Dr. Jin Google Scholar Citations
2025
Hosseini, A.; Qiu, X.; Xiong, Y.*; Chiang, K. H. N.; Catlett, J.; Kaltheuner, I.; Deng, Z.; Ghosh, S.; Shi, Y.*; Jin, J.* “Discovery of an LSD1 PROTAC Degrader”, Proceedings of the National Academy Sciences of the United States of America (PNAS), 2025, 122(20):e2425812122. PMCID: PMC12107161.
Qian, C.; Wang, Z.; Xiong, Y.; Zhang, D.; Zhong, Y.;Inuzuka, H.; Qi, Y.; Xie, L.; Chen, X.; Wei, W.* ; Jin, J.* , “Harnessing the Deubiquitinase USP1 for Targeted Protein Stabilization”. Journal of the American Chemical Society , 2025, 147(17):14564-14573. PMCID: PMC12077936.
Zhong, Y.; Kim, H. S.; Qian, C.; Xie, L.; Chen, X.; Xiong, Y.; Hu, J.; Chen, M.; Guccione, E.; Shen, Y.*; Jin, J.* , “Discovery of A Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader”. Journal of Medicinal Chemistry, 2025, 68(8): 8543–8563. PMCID: PMC12080994.
Deng, Z.; Catlett, J.; Lee, Y.; Wu, Q.; Xu, Z.; Xie, L.; Chen, X.; Xiong, Y.; Kaniskan, H. U.*; Jin, J.*; “Harnessing the SPOP E3 Ubiquitin Ligase via Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein Degradation”, Journal of Medicinal Chemistry, 2025, 68(8):8634-8647. PMCID: PMC12043353.
Yim, H.; Sun, R.; Xu, Z.; Kim, H. S.; Kim, M.; Cao, T.; Xie, L.; Chen, X.; Kaniskan, H. U.*; Jin, J.*; “Discovery of the First-in-class DOT1L PROTAC Degrader” European Journal of Medicinal Chemistry , 2025, 291:117595. PMCID: PMC12045715.
Qian,C.; Lee,Y.; Han,Y.; Zhong,Y.; Zhou,J.; Hrit, J.; Xie,L.; Chen, Q.; Kaniskan, H. U.; Chen, X.; Rothbart, S.; Cheng, X.; Xiong, Y.*; Jin, J.* , “Structure-activity Relationship Studies of DNA Methyltransferase 1 (DNMT1) Monovalent Degraders”. Journal of Medicinal Chemistry, 2025, 68(3):2903–2919. PMCID: PMC11932022.
Deng, Z; Chen, L; Qian, C; Liu,J; Wu,Q; Song,X; Xiong,Y.; Wang, Z; Hu, X; Inuzuka, H; Zhong, Y; Lin; Y; Pham, N.D.; Shi,Y; Wei ;W.*; Jin,J.* Angewandte Chemie International Edition, “The First-in-class Deubiquitinase-targeting Chimera Stabilizes and Activates cGAS.”,2025, 64(3):e202415168. PMCID: PMC11738674.
Kabir. M.; Hu, X. Martin, T. C.; Pokushalov, D.; Kim, Y. J.; Chen, Y.; Zhong, Y.; Wu, Q; Chipuk, J. Y.; Shi, Y; Xiong, Y.; Gu, W.; Parsons, R. E.; and Jin, J.* , “Harnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53”, Advanced Science, 2025, 12(7):e2413377. PMCID: PMC11831463.
Xu, Z.; Pokushalov, D.; Kabir, M.; Lee, Y.; Chattopadhyay, M.; Jenkins, E. C.; Choo, C.; Kaniskan, H. Ü.; Germain, D.*; Jin, J.*“Targeting the Mitochondrial Protease ClpP for Anticancer Therapy”. Journal of Medicinal Chemistry, 2025, 68(20):21377-21393. PMID: 41032690.
Chen, L.; Deng, Z.; Xiong, Y.; Liu, J.; Huang, D.; Wang, J.; Chen, Y.; Inuzuka, H.; Xie, L.; Chen, X.; Jin, J.*; Wei, W.* “Deubiquitinase-Targeting Chimeras Mediated Stabilization of Tumor Suppressive E3 Ligase Proteins as a Strategy for Cancer Therapy”. Journal of the American Chemical Society, 2025, 147(33):29875-29883. PMCID: PMC12395470.
