Publications

2024

      • Sakata T, Mavropoulos SA, Mazurek R, Romeo FJ, Ravichandran AJ, Marx JM,Kariya T, Ishikawa K. Reduction of left ventricular diastolic pressure as a key regulator of infarct coronary flow under mechanical left ventricular support. J Physiol. 2024 Mar 8. doi: 10.1113/JP285586. Epub ahead of print. PMID: 38457313
      • Xu Y, Korayem A, Cruz-Solbes AS, Chandel N, Sakata T, Mazurek R, Mavropoulos SA, Kariya T, Aikawa T, Yamada KP, D’Escamard V, V’Gangula B, Baker AH, Ma L, Björkegren JLM, Fuster V, Boehm M, Fish KM, Tadros R, Ishikawa K, Kovacic JC. Inhibition of endothelial to mesenchymal transition in a large animal preclinical arterio-venous fistula model leads to improved remodeling and reduced stenosis. Cardiovasc Res. 2024 Jul 26:cvae157. doi: 10.1093/cvr/cvae157.Epub ahead of print. PMID: 39056563
      • Katz MG, Eliyahu E, Ishikawa K. Gene delivery in a rodent lung transplant model. J Thorac Cardiovasc Surg. 2024 May;167(5):e142-e143. doi: 10.1016/j.jtcvs.2024.01.016. Epub 2024 Feb 15. PMID: 38363258.

2023

      • Mazurek R, Kariya T, Sakata T, Mavropoulos SA, Ravichandran AJ, Romeo FJ, Yamada KP, Ishikawa K. Negative Impact of Acute Reloading after Mechanical Left Ventricular Unloading. J Cardiovasc Transl Res. 2023 Apr 6. doi: 10.1007/s12265-023-10371-z. PMID: 37022610.
      • Santos-Gallego CG, Requena-Ibáñez JA, Picatoste B, Fardman B, Ishikawa K, Mazurek R, Pieper M, Sartori S, Rodriguez-Capitán J, Fuster V, Badimon JJ. Cardioprotective Effect of Empagliflozin and Circulating Ketone Bodies During Acute Myocardial Infarction. Circ Cardiovasc Imaging. 2023 Apr;16(4):e015298. doi: 10.1161/CIRCIMAGING.123.015298. Epub 2023 Apr 12. PMID: 37042253.
      • Gorski PA, Lee A, Lee P, Oh JG, Vangheluwe P, Ishikawa K, Hajjar R, Kho C. Identification and Characterization of p300-Mediated Lysine Residues in Cardiac SERCA2a. Int J Mol Sci. 2023 Feb 9;24(4):3502. doi: 10.3390/ijms24043502. PMID: 36834924; PMCID: PMC9959367.
      • Romeo FJ, Mavropoulos SA, Ishikawa K. Progress in Clinical Gene Therapy for Cardiac Disorders. Mol Diagn Ther. 2023 Mar;27(2):179-191. doi: 10.1007/s40291-022-00632-z. Epub 2023 Jan 15. PMID: 36641770; PMCID:PMC10023344.
      • Ravichandran AJ, Romeo FJ, Mazurek R, Ishikawa K. Barriers in Heart Failure Gene Therapy and Approaches to Overcome Them. Heart Lung Circ. 2023 Apr 11:S1443-9506(23)00115-4. doi: 10.1016/j.hlc.2023.02.011. Epub ahead of print. PMID: 37045653.
      • Uchiyama S, Sakata T, Tharakan S, Ishikawa K. Body temperature as a predictor of mortality in COVID-19. Sci Rep. 2023 Aug 16;13(1):13354. doi:10.1038/s41598-023-40414-z. PMID: 37587219; PMCID: PMC10432378.
      • Sakata T, Kohno H, Inui T, Ikeuchi H, Shiko Y, Kawasaki Y, Suzuki S, Tanaka, S, Obana M, Ishikawa K, Fujio Y, Matsumiya G. Cardioprotective effect of Interleukin-11 against warm ischemia-reperfusion injury in a rat heart donor model. Eur J Pharmacol. 2023 Dec 15;961:176145. doi:10.1016/j.ejphar.2023.176145. Epub 2023 Nov 2. PMID: 37923160

