Dr. Jin Google Scholar Citations
2026
Song, X.; Wu, Q.; Chen, L.; Inuzuka, H.; Zhong, Y.; Qi, Y.; Lin, Y.; Kabir, M.; Xiong, Y.*; Wei, W.*; Jin, J.* “Discovery of New OTUB1 Covalent Ligands via Structure-Activity Relationship Studies for Targeted Protein Stabilization” , Journal of Medicinal Chemistry, 2026 May 4;PMID: 42083385. doi: https://doi.org/10.1021/acs.jmedchem.5c03327
Luo, K.; Xue, Z.; Qin, L.; Wang, Z.; Gao, P.; Xie, L.; Su, Y.; Chen, X.; Kaniskan, H. Ü.*; Wen, H.*; Jin, J.* “Discovery of a Highly Potent and Selective ENL Degrader” Journal of Medicinal Chemistry , 2026 Apr 23;. doi: 10.1021/acs.jmedchem.6c00386 doi:https//doi.org/10.1021/acs.jmedchem.6c00386. PMID: 42025203
Chen, H.; Dutta, R. P.; Li, Z.; Zhong, Y.; Ma, A.; Park, K. S.; Kottur, J.; Park, A.; Babault, N.; Wang, K.; Wang, D.; Xiong, Y.; Kaniskan, H. Ü.; Luo, M.; Parekh, S.; Jin, J.*, “Discovery of a Potent, Selective, and In Vivo Efficacious Covalent Inhibitor for Lysine Methyltransferase SETD8”, Journal of Medicinal Chemistry, 2026, 69(4), 4255-4269. PMCID: PMC12987572, PMID: 41693203 PMID: 41693203, doi:
https://doi.org/10.1021/acs.jmedchem.5c02958
Yim, H.; Song, X.; Zhong, Y.; Hu, J.; Xiong, Y.; Jin, J.*, “Discovery of KRAS-G12D degraders via exploration of various E3 ligases”, European Journal of Medicinal Chemistry, 2026, 307, 118635. PMID: 41679196, doi: https://doi.org/10.1016/j.ejmech.2026.118635
Gao, P.; Zhong, Y.; Luo, K.; Jin, J.* “Bridged PROTAC, DNA-based PROTAC and hydrophobic tag technologies for targeted protein degradation” Advanced Drug Delivery Reviews , 2026, 232, 115819. PMID: 41707939. doi:
https://doi.org/10.1016/j.addr.2026.115819.
Srour, N.; Luo, K.; Allard, D.; Xiong, Y.; Yu, Z.; Papadopoulos, T.; Santinon, F.; Hsieh, C. H.; Parent, A.; Stagg, J.; Turcotte, S.; Barsyte-Lovejoy, D.; Lehoux, S.; Del Rincón, S. V.; Jin, J.*; Richard, S.*, “PRMT7 restricts CD8+ T cells expansion via the NF-κB pathway”, Nature Communications, 2026 Sep 6; 17(1), doi:https://doi.org/10.1038/s41467-026-77155-2. PMCID: PMC13642902.
Kabir, M.; Kim, Y. J. J.; Deng, Z.; Xiang, Y.; Sargunas, P. R.; Song, N.; Wang, Z.; Param, N.J.; Jin, C.; Sang, Z.; Yue, A.; Bundo, A.; Hossain, R.; Zhong, Y.; Lin, Y.; Xiong, Y.; Guccione, E.; Huang, K. L.; Feng, M.; Jin, J.*; Shi, Y.* bioRxiv, May 6,2026, doi:https://doi.org/10.64898/2026.05.02.722401; PMCID: PMC13174547,PMID: 42146646.
