Meet the Team

Kiyotake Ishikawa received his MD from the Nagoya University in 2002. Within 8 years of working as a cardiologist in Japan, he completed his fellowship in interventional cardiology and obtained board memberships in both internal medicine and cardiology. Kiyo moved to the US in 2009 and started his research career in the field of cardiac gene therapy with intent to approach cardiovascular diseases from more fundamental level through basic science. He was promoted to Assistant Professor at the Icahn School of Medicine at Mount Sinai in 2013.

Kiyo’s research focuses on clinical translation of novel therapeutic approaches using large animal models. These large animal models also offer studies examining disease mechanisms, physiology, diagnostic imaging and therapeutic interventions in a clinically relevant manner.

Available for presentations/seminars on following topics: Cardiac gene therapy and delivery, Acute mechanical cardiac unloading for LV failure, Large animal models of cardiac diseases

   Renata Mazurek completed her MD at the Medical School for International Health at Ben-Gurion University in Israel, followed by her first postdoctoral fellowship at the Yale Cardiovascular Research Center where she studied pathophysiologic mechanisms of pulmonary hypertension development. She is committed to impacting cardiac patient care through the expansion of translational research, particularly in the areas of heart failure and the chronic management of heart disease. Email:

Tomoki Sakata received his MD from Chiba University (Japan), and finished the senior residency training in cardiovascular surgery at the University Hospital and affiliated hospitals. He obtained board certification for cardiovascular surgery in 2020.  He has engaged in clinical research related to the tricuspid valve and right ventricular function throughout the residency. He also investigated cardioprotective effects of cytokine on ischemia/reperfusion injury in heart transplantation rat model. Email:

Spyros Mavropoulos received both his MD and PhD from the Zucker School of Medicine at Hofstra University.  Pursuing his long-time interest in cardiovascular medicine, he studied the effects of stimulating the cholinergic system on reperfusion injury after acute MI for his thesis.  Dr. Mavropoulos has several years of experience in rodent surgery and molecular biology techniques, and now seeks to shift his research in a more translational direction.  He joined the Ishikawa Lab in June 2021 where he is investigating cardiac remodeling genes involved in heart failure and type 4 cardiorenal syndrome. Email:

Francisco Romeo received his MD degree from the Instituto Universitario Hospital Italiano, Buenos Aires, Argentina in 2010. After 5 years of medical training, he finished both Cardiology residency program and Chief Resident position at Hospital Italiano de Buenos Aires, achieving board certification in Cardiology. In 2016, he joined the Pauley Heart Center at the Virginia Commonwealth University under the mentorship of Dr. Fadi Salloum, PhD, where he learned molecular cardiology, mice and rabbit surgery focusing on ischemia-reperfusion injury as well as animal cardiac imaging focusing on LV function post-MI. In 2017, Dr. Romeo came back to Argentina and finished a 3-year Interventional Cardiology fellowship training under the supervision of Dr. Daniel Berrocal, MD, PhD at Hospital Italiano de Buenos Aires. Finally, he started his residency in Internal Medicine at Mount Sinai West & Morningside in 2020. Parallel to his residency, he started his career as a research fellow at Cardiovascular Research Institute at Mount Sinai since 2021. His research focuses on the impact of LV unloading post-MI using large animal models and the implications on the prevention of heart failure development through novel gene expression analysis. Email:

Anjali J. Ravichandran received her B.S. in Biochemistry and Molecular Biology from University of Miami in 2020. She has completed basic and chemical genetics research at Miller School of Medicine, and translational research with Columbia University’s Department of Surgery, Division of Cardiac, Thoracic and Vascular Surgery to improve transplant outcomes. She also has experience in population and public health research. She is currently involved in research investigating the molecular mechanisms of right heart dysfunction in large animal models of pulmonary hypertension. Throughout her education and research, she is committed to bridging the gap between benchwork research and their clinical applications to address heart failure and cardiovascular diseases.

Serena Tharakan received her B.S. in Molecular, Cellular, and Developmental Biology from Yale University in 2018. There, she worked in the lab of Dr. Lloyd Cantley studying the immune response to acute kidney disease. She is currently in her third year of medical school at the Icahn School of Medicine at Mount Sinai.