2022

      • Romeo FJ, Mazurek R, Sakata T, Mavropoulos SA, Ishikawa K. Device-Based Approaches Targeting Cardioprotection in Myocardial Infarction: The Expanding Armamentarium of Innovative Strategies. J Am Heart Assoc. 2022 Nov 16:e7728. doi: 10.1161/JAHA.122.026474. Epub ahead of print. PMID: 36382949.
      • Li J, Kelly SC, Ivey JR, Thorne PK, Fertig B, Ling J, Nollet EE, Dobi S, Busiau T, Ishikawa K, Yamada K, Lee A, Kho C, Wills L, Tibbo AJ, Scott M, Grant K, Campbell KS, Birks EJ, MacQuaide N, Hajjar R, Smith GL, van der Velden J, Baillie GS. SUMOylation does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca2+. FEBS J. 2022 May 27. doi: 10.1111/febs.16537. Epub ahead of print. PMID: 35633070.
      • Sakata T, Mazurek R, Mavropoulos SA, Romeo FJ, Ravichandran AJ, Watanabe S, Kariya T, Ishikawa K. Impact of ischemia on left atrial remodeling and dysfunction in swine models of mitral regurgitation. Am J Physiol Heart Circ Physiol. 2022 Jun 1;322(6):H914-H923. doi: 10.1152/ajpheart.00009.2022. Epub 2022 Mar 25. PMID: 35333115;
      • Bikou O., Tharakan S., Yamada KP, Kariya T., Aguero J., Gordon A., Mazurek R., Aikawa T., Kohlbrenner E., Fish K., Hajjar R.J., Ishikawa K. Endo-bronchial aerosolized AAV1.SERCA2a gene therapy in a pulmonary hypertension pig model: addressing the lung delivery bottleneck. Hum Gene Ther. 2022 Mar 16. doi: 10.1089/hum.2021.274. PMID: 35293228
      • Sakata T, Watanabe S, Mazurek R, Mavropoulos S, Romeo F, Yamada KP, Ishikawa K. Impaired Diastolic Function Predicts Improved Ischemic Myocardial Flow by Mechanical Left Ventricular Unloading in a Swine Model of Ischemic Heart Failure. 2022;8. doi: 10.3389/fcvm.2021.795322
      • Koplev S, Seldin M, Sukhavasi K, Ermel R, Pang S, Zeng L, Bankier S, Di Narzo A, Cheng H, Meda V, Ma A, Talukdar H, Cohain A, Amadori L, Argmann C, Houten SM, Franzén O, Mocci G, Meelu OA, Ishikawa K, Whatling C, Jain A, Jain RK, Gan L-M, Giannarelli C, Roussos P, Hao K, Schunkert H, Michoel T, Ruusalepp A, Schadt EE, Kovacic JC, Lusis AJ, Björkegren JLM (2022) A mechanistic framework for cardiometabolic and coronary artery diseases. Nature Cardiovascular Research 1 (1):85-100. doi:10.1038/s44161-021-00009-1

2021

      • Ishikawa K, Meyns B, Kapur NK. Editorial: Science in Mechanical Circulatory Support. Front Cardiovasc Med. 2021 May 17;8:676595. doi: 10.3389/fcvm.2021.676595. eCollection 2021.PMID: 34079830
      • Yamada KP, Kariya T, Aikawa T, Ishikawa K. Effects of Therapeutic Hypothermia on Normal and Ischemic Heart. Front Cardiovasc Med. 2021 Feb 15;8:642843. doi: 10.3389/fcvm.2021.642843. PMID: 33659283; PMCID: PMC7919696.
      • Sahoo S, Kariya T, Ishikawa K. Targeted delivery of therapeutic agents to the heart. Nat Rev Cardiol. 2021 Jan 26. doi: 10.1038/s41569-020-00499-9. Epub ahead
        of print. PMID: 33500578.
      • Aikawa T, Takagi H, Ishikawa K, Kuno T. Myocardial injury characterized by elevated cardiac troponin and in-hospital mortality of COVID-19: An insight from a meta-analysis. J Med Virol. 2021;93(1):51-5. Epub 2020/06/03. doi: 10.1002/jmv.26108. PubMed PMID: 32484975; PubMed Central PMCID: PMC7301031.
      •  Miyashita S, Kariya T, Yamada KP, Bikou O, Tharakan S, Kapur NK, Ishikawa K. Left Ventricular Assist Devices for Acute Myocardial Infarct Size Reduction: Meta-analysis. J Cardiovasc Transl Res.2021;14(3):467-75. Epub 2020/08/30. doi: 10.1007/s12265-020-10068-7. PubMed PMID: 32860130; PMCID: PMC7914262.