Hu, X.; Graciano, K.; Hu, J.; Liu, C.; Zhang, J.; Xie, L.; Chen, X.; Xiong, Y.; Jin, J.*; Xu, J.* “Discovery of the first-in-class Aurora B kinase selective degrader” European Journal of Medicinal Chemistry, 2025, 298: 118006. PMCID: PMC12379206.
Wang, Z.; Qian, C.; Xiong, Y.; Zhang, D.; Inuzuka, H.; Zhong, Y.; Xie, L.; Chen, X.; Jin, J.*; Wei, W.*, “USP28-Based Deubiquitinase-Targeting Chimeras for Cancer Treatment”, Journal of the American Chemical Society,2025, 147(16):13754–13763. PMCID: PMC12105324.
Zhu, Z.; Chen, H.; Qiu, X.; Kaniskan, H. Ü.; Xie, L.; Chen, X.; Jin, J.*; Liu, P.* “(GGAA)3-based TF-PROTACs enable targeted degradation of ETV6 to inhibit Ewing sarcoma growth”, Journal of the American Chemical Society, 2025, 147(16):13396–13404. PMID: 40215343.
Teichman , E. M.; Hu , J.; in, H.; Fisher, R. F.; Blando, A.; Hu, X.; Kaniskan , H. U; Montgomery, S. E.; Cai, M.; Parise, L.; Wang, J.; Russo, S.; Han, M.*; Jin , J.*; Morel, C.* , “Design and validation of novel brain-penetrant HCN channel inhibitors to ameliorate social stress-induced susceptible phenotype”. Molecular Psychiatry, 2025, 30(9):3937-3950.PMCID: PMC12339378.
Xie, L; Sheehy, RN; Muneer, A; Xiong, Y; Wrobel, JA; Zhang, F; Park, KS; Velez, J; Liu, J; Luo, YJ; Asrican, B; Dong, P; Li, YD; Damian, C; Quintanilla, L; Li, Y; Xu, C; Deshmukh, M; Coleman, LG Jr; Ming, GL; Song, H; Wen, Z; Jin, J*; Song, J*; Chen, X*. “Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology”. Nature Communication, 2025. 16(1):4222. PMCID: PMC12056044.
Martinez, Criseyda; Xiong, Yan; Bartkowski, Alison; Harada, Ibuki; Ren, Xiaoxiao; Byerly, Jessica; Port, Elisa; Jian Jin*; Irie, Hanna*. “A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells”, Cell Chemical Biology, 2025, 32(2):255-266.E8. PMCID: PMC11845306.
Nelson, T.; Kemper, R.; Chiarella, A.; Gonzalez, T. S.; Carroll, M.; Tripathi, S.; Clarke, B.; Yu, X.; Hu, X.; Cooke, A.; Chirumamilla, B.; Chandler, A.; McGilvary, E.; Pattenden, S.; Jin, J.; Crona, D.*; Hathaway, N.* “A first-in-class chemical-induced proximity system achieves dose-dependent control of Tumor Protein 53 (TP53) gene activation in preclinical models of gastric cancer”, ACS Pharmacology & Translational Science, 2025, 8(10):3585-3599. PMCID: PMC12519258.
Wang, SE; Cheng, Y; Lim, J; Jang, MA; Forrest, EN; Kim, Y; Donahue, M; Jo, S; Qiao, SN; Lee, DE; Hong, JY; Xiong, Y; Jin, J; Wang, S; Jiang, YH. “Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome”. Nature Communication, 2025, 16(1):6125. PMCID: PMC12229668.
Atienza Párraga, A.; Nylund, P.; Diamanti, K.; Garrido-Zabala, B.; Tziola, S. I.; Vasquez, L.; Pyl, P. T.; Raykova, D.; Skaftason, A.; Ma, A.; Jin, J.; Martín-Subero, J. I.; Öberg, F.; De Bruyne, E.; Komorowski, J.; Jernberg Wiklund, H.*; Kalushkova, A.* “Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation” Scientific Reports, 2025, 15(1):31568. PMCID: PMC12391466.
