Our Giotto paper has been published in Genome Biology. Giotto is a comprehensive and open-source software package for spatial data analysis and visualization. It contains many functionalities such as cell-type identification, deconvolution, spatial pattern detection, cell neighborhood analysis, ligand-receptor detection, and interactive visualization.  We welcome users to check out our project and GitHub websites.

The DNA seqFISH+ paper has been published in Nature. We use super-resolution imaging combined with multiplex DNA barcoding to visualize the 3D chromatin structure in individual cells. We found extensive chromatin structure heterogeneity within transcriptionally similar cell states. It was a great collaboration with Dr. Long Cai’s lab.

After fourteen fruitful and memorable years in Boston, the Yuan Lab officially moved to New York! We are excited about this new phase of adventure and look forward to working with the fantastic scientists and doctors at Mount Sinai to advance science and improve human health. We are also recruiting passionate graduate students, postdoctoral fellows, and data analysts to join our new team.