2020

      • Santos-Gallego CG, Requena-Ibanez JA, San Antonio R, Garcia-Ropero A, Ishikawa K, Watanabe S, Picatoste B, Vargas-Delgado AP, Flores-Umanzor EJ, Sanz J, Fuster V, Badimon JJ. Empagliflozin Ameliorates Diastolic Dysfunction and Left Ventricular Fibrosis/Stiffness in Nondiabetic Heart Failure: A Multimodality Study. JACC Cardiovasc Imaging. 2020 Oct 28:S1936-878X(20)30799-3. doi: 10.1016/j.jcmg.2020.07.042. Epub ahead of print. PMID: 33129742.
      • Kariya T,Yamada KP, Bikou O, Tharakan S, Miyashita S, Ishikawa K. Novel Porcine Model of Coronary Dissection Reveals the Impact of Impella on Dissected Coronary Arterial Hemodynamics. Front Cardiovasc Med. 2020 Sep 15;7:162. doi: 10.3389/fcvm.2020.00162. PMID: 33110912; PMCID: PMC7522595.
      • Nahrendorf M, Hoyer FF, Meerwaldt AE, van Leent MMT, Senders ML, Calcagno C, Robson PM, Soultanidis G, Pérez-Medina C, Teunissen AJP, Toner YC, Ishikawa K, Fish K, Sakurai K, van Leeuwen EM, Klein ED, Sofias AM, Reiner T, Rohde D, Aguirre AD, Wojtkiewicz G, Schmidt S, Iwamoto Y, Izquierdo-Garcia D, Caravan P,
        Swirski FK, Weissleder R, Mulder WJM. Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor <sup>64</sup>Cu-Macrin
        in Mice, Rabbits, and Pigs.         Circ Cardiovasc Imaging. 2020 Oct;13(10):e010586. doi: 10.1161/CIRCIMAGING.120.010586. Epub 2020 Oct 20. PMID: 33076700; PMCID:
        PMC7583675.
      • Aikawa T, Kariya T, Yamada KP, Miyashita S, Bikou O, Tharakan S, Fish K, Ishikawa K. Impaired left ventricular global longitudinal strain is associated with elevated left ventricular filling pressure after myocardial infarction. Am J Physiol Heart Circ Physiol. 2020 Oct 9. doi: 10.1152/ajpheart.00502.2020. Epub ahead of print. PMID: 33035440.
      • Garcia-Ropero A, Santos-Gallego CG, Vargas-Delgado AP, Requena-Ibanez JA, Picatoste B, Ishikawa K, Sanz J, Tunon J, Badimon JJ. Correlation between myocardial strain and adverse remodeling in a non-diabetic model of heart failure following empagliflozin therapy. Expert Rev Cardiovasc Ther. 2020
        Sep;18(9):635-642. doi: 10.1080/14779072.2020.1802247. Epub 2020 Aug 9. PMID: 32713221.
      • Nix C, Ishikawa K, Meyns B, Yasuda S, Adriaenssens T, Barth S, Zayat R, Leprince P, Lebreton G. Comparison of Hemodynamic Support by Impella vs. Peripheral Extra-Corporeal Membrane Oxygenation: A Porcine Model of Acute Myocardial Infaction. Front Cardiovasc Med. 2020 Jun 10;7:99. doi: 10.3389/fcvm.2020.00099. PMID: 32587862; PMCID: PMC7299088.
      • Tharakan S, Nomoto K, Miyashita S, Ishikawa K. Body temperature correlates with mortality in COVID-19 patients. Version 2. Crit Care. 2020 Jun 5;24(1):298. doi: 10.1186/s13054-020-03045-8. PMID: 32503659; PMCID: PMC7274509.
      • Yamada KP, Tharakan S, Ishikawa K. Consideration of clinical translation of cardiac AAV gene therapy. Cell & Gene Therapy Insights. 2020 May; 6(5):609-615. NIHMSID: NIHMS1607304.doi: 10.18609/cgti.2020.073.

2019

      • Oh JG, Ishikawa K. Recent highlights and advances in cardiac gene therapy. Discov Med. 2019 Nov-Dec;28(155):229-235. PubMed PMID: 32053763.
      •  Miyashita S, Hammoudi N, Watanabe S, Bikou O, Yamada K, Aguero J, Nomoto K, Kariya T, Fish K, Hajjar RJ, Ishikawa K. Echocardiographic Left Ventricular Mass Estimation: Two-Dimensional Area-Length Method is Superior to M-Mode Linear Method in Swine Models of Cardiac Diseases. J Cardiovasc Transl Res. 2019 Dec 11. doi: 10.1007/s12265-019-09937-7. [Epub ahead of print] PubMed PMID: 31828537.
      •  Yamada KP, Kariya T, Ishikawa K. AAV shedding after intracoronary delivery: just a safety concern? Gene Ther. 2019 Dec 3. doi: 10.1038/s41434-019-0115-2. [Epub ahead of print] PubMed PMID: 31796896.
      •  Bikou O, Tharakan S, Yamada KP, Kariya T, Gordon A, Miyashita S, Watanabe S, Sassi Y, Fish K, Ishikawa K. A Novel Large Animal Model of Thrombogenic Coronary  Microembolization. Front Cardiovasc Med. 2019 Nov 5;6:157. doi: 10.3389/fcvm.2019.00157. eCollection 2019. PubMed PMID: 31750316; PubMed Central PMCID: PMC6848058.
      •  Kariya T, Ishikawa K. The Art of War in Drug Development. JACC Basic Transl Sci. 2019 Oct 28;4(6):715-716. doi: 10.1016/j.jacbts.2019.09.002. eCollection 2019 Oct. PubMed PMID: 31713541; PubMed Central PMCID: PMC6834934.
      •  Santos-Gallego CG, Requena-Ibanez JA, San Antonio R, Ishikawa K, Watanabe S, Picatoste B, Flores E, Garcia-Ropero A, Sanz J, Hajjar RJ, Fuster V, Badimon JJ.  Empagliflozin Ameliorates Adverse Left Ventricular Remodeling in Nondiabetic Heart Failure by Enhancing Myocardial Energetics. J Am Coll Cardiol. 2019 Apr 23;73(15):1931-1944. doi: 10.1016/j.jacc.2019.01.056. PubMed PMID: 30999996.
      •  Katz MG, Fargnoli AS, Gubara SM, Fish K, Weber T, Bridges CR, Hajjar RJ, Ishikawa K. Targeted Gene Delivery through the Respiratory System: Rationale for  Intratracheal Gene Transfer. J Cardiovasc Dev Dis. 2019 Feb 15;6(1). pii: E8. doi: 10.3390/jcdd6010008. Review. PubMed PMID: 30781363.
      • Chandrasekaran U, Burkhoff D, Ishikawa K, Swain L, Sunagawa K, Møller J, Santos-Gallego C, Annamalai S, Udelson J, Westenfeld R, Kapur N, Qiao X, Wiora J, Schäfer A, Bernhardt A, Kochar A, Kloner R, Faraz H. Proceedings of the 3rd annual Acute Cardiac Unloading and REcovery (A-CURE) symposium. BMC Cardiovasc Disord. 2019 Feb 7;19(Suppl 2):27. doi: 10.1186/s12872-019-1000-z. PubMed PMID: 30732562; PubMed Central PMCID: PMC6366036.
      • Oh JG, Kho C, Hajjar RJ, Ishikawa K. Experimental models of cardiac physiology and pathology. Heart Fail Rev. 2019 Jan 22. doi: 10.1007/s10741-019-09769-2. [Epub ahead of print] Review. PubMed PMID: 30666533.

