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  • Zhang, K., Su A., Wang X., Wei T., Li Z., Zhu J., Chen, Y.W. (2022) Prognostic nomogram and competing risk analysis of death for primary thyroid lymphoma: a long-term survival study of 1638 patients. Ann. Surg. Open, 3(4):p e226, December 2022. | DOI: 10.1097/AS9.0000000000000226  
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  • Zhang, K., Su, A., Wang, X., Zhao, W., He, L., Wei, T., Li, Z., Zhu, J., Chen, Y.W. (2022) Non-linear correlation between tumor size and survival outcomes for parathyroid carcinoma: a SEER population-based cohort study. Front. Endocrinol., 13:882579. Doi: 10.3389/fendo.2022.882579.
  • Li, C., Peinado, N., Smith, SM., Zhou, J., Gao, F., Kohbodi, G., Zhou, B.,Thronton, M., Grubbs, BH., Lee, MK., Bellusci, S., Borok, Z., Chen, Y.W., Minoo, P. (2022) Wnt5a promotes AT1 and repressess AT2 lineage specific gene expression in a cell-context-dependent manner. Stem Cells,
  • Lian, Q., Zhang, K., Zhang, Z., Duan, F., Guo, L., Luo, W., Mok, B., Thakur, A., Ke, X., Motallebnejad, P., Nicolaescu, V., Chen, J., Ma, C., Zhou, X., Han, S., Han, T., Zhang, W., Tan, A., Zhang, T., Wang, X., Xu, D., Xiang, J., Xu, A., Liao, C., Huang, F.P., Chen, Y.W., Na, J., Randall, G., Tse, H.F., Chen, Z., Chen, Y., Chen J. (2021) Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model. Nat.  Commu. 2022.13: 2028. DOI: 10.1038/s41467-022-29731-5


  • Chen, H.Y., Huang, C., Tian, L., Huang, X., Zhang, C., Llewellyn, G., Rogers, G., Chen, Y.W., Cannon, P. (2021) Cytoplasmic tail truncation of SARS-CoV-2 spike protein enhances of speudotyped vectors but masks the effect of the D614G mutation. Virol. JVI00966-21R2.
  • Rodrigues Toste de Carvalho, A. L., Liu, H.Y., Chen, Y.W., Moscona, A., Porotto, M., Snoeck, H.W. (2021) The in vitro multi-lineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D. Protoc, 16, 1802-1829.


  • Lu, T., Gao, J., Garcia, I., Chen, H., Castaldi, A., Chen, Y.W. (2020). Human pluripotent stem cell‐derived lung organoids: Potential applications in development and disease modeling. WIREs Developmental Biology, DOI: 10.1002/wdev.399.
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  • Strikoudis, A., Cieslak, A., Loffredo, L., Chen, Y.W., Patel, N., Saqi, A., Lederer, D., & Snoeck, H.W. (2019) Modeling of fibrotic lung disease using 3D organoids derived from human pluripotent stem cells. Cell Reports, 27(12), 3709-3723.
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  • Zhang, Y., Yang, Y., Jiang, M., Huang, S. X., Zhang, W., Al Alam, D., Danopoulos, S., Mori, M., Chen, Y. W., Balasubramanian, R., Chuva de Sousa Lopes, S. M., Serra, C., Bialecka, M., Kim, E., Lin, S., Toste de Carvalho, A. L. R., Riccio, P. N., Cardoso, W. V., Zhang, X., Snoeck, H. W., & Que, J. (2018). 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling. Cell Stem Cell, 23(4), 516-529 e515. doi:10.1016/j.stem.2018.08.009
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  • Chen, Y. W., Huang, S. X., de Carvalho, A., Ho, S. H., Islam, M. N., Volpi, S., Notarangelo, L. D., Ciancanelli, M., Casanova, J. L., Bhattacharya, J., Liang, A. F., Palermo, L. M., Porotto, M., Moscona, A., & Snoeck, H. W. (2017). A three-dimensional model of human lung development and disease from pluripotent stem cells. Nat Cell Biol, 19(5), 542-549. doi:10.1038/ncb3510
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  • Chen, Y. W., Yin, S., Lai, Y. J., Johnson, M. D., & Lin, C. Y. (2016). Plasminogen-Dependent Matriptase Activation Accelerates Plasmin Generation by Differentiating Primary Human Keratinocytes. J Invest Dermatol, 136(6), 1210-1218. doi:10.1016/j.jid.2016.01.029


  • Huang, S. X., Green, M. D., de Carvalho, A. T., Mumau, M., Chen, Y. W., D’Souza, S. L., & Snoeck, H. W. (2015). The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc, 10(3), 413-425. doi:10.1038/nprot.2015.023


  • Wu, B. Y., Lee, S. P., Hsiao, H. C., Chiu, H., Chen, C. Y., Yeo, Y. H., Lee, H. S., Chen, Y. W., Kaul, M., Kataoka, H., Johnson, M. D., Wang, J. K., & Lin, C. Y. (2014). Matriptase expression and zymogen activation in human pilosebaceous unit. J Histochem Cytochem, 62(1), 50-59. doi:10.1369/0022155413505599
  • Huang, S. X., Islam, M. N., O’Neill, J., Hu, Z., Yang, Y. G., Chen, Y. W., Mumau, M., Green, M. D., Vunjak-Novakovic, G., Bhattacharya, J., & Snoeck, H. W. (2014). Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol, 32(1), 84-91. doi:10.1038/nbt.2754
  • Chen, Y. W., Wang, J. K., Chou, F. P., Wu, B. Y., Hsiao, H. C., Chiu, H., Xu, Z., Baksh, A. N. H., Shi, G., Kaul, M., Barndt, R., Shanmugam, V. K., Johnson, M. D., & Lin, C. Y. (2014). Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytes. J Invest Dermatol, 134(2), 405-414. doi:10.1038/jid.2013.320