Xia, Z.; Yang, X.; Samovich, S. N.; Tyurina, Y. Y.; Tyurin, V. A.; Kon, N.; Zhang, J.; Jiang, X.; Stockwell, B. R.; Jin, J.; Bayir, H.; Kagan, V. E.; Gu, W.*, “A GPX1–OSBPL8 Axis Mediates Noncanonical In Vivo Ferroptosis and Cancer Growth Suppression”, Cell , 2026, Feb 19, doi:https://doi.org/10.1016/j.cell.2026.01.009 PMCID: PMC12927606. PMID: 41720096
Gelles, J. D.; Chen, Y.; Luna-Vargas, M. P. A.; Viacava Follis, A.; Al Noman, M. A.; Kabir, M.; Bayiokos, S. G.; Mohammed, J. N.; Sebastian, T. M.; Pham, N. D.; Shi, Y.; Jin, J.; Kriwacki, R. W.; Chipuk, J. E.*, “A gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function”, Nature Communications , 2026, Feb 25. PMID: 41741428 ; PubMed Central PMCID: PMC13046825. DOI: 10.1016/j.cell.2026.01.009 https://doi.org/10.1016/j.cell.2026.01.009
Wang, Y.; Xiong, Y.; Liu, S.; Bao, L.; Qiu, X.; Korboukh, I.; Song, X.; Toffessi Tcheuyap, V.; Wu, S.; Chen, M.; Brugarolas, J.; Jin, J.; Wang, Y.; Luo, W.*, “HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer”, Cell Reports Medicine, 2026, Feb 18, 102630. PMID: 41713410, 41713410 doi:
10.1016/j.xcrm.2026.102630. https://doi.org/10.1016/j.xcrm.2026.102630
Yi, Y.; Li, Y.; Wang, R.; Yu, X.; Liu, Q.; Yum, C.; Zhang, Y.; Qiao, Y.; Szczepanski, A.; Wu, S.; Li, Q.; Fazli, L.; Shen, J.; Wang, X.; Li, X.; Mu, P.; Schaeffer, E. M.; Hundley, H. A.; Niu, H.; Chinnaiyan, A. M.; Wang, L.; Shi, J.; Jin, J.; Dong, X.; Zhao, W.; Chen, K.; Cao, Q.*, “A dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR”, Nature Communications, 2026, PMID: 41882000
Yi, Y.; Fry, J.; Yum, C.; Wang, R.; Wu, S.; Narayan, S.; Liu, Q.; Zhang, X.; Oo, H. Z.; Xie, N.; Li, Y.; Gao, X.; Yu, X.; Hu, X.; Li, Q.; Keseroglu, K.; Özbudak, E. M.; Abdulkadir, S. A.; Chen, K.; Jin, J.; Zhao, J. C.; Dong, X.; Arango, D.; Yang, R.; Cao, Q.*, “EZH2 crosstalk with RNA methylation promotes prostate cancer progression through modulation of the m6A autoregulation pathway” Journal of Clinical Investigation, 2026, 136(2). doi: 10.1172/JCI195840. https://doi.org/10.1172/JCI195840 PMCID: PMC12807473.
Huang, D.; Duplaquet, L.; Wang, J.; Cai, G.; Duan, J.; Hu, X.; Chen, L.; Yan, P.; Jiang, W.; Hou, T.; Xiong, Y.; Inuzuka, H.; Jin, J.; Oser, M. G.; Wei, W.*, “USP2 stabilizes POU2F3 and represents a therapeutic vulnerability in POU2F3-positive small cell lung cancer”, Cell Press Blue 2026, 1 (5), 100071.
Kim, A.; Pan, B.; Yu, X.; Gao, X.; Khudaverdyan, N.; Taherian, F.; Xu, C.; Zhong, H.; Xiong, Y.; Kaniskan, H. Ü.; Vedadi, M.; Song, J.; Jin, J.; Cai, L.*; Wang, G. G, “An EZH2-SREBP2 axis promotes cholesterol biosynthesis and represents a noncanonical vulnerability in tumorigenesis”, Nature Cell Biology , 2026 Oct;28(10):2138-2154. PMCID: PMC13527670.
