We are excited about the opportunity to reshape our team due to relocation. Currently, we have multiple openings at various levels in the following areas.

1. Spatial Transcriptomics. During the past few years, numerous technologies have been developed to profile spatial transcriptomics and/or multiplexed proteins. We aim to develop generally applicable and user-friendly computational tools that will enable comprehensive, robust, efficient computational analyses of such data. We have developed Giotto, the first comprehensive toolbox specifically designed for spatial transcriptomic data analysis and visualization. We have also developed a number of novel methods for characterizing the spatial patterns (Zhu et al. 2018) and cell-cell interaction pathways (Dries et al. 2020). Our bioinformatic expertise has also contributed to the development of several pioneering technologies (Eng et al. 2020; Takei et al. 2020). We welcome new members to continue developing the Giotto project, and develop new creative and powerful computational tools.

2. Single-cell Multi-omic Analysis. Single-cell analysis has entered a new phase where multiple modalities of information, such as RNA, DNA, protein, or epigenome, can be measured in the same cells.  This development opens up new possibilities to investigate the relationship between the different modalities, while at the same time brings up a conceptual question how to define cell states from the aggregated information. We welcome new members who are interested to develop innovative computational methods to tackle these important issues.

3. Epigenetics. Epigenetic regulation plays an essential role in maintaining cell-type specific transcriptional programs. Abnormal activities of epigenetic regulators have been linked to various human diseases. Our lab has a long-term interest in studying the epigenetic mechanisms in development and diseases. We welcome new members to develop and apply cutting-edge methods to study cancer and neurological diseases.

Please send a cover letter, updated CV, and contact information for at least two references via email to Dr. Guo-Cheng Yuan.