore KA. Memory of divisional history directs the continuous process of primitive hematopoietic lineage commitment. Stem Cell Reports 14(4):561-574 (2020) PMID: 32243840

Lachmann A, Clarke DJB, Torre D, Xie Z, Ma’ayan A. Interoperable RNA-seq analysis in the cloud. Biochimica et Biophysica Acta Gene Regulatory Mechanisms 1863(6):194521 (2020) PMID: 32156561

Edwards JJ, Rouillard AD, Fernandez NF, Wang Z, Lachmann A, Shankaran SS, Bisgrove BW, Demarest B, Turan N, Srivastava D, Bernstein D, Deanfield J, Giardini A, Porter G, Kim R, Roberts AE, Newburger JW, Goldmuntz E, Brueckner M, Lifton RP, Seidman CE, Chung WK, Tristani-Firouzi M, Yost HJ, Ma’ayan A, Gelb BD. Systems analysis implicates WAVE2 complex in the pathogenesis of developmental left-sided obstructive heart defects. JACC Basic to Translational Science 5(4):376-386 (2020) PMID: 32368696

Heitman N, Sennett R, Mok KW, Saxena N, Srivastava D, Martino P, Grisanti L, Wang Z, Ma’ayan A, Rompolas P, Rendl M. Dermal sheath contraction powers stem cell niche relocation during hair cycle regression. Science 367(6474):161-166 (2020) PMID: 31857493


Clarke DJB, Wang L, Jones A, Wojciechowicz ML, Torre D, Jagodnik KM, Jenkins SL, McQuilton P, Flamholz Z et al. […] Ma’ayan A. FAIRshake: Toolkit to evaluate the FAIRness of research digital resources. Cell Systems 9(5):417-421 (2019) PMID: 31677972

Ochsner SA, Abraham D, Martin K, Ding W, McOwiti A, Kankanamge W, Wang Z, Andreano K, Hamilton RA, Chen Y, Hamilton A, Gantner ML, Dehart M, Qu S, Hilsenbeck SG, Becnel LB, Bridges D, Ma’ayan A, Huss JM, Stossi F, Foulds CE, Kralli A, McDonnell DP, McKenna NJ. The Signaling Pathways Project, an integrated ‘omics knowledgebase for mammalian cellular signaling pathways. Scientific Data 6(1):252 (2019) PMID: 31672983

Duncan A, Heyer MP, Ishikawa M, Caligiuri SPB, Liu XA, Chen Z, Vittoria Micioni Di Bonaventura M, Elayouby KS, Ables JL, Howe WM, Bali P, Fillinger C, Williams M, O’Connor RM, Wang Z, Lu Q, Kamenecka TM, Ma’ayan A, O’Neill HC, Ibanez-Tallon I, Geurts AM, Kenny PJ. Habenular TCF7L2 links nicotine addiction to diabetes. Nature 574(7778):372-377 (2019) PMID: 31619789

Fernandez DM, Rahman AH, Fernandez NF, Chudnovskiy A, Amir ED, Amadori L, Khan NS, Wong CK, Shamailova R, Hill CA, Wang Z, Remark R, Li JR, Pina C, Faries C, Awad AJ, Moss N, Bjorkegren JLM, Kim-Schulze S, Gnjatic S, Ma’ayan A, Mocco J, Faries P, Merad M, Giannarelli C. Single-cell immune landscape of human atherosclerotic plaques. Nature Medicine (10):1576-1588 (2019) PMID: 31591603

Niepel M, Hafner M, Mills CE, Subramanian K, Williams EH, Chung M, Gaudio B, Barrette AM, Stern AD, Hu B, Korkola JE, LINCS Consortium et al. A Multi-center study on the reproducibility of drug-response assays in mammalian cell lines. Cell Systems 9(1):35-48.e5 (2019) PMID: 31302153

Lachmann A, Schilder BM, Wojciechowicz ML, Torre D, Kuleshov MV, Keenan AB, Ma’ayan A. Geneshot: search engine for ranking genes from arbitrary text queries. Nucleic Acids Research 47(W1):W571-W577 (2019) PMID: 31114885

Keenan AB, Torre D, Lachmann A, Leong AK, Wojciechowicz ML, Utti V, Jagodnik KM, Kropiwnicki E, Wang Z, Ma’ayan A. ChEA3: transcription factor enrichment analysis by orthogonal omics integration. Nucleic Acids Research 47(W1):W212-W224 (2019) PMID: 31114921

Kuleshov MV, Diaz JEL, Flamholz ZN, Keenan AB, Lachmann A, Wojciechowicz ML, Cagan RL, Ma’ayan A. modEnrichr: a suite of gene set enrichment analysis tools for model organisms. Nucleic Acids Research 47(W1):W183-W190 (2019) PMID: 31069376

Nakahara F, Borger DK, Wei Q, Pinho S, Maryanovich M, Zahalka AH, Suzuki M, Cruz CD, Wang Z, Xu C, Boulais PE, Ma’ayan A, Greally JM, Frenette PS. Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells. Nature Cell Biology 21(5):560-567 (2019) PMID: 30988422

Keenan AB, Wojciechowicz ML, Wang Z, Jagodnik KM, Jenkins SL, Lachmann A, Ma’ayan A. Connectivity mapping: methods and applications. Annual Review of Biomedical Data Science 2:69-92 (2019)

Tohme R, Izadmehr S, Gandhe S, Tabaro G, Vallabhaneni S, Thomas A, Vasireddi N, Dhawan NS, Ma’ayan A, Sharma N, Galsky MD, Ohlmeyer M, Sangodkar J, Narla G. Direct activation of PP2A for the treatment of tyrosine kinase inhibitor-resistant lung adenocarcinoma. JCI Insight 4(4) pii: 125693 (2019) PMID: 30830869

Ellis RJ, Wang Z, Genes N, Ma’ayan A. Predicting opioid dependence from electronic health records with machine learning. BioData Mining 12:3 (2019) PMID: 30728857

Mok KW, Saxena N, Heitman N, Grisanti L, Srivastava D, Muraro MJ, Jacob T, Sennett R, Wang Z, Su Y, Yang LM, Ma’ayan A, Ornitz DM, Kasper M, Rendl M. Dermal condensate niche fate specification occurs prior to formation and is placode progenitor dependent. Developmental Cell 48(1):32-48 (2019) PMID: 30595537

