2024
- Zhang, K., Wei T., Li Z., Zhu J., Chen, Y.W. (2024) Radioactive iodine therapy improves overall survival outcome in Hürthle Cell Carcinomas by Reducing Death Risks from Non-Cancer Causes: A Competing Risk Analysis of 4641 Patients. Accepted: Head & