Paolo Palacio-Mancheno, PhD


Postdoctoral Fellow, Orthopaedics
Icahn School of Medicine at Mount Sinai
paolo.palacio-mancheno@mssm.edu

LinkedIn Profile

Hometown
New York City, (NY) USA

Education
The City College of New York , Ph.D in Biomedical Engineering

Research
My laboratory is investigating the phenotypic changes of the intervertebral disc with aging and degeneration. We found that the expressions of osmosensitive and mechanosensation channels are possible targets regulating the intervertebral disc cell and matrix behavior in-vivo. Positive result can provide useful information for the improvement of disc function.
Also, my laboratory is working in discerning the effects of exogenous advanced glycation end-product on the micro structure of bone with age and sex. Advanced glycation end-product are non enzymatic glycations that affect the bone quality and quantity making the organ more prone to fracture. Answering this scientific question will provide insight into biologics affecting bone mechanical competence with obesity and diabetes.

Future Plans
I’m interested in medical research that translates scientific innovation to clinical practice. I am interested in all aspects of orthopedics but concentrated mainly in bone and intervertebral disc mechano sensation, phenotyping and mechanical behavior. Finally, I am interested in project management and design and proposal, and administration.

Publications

  • Palacio-Mancheno P.E., Larriera A.I., Doty S.B., Cardoso L., Fritton S.P, “3D Assessment of Cortical Bone Porosity and Tissue Mineral Density Using High‐Resolution µCT: Effects of Resolution and Threshold Method”, Journal of Bone and Mineral Research. 2014, 29 (1); 142-150. PMID
  • Gu X., Palacio-Mancheno P.E (co-auhor)., Leong D.J., Borisov Y.A., Williams E., Maldonado N., Laudier D., Majeska R.J., Schaffler M.B., Sun H.B., Cardoso L, “High resolution micro arthrography of hard and soft tissues in a murine model”, Osteoarthritis and Cartilage. 2012, 20 (9); 1011-1019. PMID
  • Souzanchi M.F., Palacio‐Mancheno P.E., Borisov Y.A., Cardoso L., Cowin S.C., “Microarchitecture and bone quality in the human calcaneus: local variations of fabric anisotropy”, Journal of Bone and Mineral Research. 2012, 27 (12); 2562-2572. PMID
  • Benalla M., Palacio-Mancheno P.E., Fritton S.P., Cardoso L., Cowin S.C., “Dynamic permeability of the lacunar–canalicular system in human cortical bone”, Biomechanics and Modeling in Mechanobiology. 2013, 13 (4); 801-12. PMID
  • Shi L., Palacio-Mancheno P.E., Badami J., Shin D., Zeng M., Cardoso L., Tu R., B Fu., “Quantification of Transient Increase of the Blood Brain Barrier Permeability to Macromolecules by Optimized Focused Ultrasound Combined with Microbubbles”, International Journal of Nanomedicine. 2014, 9 (1); 4437-4448. PMID
  • Souzanchi M.F., Palacio-Mancheno P.E., Cowin S.C., Cardoso L., “Fabric Tensor Microarchitecture Predicts Direction-Dependent Elastic and Yield Behavior of Human trabecular bone”. In review, Journal of Biomechanics, 2017
  • Larriera A.I., Palacio-Mancheno P.E., Gatti V., Cardoso L., Fritton S.P., “Alterations in Vascular Canal and Bone Blood Vessel Morphology due to Estrogen Deficiency in a Murine Model”. Under Review; Bone, 2017
  • Sharma, D., Larriera, A.I., Palacio-Mancheno, P.E., Levy, J.D., Gatti, V., Cardoso, L., Doty, S.B., and Fritton, S.P., “The Effects of Reduced Estrogen Levels on Cortical Bone Microporosity and Mineralization”. Under Review, Bone, 2017