Wang Z, Lachmann A, Ma’ayan A. Mining data and metadata from the gene expression omnibus. Biophysical Reviews 11(1):103-110 (2019) PMID: 30594974


Torre D, Lachmann A, Ma’ayan A. BioJupies: Automated Generation of Interactive Notebooks for RNA-Seq Data Analysis in the Cloud. Cell Systems 7(5):556-561 (2018) PMID: 30447998

Oprea TI, Jan L, Johnson GL, Roth BL, Ma’ayan A, Schurer S, Shoichet BK, Sklar LA, McManus MT. Far away from the lamppost. PLoS Biology 16(12):e3000067 (2018) PMID: 30532236

Breen MS, Ozcan S, Ramsey JM, Wang Z, Ma’ayan A, Rustogi N, Gottschalk MG, Webster MJ, Weickert CS, Buxbaum JD, Bahn S. Temporal proteomic profiling of postnatal human cortical development. Translational Psychiatry 8(1):267 (2018) PMID: 30518843

Gomes AM, Kurochkin I, Chang B, Daniel M, Law K, Satija N, Lachmann A, Wang Z, Ferreira L, Ma’ayan A, Chen BK, Papatsenko D, Lemischka IR, Moore KA, Pereira CF. Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming. Cell Reports 25(10):2821-2835 (2018) PMID: 30517869

Wang Z, He E, Sani K, Jagodnik KM, Silverstein M, Ma’ayan A. Drug Gene Budger (DGB): An application for ranking drugs to modulate a specific gene based on transcriptomic signatures. Bioinformatics (2018) PMID: 30169739

Strub T, Ghiraldini FG, Carcamo S, Li M, Wroblewska A, Singh R, Goldberg MS, Hasson D, Wang Z, Gallagher SJ, Hersey P, Ma’ayan A, Long GV, Scolyer RA, Brown B, Zheng B, Bernstein E. SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling. Nature Communications 9(1):3440 (2018) PMID: 30143629

Guo Y, Pace J, Li Z, Ma’ayan A, Wang Z, Revelo MP, Chen E, Gu X, Attalah A, Yang Y, Estrada C, Yang VW, He JC, Mallipattu SK. Podocyte-specific induction of Krüppel-Like Factor 15 restores differentiation markers and attenuates kidney injury in proteinuric kidney disease.. Journal of the America Society of Nephrology pii: ASN.2018030324(2018) PMID: 30143559

Clarke DJB, Kuleshov MV, Schilder BM, Torre D, Duffy ME, Keenan AB, Lachmann A, Feldmann AS, Gundersen GW, Silverstein MC, Wang Z, Ma’ayan A. eXpression2Kinases (X2K) Web: linking expression signatures to upstream cell signaling networks. Nucleic Acids Research 46(W1):W171-W179 (2018) PMID: 29800326

Han S, Tan C, Ding J, Wang J, Ma’ayan A, Gouon-Evans V. Endothelial cells instruct liver specification of embryonic stem cell-derived endoderm through endothelial VEGFR2 signaling and endoderm epigenetic modifications. Stem Cell Research 30:163-170 (2018) PMID: 29936335

Stathias V, Koleti A, Vidović D, Cooper DJ, Jagodnik KM, Terryn R, Forlin M, Chung C, Torre D, Ayad N, Medvedovic M, Ma’ayan A, Pillai A, Schurer SC. Sustainable data and metadata management at the BD2K-LINCS Data Coordination and Integration Center. Scientific Data 5:180117 (2018) PMID: 29917015

Grimes M, Hall B, Foltz L, Levy T, Rikova K, Gaiser J, Cook W, Smirnova E, Wheeler T, Clark NR, Lachmann A, Zhang B, Hornbeck P, Ma’ayan A, Comb M. Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks. Science Signaling 11(531) (2018) PMID: 29789295

Lachmann A, Torre D, Keenan AB, Jagodnik KM, Lee HJ, Wang L, Silverstein MC, Ma’ayan A. Massivc mining of publicly available RNA-sq data from human and mouse. Nature Communications 9(1):1366 (2018) PMID: 29636450

Torre D, Krawczuk P, Jagodnik KM, Lachmann A, Wang Z, Wang L, Kuleshov MV, Ma’ayan A. Datasets2Tools, repository and search engine for bioinformatics datasets, tools and canned analyses. Scientific Data 5, 180023 (2018) PMID: 29485625

Oprea TI, Bologa CG, Brunak S, Campbell A, Gan GN, Gaulton A, Gomez SM, Guha R, Hersey A, Holmes J, Jadhav A, Jensen LJ, Johnson GL, Karlson A, Leach AR, Ma’ayan A et al. Unexplored therapeutic opportunities in the human genome. Nature Review Drug Discovery (2018) PMID: 29572638

Czarnowicki T, Dohlman AB, Malik K, Antonini D, Bissonnette R, Chan TC, Zhou L, Wen HC, Estrada Y, Xu H, Bryson C, Shen J, Lala D, Ma’ayan A, McGeehan G, Gregg R, Guttman-Yassky E. Short-term LXR activation improves epidermal barrier features in mild-to-moderate atopic dermatitis: a randomized controlled trial. Annals of Allergy, Asthma and Immunology S1081-1206(18)30211-4 (2018) PMID: 29567358

Wang Z, Lachmann A, Keenan AB, Ma’ayan A. L1000FWD: Fireworks visualization of drug-induced transcriptomic signatures. Bioinformatics 34(12)2150-2152 (2018) PMID: 29420694

Koplev S, Lin K, Dohlman AB, Ma’ayan A. Integration of pan-cancer transcriptomics with RPPA proteomics reveals mechanisms of epithelial-mesenchymal transition. PLoS Computational Biology 14(1):e1005911 (2018) PMID: 29293502

Hodos R, Zhang P, Lee HC, Duan Q, Wang Z, Clark NR, Ma’ayan A, Wang F, Kidd B, Hu J, Sontag D, Dudley J. Cell-specific prediction and application of drug-induced gene expression profiles. Pacific Symposium on Biocomputing 23:32-43 (2018) PMID: 29218867

Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, Lachmann A, Kuleshov MV, Ma’ayan A et al. The Library of Integrated Network-Based Cellular Signatures NIH program: System-level cataloging of human cells response to perturbations. Cell Systems  6(1):13-24 (2018) PMID: 29199020