Orive-Ramos, A.; Gaire, B.; Adamopoulos, C.; Baars, B.; Desaunay, M.; Kou, Z.; Matenoglou, E.; Coma, S.; Gutiérrez Trejo, N.; Mohammed, K.; Aaronson, S. A.; Jin, J.; Martin, T. C.; Guccione, E.; Gavathiotis, E.; Pachter, J. A.; Poulikakos, P. I.*, “Spatial modulation of RAF by RAF/MEK glue enables full-dose combination with pan-RAF inhibitor and potent RAS-mutant tumor-selective MAPK and growth inhibition”, Cancer Discovery Sep 29,2026;. doi: 10.1158/2159-8290.CD-25-1596. [Epub ahead of print] PubMed PMID: 42810411.
Waqas, A.; Li, X.; Shabangu, C. S.; Chen, H.; Katuwal, N.; Kirchherr, J.; Liu, W. R.; Li, X.; Song, Y.; Luo, K.; Kaniskan, H. U.; Jin, J.; Gianella, S.; Margolis, D. M.; Archin, N. M.; Tang, Y.; Jiang, G.*, “The ENL–USP7 Complex Regulates HIV Latency Through BRD4 Stabilization”, Cell Reports , 2026 Oct 10;45(10):118120. doi: 10.1016/j.celrep.2026.118120. [Epub ahead of print] PubMed PMID: 42858251.
2025 (showing 16 out of 34 publications)
Hosseini, A.; Qiu, X.; Xiong, Y.*; Chiang, K. H. N.; Catlett, J.; Kaltheuner, I.; Deng, Z.; Ghosh, S.; Shi, Y.*; Jin, J.* “Discovery of an LSD1 PROTAC Degrader”, Proceedings of the National Academy Sciences of the United States of America (PNAS), 2025, 122(20):e2425812122. PMCID: PMC12107161.
Qian, C.; Wang, Z.; Xiong, Y.; Zhang, D.; Zhong, Y.;Inuzuka, H.; Qi, Y.; Xie, L.; Chen, X.; Wei, W.* ; Jin, J.* , “Harnessing the Deubiquitinase USP1 for Targeted Protein Stabilization”. Journal of the American Chemical Society , 2025, 147(17):14564-14573. PMCID: PMC12077936.
Zhong, Y.; Kim, H. S.; Qian, C.; Xie, L.; Chen, X.; Xiong, Y.; Hu, J.; Chen, M.; Guccione, E.; Shen, Y.*; Jin, J.* , “Discovery of A Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader”. Journal of Medicinal Chemistry, 2025, 68(8): 8543–8563. PMCID: PMC12080994.
Deng, Z.; Catlett, J.; Lee, Y.; Wu, Q.; Xu, Z.; Xie, L.; Chen, X.; Xiong, Y.; Kaniskan, H. U.*; Jin, J.*; “Harnessing the SPOP E3 Ubiquitin Ligase via Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein Degradation”, Journal of Medicinal Chemistry, 2025, 68(8):8634-8647. PMCID: PMC12043353.
Yim, H.; Sun, R.; Xu, Z.; Kim, H. S.; Kim, M.; Cao, T.; Xie, L.; Chen, X.; Kaniskan, H. U.*; Jin, J.*; “Discovery of the First-in-class DOT1L PROTAC Degrader” European Journal of Medicinal Chemistry , 2025, 291:117595. PMCID: PMC12045715.
Qian,C.; Lee,Y.; Han,Y.; Zhong,Y.; Zhou,J.; Hrit, J.; Xie,L.; Chen, Q.; Kaniskan, H. U.; Chen, X.; Rothbart, S.; Cheng, X.; Xiong, Y.*; Jin, J.* , “Structure-activity Relationship Studies of DNA Methyltransferase 1 (DNMT1) Monovalent Degraders”. Journal of Medicinal Chemistry, 2025, 68(3):2903–2919. PMCID: PMC11932022.
Deng, Z; Chen, L; Qian, C; Liu,J; Wu,Q; Song,X; Xiong,Y.; Wang, Z; Hu, X; Inuzuka, H; Zhong, Y; Lin; Y; Pham, N.D.; Shi,Y; Wei ;W.*; Jin,J.* Angewandte Chemie International Edition, “The First-in-class Deubiquitinase-targeting Chimera Stabilizes and Activates cGAS.”,2025, 64(3):e202415168. PMCID: PMC11738674.