  • Chou, F. P., Chen, Y. W., Zhao, X. F., Xu-Monette, Z. Y., Young, K. H., Gartenhaus, R. B., Wang, J. K., Kataoka, H., Zuo, A. H., Barndt, R. J., Johnson, M., & Lin, C. Y. (2013). Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas. Am J Pathol, 183(4), 1306-1317. doi:10.1016/j.ajpath.2013.06.024
  • Chen, Y. W., Xu, Z., Baksh, A. N., Wang, J. K., Chen, C. Y., Swanson, R., Olson, S. T., Kataoka, H., Johnson, M. D., & Lin, C. Y. (2013). Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes. PLoS One, 8(5), e62826. doi:10.1371/journal.pone.0062826


  • Xu, H., Xu, Z., Tseng, I. C., Chou, F. P., Chen, Y. W., Wang, J. K., Johnson, M. D., Kataoka, H., & Lin, C. Y. (2012). Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1. Am J Physiol Cell Physiol, 302(2), C453-462. doi:10.1152/ajpcell.00344.2011
  • Chiu, Y. J., Huang, T. H., Chiu, C. S., Lu, T. C., Chen, Y. W., Peng, W. H., & Chen, C. Y. (2012). Analgesic and Antiinflammatory Activities of the Aqueous Extract from Plectranthus amboinicus (Lour.) Spreng. Both In Vitro and In Vivo. Evid Based Complement Alternat Med, 2012, 508137. doi:10.1155/2012/508137
  • Chen, Y. W., Eckert, R. L., Johnson, M., & Lin, C. Y. (2012). The transmembrane serine protease matriptase: implications for cellular biology and human diseases. J Med Sci. 32, 97-108. DOI:10.6136/JMS.2012.32(3).097


  • Xu, Z., Chen, Y. W., Battu, A., Wilder, P., Weber, D., Yu, W., Mackerell, A. D., Chen, L. M., Chai, K. X., Johnson, M. D., & Lin, C. Y. (2011). Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade. J Med Chem, 54(21), 7567-7578. doi:10.1021/jm200920s
  • Chou, F. P., Xu, H., Lee, M. S., Chen, Y. W., Richards, O. X., Swanson, R., Olson, S. T., Johnson, M. D., & Lin, C. Y. (2011). Matriptase is inhibited by extravascular antithrombin in epithelial cells but not in most carcinoma cells. Am J Physiol Cell Physiol, 301(5), C1093-1103. doi:10.1152/ajpcell.00122.2011
  • Chen, C. J., Wu, B. Y., Tsao, P. I., Chen, C. Y., Wu, M. H., Chan, Y. L., Lee, H. S., Johnson, M. D., Eckert, R. L., Chen, Y. W., Chou, F., Wang, J. K., & Lin, C. Y. (2011). Increased matriptase zymogen activation in inflammatory skin disorders. Am J Physiol Cell Physiol, 300(3), C406-415. doi:10.1152/ajpcell.00403.2010


  • Jiang, H., Jans, R., Xu, W., Rorke, E. A., Lin, C. Y., Chen, Y. W., Fang, S., Zhong, Y., & Eckert, R. L. (2010). Type I transglutaminase accumulation in the endoplasmic reticulum may be an underlying cause of autosomal recessive congenital ichthyosis. J Biol Chem, 285(41), 31634-31646. doi:10.1074/jbc.M110.128645
  • Chen, Y. W., Wang, J. K., Chou, F. P., Chen, C. Y., Rorke, E. A., Chen, L. M., Chai, K. X., Eckert, R. L., Johnson, M. D., & Lin, C. Y. (2010). Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation. J Biol Chem, 285(41), 31755-31762. doi:10.1074/jbc.M110.150367
  • Chen, Y. W., Lee, M. S., Lucht, A., Chou, F. P., Huang, W., Havighurst, T. C., Kim, K., Wang, J. K., Antalis, T. M., Johnson, M. D., & Lin, C. Y. (2010). TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells. Am J Pathol, 176(6), 2986-2996. doi:10.2353/ajpath.2010.090665


  • Wang, J. K., Lee, M. S., Tseng, I. C., Chou, F. P., Chen, Y. W., Fulton, A., Lee, H. S., Chen, C. J., Johnson, M. D., & Lin, C. Y. (2009). Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition. Am J Physiol Cell Physiol, 297(2), C459-470. doi:10.1152/ajpcell.00201.2009


  • Lin, C. Y., Tseng, I. C., Chou, F. P., Su, S. F., Chen, Y. W., Johnson, M. D., & Dickson, R. B. (2008). Zymogen activation, inhibition, and ectodomain shedding of matriptase. Front Biosci, 13, 621-635.

Book Chapters

  • Lu T., Zheng C., Rea M., Chen, Y.W. Lung organoids: a new pathway into lung regeneration and repair. Stem Cell Biology and Regenerative Medicine,
  • Lin CY., Chen YW., Xu ZH., Johnson MD. MS. 681|Matriptase. Handbook of Proteolytic Enzymes (Third edition).