Koleti A, Terryn R, Stathias V, Chung C, Cooper DJ, Turner JP, Vidovic D, Forlin M, Kelley TT, D’Urso A, Allen BK, Torre D, Jagodnik KM, Wang L, Jenkins SL, Mader C, Niu W, Fazel M, Mahi N, Pilarczyk M, Clark N, Shamsaei B, Meller J, Vasiliauskas J, Reichard J, Medvedovic M, Ma’ayan A, Pillai A, Schurer SC. Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: integrated access to diverse large-scale cellular perturbation response data. Nucleic Acids Research 46(D1):D558-D566 (2018) PMID: 29140462


Wang Z, Li L, Glicksberg BS, Israel A, Dudley JT, Ma’ayan A. Predicting age by mining electronic medical records with deep learning characterizes differences between chronological and physiological age. Journal of Biomedical Informatics pii: S1532-0464(17)30240-X (2017) PMID: 29113935

Fu J, Wang Z, Lee K, Wei C, Liu Z, Zhang M, Zhoud M, Cai M, Zhang W, Chuang PY, Ma’ayan A, He JC, Liu Z. Transcriptomic analysis uncovers novel synergistic mechanisms in combination therapy for lupus nephritis. Kidney International pii: S0085-2538(17)30671-3 (2017) PMID: 29102373

Niepel M, Hafner M, Duan Q, Wang Z, Paull EO, Chung M, Lu X, Stuart JM, Golub TR, Subramanian A, Ma’ayan A, Sorger PK. Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling. Nature Communications 8(1):1186 (2017) PMID: 29084964

Fernandez NF, Gundersen GW, Rahman A, Grimes ML, Rikova K, Hornbeck P, Ma’ayan A. Clustergrammer, a web-based heatmap visualization and analysis tool for high-dimensional biological data. Scientific Data 4:170151 (2017) PMID: 28994825

Ma’ayan A. Complex systems biology. Journal of the Royal Society, Interface 14(134) pii: 20170391 (2017) PMID: 28931638

Lachmann A, Torre D, Keenan AB, Jagodnik KM, Lee HJ, Silverstein MC, Wang L, Ma’ayan A. Massive mining of publicly available RNA-seq data from human and mouse. bioRxiv 189092 (2017)

Sangodkar J, Perl A, Tohme R, Kiselar J, Kastrinsky DB, Zaware N, Izadmehr S, Mazhar S, Wiredja DD, O’Connor CM, Hoon D, Dhawan NS, Schlatzer D, Yao S, Leonard D, Borczuk AC, Gokulrangan G, Wang L, Svenson E, Farrington CC, Yuan E, Avelar RA, Stachnik A, Smith B, Gidwani V, Giannini HM, McQuaid D, McClinch K, Wang Z, Levine AC, Sears RC, Chen EY, Duan Q, Datt M, Haider S, Ma’ayan A, DiFeo A, Sharma N, Galsky MD, Brautigan DL, Ioannou YA, Xu W, Chance MR, Ohlmeyer M, Narla G. Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth. The Journal of Clinical Investigation pii: 89548 (2017) PMID: 28504649

Jagodnik KM, Koplev S, Jenkins S, Ohno-Machado L, Paten B, Schurer SC, Dumontier M, Verborgh R, Bui A, Ping P, McKenna NJ, Madduri R, Pillai A, Ma’ayan ADeveloping a Framework for Digital Objects in the Big Data to Knowledge (BD2K) Commons: Report from the Commons Framework Pilots Workshop. Journal of Biomedical Informatics pii: S1532-0464(17)30101-6 (2017) PMID: 28501646

Asada N, Kunisaki Y, Pierce H, Wang Z, Fernandez NF, Birbrair A, Ma’ayan A, Frenette PS. Differential cytokine contributions of perivascular haematopoietic stem cell niches. Nature Cell Biology 19(3):214-22 (2017) PMID: 28218906

Shameer K, Glicksberg BS, Hodos R, Johnson KW, Badgeley MA, Readhead B, Tomlinson MS, O’Connor T, Miotto R, Kidd BA, Chen R, Ma’ayan A, Dudley JT. Systematic analyses of drugs and disease indications in RepurposeDB reveal pharmacological, biological and epidemiological factors influencing drug repositioning. Briefings in Bioinformatics (2017) PMID: 28200013

Nguyen DT, Mathias S, Bologa C, Brunak S, Fernandez N, Gaulton A, Hersey A, Holmes J, Jensen LJ, Karlsson A, Liu G, Ma’ayan A, Mandava G, Mani S, Mehta S, Overington J, Patel J, Rouillard AD, Schürer S, Sheils T, Simeonov A, Sklar LA, Southall N, Ursu O, Vidovic D, Waller A, Yang J, Jadhav A, Oprea TI, Guha R. Pharos: Collating protein information to shed light on the druggable genomeNucleic Acids Research 45(D1):D995-D100 (2017) PMID: 27903890


Pfau ML, Purushothaman I, Feng J, Golden SA, Aleyasin H, Lorsch ZS, Cates HM, Flanigan ME, Menard C, Heshmati M, Wang Z, Ma’ayan A, Shen L, Hodes GE, Russo SJ. Integrative Analysis of Sex-Specific microRNA Networks Following Stress in Mouse Nucleus Accumbens. Frontiers in Molecular Neuroscience 9:144 (2016) PMID: 28066174

Gundersen GW, Jagodnik KM, Woodland H, Fernandez NF, Sani K, Dohlman AB, Ung PM, Monteiro CD, Schlessinger A, Ma’ayan AGEN3VA: aggregation and analysis of gene expression signatures from related studiesBMC Bioinformatics 17(1):461 (2016) PMID: 27846806

