Mount Sinai Center for Eosinophilic Disorders
Jaffe Food Allergy Institute
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place, Box 1198
New York, NY 10029
Tel: (212) 241-4880
Fax: (212) 426-1902
Posted: October 4, 2019
This Postdoctoral Fellow position is in the Division of Allergy and Immunology, Department of Pediatrics at the Icahn School of Medicine at Mount Sinai. The Postdoctoral Fellow will will in conjunction with the Principal Investigator (Mirna Chehade, MD, MPH) at the Mount Sinai Center for Eosinophilic Disorders (MSCED), investigating the immunopathology of eosinophilic esophagitis (EoE).
We are seeking a highly motivated individual to work in the field of eosinophilic gastrointestinal disorders. The successful candidate will participate in a research project focused on the effect of proton pump inhibitors (PPI’s) on the esophageal transcriptome in EoE subtypes, and the role of various immune and signaling pathways in PPI-mediated suppression of esophageal eosinophilia. The candidate will be participating in an exciting journey intergrating in silico and wet Lab approaches to establish a new paradigm for translating gene expression profiles into mechanistic insights and eventually personalized precision patient care. In silico approaches including analyses of NGS data (including genome wide association studies, RNA sequencing (single cell and whole tissue)), bioinformatics strategies to study the genetic basis of EoE, and wet Lab assays including molecular analyses of primary esophageal cell culture systems, will be conducted.
The successful candidate must hold a PhD or equivalent degree with a background knowledge in immunology. Working knowledge of principles of immunology and molecular biology is required. The candidate must also demonstrate competency in RNA isolation from tissue/cells, RNAseq analysis and immunohistochemistry, as well as demonstrated experience in cell culture techniques, qRT-PCR, cytokine assays and flow cytometry. The candidate will have access to highly collaborative research teams with expertise in the required areas of research, including the Center for Bioinformatics and the Genomics Core and Pathology Core Facilities at the Icahn School of Medicine at Mount Sinai in New York City.
As the current MSCED team members have a strong clinical background and are all highly invested in research, the candidate will present data to the team. Ability to work autonomously with minimal supervision and collaboratively as part of the MSCED team, and ability to analyze and communicate experimental results clearly to other team members is required. Exceptional work ethic, strong written and verbal communication skills, strong organizational skills and ability to multi-task and prioritize are required for the position.
This is a unique opportunity to develop expertise in this growing area of EGIDs, which can serve as a platform for a potential future career as an independent research investigator at the MSCED.
The MSCED will provide the candidate with necessary support on all aspects of the project.
Full-time employment at Mount Sinai includes a competitive salary, medical/dental/vision benefits, paid vacation/sick leave, and employer contributions to a retirement plan (403b).
Interested candidates should include their full curriculum vitae, a cover letter briefly stating their career goals, specific research experience and areas of interest, and contact information of three references in their application, and send it to: MountSinaiEosCenter@mssm.edu
About the Mount Sinai Center for Eosinophilic Disorders (MSCED)
The MSCED is a comprehensive center that focuses on the diagnosis, treatment and research for EGIDs including EoE. At the MSCED, we believe that patients with EGIDs have specific needs that are best treated by a team approach to management. Our specialists include a gastroenterologist, allergists, pathologists and a nutritionist. In addition, patients have access to a psychiatrist. Our team also comprises several research coordinators and an administrative assistant. For more information on the MSCED, our Mount Sinai webpage is:
About the Mount Sinai Health System
Over 38,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.
Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospital campuses, including Mount Sinai Beth Israel, Mount Sinai Beth Israel Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.
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