We are proud to release Giotto Suite after several years’ preparation. Giotto Suite greatly extends the functionality, flexibility, scalability, and interoperability compared to the original Giotto package. It implements a completely new design of the core data framework allowing technology-agnostic, multi-scale spatial multi-omic data analysis. This has been a great collaboration with Ruben Dries’ lab at Boston University. Many thanks to Jiaji (George) Chen, Joselyn Chavez, and the entire Giotto team!