Wang Z, Monteiro CD, Jagodnik KM, Fernandez NF, Gundersen GW, Rouillard AD, Jenkins SL, Feldmann AS, Hu KS, McDermott MG, Duan Q, Clark NR, Jones MR, Kou Y, Goff T, Woodland H, Amaral FM, Szeto GL, Fuchs O, Schüssler-Fiorenza Rose SM, Sharma S, Schwartz U, Bausela XB, Szymkiewicz M, Maroulis V, Salykin A, Barra CM, Kruth CD, Bongio NJ, Mathur V, Todoric RD, Rubin UE, Malatras A, Fulp CT, Galindo JA, Motiejunaite R, Jüschke C, Dishuck PC, Lahl K, Jafari M, Aibar S, Zaravinos A, Steenhuizen LH, Allison LR, Gamallo P, de Andres Segura F, Dae Devlin T, Pérez-García V, Ma’ayan AExtraction and analysis of signatures from the Gene Expression Omnibus by the crowd. Nature Communications 7:12846 (2016) PMID: 27667448

Duan Q, Reid SP, Clark NR, Wang Z, Fernandez NF, Rouillard AD, Readhead B, Tritsch SR, Hodos R, Hafner M, Niepel M, Sorger PK, Dudley JT, Bavari S, Panchal RG, Ma’ayan AL1000CDS2: LINCS L1000 characteristic direction signatures search enginenpj Systems Biology and Applications 2, 16015 (2016)

von Schimmelmann M, Feinberg PA, Sullivan JM, Ku SM, Badimon A, Duff MK, Wang Z, Lachmann A, Dewell S, Ma’ayan A, Han MH, Tarakhovsky A, Schaefer A. Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration. Nature Neuroscience 19(10):1321-30 (2016) PMID: 27526204

Rouillard AD, Gundersen GW, Fernandez NF, Wang Z, Monteiro CD, McDermott MG, Ma’ayan AThe harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteinsDatabase (Oxford) pii: baw100 (2016) PMID: 27374120

Wang Z, Ma’ayan A. An open RNA-Seq data analysis pipeline tutorial with an example of reprocessing data from a recent Zika virus studyF1000Research 5:1574 (2016) PMID: 27583132

Mallipattu SK, Guo Y, Revelo MP, Roa-Peña L, Miller T, Ling J, Shankland SJ, Bialkowska AB, Ly V, Estrada C, Jain MK, Lu Y, Ma’ayan A, Mehrotra A, Yacoub R, Nord EP, Woroniecki RP, Yang VW, He JC. Krüppel-Like Factor 15 Mediates Glucocorticoid-Induced Restoration of Podocyte Differentiation Markers. Journal of the American Society of Nephrology pii: ASN.2015060672 (2016) PMID: 27288011

Morgan DJ, Poolman TM, Williamson AJ, Wang Z, Clark NR, Ma’ayan A, Whetton AD, Brass A, Matthews LC, Ray DW. Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production. Scientific Reports 6:26419 (2016) PMID: 27226058

Kuleshov MV, Jones MR, Rouillard AD, Fernandez NF, Duan Q, Wang Z, Koplev S, Jenkins SL, Jagodnik KM, Lachmann A, McDermott M, Monteiro CD, Gundersen GW, Ma’ayan A. Enrichr: A Comprehensive Gene Set Enrichment Analysis Web Server 2016 Update. Nucleic Acids Research 44(W1):W90-7 (2016) PMID: 27141961

Wang Z, Clark NR, Ma’ayan A. Drug Induced Adverse Events Prediction with the LINCS L1000 Data. Bioinformatics 32(15):2338-45  (2016) PMID: 27153606

Rezza A, Wang Z, Sennett R, Qiao W, Wang D, Heitman N, Mok KW, Clavel C, Yi R, Zandstra P, Ma’ayan A, Rendl M. Signaling Networks among Stem Cell Precursors, Transit-Amplifying Progenitors, and their Niche in Developing Hair Follicles. Cell Reports pii: S2211-1247(16)30213-3 (2016) PMID: 27009580

Scheckel C, Drapeau E, Frias MA, Park CY, Fak J, Zucker-Scharff I, Kou Y, Haroutunian V, Ma’ayan A, Buxbaum JD, Darnell RB. Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain. Elife pii: e10421 (2016) PMID: 26894958

Kong DS, Kim J, Lee IH, Kim ST, Seol HJ, Lee JI, Park WY, Ryu G, Wang Z, Ma’ayan A, Nam DH. Integrative radiogenomic analysis for multicentric radiophenotype in glioblastoma. Oncotarget 7(10):11526-38 (2016) PMID: 26863628

Khan JA, Mendelson A, Kunisaki Y, Birbrair A, Kou Y, Arnal-Estapé A, Pinho S, Ciero P, Nakahara F, Ma’ayan A, Bergman A, Merad M, Frenette PS. Fetal liver hematopoietic stem cell niches associate with portal vessels. Science 351(6269):176-80 (2016) PMID: 26634440


Clark NR, Szymkiewicz M, Wang Z, Monteiro CD, Jones MR, Ma’ayan A. Principal Angle Enrichment Analysis (PAEA): Dimensionally reduced multivariate gene set enrichment analysis tool. Proceedings (IEEE Int Conf Bioinformatics Biomed) (2015) PMID: 26848405

Liang R, Campreciós G, Kou Y, McGrath K, Nowak R, Catherman S, Bigarella CL, Rimmele P, Zhang X, Gnanapragasam MN, Bieker JJ, Papatsenko D, Ma’ayan A, Bresnick E, Fowler V, Palis J, Ghaffari S. A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis. PLoS Genetics 11(10):e1005526 (2015) PMID: 26452208

Sennett R, Wang Z, Rezza A, Grisanti L, Roitershtein N, Sicchio C, Mok KW, Heitman NJ, Clavel C, Ma’ayan A, Rendl M. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin. Developmental Cell 34(5):577-91 (2015) PMID:26256211

Stockton SD Jr, Gomes I, Liu T, Moraje C, Hipólito L, Jones MR, Ma’ayan A, Morón JA, Li H, Devi LA. Morphine regulated synaptic networks revealed by integrated proteomics and network analysis. Molecular and Cellular Proteomics pii: mcp.M115.047977 (2015) PMID: 26149443

Rouillard AD, Wang Z, Ma’ayan A. Abstraction for data integration: Fusing mammalian molecular, cellular and phenotype big datasets for better knowledge extraction. Computational Biology and Chemistry pii: S1476-9271(15)00083-3 (2015) PMID: 26297300

Wang Z, Clark NR, Ma’ayan A. Dynamics of the discovery process of protein-protein interactions from low content studies. BMC Systems Biology 9(1):26 (2015) PMID: 26048415