2018

      • Kapur NK, Annamalai S, Reyelt L, Karmiy SJ, Razavi AA, Foroutanjazi S, Chennojwala A, Ishikawa K. From bedside to bench and back again: translational studies of mechanical unloading of the left ventricle to promote recovery after acute myocardial infarction. F1000Res. 2018 Nov 27;7. pii: F1000 Faculty Rev-1852. doi: 10.12688/f1000research.14597.1. eCollection 2018. Review. PubMed PMID: 30542612; PubMed Central PMCID: PMC6259487.
      • Bikou O, Kho C, Ishikawa K. Atrial stretch and arrhythmia after myocardial infarction. Aging (Albany NY). 2018 Dec 28;11(1):11-12. doi: 10.18632/aging.101729. PubMed PMID: 30594913; PubMed Central PMCID: PMC6339802.
      • Motloch LJ, Cacheux M, Ishikawa K, Xie C, Hu J, Aguero J, Fish KM, Hajjar RJ,  Akar FG. Primary Effect of SERCA 2a Gene Transfer on Conduction Reserve in Chronic Myocardial Infarction. J Am Heart Assoc. 2018 Sep 18;7(18):e009598. doi:  10.1161/JAHA.118.009598. PubMed PMID: 30371209; PubMed Central PMCID: PMC6222964.
      • Ishikawa K, Weber T, Hajjar RJ. Human Cardiac Gene Therapy. Circ Res. 2018 Aug
        17;123(5):601-613. doi: 10.1161/CIRCRESAHA.118.311587. PubMed PMID: 30355138.
      • Watanabe S, Ishikawa K, Plataki M, Bikou O, Kohlbrenner E, Aguero J, Hadri L, Zarragoikoetxea I, Fish K, Leopold JA, Hajjar RJ. Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension. Pulm Circ. 2018 Oct-Dec;8(4):2045894018799738. doi:
        10.1177/2045894018799738. Epub 2018 Aug 21. PubMed PMID: 30129881
      • Ishikawa K, Watanabe S, Lee P, Akar FG, Lee A, Bikou O, Fish K, Kho C, Hajjar RJ. Acute Left Ventricular Unloading Reduces Atrial Stretch and Inhibits Atrial Arrhythmias. J Am Coll Cardiol. 2018 Aug 14;72(7):738-750. doi:10.1016/j.jacc.2018.05.059. PMID: 30092950.
      • Ishikawa K, Meyns B. Acute Mechanical LV Unloading in Ischemia Reperfusion Injury: Be Prepared. J Am Coll Cardiol. 2018 Jul 31;72(5):515-517. doi: 10.1016/j.jacc.2018.05.035. PMID: 30049312.
      • Mathiyalagan P, Adamiak M, Mayourian J, Sassi Y, Liang Y, Agarwal N, Jha D, Zhang S, Kohlbrenner E, Chepurko E, Chen J, Trivieri MG, Singh R, Bouchareb R, Fish K, Ishikawa K, Lebeche D, Hajjar RJ, Sahoo S. FTO-Dependent m6A Regulates Cardiac Function During Remodeling and Repair. Circulation. 2018 Jul 11. pii: CIRCULATIONAHA.118.033794. doi: 10.1161/CIRCULATIONAHA.118.033794. PMID: 29997116.
      • Ziegler T, Ishikawa K, Hinkel R, Kupatt C. Translational Aspects of Adeno-Associated Virus-Mediated Cardiac Gene Therapy. Hum Gene Ther. 2018 Jul 24. doi: 10.1089/hum.2017.229. PMID: 29848073.
      • Hammoudi N, Watanabe S, Bikou O, Ceccaldi A, Fish K, Yamada KP, Miyashita S, Lebreton G, Hajjar RJ, Ishikawa K. Speckle-Tracking Echocardiographic Strain Analysis Reliably Estimates Degree of Acute LV Unloading During Mechanical LV Support by Impella. J Cardiovasc Transl Res. 2018 May 29. doi: 10.1007/s12265-018-9812-2. PMID: 29845440.
      • Ishikawa K. LV-MEMS: A New Challenger Against the CHAMPION?  Circ Cardiovasc Interv. 2018 May;11(5):e006768. doi: 10.1161/CIRCINTERVENTIONS.118.006768. PMID: 29748221;
      • Rodriguez P, Sassi Y, Troncone L, Benard L, Ishikawa K, Gordon RE, Lamas S, Laborda J, Hajjar RJ, Lebeche D. Deletion of delta-like 1 homologue accelerates fibroblast-myofibroblast differentiation and induces myocardial fibrosis. Eur Heart J. 2018 Apr 13. doi: 10.1093/eurheartj/ehy188. PMID: 29668883.
      • Watanabe S, Fish K, Kovacic JC, Bikou O, Leonardson L, Nomoto K, Aguero J, Kapur NK, Hajjar RJ, Ishikawa K. Left Ventricular Unloading Using an Impella CP Improves Coronary Flow and Infarct Zone Perfusion in Ischemic Heart Failure.
        J Am Heart Assoc. 2018 Mar 7;7(6). pii: e006462. doi: 10.1161/JAHA.117.006462. Erratum in: J Am Heart Assoc. 2018 Apr 23;7(9):. PMID: 29514806