Haspula, D.; Cui, Z.; Pittala, S.; Cui, Y.; Lu, H.; Xiong, Y.; Jin, J.; Gavrilova, O.; Hwang, E.; Ajwani, J.; Portillo, B.; Williams, K. W.; Inoue, A.; Weiss, J.* “G proteins of the G12 family expressed by POMC neurons regulate key metabolic functions” Science Advances, 2025, 11(28):eadu1670. PMCID: PMC12248387.
Gumpper, R. H.*; Jain, M. K.; Kim, K.; Sun, R.; Sun, N.; Xu, Z.; DiBerto, J. F.; Krumm, B. E.; Kapolka, N. J.; Kaniskan, H. U.; Nichols, D. E.; Jin, J.; Fay, J. F.; Roth, B. L.* “The Structural Diversity of Psychedelic Drug Actions Revealed”, Nature Communications, 2025, 16:2734. PMID: 40108183.
H, Su; Sun, Y; Han, G; Chen, S; Liu, S; Gao, A; Zhao, R; Glen, R; Jin, J; Qu, C; Yu, M; Klug, C.; K., A.; Zheng, G., Y.; Ballinger, S.; Kutny, M.; Chen, Y.; Luo, M*; Zhao, X.*, “PRMT1-Mediated Metabolic Reprogramming Promotes Leukemogenesis”. eLife, 2025, 14: RP105318. PMCID: PMC12349897.
Bauer, L.G., Ward, J.A., Díaz-Sáez, L., Sundström, Y., Tolvanen, T., Barrera, J. C. A., Kostidis, S., Rogers, C.M., Panagakou, I., Singh, U., Rothweiler, E.M., Gonzalez, Orta A, Kaniskan, H. Ü., Hu, J., Jin, J., Sievers, S., Waldmann, H., Giera, M., Sundström, M., Berg, L., Huber, K., “Phenomics-based Discovery of Novel Orthosteric Choline Kinase Inhibitors”. Angewandte Chemie International Edition, 2025, 64(7):e202420149. PMID:39740997
Tian, Y.; Bhattacharya, R.; Yoo, S.; Jiang, F.; Park, E.; Laragranados, G.; Shen, Y.; Park, K.-S.; Kaniskan, H. U,; Jin, J.; Hopkins, B.; Zhu, J.; Watanabe, H.*. “Epigenomic Analysis Identifies DTP Subpopulation Using HOPX to Develop Targeted Therapy Resistance in Lung Adenocarcinoma ”, iScience , 2025, 28(5):112387. PMCID: PMC12063144.
Muneer, A.; Xie, L.; Xie, X.; Zhang, F.; Wrobel, J. A.; Xiong, Y.; Yu, X.; Wang. C.; Gheorghe, C.; Wu, P.; Song, J.; Ming, G. L.; Jin, J.; Song, H.; Shi, P. Y.; Chen, X.* “Targeting G9a-m6A translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae” , iScience, 2025, 28(6):112632. PMCID: PMC12159498.
Yum, C.; Schaefer, R.; Wang, R.; Wang, T.; Lu, X.; Liu, Q.; Ren, Y.; Meng, Q.; Yang, Y.; Zhang, X.; Xiong, Y.; Yu, X.; Zhang, X.; Jin, J.; Dong, X.; Yi, Y.; Yang, R.; Cao, Q.* “Ketone drink enhances therapeutic efficacy in prostate cancer by targeting EZH2”, Oncogenesis, 2025, 14(1):24. PMCID: PMC12255682.
Zhu, S.; Gao, H.; Jiang, D.; Guo, G.; Hou, J.; Han, Y.; Zhang, C.; Hu, X.; Indulkar, S.; Kloeber, J. A.; Hu, Q.; Jiang, Y.; Zeng, X.; Ouyang, Y.; Lu, J.; Yin, P.; Luo, K.; Huang, J.; Wu, Z.; Chen, B.; Xiao, H.; Dragojevic, S.; Qin, H.; Zhou, X.; Jin, J.; Tu, X.; Wang, L.; Luo, Z.* “Isoform-Specific Function of NSD3 in DNA Replication Stress Confers Resistance to PARP Inhibitors in Prostate Cancer”, Molecular Cell, 2025, 85(14):2673-2687.e8. PMCID: PMC12276998.