Gundersen GW, Jones MR, Rouillard AD, Kou Y, Monteiro CD, Feldmann AS, Hu KS, Ma’ayan A. GEO2Enrichr: browser extension and server app to extract gene sets from GEO and analyze them for biological functions. Bioinformatics pii: btv297 (2015) PMID: 25971742

Mallipattu SK, Horne SJ, D’Agati V, Narla G, Liu R, Frohman MA, Dickman K, Chen EY, Ma’ayan A, Bialkowska AB, Ghaleb AM, Nandan MO, Jain MK, Daehn I, Chuang PY, Yang VW, He JC. Kruppel-like factor 6 regulates mitochondrial function in the kidney. Journal of Clinical Investigation 215(3):1347-61 (2015) PMID: 25689250


Duarte LF, Young AR, Wang Z, Wu HA, Panda T, Kou Y, Kapoor A, Hasson D, Mills NR, Ma’ayan A, Narita M, Bernstein E. Histone H3.3 and its proteolytically processed form drive a cellular senescence programme. Nature Communications 5:5210 (2014) PMID: 25394905

De Rubeis S, He X, Goldberg AP, Poultney CS, Samocha K, Ercument Cicek A, Kou Y, Liu L, Fromer M, Walker S, Singh T, Klei L, Kosmicki J, Fu SC, Aleksic B, Biscaldi M, Bolton PF, Brownfeld JM, Cai J, Campbell NG, Carracedo A, Chahrour MH, Chiocchetti AG, Coon H, Crawford EL, Crooks L, Curran SR, Dawson G, Duketis E, Fernandez BA, Gallagher L, Geller E, Guter SJ, Sean Hill R, Ionita-Laza I, Jimenez Gonzalez P, Kilpinen H, Klauck SM, Kolevzon A, Lee I, Lei J, Lehtimaki T, Lin CF, Ma’ayan A, Marshall CR, McInnes AL, Neale B, Owen MJ, Ozaki N, Parellada M, Parr JR et al. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 515(7526):209-15 (2014) PMID: 25363760

Ma’ayan A, Duan Q. A blueprint of cell identity. Nature Biotechnology 32(10):1007-1008 (2014) PMID: 25299921

Xu H, Ang YS, Sevilla A, Lemischka IR, Ma’ayan A. Construction and validation of a regulatory network for pluripotency and self-renewal of mouse embryonic stem cells. PLoS Computational Biology 10(8):e1003777 (2014) PMID: 25122140

Ma’ayan A, Rouillard AD, Clark NR, Wang Z, Duan Q, Kou Y. Lean Big Data integration in systems biology and systems pharmacology. Trends in Pharmacological Sciences 35(9):450-460 (2014) PMID: 25109570

Duan Q, Wang Z, Fernandez NF, Rouillard AD, Tan CM, Benes CH, Ma’ayan A. Drug/Cell-line Browser (DCB): Interactive Canvas Visualization of Cancer Drug/Cell-Line Viability Assay Datasets. Bioinformatics pii: btu526 (2014) PMID: 25100688

Hays T, Ma’ayan A, Clark NR, Tan CM, Teixeira A, Teixeira A, Choi JW, Burdis N, Jung SY, Bajaj AO, O’Malley BW, He JC, Hyink DP, Klotman PE. Proteomics Analysis of the Non-Muscle Myosin Heavy Chain IIa-Enriched Actin-Myosin Complex Reveals Multiple Functions within the Podocyte. PLoS One 9(6):e100660 (2014) PMID: 24949636

Duan Q, Flynn C, Niepel M, Hafner M, Muhlich JL, Fernandez NF, Rouillard AD, Tan CM, Chen EY, Golub TR, Sorger PK, Subramanian A, Ma’ayan A. LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures. Nucleic Acids Research pii: gku476 (2014) PMID: 24906883

Clark NR, Hu KS, Feldmann AS, Kou Y, Chen EY, Duan Q, Ma’ayan A. The characteristic direction: a geometrical approach to identify differentially expressed genes. BMC Bioinformatics 15:79 (2014) PMID: 24650281

Liu L, Lei J, Sanders SJ, Willsey AJ, Kou Y, Cicek AE, Klei L, Lu C, He X, Li M, Muhle RA, Ma’ayan A, Noonan JP, Sestan N, McFadden KA, State MW, Buxbaum JD, Devlin B, Roeder K. DAWN: A framework to identify autism genes and subnetworks using gene expression and genetics. Molecular Autism 5(1):22 (2014) PMID: 24602502

Baker SJ, Ma’ayan A, Lieu YK, John P, Reddy MV, Chen EY, Duan Q, Snoeck HW, Reddy EP. B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development. Proc Natl Acad Sci U S A 111(8):3122-7 (2014) PMID: 24516162

Azeloglu EU, Hardy SV, Eungdamrong NJ, Chen Y, Jayaraman G, Chuang PY, Fang W, Xiong H, Neves SR, Jain MR, Li H, Ma’ayan A, Gordon RE, He JC, Iyengar R. Interconnected network motifs control podocyte morphology and kidney function. Science Signaling 7(311):ra12 (2014) PMID: 24497609

Kleensang A, Maertens A, Rosenberg M, Fitzpatrick S, Lamb J, Auerbach S, Brennan R, Crofton KM, Gordon B, Fornace Jr AJ, Gaido K, Gerhold D, Haw R, Henney A, Ma’ayan A, McBride M, Monti S, Ochs MF, Pandey A, Sharan R, Stierum R, Tugendreich S, Willett C, Wittwehr C, Xia J, Patton GW, Arvidson K, Bouhifd M, Hogberg HT, Luechtefeld T, Smirnova L, Zhao L, Adeleye Y, Kanehisa M, Carmichael P, Andersen ME, Hartung T. t4 Workshop Report: Pathways of Toxicity. ALTEX  31(1):53-61 (2014) PMID: 24127042


Poultney CS, Goldberg AP, Drapeau E, Kou Y, Harony-Nicolas H, Kajiwara Y, De Rubeis S, Durand S, Stevens C, Rehnström K, Palotie A, Daly MJ, Ma’ayan A, Fromer M, Buxbaum JD. Identification of Small Exonic CNV from Whole-Exome Sequence Data and Application to Autism Spectrum Disorder. American Journal of Human Genetics 93(4):607-619 (2013) PMID: 24094742