2017

      • Hajjar RJ, Ishikawa K, Kovacic JC, Fuster V. Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai  Translational Mission. Circ Res. 2017 Dec 8;121(12):1316-1319. doi: 10.1161/ PubMed [citation] PMID: 29217711
      • Ishikawa K, Watanabe S, Hammoudi N, Aguero J, Bikou O, Fish K, Hajjar RJ. Reduced Longitudinal Contraction is Associated with Ischemic Mitral Regurgitation after Posterior MI. Am J Physiol Heart Circ Physiol. 2017 Nov 3: ajpheart.00546.2017. doi: 10.1152/ajpheart.00546.2017.  PMID: 29101180
      • Fish KM, Ishikawa K, Hajjar RJ. Stem cell therapy for acute myocardialinfarction: on the horizon or still a dream? Coron Artery Dis. 2017 Nov 14. doi: 10.1097/MCA.0000000000000589. PMID: 29140809
      • Watanabe S, Ishikawa K, Fish K, Oh JG, Motloch LJ, Kohlbrenner E, Lee P, Xie C, Lee A, Liang L, Kho C, Leonardson L, McIntyre M, Wilson S, Samulski RJ, Kranias EG, Weber T, Akar FG, Hajjar RJ. Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonischemic Heart Failure. Journal of the American College of Cardiology. 2017; 70(14):1744-1756. PubMed [journal] PMID: 28958332
      • Watanabe S, Fish K, Bonnet G, Santos-Gallego CG, Leonardson L, Hajjar RJ, Ishikawa K. Echocardiographic and hemodynamic assessment for predicting early clinical events in severe acute mitral regurgitation. The international journal of cardiovascular imaging. 2017; PubMed [journal] PMID: 28735413
      • Bikou O, Ishikawa K. Gene therapy for heart failure: status quo and quo vadis. Discovery medicine. 2017; 23(129):371-377. PubMed [journal] PMID: 28877448
      • Motloch LJ, Ishikawa K, Xie C, Hu J, Aguero J, Fish KM, Hajjar RJ, Akar FG. Increased afterload following myocardial infarction promotes conduction-dependent arrhythmias that are unmasked by hypokalemia. JACC. Basic to translational science. 2017; 2(3):258-269. NIHMSID: NIHMS881712 PubMed [journal] PMID: 28798965, PMCID: PMC5547890
      • Watanabe S, Ishikawa K. Editorial Commentary: Clinical gene therapy trials for heart failure: Did they fail? Trends in cardiovascular medicine. 2017; 27(3):223-224. PubMed [journal] PMID: 28040326
      • Aguero J, Lobo Gonzalez M, Ishikawa K. Route TESI: Main Street for MSC? Circulation research. 2017; 120(7):1055-1056. PubMed [journal] PMID: 28360340
      • Ishikawa K. The Transgenic Diabetic Pig Heart: A “Sweet Heart” for Translational  Cardiovascular Research. Journal of the American College of Cardiology. 2017; 69(2):144-146. PubMed [journal] PMID: 28081823
      • Hajjar RJ, Ishikawa K. Introducing Genes to the Heart: All About Delivery. Circulation research. 2017; 120(1):33-35. NIHMSID: NIHMS827918 PubMed [journal] PMID: 28057788, PMCID: PMC5221570