Zwergel, C.; Lambona, C.; Fioravanti, R.; Raucci, A.; Fiorentino, F.; Nchugoua Tchieh, G.; Jallet, C.;Lacroix, L.; Pierrettori, M.; Pellegrini, F. R.; Xiong, Y.; Jin, J.; Arimondo, P.; Trisciuoglio, D.; Mai,A.*; Valente, S.* “Quinoline-Based DNA Methyltransferase Inhibitors Featuring Basic Side Chains: Design, Synthesis, and Insight in Biochemical and Anticancer Cell Properties”, Journal of Medicinal Chemistry , 2025, 68, 23886-23909. PMCID: PMC12670401
Chen, L.; Bu, X.; Sun, Y.; Huang, D.; Chen, Y.; Hou, T.; Hu, X.; Wang, J.; Yan, P.; Qi, Y.; Jiang, W.;Xiong, Y.; Liu, J.; Gao, Y.; Huan, M.; Wang, B.; Liu, Q.; Dai, X.; Dang, F.; Asara, J. M.; Fujimoto,M.; Inuzuka, H.; Jin, J.; Zhang, J.*; Freeman, G. J.*; Wei, W.* “Targeted destruction of VISTA boosts anti-tumor immunotherapy”, Cell Research, 2025, DOI:
https://doi.org/doi:10.1038/s41422-025-01194-5
Vogt, K. C.; Panagiotakopoulou, M.; Manzari Honu, M. T.; Perea, A. M.; Hu, X.; Yu, X.; Raziuddin, R.;LaPlant, Q.; Ruiz, S.; Raju, G. P.; Jin, J.; Scheinberg, D. A.; Heller, D. A.* “Tumor microenvironment-targeted PROTAC nanoparticle self-assembly broadly predicted by structural descriptors” Science Advances, 2025, 11(49):eadu2292.
Dutta, R. P.; Lee, H. H.; Leshchenko, V. V.; Shukla, R. P.; Yan, F.; Liu, Y.; Kaniskan, H. Ü.; Qiu, X.; Jin, J.; Alinari, L.; Wang, M.; Parekh, S.* “SOX11 Modulates BCR Signaling Through the PAX5/CD19 Axis for Therapeutic Targeting in BTK Resistant Mantle Cell Lymphoma”, Blood Advances, 2025, doi: 10.1182/bloodadvances.2025016801. PMID: 40845256.
Tiedje, V.; Greenberg, J.; Qin, T.; Im, S. Y.; Krishnamoorthy, G. P.; Boucai, L.; Xu, B.; French, J. D.; Sherman, E. J.; Ho, A. L.; de Stanchina, E.; Socci, N. D.; Jin, J.; Ghossein, R. A.; Knauf, J. A.; Koche, R. P.; Fagin, J. A.* “Loss of tumor cell MHC class II drives MAPK inhibitor insensitivity of BRAF-mutant anaplastic thyroid cancers” The Journal of Clinical Investigation, 2025, 135(20): e191781. PMCID: PMC12520682
Yi, Y.; Fry, J.; Yum, C.; Wang, R.; Wu, S.; Narayan, S.; Liu, Q.; Zhang, X.; Oo, H. Z.; Xie, N.; Li, Y.;Gao, X.; Yu, X.; Hu, X.; Li, Q.; Keseroglu, K.; Özbudak, E. M.; Abdulkadir, S. A.; Chen, K.; Jin, J.; Zhao, J. C.; Dong, X.; Arango, D.; Yang, R.; Cao, Q.* “EZH2 crosstalk with RNA methylation promotes prostate cancer progression through modulation of the m6A autoregulation pathway” Journal of Clinical Investigation , 2025, Nov 18:e195840. doi: 10.1172/JCI195840.
Yu, Y.; Yu, X.; Pan, B.; Chan, H. M.; Kaniskan, H. Ü.; Jin, J.; Cai, L.*; Wang, G. G.*, “Pharmacologic degradation of WDR5 suppresses oncogenic activities of SS18::SSX and provides a therapeutic of synovial sarcoma”. Science Advances , 2025, 11:eads7876. PMCID: PMC12017321.
Liu, Z.; et al, Jin, J.; et al, Veschi, V.* “SGSS05-NS3 as a potent and selective SETD8 inhibitor that activates p53 pathway in Neuroblastoma” Journal of Experimental & Clinical Cancer Research, in press.