Jakubzick C, Gautier EL, Gibbings SL, Sojka DK, Schlitzer A, Johnson TE, Ivanov S, Duan Q, Bala S, Condon T, van Rooijen N, Grainger JR, Belkaid Y, Ma’ayan A, Riches DW, Yokoyama WM, Ginhoux F, Henson PM, Randolph GJ. Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. Immunity 39(3):599-610 (2013) PMID: 24012416

Xu H, Baroukh C, Dannenfelser R, Chen EY, Tan CM, Kou Y, Kim YE, Lemischka IR, Ma’ayan A. ESCAPE: database for integrating high-content published data collected from human and mouse embryonic stem cells. Database (Oxford) bat045 (2013) PMID: 23794736

Pereira CF, Chang B, Qiu J, Niu X, Papatsenko D, Hendry CE, Clark NR, Nomura-Kitabayashi A, Kovacic JC, Ma’ayan A, Schaniel C, Lemischka IR, Moore K. Induction of a Hemogenic Program in Mouse Fibroblasts. Cell Stem Cell 13(2):205-18 (2013) PMID: 23770078

Tan CM,  Chen EY, Dannenfelser R, Clark NR, Ma’ayan A. Network2Canvas: network visualization on a canvas with enrichment analysis. Bioinformatics 29(15):1872-8 (2013) PMID: 23749960

Sillivan SE, Whittard JD, Jacobs MM, Ren Y, Mazloom AR, Caputi FF, Horvath M, Keller E, Ma’ayan A, Pan YX, Chiang LW, Hurd YL. ELK1 Transcription Factor Linked to Dysregulated Striatal Mu Opioid Receptor Signaling Network and OPRM1 Polymorphism in Human Heroin Abusers. Biological Psychiatry 74(7):511-9 (2013) PMID: 23702428

Chen EY, Tan CM, Kou Y, Duan Q, Wang Z, Meirelles GV, Clark NR, Ma’ayan  A. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinformatics 14:128 (2013) PMID: 23586463

Zhong Y, Chen EY, Liu R, Chuang PY, Mallipattu SK, Tan CM, Clark NR, Deng Y, Klotman PE, Ma’ayan A, He JC. Renoprotective Effect of Combined Inhibition of Angiotensin-Converting Enzyme and Histone Deacetylase. Journal of the American Society of Nephrology 24(5):801-11(2013) PMID: 23559582

Duan Q, Kou Y, Clark NR, Gordonov S, Ma’ayan A. Metasignatures identify two major subtypes of breast cancer. CPT: Pharmacometrics & Systems Pharmacology 2:e35 (2013) PMID: 23836026

Jenkins SL, Ma’ayan A. Systems pharmacology meets predictive, preventive, personalized and participatory medicine. Pharmacogenomics 14(2):119-22 (2013) PMID: 23327571

Mallipattu SK, Liu R, Zhong Y, Chen EY, D’Agati V, Kaufman L, Ma’ayan A, Klotman PE, Chuang PY, He JC. Expression of HIV transgene aggravates kidney injury in diabetic mice. Kidney International 83(4):626-34 (2013) PMID: 23325078


Ma’ayan A. Colliding dynamical complex network models: Biological attractors versus attractors from material physics. Biophysical Journal 103(9):1816-1817 (2012) PMID: 23199907

Rabinowitz KM, Wang Y, Chen E, Hovhannisyan Z, Chiang D, Berin MC, Dahan S, Chaussabel D, Ma’ayan A, Mayer L. Transforming Growth Factor-b Signaling Controls Activities of Human Intestinal CD8 T Suppressor Cells. Gastroenterology pii: S0016-5085(12)01744-1 (2012) PMID: 23232296

Clavel C, Grisanti L, Zemla R, Rezza A, Barros R, Sennett R, Mazloom AR, Chung CY, Cai X, Cai CL, Pevny L, Nicolis S, Ma’ayan A, Rendl M. Sox2 in the Dermal Papilla Niche Controls Hair Growth by Fine-Tuning BMP Signaling in Differentiating Hair Shaft Progenitors. Developmental Cell 23(5):981-94 (2012) PMID: 23153495

Macarthur BD, Sevilla A, Lenz M, Müller FJ, Schuldt BM, Schuppert AA, Ridden SJ, Stumpf PS, Fidalgo M, Ma’ayan A, Wang J, Lemischka IR. Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity. Nature Cell Biology 14(11):1139-47 (2012) PMID: 23103910

Gautier EL, Shay T, Miller J, Greter M, Jakubzick C, Ivanov S, Helft J, Chow A, Elpek KG, Gordonov S, Mazloom AR, Ma’ayan A, Chua WJ, Hansen TH, Turley SJ, Merad M, Randolph GJ; the Immunological Genome Consortium. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nature Immunology 13(11):1118-1128 (2012) PMID: 23023392

Clark NR, Dannenfelser R, Tan CM, Komosinski ME, Ma’ayan A. Sets2Networks: network inference from repeated observations of sets. BMC Systems Biology 6(1):89 (2012) PMID 22824380

Zhou Q, Lv H, Mazloom AR, Xu H, Ma’ayan A, Gallo JM. Activation of Alternate Pro-Survival Pathways Accounts for Acquired Sunitinib Resistance in U87MG Glioma Xenografts. Journal of Pharmacology and Experimental Therapeutics 343(2):509-19 (2012) PMID: 22869928

Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moore KA, Snoeck HW, Ma’ayan A, Schaniel C, Lemischka IR. Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling. Cell Stem Cell 11(2):179-94 (2012) PMID: 22862944

Dannenfelser R, Clark NR, Ma’ayan A. Genes2FANs: connecting genes through functional association networks. BMC Bioinformatics 2;13(1):156 (2012) PMID: 22748121

Kou Y, Betancur C, Xu H, Buxbaum JD, Ma’ayan A. Network- and attribute-based classifiers can prioritize genes and pathways for autism spectrum disorders and intellectual disability. American Journal of  Medical Genetics Part C: Seminars in Medical Genetics 160C(2):130-42 (2012) PMID: 22499558

Neale BM, Kou Y, Liu L, Ma’ayan A, Samocha KE et al. Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature 485(7397):242-5 (2012) PMID: 22495311