2016

      • Hulot JS, Ishikawa K, Hajjar RJ. Gene therapy for the treatment of heart failure: promise postponed. European heart journal. 2016; 37(21):1651-8. PubMed [journal]  PMID: 26922809, PMCID: PMC4887702
      • Aguero J, Ishikawa K, Hadri L, Santos-Gallego CG, Fish KM, Kohlbrenner E, Hammoudi N, Kho C, Lee A, Ibáñez B, García-Alvarez A, Zsebo K, Maron BA, Plataki  M, Fuster V, Leopold JA, Hajjar RJ. Intratracheal Gene Delivery of SERCA2a Ameliorates Chronic Post-Capillary Pulmonary Hypertension: A Large Animal Model.  Journal of the American College of Cardiology. 2016; 67(17):2032-46. PubMed [journal] PMID: 27126531
      • Santos-Gallego CG, Vahl TP, Goliasch G, Picatoste B, Arias T, Ishikawa K, Njerve  IU, Sanz J, Narula J, Sengupta PP, Hajjar RJ, Fuster V, Badimon JJ. Sphingosine-1-Phosphate Receptor Agonist Fingolimod Increases Myocardial Salvage and Decreases Adverse Postinfarction Left Ventricular Remodeling in a Porcine Model of Ischemia/Reperfusion. Circulation. 2016; 133(10):954-66. PubMed [journal] PMID: 26826180
      • Turnbull IC, Eltoukhy AA, Fish KM, Nonnenmacher M, Ishikawa K, Chen J, Hajjar RJ, Anderson DG, Costa KD. Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression. Molecular therapy : the journal of the American Society of Gene Therapy. 2016; 24(1):66-75. PubMed [journal] PMID: 26471463, PMCID: PMC4754552

2015

      • Ishikawa K, Hajjar RJ. Revisiting Old Players in the Revitalized Field of Cardiovascular Gene Therapy. Journal of the American College of Cardiology. 2015; 66(2):166-8. PubMed [journal] PMID: 26160632
      • Ishikawa K. Response to Letter Regarding Article, “Intracoronary Injection of Large Stem Cells: Size Matters”. Circulation. Cardiovascular interventions. 2015; 8(7):e002855. PubMed [journal] PMID: 26136422
      • Ishikawa K, Aguero J, Oh JG, Hammoudi N, Fish LA, Leonardson L, Picatoste B, Santos-Gallego CG, Fish KM, Hajjar RJ. Increased stiffness is the major early abnormality in a pig model of severe aortic stenosis and predisposes to congestive heart failure in the absence of systolic dysfunction. Journal of the American Heart Association. 2015; 4(5). PubMed [journal] PMID: 25994443, PMCID: PMC4599422
      • Ishikawa K. Intracoronary injection of large stem cells: size matters. Circulation. Cardiovascular interventions. 2015; 8(5). PubMed [journal] PMID: 25953824
      • Hammoudi N, Ishikawa K, Hajjar RJ. Adeno-associated virus-mediated gene therapy in cardiovascular disease. Current opinion in cardiology. 2015; 30(3):228-34. NIHMSID: NIHMS678838 PubMed [journal] PMID: 25783685, PMCID: PMC4417622
      • Fish KM, Ishikawa K. Advances in gene therapy for heart failure. Discovery medicine. 2015; 19(105):285-91. PubMed [journal] PMID: 25977191
      • Ishikawa K, Aguero J, Tilemann L, Ladage D, Hammoudi N, Kawase Y, Santos-Gallego  CG, Fish K, Levine RA, Hajjar RJ. Reply to “Letter to the editor: Characterizing preclinical model of ischemic heart failure: difference between LAD and LCx infarctions”. American journal of physiology. Heart and circulatory physiology. 2015; 308(4):H365-6. PubMed [journal] PMID: 25684739
      • Aguero J, Ishikawa K, Fish KM, Hammoudi N, Hadri L, Garcia-Alvarez A, Ibanez B, Fuster V, Hajjar RJ, Leopold JA. Combination proximal pulmonary artery coiling and distal embolization induces chronic elevations in pulmonary artery pressure in Swine. PloS one. 2015; 10(4):e0124526. PubMed [journal] PMID: 25923775, PMCID: PMC4414513
      • Ishikawa K, Fish K, Aguero J, Yaniz-Galende E, Jeong D, Kho C, Tilemann L, Fish L, Liang L, Eltoukhy AA, Anderson DG, Zsebo K, Costa KD, Hajjar RJ. Stem cell factor gene transfer improves cardiac function after myocardial infarction in swine. Circulation. Heart failure. 2015; 8(1):167-74. NIHMSID: NIHMS637932 PubMed [journal] PMID: 25342737, PMCID: PMC4303518