Conference Proceedings

  • Noelle Aly, Paolo Palacio-Mancheno, PhD, James Iatridis, PhD, Marina Tadros, Devina Purmessur, PhD. “Effects of Osmolarity on Nucleus Pulposus Matrix and Cellular Phenotype in a Mouse Whole IVD Organ Culture Model: Contributions of TRPV4 and Aquaporins” Gordon Bioengineering Conference, August 2016.
  • Noelle Aly, Paolo Palacio-Mancheno, PhD, James Iatridis, PhD, Marina Tadros, Devina Purmessur, PhD. “Effects of Osmolarity on Nucleus Pulposus Matrix and Cellular Phenotype in a Mouse Whole IVD Organ Culture Model: Contributions of TRPV4 and Aquaporins” Orthopedic Research Society Annual Meeting, March 2016.
  • Gatti, V., Palacio-Mancheno, P.E., Zanzonico, P.B., Rajasekhar, V.K., DiResta, G.R., Healey, J.H. and Fritton, S.P.,  “Accurate Assessment of Bone Tumors in a Rat Model of Metastasis,” Orthopaedic Research Society Annual Meeting, 2016.
  • Marina Tadros1, Paolo Palacio-Mancheno2, Faraz Ahmed1, Noelle Aly1, Devina Purmessur, PhD3, James Iatridis2. “Injury-related Changes to the IVD Phenotype Are Associated With Aquaporin Expression, Independent Of Trpv4, In The Inner Annulus Fibrosus”. Orthopedic Research Society Annual Meeting, March 2016.
  • Noelle Aly., Paolo Palacio-Mancheno., Marina Tadros., Devina Purmessur.,  James Iatridis. “Acute Exposure to Hyperosmolar Conditions Increased CK8 Activity Independent of TRPV4  and Maintained a Notochordal Nucleus Pulposus Phenotype in a Mouse Organ Culture Model”. Orthopedic Research Society International Spine Research Symposium, November 2015.
  • Noelle Aly, Paolo Palacio-Mancheno, PhD, James Iatridis, PhD, Marina Tadros, Devina Purmessur, PhD. “Effects of Osmolarity on Nucleus Pulposus Matrix and Cellular Phenotype in a Mouse Whole IVD Organ Culture Model: Contributions of TRPV4 and Aquaporins” Winner of Arnold and Madaleine Penner 4th Annual Musculoskeletal Repair and Regeneration Symposium Young Investigator Award October 2015.
  • Palacio-Mancheno P.E., Moawad C., Ghatak S., Mejia M., Souzanchi M.F., Cowin SC., Cardoso L., “Predicting Direction-Dependent Failure Properties of Human Trabecular Bone: Effects of Fabric Anisotropy, Poroelastic Ultrasound and Individual Trabecular Morphology”, 3rd Annual Musculoskeletal Repair and Regeneration Symposium, October 2, 2014.
  • Palacio-Mancheno P.E., Souzanchi M.F., Ghatak S., Cowin, S.C., Cardoso, L., “Multidirectional Poroelastic- Ultrasound and Structural-Anisotropy Predict Multidirectional Yield Behavior of Trabecular Bone”, Annual American Society of Bone and Mineral Research, September 14, 2014.
  • Palacio-Mancheno P.E., Gatti V., Kanjilal D., Baylosis M.C., Cardoso L., Fritton S.P., “Changes in the Bone Fluid Flow Microenvironment due to Estrogen Deficiency”, Twelfth International Bone Fluid Flow Workshop, September 11, 2014.
  • De Paolis A., Palacio-Mancheno P.E., Gathak S., Cowin S.C., Cardoso L., “Trabecular Microarchitecture Predicts Fabric Tensor and Anisotropic Mechanical Behavior of Trabecular Bone”, 7th World Congress of Biomechanics, July 11, 2014.
  • Palacio-Mancheno P.E., Mejia M., Souzanchi M.F., Cowin S.C., Cardoso L., “Fabric-Microarchitecture Predicts Both Elastic and Yield Shear Behavior of Anisotropic Trabecular Bone”, 7th World Congress of Biomechanics, July 9, 2014.
  • Souzanchi M.F., Palacio-Mancheno P.E., Cardoso L., Cowin S.C., “Fabric Microarchitecture Predicts Both Elastic and Yield Behavior of Anisotropic Human Trabecular Bone”, Transactions of the annual Meeting of the Orthopaedic Research Society, May 17, 2014.