2024 ( showing 10 out of 15 publications)
Inuzuka, H; Qian, Chao; Qi,Y; Xiong, Y; Wang, C;Wang,Z; Zhang, D;Zhang, C; Jin, J*; Wei, W*; ACS Pharmacology & Translational Science , “Targeted Degradation of Receptor-Interacting Protein Kinase 1 to Modulate the Necroptosis Pathway”, 2024, 7, 3518-3526. PMCID: PMC11555510.
Xue Z; Qin L; Xuan H.; Luo K.; Huang M; Xie, L; Su, Y.; Xu L; Harsh, J.; Dale, B.; Shi, X.; Chen, X.; Kaniskan, HÜ.; Jin, J*., Wen, H.*, Science Advances, “A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression”. 2024 Aug 30;10(35).eado1432. PMID:39196923. PMCID: PMC11352836
Hu,X; Kabir, M; Lin, Y; Xiong Y; Parsons, R; Gu, W; Jin, J*. Journal of Medicinal Chemistry “Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs)”, , August, 2024, 67, 14633−14648 PMID:39169826.
Wang, S, E.; Xiong, Y.;Jang, M, A,; Park, K, S.; Donahue, M.; Velez J.; Jin J.*; Jiang, Y, H.*, Molecular Therapy, “Newly developed oral bioavailable EHMT2 inhibitor as a potential epigenetic therapy for Prader-Willi syndrome”, 2024 Aug 7;32(8):2662-2675. PMID: 38796700;.doi: https://doi.org/doi:10.1016/j.ymthe.2024.05.034
Kabir, M.; Qin, L.; Luo, K.; Xiong, Y.; Sidi, R. A.; Park, K.-S.*; Jin, J.*, “Discovery and characterization of a novel Cereblon-recruiting PRC1 bridged PROTAC degrader.” Journal of Medicinal Chemistry. 2024, 67:6880-6892. PMID: 38607318.
Velez, J.; Han, Y.; Yim, H.; Yang, P.; Deng, Z.; Park, K.-s.; Kabir, M.; Kaniskan, H. Ü.; Xiong, Y.*; Jin, J.*, Discovery of the first-in-class G9a/GLP PROTAC degrader. Journal of Medicinal Chemistry. 2024, 67(8):6397-6409. PMID: 28602846.
Liu, J; Hu, X.; Luo, K; Xiong, Y; Chen, L.; Wang, Z.; Inuzuka, H.; Qian, C.; Yu, X.; Xie, L.; Muneer, A.; Zhang, D.; Paulo, J. A.; Chen, X.; Jin, J.*; Wei, W.*, Journal of the American Chemical Society“, USP7-based deubiquitinase-targeting chimeras stabilize AMPK.” 2024, 146, 16, 11507–11514; PMID: 38597345.
Xiong, Y.; Greschik, H.; Johansson, C.; Seifert, L.; Gamble, V.; Park, K.-s.; Fagan, V.; Li, F.; Chau, I.; Vedadi, M.; Arrowsmith, C. H.; Brennan, P.; Fedorov, O.; Jung, M.; Farnie, G.; Liu, J.; Oppermann, U. *; Schüle, R. *; Jin, J. *, Discovery of a potent, selective, and cell-active SPIN1 inhibitor. Journal of Medicinal Chemistry. 2024, 67(7):5837-5853. PMID: 38533580.
Wang, Z.; Zhang, D.; Qiu, X.; Inuzuka, H.; Xiong, Y.; Liu, J.; Chen, L.; Chen, H.; Xie, L.; Kaniskan, H. Ü.; Chen, X.; Jin, J. *; Wei, W. *, Journal of the American Chemical Society . “Structurally specific Z-DNA proteolysis targeting chimera enables targeted degradation of adenosine deaminase acting on RNA”, 2024, 146 (11): 7584-7593. PMID: 38469801.
Velez, J.; Dale, B.; Park, K.-S.; Kaniskan, H. Ü.; Yu, X. *; Jin, J. *, “Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2”. European Journal of Medicinal Chemistry, 2024, 267, 116154. PMID: 38602846.,
2023 ( Showing 12 out of 24 publications)
Dang, F.; Bai, L.; Dong, J.; Hu, X.; Wang, J.; Paulo, J. A.; Xiong, Y.; Liang, X.; Sun, Y.; Chen, Y.; Guo, M.; Wang, X.; Huang, Z.; Inuzuka, H.; Chen, L.; Chu, C.; Liu, J.; Zhang, T.; Rezaeian, A.-H.; Liu, J.; Kaniskan, H. Ü.; Zhong, B.; Zhang, J.; Letko, M.; Jin, J. *; Lan, K. *; Wei, W. *, USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice. Science Translational Medicine. 2023, 15 (725): eadh7668. PMID: 38055802.