2014

      • Ishikawa K, Fish KM, Tilemann L, Rapti K, Aguero J, Santos-Gallego CG, Lee A, Karakikes I, Xie C, Akar FG, Shimada YJ, Gwathmey JK, Asokan A, McPhee S, Samulski J, Samulski RJ, Sigg DC, Weber T, Kranias EG, Hajjar RJ. Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic  heart failure. Molecular therapy : the journal of the American Society of Gene Therapy. 2014; 22(12):2038-45. PubMed [journal] PMID: 25023328, PMCID: PMC4429688
      • Ishikawa K, Aguero J, Tilemann L, Ladage D, Hammoudi N, Kawase Y, Santos-Gallego  CG, Fish K, Levine RA, Hajjar RJ. Characterizing preclinical models of ischemic heart failure: differences between LAD and LCx infarctions. American journal of physiology. Heart and circulatory physiology. 2014; 307(10):H1478-86. PubMed [journal] PMID: 25217654, PMCID: PMC4233300
      • Aguero J, Ishikawa K, Hadri L, Santos-Gallego C, Fish K, Hammoudi N, Chaanine A,  Torquato S, Naim C, Ibanez B, Pereda D, García-Alvarez A, Fuster V, Sengupta PP,  Leopold JA, Hajjar RJ. Characterization of right ventricular remodeling and failure in a chronic pulmonary hypertension model. American journal of physiology. Heart and circulatory physiology. 2014; 307(8):H1204-15. PubMed [journal] PMID: 25158063, PMCID: PMC4200337

2013

      • Tilemann L, Lee A, Ishikawa K, Aguero J, Rapti K, Santos-Gallego C, Kohlbrenner E, Fish KM, Kho C, Hajjar RJ. SUMO-1 gene transfer improves cardiac function in a large-animal model of heart failure. Science translational medicine. 2013; 5(211):211ra159. PubMed [journal] PMID: 24225946
      • Ishikawa K, Aguero J, Naim C, Fish K, Hajjar RJ. Percutaneous approaches forefficient cardiac gene delivery. Journal of cardiovascular translational research. 2013; 6(4):649-59. PubMed [journal] PMID: 23749638
      • Hadri L, Kratlian RG, Benard L, Maron BA, Dorfmüller P, Ladage D, Guignabert C, Ishikawa K, Aguero J, Ibanez B, Turnbull IC, Kohlbrenner E, Liang L, Zsebo K, Humbert M, Hulot JS, Kawase Y, Hajjar RJ, Leopold JA. Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension. Circulation. 2013; 128(5):512-23. NIHMSID: NIHMS546892 PubMed [journal] PMID: 23804254, PMCID: PMC3908449
      • Fish KM, Ladage D, Kawase Y, Karakikes I, Jeong D, Ly H, Ishikawa K, Hadri L, Tilemann L, Muller-Ehmsen J, Samulski RJ, Kranias EG, Hajjar RJ. AAV9.I-1c delivered via direct coronary infusion in a porcine model of heart failure improves contractility and mitigates adverse remodeling. Circulation. Heart failure. 2013; 6(2):310-7. NIHMSID: NIHMS439923 PubMed [journal] PMID: 23271792, PMCID: PMC3605211
      • Ladage D, Yaniz-Galende E, Rapti K, Ishikawa K, Tilemann L, Shapiro S, Takewa Y,Muller-Ehmsen J, Schwarz M, Garcia MJ, Sanz J, Hajjar RJ, Kawase Y. Stimulating myocardial regeneration with periostin Peptide in large mammals improves function post-myocardial infarction but increases myocardial fibrosis. PloS one. 2013; 8(5):e59656. PubMed [journal] PMID: 23700403, PMCID: PMC3659021