Kabir. M.; Hu, X. Martin, T. C.; Pokushalov, D.; Kim, Y. J.; Chen, Y.; Zhong, Y.; Wu, Q; Chipuk, J. Y.; Shi, Y; Xiong, Y.; Gu, W.; Parsons, R. E.; and Jin, J.* , “Harnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53”, Advanced Science, 2025, 12(7):e2413377. PMCID: PMC11831463.
Xu, Z.; Pokushalov, D.; Kabir, M.; Lee, Y.; Chattopadhyay, M.; Jenkins, E. C.; Choo, C.; Kaniskan, H. Ü.; Germain, D.*; Jin, J.*“Targeting the Mitochondrial Protease ClpP for Anticancer Therapy”. Journal of Medicinal Chemistry, 2025, 68(20):21377-21393. PMID: 41032690. PMCID: . PMC12700136
Chen, L.; Deng, Z.; Xiong, Y.; Liu, J.; Huang, D.; Wang, J.; Chen, Y.; Inuzuka, H.; Xie, L.; Chen, X.; Jin, J.*; Wei, W.* “Deubiquitinase-Targeting Chimeras Mediated Stabilization of Tumor Suppressive E3 Ligase Proteins as a Strategy for Cancer Therapy”. Journal of the American Chemical Society, 2025, 147(33):29875-29883. PMCID: PMC12395470.
Hu, X.; Graciano, K.; Hu, J.; Liu, C.; Zhang, J.; Xie, L.; Chen, X.; Xiong, Y.; Jin, J.*; Xu, J.* “Discovery of the first-in-class Aurora B kinase selective degrader” European Journal of Medicinal Chemistry, 2025, 298: 118006. PMCID: PMC12379206.
Wang, Z.; Qian, C.; Xiong, Y.; Zhang, D.; Inuzuka, H.; Zhong, Y.; Xie, L.; Chen, X.; Jin, J.*; Wei, W.*, “USP28-Based Deubiquitinase-Targeting Chimeras for Cancer Treatment”, Journal of the American Chemical Society,2025, 147(16):13754–13763. PMCID: PMC12105324, PMID: 40214647. DOI: 10.1021/jacs.5c01889
Zhu, Z.; Chen, H.; Qiu, X.; Kaniskan, H. Ü.; Xie, L.; Chen, X.; Jin, J.*; Liu, P.* “(GGAA)3-based TF-PROTACs enable targeted degradation of ETV6 to inhibit Ewing sarcoma growth”, Journal of the American Chemical Society, 2025, 147(16):13396–13404. PMID: 40215343.
Teichman , E. M.; Hu , J.; in, H.; Fisher, R. F.; Blando, A.; Hu, X.; Kaniskan , H. U; Montgomery, S. E.; Cai, M.; Parise, L.; Wang, J.; Russo, S.; Han, M.*; Jin , J.*; Morel, C.* , “Design and validation of novel brain-penetrant HCN channel inhibitors to ameliorate social stress-induced susceptible phenotype”. Molecular Psychiatry, 2025, 30(9):3937-3950.PMCID: PMC12339378.
Xie, L; Sheehy, RN; Muneer, A; Xiong, Y; Wrobel, JA; Zhang, F; Park, KS; Velez, J; Liu, J; Luo, YJ; Asrican, B; Dong, P; Li, YD; Damian, C; Quintanilla, L; Li, Y; Xu, C; Deshmukh, M; Coleman, LG Jr; Ming, GL; Song, H; Wen, Z; Jin, J*; Song, J*; Chen, X*. “Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology”. Nature Communication, 2025. 16(1):4222. PMCID: PMC12056044.
Martinez, Criseyda; Xiong, Yan; Bartkowski, Alison; Harada, Ibuki; Ren, Xiaoxiao; Byerly, Jessica; Port, Elisa; Jian Jin*; Irie, Hanna*. “A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells”, Cell Chemical Biology, 2025, 32(2):255-266.E8. PMCID: PMC11845306. PMID: 40328756.