Mallipattu SK, Liu R, Zheng F, Narla G, Ma’ayan A, Dikman S, Jain MK, Saleem M, D’Agati V, Klotman P, Chuang PY, He JC. Kruppel-Like factor 15 (KLF15) is a key regulator of podocyte differentiation. Journal of Biological Chemistry 287(23):19122-35 (2012) PMID: 22493483

Jin Y, Ratnam K, Chuang PY, Fan Y, Zhong Y, Dai Y, Mazloom AR, Chen EY, D’Agati V, Xiong H, Ross MJ, Chen N, Ma’ayan A, He JC. A systems approach identifies HIPK2 as a key regulator of kidney fibrosis. Nature Medicine 18(4):580-8 (2012) PMID: 22406746

Rozenfeld R, Bushlin I, Gomes I, Tzavaras N, Gupta A, Neves S, Battini L, Gusella GL, Lachmann A, Ma’ayan A, Blitzer RD, Devi LA. Receptor heteromerization expands the repertoire of cannabinoid signaling in rodent neurons. PLoS One 7(1):e29239 (2012) PMID: 22235275

Chen EY, Xu H, Gordonov S, Lim MP, Perkins MH, Ma’ayan A. Expression2Kinases: mRNA profiling linked to multiple upstream regulatory layers. Bioinformatics 28(1):105-11 (2012) PMID: 22080467

He JC, Chuang PY, Ma’ayan A, Iyengar R. Systems biology of kidney diseases. Kidney International 81(1):22-39 (2012) PMID: 21881558

Ding J, Xu H, Faiola F, Ma’ayan A, Wang J. Oct4 links multiple epigenetic pathways to the pluripotency network. Cell Research 22(1):155-67 (2012) PMID: 22083510


Mazloom AR, Dannenfelser R, Clark NR, Grigoryan AV, Linder KM, Cardozo TJ, Bond JC, Boran ADW, Iyengar R, Malovannaya A, Lanz RB, Ma’ayan A. Recovering protein-protein and domain-domain interactions from aggregation of IP-MS proteomics of coregulator complexes. PLoS Computational Biology 7(12):e1002319 (2011) PMID: 22219718

Xu H, Ma’ayan A. Visualization of Patient Samples by Dimensionality Reduction of Genome-Wide Measurements. Lecture Notes Computer Science 7058:15-22 (2011)

Abul-Husn NS, Annangudi SP, Ma’ayan A, Ramos-Ortolaza DL, Stockton SD Jr, Gomes I, Sweedler JV, Devi LA. Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis. PLoS One 6(10):e25535 (2011) PMID: 22043286

Baroukh C, Jenkins SL, Dannenfelser R, Ma’ayan A. Genes2WordCloud: a quick way to identify biological themes from gene lists and free text. Source Code for Biology and Medicine 6(1):15 (2011) PMID:  21995939

Ma’ayan A. Introduction to network analysis in systems biology. Science Signaling 4(190):tr5 (2011) PMID: 21917719

Clark NR, Ma’ayan A. Introduction to statistical methods for analyzing large data sets: gene-set enrichment analysis. Science Signaling 4(190):tr4 (2011) PMID: 21917718

Clark NR, Ma’ayan A. Introduction to statistical methods to analyze large data sets: principal components analysis. Science Signaling 4(190):tr3 (2011) PMID: 21917717

Dannenfelser R, Lachmann A, Szenk M, Ma’ayan A. FNV: Light-weight Flash-based network and pathway viewer. Bioinformatics 27(8):1181-2 (2011) PMID: 21349871

Webb RL, Ma’ayan A. Sig2BioPAX: Java tool for converting flat files to BioPAX Level 3 format. Source Code for Biology and Medicine 6:5 (2011) PMID: 21418653


Xu H, Lemischka IR, Ma’ayan A. SVM classifier to predict genes important for self-renewal and pluripotency of mouse embryonic stem cells. BMC Systems Biology 4(1):173 (2010) PMID: 21176149

Carcea I, Ma’ayan A, Mesias R, Sepulveda B, Salton SR, Benson DL. Flotillin-mediated endocytic events dictate cell type-specific responses to Semaphorin 3A. Journal of Neuroscience 30(45):15317-29 (2010) PMID: 21068336

Lachmann A, Xu H, Krishnan J, Berger SI, Mazloom AR, Ma’ayan A. ChEA: Transcription factor regulation inferred from integrating genome-wide ChIP-X experiments. Bioinformatics 26(19):2438-44 (2010) PMID: 20709693

Méndez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, Scadden DT, Ma’ayan A, Enikolopov GN, Frenette PS. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 466(7308):829-34 (2010) PMID: 20703299

Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma’ayan A, Gygi SP, Lefkowitz RJ. Global phosphorylation analysis of {beta}-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci U S A 107(34):15299-304 (2010) PMID: 20686112

Ma’ayan A, He JC. Protein kinase target discovery from genome-wide messenger RNA expression profiling. Mount Sinai Journal of Medicine 77(4):345-9 (2010) PMID: 20687179

MacArthur BD, Sanchez-Garcia RJ, Ma’ayan A. Microdynamics and criticality of adaptive regulatory networks. Physical Review Letters 104(16):168701 (2010) PMID: 20482087

Berger SI, Ma’ayan A, Iyengar R. Systems pharmacology of arrhythmias. Science Signaling 3(118):ra30 (2010) PMID:20407125

Hernandez M, Lachmann A, Zhao S, Xiao K, Ma’ayan A. Inferring the sign of kinase-substrate interactions by combining SILAC phosphoproteomics with a literature-based mammalian kinome network. 10th IEEE International Conference on Bioinformatics and BioEngineering (2010) BIBE.