2012

      • Shimada YJ, Ishikawa K, Kawase Y, Ladage D, Tilemann L, Shiota T, Hajjar RJ. Comparison of left ventricular stroke volume assessment by two- and three-dimensional echocardiography in a swine model of acute myocardial infarction validated by thermodilution method. Echocardiography (Mount Kisco,
        N.Y.). 2012; 29(9):1091-5. PubMed [journal] PMID: 22672366
      • Ishikawa K, Kawase Y, Ladage D, Chemaly ER, Tilemann L, Fish K, Sanz J, Garcia MJ, Hajjar RJ. Temporal changes of strain parameters in the progress of chronic ischemia: with comparison to transmural infarction. The international journal of cardiovascular imaging. 2012; 28(7):1671-81. PubMed [journal] PMID: 22231467
      • Ishikawa K, Tilemann L, Ladage D, Aguero J, Leonardson L, Fish K, Kawase Y. Cardiac gene therapy in large animals: bridge from bench to bedside. Gene therapy. 2012; 19(6):670-7. PubMed [journal] PMID: 22301438
      • Ladage D, Ishikawa K, Tilemann L, Müller-Ehmsen J, Kawase Y. Percutaneous methods of vector delivery in preclinical models. Gene therapy. 2012; 19(6):637-41. PubMed [journal] PMID: 22418064
      • Ishikawa K, Chemaly ER, Tilemann L, Fish K, Ladage D, Aguero J, Vahl T, Santos-Gallego C, Kawase Y, Hajjar RJ. Assessing left ventricular systolic dysfunction after myocardial infarction: are ejection fraction and dP/dt(max) complementary or redundant? American journal of physiology. Heart and circulatory physiology. 2012; 302(7):H1423-8. PubMed [journal] PMID: 22307667, PMCID: PMC3330783
      • Ishikawa K, Aoyama Y, Hirayama H. Management of drug-eluting stent restenosis. The Journal of invasive cardiology. 2012; 24(4):178-82. PubMed [journal] PMID: 22477755
      • Tilemann L, Ishikawa K, Weber T, Hajjar RJ. Gene therapy for heart failure. Circulation research. 2012; 110(5):777-93. NIHMSID: NIHMS361108 PubMed [journal] PMID: 22383712, PMCID: PMC3594844
      • Karakikes I, Hadri L, Rapti K, Ladage D, Ishikawa K, Tilemann L, Yi GH, Morel C, Gwathmey JK, Zsebo K, Weber T, Kawase Y, Hajjar RJ. Concomitant intravenous nitroglycerin with intracoronary delivery of AAV1.SERCA2a enhances gene transfer in porcine hearts. Molecular therapy : the journal of the American Society of Gene Therapy. 2012; 20(3):565-71. PubMed [journal] PMID: 22215018, PMCID: PMC3293603
      • Rapti K, Louis-Jeune V, Kohlbrenner E, Ishikawa K, Ladage D, Zolotukhin S, Hajjar RJ, Weber T. Neutralizing antibodies against AAV serotypes 1, 2, 6, and 9 in sera of commonly used animal models. Molecular therapy : the journal of the American Society of Gene Therapy. 2012; 20(1):73-83. PubMed [journal] PMID: 21915102, PMCID: PMC3255603

2011

      • Ladage D, Tilemann L, Ishikawa K, Correll RN, Kawase Y, Houser SR, Molkentin JD, Hajjar RJ. Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury. Circulation research. 2011; 109(12):1396-400. NIHMSID: NIHMS337120 PubMed [journal] PMID: 21998327, PMCID: PMC3237728
      • Ladage D, Turnbull IC, Ishikawa K, Takewa Y, Rapti K, Morel C, Karakikes I, Hadri L, Müller-Ehmsen J, Costa KD, Hajjar RJ, Kawase Y. Delivery of gelfoam-enabled cells and vectors into the pericardial space using a percutaneous approach in a porcine model. Gene therapy. 2011; 18(10):979-85. NIHMSID: NIHMS454798 PubMed [journal] PMID: 21512506, PMCID: PMC3651891
      • Ishikawa K, Tilemann L, Fish K, Hajjar RJ. Gene delivery methods in cardiac gene therapy. The journal of gene medicine. 2011; 13(10):566-72. PubMed [journal] PMID: 21954037
      • Ishikawa K, Ladage D, Takewa Y, Yaniz E, Chen J, Tilemann L, Sakata S, Badimon JJ, Hajjar RJ, Kawase Y. Development of a preclinical model of ischemic cardiomyopathy in swine. American journal of physiology. Heart and circulatory physiology. 2011; 301(2):H530-7. PubMed [journal] PMID: 21551276, PMCID: PMC3154674
      • Ishikawa K, Ladage D, Tilemann L, Fish K, Kawase Y, Hajjar RJ. Gene transfer for ischemic heart failure in a preclinical model. Journal of visualized experiments : JoVE. 2011; (51). PubMed [journal] PMID: 21633324, PMCID: PMC3197127
      • Ishikawa K, Ladage D, Tilemann L, Kawase Y, Hajjar RJ. Sterile abscess in the myocardium after direct intramyocardial injection related to gene therapy in a Swine model. ISRN cardiology. 2011; 2011:319453. PubMed [journal] PMID: 22347637, PMCID: PMC3262519

2010

      • Ishikawa K, Ladage D, Rapti K, Fernandez-Friera L, Maria Garcia-Lopez A, Sanz J, Hajjar RJ, Kawase Y, Garcia MJ. Multimodality imaging of chronic ischemia. Cardiology research and practice. 2010; 2011:739702. PubMed [journal] PMID: 20981290, PMCID: PMC2963130
      • Hadri L, Bobe R, Kawase Y, Ladage D, Ishikawa K, Atassi F, Lebeche D, Kranias EG, Leopold JA, Lompré AM, Lipskaia L, Hajjar RJ. SERCA2a gene transfer enhances eNOS expression and activity in endothelial cells. Molecular therapy : the journal of the American Society of Gene Therapy. 2010; 18(7):1284-92. PubMed [journal] PMID: 20461063, PMCID: PMC2911258