Previous members

Kelly Yamada received her VMD from the University of Pennsylvania School of Veterinary Medicine in 2002. Prior to veterinary school, she was introduced to cardiovascular research as an undergraduate student of Biomedical Engineering at the Johns Hopkins University where she was a member of the laboratory of Dr. Artin Shoukas. In 2003, Kelly began a research postdoctoral fellowship in the laboratory of Dr. Seiryo Sugiura at the University of Tokyo using functional assays of isolated cardiomyocytes. Upon her return to the United States, she worked in preclinical Safety Assessment in large animal models at GlaxoSmithKline. Kelly subsequently completed a three year postdoctoral fellowship at the Tri-Institutional Training Program in Laboratory Animal Medicine and Science at Memorial Sloan-Kettering Cancer Center, Weill Cornell Medicine, and the Rockefeller University in New York City. She achieved board certification from the American College of Laboratory Animal Medicine in 2011 while employed as a Clinical Veterinarian at the Institute of Comparative Medicine of Columbia University Medical Center. She joined the Cardiovascular Research Center at Mount Sinai under Dr. Roger Hajjar in January 2018.   Email:

Olympia Bikou studied medicine at the Ludwig- Maximilian University of Munich, University of Heraklion, Greece and the University of Heidelberg, Germany. She received her MD with distinction from the University of Heidelberg 2006. Parallel to her residency at the Cardiology Department at the University of Heidelberg she performed research on large animals, focusing on gene therapy of arrhythmias and heart failure.

In order to get a deeper understanding of molecular and especially microRNA biology, she joined the lab of Stefan Engelhardt at the Technical University of Munich. Since 2017 she has been working at the Cardiovascular Research Center at Mount Sinai under R. J. Hajjar. Her research focuses on microRNA regulation in cardiac diseases and pulmonary hypertension.


Taro Kariya received his MD from the University of Tokyo, Japan, in 2006. During 12 years of clinical commitment, he achieved three Japanese boards — internal medicine, cardiology, and anesthesiology. In 2012 he joined Eiki Takimoto Lab at the Johns Hopkins University, where he learned molecular cardiology, mouse heart failure model and mouse hemodynamics study. He received his PhD in medicine from the University of Tokyo in 2015. After 3-year Assistant Professor of Anesthesiology at the University of Tokyo Hospital, he joined the Lab in September 2018.

His research focuses on differences in response between the right and left ventricles using various heart disease animal models, hemodynamics using large animals, and preclinical translational investigations.

Satoshi Miyashita Dr. Miyashita received his MD from Nippon Medical School in 2015. After two years of residency as a general practitioner in Nippon Medical School Hospital, he started his residency in internal medicine at Mount Sinai Beth Israel Medical Center in 2017. Parallel to his residency, he started his career as a research fellow at Cardiovascular Research Institute at Mount Sinai since 2018. His research focuses on cardiac imaging and uses large animal models of cardiac diseases to investigate the utility and accuracy of various diagnostic approaches and left ventricular assist device use for infarct size reduction in myocardial infarction in animal models.

Tadao Aikawa received his MD degree from Asahikawa Medical University, Japan, in 2009. After completing his fellowship in cardiology, he acquired his PhD from Hokkaido University, Japan in 2017, studying noninvasive quantification of myocardial perfusion, fibrosis, and sympathetic nervous innervation using positron emission tomography and cardiac magnetic resonance imaging.

In order to develop translational approaches in quantifying and understanding the mechanisms of cardiovascular disease using a large animal model, he joined the Lab in September 2019. His current research is focused on a novel gene therapy in heart disease animal models.

Dr. Watanabe received a MD degree from Toyama Medical and Pharmaceutical University of Medicine (Japan) in 2001 and Ph.D. in medical science from Kyoto University (Japan) in 2011. After 10 years of clinical practice as an interventional cardiologist in Japan, Dr. Watanabe joined the Cardiology Laboratory for Translational Research under Dr. Roger J Hajjar in 2015 as a post-doctoral research fellow.

His work involves research in translational gene therapy in large animal models of heart failure. Multiple heart failure models including aortic constriction, acute myocardial infarction, chronic coronary occlusion, and mitral valve regurgitation are created, followed by gene therapies using viral and non-viral vectors. As such, Dr. Watanabe’s focus is on bridging novel therapeutic tools from basic biological research to bedside applications.