Xu H, Schaniel C, Lemischka IR, Ma’ayan A. Toward a complete in-silico, multi-layered embryonic stem cell regulatory network. Wiley Interdisciplinary Reviews: Systems Biology and Medicine 2(6):708-33 (2010) PMID 20890967

Lachmann A, Ma’ayan A. Lists2Networks: Integrated analysis of gene/protein lists. BMC Bioinformatics 11:87 (2010) PMID: 20152038

MacArthur BD, Lachmann A, Lemischka IR, Ma’ayan A. GATE: Software for the analysis and visualization of high-dimensional time-series expression data. Bioinformatics 26(1) 143-144 (2010) PMID: 19892805


Lu R, Markowetz F, Unwin RD, Leek JT, Airoldi EM, MacArthur BD, Lachmann A, Rozov R, Ma’ayan A, Boyer LA, Troyanskaya OG, Whetton AD, Lemischka IR. Systems-level dynamic analyses of fate change in murine embryonic stem cells. Nature 462(7271) 358-362 (2009) PMID: 19924215

Cordeddu V, Di Schiavi E, Pennacchio LA, Ma’ayan A, Sarkozy A, Fodale V, Cecchetti S, Cardinale A, et al. Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair. Nature Genetics. 41(9) 1022-6 (2009) PMID: 19684605

MacArthur BD, Ma’ayan A, Lemischka IR. Systems biology of stem cell fate and cellular reprogramming. Nature Reviews: Molecular Cell Biology (10) 672-81 (2009) PMID: 19738627

Abul-Husn NS, Bushlin I, Morón JA, Jenkins SL, Dolios G, Wang R, Iyengar R, Ma’ayan A, Devi LA. Systems approach to explore components and interactions in the presynapse. Proteomics 9(12):3303-15 (2009) PMID: 19562802

Lachmann A, Ma’ayan A. KEA: Kinase enrichment analysis. Bioinformatics 25(5) 684-6 (2009) PMID: 19176546

Ma’ayan A, Jenkins SL, Barash A, Iyengar R. Neuro2A differentiation by Galphai/o pathway. Science Signaling 2(54):cm1 (2009) PMID: 19155528

Ma’ayan A, Jenkins SL, Webb RL, Berger SI, Purushothaman SP, Abul-Husn N, Posner JM, Flores T, Iyengar R. SNAVI: Desktop Application for Analysis and Visualization of Large-Scale Signaling Networks. BMC Systems Biology 3;10 (2009) PMID: 19154595

Ma’ayan A. Insights into the organization of biochemical regulatory networks using graph theory analyses. Journal of Biological Chemistry 284(9) 5451-5 (2009) PMID: 18940806


Ma’ayan A, Cecchi GA, Wagner J, Rao AR, Iyengar R, Stolovitzky G. Ordered Cyclic Motifs Contributes to Dynamic Stability in Biological and Engineered Networks. Proc Natl Acad Sci U S A 105(49) 19235-40 (2008) PMID: 19033453

MacArthur BD, Ma’ayan A, Lemischka IR. Toward stem cell systems biology: from molecules to networks and landscapes. Cold Spring Harbor Symposium on Quantitative Biology 73;211-5 (2008) PMID: 19329576

Ma’ayan A. Network integration and graph analysis in mammalian molecular systems biology. IET Systems Biology 2(5) 206-21 (2008) PMID: 19045817

Lu TC, Wang Z, Feng X, Chuang P, Fang W, Chen Y, Neves S, Ma’ayan A, Xiong H, Liu Y, Iyengar R, Klotman PE, He JC. Retinoic acid utilizes CREB and USF-1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in HIV-infected podocytes. Molecular and Cellular Biology 28(18) 5785-94 (2008) PMID: 18625721

Bromberg KD, Ma’ayan A, Neves SR, Iyengar R. Design of a CB1 receptor signaling network to trigger neurite outgrowth. Science 320, 903-909 (2008) PMID: 18487186

Ma’ayan A, Lipshtat A, Iyengar R, Sontag ED. Proximity of Intracellular Regulatory Networks to Monotone Systems. IET Systems Biology 2, 103-112 (2008) PMID: 18537452

Ma’ayan A. PubMedAlertMe – Standalone Windows-based PubMed SDI Software. Computers in Biology and Medicine 38:620-622 (2008) PMID: 18402930

Lipshtat A, Purushothaman SP, Iyengar R, Ma’ayan A. Functions of bifans in context of multiple regulatory motifs in signaling network. Biophysical Journal 94, 2566-2579 (2008) PMID: 18178648


White AG, Ma’ayan A. Connecting seed lists of mammalian proteins using steiner trees. ACSSC 2007. Conference Record of the Forty-First Asilomar Conference on Signals, Systems and Computers, 2007. 4-7 Nov. 2007 page(s): 155-159 Pacific Grove, CA, USA

Caplan AJ, Ma’ayan A, Willis IM. Multiple kinases and system robustness: A link between Cdc37 and genome integrity. Cell Cycle 6:3145 (2007) PMID: 18075309

Berger SI, Posner JM, Ma’ayan A. Genes2Networks: connecting lists of proteins by using background literature-based mammalian networks. BMC Bioinformatics 8:372 (2007) PMID: 17916244

Berger SI, Iyengar R, Ma’ayan A. AVIS: AJAX Viewer of Interactive Signaling Networks. Bioinformatics 23, 2803-5 (2007) PMID: 17855420

Zaidel-Bar R, Itzkovitz S, Ma’ayan A, Iyengar R, Geiger B. Functional Atlas of the Integrin Adhesome. Nature Cell Biology 9, 858 (2007) PMID: 17671451

Ma’ayan A, Jenkins SL, Goldfarb J, Iyengar R. Network analysis of FDA approved drugs and their targets. Mount Sinai Journal of Medicine 74, 27 (2007) PMID: 17516560

Hasseldine A, Lipshtat A, Iyengar R, Ma’ayan A. (2007) Modeling Cell Signaling Networks. In “Bioinformatics – From Genomes to Therapies” Vol. 2 Edited by Thomas Lengauer. Pages 829- 860 (WILEY-VCH, Weinheim, Germany)


Ma’ayan A, Gardiner K, Iyengar R. The cognitive phenotype of Down syndrome: Insights from intracellular network analysisNeuroRx 3, 396 (2006) PMID: 16815222

Ma’ayan A, Lipshtat A, Iyengar R. Topology of resultant signaling network shaped by evolutionary pressurePhysical Review: E, Statistical, Nonlinear and Soft Matter Physics 73, 061912 (2006) PMID: 16906869

Ma’ayan A, Iyengar R. From components to regulatory network motifs in signaling networks. Briefings in Functional Genomics and Proteomics 5, 57 (2006) PMID: 16769680


Ma’ayan A, Blitzer RD, Iyengar R. Toward predictive models of mammalian cells. Annual Review of Biophysics and Biomolecular Structure 34, 319 (2005) PMID: 15869393

Ma’ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R. Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science 309 (5737)1078 (2005) PMID: 16099987