2024 (showing 10 out of 15 publications)
Inuzuka, H; Qian, Chao; Qi,Y; Xiong, Y; Wang, C;Wang,Z; Zhang, D;Zhang, C; Jin, J*; Wei, W*; ACS Pharmacology & Translational Science , “Targeted Degradation of Receptor-Interacting Protein Kinase 1 to Modulate the Necroptosis Pathway”, 2024, 7, 3518-3526. PMCID: PMC11555510.
Xue Z; Qin L; Xuan H.; Luo K.; Huang M; Xie, L; Su, Y.; Xu L; Harsh, J.; Dale, B.; Shi, X.; Chen, X.; Kaniskan, HÜ.; Jin, J*., Wen, H.*, Science Advances, “A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression”. 2024 Aug 30;10(35).eado1432. PMID:39196923. PMCID: PMC11352836
Hu,X; Kabir, M; Lin, Y; Xiong Y; Parsons, R; Gu, W; Jin, J*. Journal of Medicinal Chemistry “Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs)”, , August, 2024, 67, 14633−14648 PMID:39169826.
Wang, S, E.; Xiong, Y.;Jang, M, A,; Park, K, S.; Donahue, M.; Velez J.; Jin J.*; Jiang, Y, H.*, Molecular Therapy, “Newly developed oral bioavailable EHMT2 inhibitor as a potential epigenetic therapy for Prader-Willi syndrome”, 2024 Aug 7;32(8):2662-2675. PMID: 38796700.
Kabir, M.; Qin, L.; Luo, K.; Xiong, Y.; Sidi, R. A.; Park, K.-S.*; Jin, J.*, “Discovery and characterization of a novel Cereblon-recruiting PRC1 bridged PROTAC degrader.” Journal of Medicinal Chemistry. 2024, 67:6880-6892. PMID: 38607318.
Velez, J.; Han, Y.; Yim, H.; Yang, P.; Deng, Z.; Park, K.-s.; Kabir, M.; Kaniskan, H. Ü.; Xiong, Y.*; Jin, J.*, Discovery of the first-in-class G9a/GLP PROTAC degrader. Journal of Medicinal Chemistry. 2024, 67(8):6397-6409. PMID: 28602846.
Liu, J; Hu, X.; Luo, K; Xiong, Y; Chen, L.; Wang, Z.; Inuzuka, H.; Qian, C.; Yu, X.; Xie, L.; Muneer, A.; Zhang, D.; Paulo, J. A.; Chen, X.; Jin, J.*; Wei, W.*, Journal of the American Chemical Society“, USP7-based deubiquitinase-targeting chimeras stabilize AMPK.” 2024, 146, 16, 11507–11514; PMID: 38597345.
Xiong, Y.; Greschik, H.; Johansson, C.; Seifert, L.; Gamble, V.; Park, K.-s.; Fagan, V.; Li, F.; Chau, I.; Vedadi, M.; Arrowsmith, C. H.; Brennan, P.; Fedorov, O.; Jung, M.; Farnie, G.; Liu, J.; Oppermann, U. *; Schüle, R. *; Jin, J. *, Discovery of a potent, selective, and cell-active SPIN1 inhibitor. Journal of Medicinal Chemistry. 2024, 67(7):5837-5853. PMID: 38533580.
Wang, Z.; Zhang, D.; Qiu, X.; Inuzuka, H.; Xiong, Y.; Liu, J.; Chen, L.; Chen, H.; Xie, L.; Kaniskan, H. Ü.; Chen, X.; Jin, J. *; Wei, W. *, Journal of the American Chemical Society . “Structurally specific Z-DNA proteolysis targeting chimera enables targeted degradation of adenosine deaminase acting on RNA”, 2024, 146 (11): 7584-7593. PMID: 38469801.
Velez, J.; Dale, B.; Park, K.-S.; Kaniskan, H. Ü.; Yu, X. *; Jin, J. *, “Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2”. European Journal of Medicinal Chemistry, 2024, 267, 116154. PMID: 38602846.,
For papers published before 2023, please see Dr. Jin’s full publication list