  • Palacio-Mancheno P.E., Kanjilal D., Baylosis M.C., Cardoso L., and Fritton S.P., “Alterations in Bone Blood Vessel Morphology due to Estrogen Deficiency”, Transactions of the Annual Meeting of the Orthopaedic Research Society, May 15, 39:1484, 2014.
  • Souzanchi M.F., Palacio-Mancheno P.E., Cardoso L., Cowin S.C., “The Fabric Anisotropy Effect on Elastic and Yield behavior of the Human Calcaneus trabecular Bone”, 5th BIOT Conference on Poromechanics, July 11, 2013.
  • Bajaj D., Palacio-Mancheno P.E., Patel M., Reyes G., Cardoso L., Schaffler M.B., Fritton J.C., “Decreased Cortical Tissue Toughness Upon Remobilization after Anti-Resorptive Treatment with Risedronate”, Transactions of the Annual Meeting of the Orthopaedic Research Society, January 27, 2013.
  • Palacio-Mancheno P.E., Borisov Y.A., Souzanchi M.F., Cowin S.C., Cardoso L., “In-vitro Evidence of Fast and Slow Wave Propagation in the Human Calcaneus”, Proceedings of the Annual Fall Meeting of the Biomedical Engineering Society, October 14, 2011.
  • Souzanchi M.F., Palacio-Mancheno P.E., Borisov Y., Cardoso L., Cowin S.C., “The Microstructure of the Human Calcaneus and its Effect on Anisotropic Poroelastic Ultrasound”, Transactions of the annual Meeting of the Orthopaedic Research Society, February 5, 2012.
  • Souzanchi M.F., Palacio-Mancheno P.E., Borisov Y.A., Cardoso L., Cowin S.C., “The Characterization of Local Microstructure of the Human Calcaneus”, Proceedings of the Annual Fall Meeting of the Biomedical Engineering Society, October 14, 2011.
  • Palacio-Mancheno, P.E., Bajaj D., Schaffler M.B., Cardoso L., Fritton J.C., “Partial Preservation and Restoration of Bone Lost to Disuse with Bisphosphonate and Remobilization”, Proceedings of the Annual Fall Meeting of the Biomedical Engineering Society, October 13, 2011.
  • Gu, X., Palacio-Mancheno P.E., Leong D., Laudier D., Majeska R.J., Schaffler M.B., Sun H.B., Cardoso L., “Ultra-high Resolution micro-Arthrography Approach to Accessing Cartilage Thickness in a Murine Model”, Proceedings of the Annual Fall Meeting of the Biomedical Engineering Society, October 12, 2011.
  • Borisov Y.A., Palacio Mancheno P.E., Souzanchi M.F., Cowin S.C., Cardoso L., “3D Numerical Evidence of Poroelastic Wave Propagation in Whole Human Calcaneus “, Proceedings of the Annual Fall Meeting of the Biomedical Engineering Society, October 12, 2011.
  • Larriera A.I., Palacio-Mancheno P.E., Cardoso L., Fritton S.P., “Accurate Quantification of Cortical Bone Porosity Using High-Resolution ΜCT”, Transactions of the Annual Meeting of the Orthopaedic Research Society, January 16, 2011.
  • Souzanchi M.F., Palacio-Mancheno P.E., Borisov Y.A., Cardoso L., Cowin S.C., “Local Variations of Fabric Anisotropy in the Human Calcaneus”, Transactions of the Annual Meeting of the Orthopaedic Research Society, January 15, 2011.
  • Palacio-Mancheno P.E., Borisov Y.A., Souzanchi M.F., Cowin S.C., Cardoso L., “In vitro Evidence of Poroelastic Wave Propagation in the Human Calcaneus”, Transactions of the Annual Meeting of the Orthopaedic Research Society, January 15, 2011.
  • Fritton S.P., Larriera A.I., Palacio-Mancheno P.E., Doty S.B., Cardoso L., “Effects of Reduced Estrogen Levels on Cortical Bone Microporosity”, Eleventh International Bone Fluid Flow Workshop, October 13, 2010.
  • Palacio-Mancheno P.E., Sharma D., Healey J.H., DiResta G.R., Fritton S.P., “Enhancement of Drug Uptake into Bone Tumors Using Non-invasive Mechanical Loading”, Proceedings of the Annual Fall Meeting of the Biomedical Engineering Society, 2010.