GPCR ligands

Our Biased Ligands for G Protein-coupled Receptors:

UNC9994: ß-Arrestin biased D2R ligand (PMID: 22025698 &PMID: 27911814)

UNC9975: ß-Arrestin biased D2R ligand (PMID: 22025698 & PMID: 26129680)

MS1768 (Compound 38): G-protein biased D2R partial agonist (PMID:30964661)

Compound 21: Selective agonist at excitatory (hM3Dq) & inhibitory (hM4Di) (PMID: 25587888 & PMID:30868140)

Compound 10: Non-catechol D1R full agonist (PMID: 31387346)

Compound 71: Selective GPR68 PAM (PMID: 31298539)