Yu, X.; Li, D.; Kottur, J.; Kim, H. S.; Herring, L. E.; Yu, Y.; Xie, L.; Hu, X.; Chen, X.; Cai, L.; Liu, J.; Aggarwal, A. K.; Wang, G. G. *; Jin, J.*, Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer. Journal of Medicinal Chemistry. 2023, 66(23): 16168–16186. PMID: 38019706.
Kabir, M.; Sun, N.; Hu, X.; Martin, T. C.; Yi, J.; Zhong, Y.; Xiong, Y.; Kaniskan, H. Ü.; Gu, W.; Parsons, R.; Jin, J.*; Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53. Journal of the American Chemical Society 2023, 145(27):14932-14944. PMID: 37365684.
Wang Z.; Liu J.; Qiu X.; Zhang D.; Inuzuka H.; Chen L.; Chen H.; Xie L.; Kaniskan HÜ.; Chen X.; Jin J.* ; Wei W.* , Methylated Nucleotide-Based Proteolysis-Targeting Chimera Enables Targeted Degradation of Methyl-CpG-Binding Protein 2. Journal of the American Chemical Society . 2023, 145(40): 21871–21878. PMID: 37774414.
Velez, J.; Kaniskan, H. Ü.*; Jin, J.*; Recent advances in developing degraders & inhibitors of lysine methyltransferases. Current Opinion in Chemical Biology, 2023, 76:102356. PMID: 37379717.
Kabir, M.; Yu, X.; Kaniskan, H. Ü.*; Jin, J.*; Chemically induced degradation of epigenetic targets. Chemical Society Reviews, 2023, 52(13):4313-4342. PMID: 37314393.
Zhao, N.; Ho, J. S. Y.; Meng, F.; Zheng, S.; Kurland, A. P.; Tian, L.; Rea-Moreno, M.; Song, X.; Seo, J. S.; Kaniskan, H. Ü.; Te Velthuis, A. J. W.; Tortorella, D.; Chen, Y. W.; Johnson, J. R.; Jin, J.*; Marazzi, I.*; Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics. Cell Host Microbe, 2023, 31(7):1154-1169.e10. PMID: 37339625.
Wang, Z.; Liu, J.; Chen, H.; Qiu, X.; Xie, L.; Kaniskan, H. Ü.; Chen, X.; Jin, J.*; Wei, W.*; Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins. Journal of the American Chemical Society. 2023, 145(19):10872-10879. PMID: 37141574.
Yu, X.; Wang, J.; Gong, W.; Ma, A.; Shen, Y.; Zhang, C.; Liu, X.; Cai, L.; Liu, J.; Wang, G. G.*; Jin, J.*; Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader. Oncogene, 2023, 42(13):994-1009. PMID: 36747009.
Park, K. S.; Qin, L.; Kabir, M.; Luo, K.; Dale, B.; Zhong, Y.; Kim, A.; Wang, G. G.; Kaniskan, H. Ü.; Jin, J*; Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy. Advanced science (Weinheim, Baden-Württemberg, Germany). 2023, 10(10):e2205573. PMID: 36737841.
Sun, N.; Kabir, M.; Lee, Y.; Xie, L.; Hu, X.; Velez, J.; Chen, X.; Kaniskan, H. Ü.*; & Jin, J*; Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. Journal of Medicinal Chemistry. 2023, 66(1):596-610. PMID: 36538511.
Marcellino, B. K.; Yang, X.; Ümit Kaniskan, H.; Brady, C.; Chen, H.; Chen, K.; Qiu, X.; Clementelli, C.; Herschbein, L.; Li, Z.; Elghaity-Beckley, S.; Arandela, J.; Kelly, B.; Hoffman, R.; Liu, J.; Xiong, Y.; Jin, J.*; Shih, A. H.*; An MDM2 degrader for treatment of acute leukemias. Leukemia, 2023, 37(2):370-378. PMID: 36309559
For papers published before 2023, please see Dr. Jin’s full publication list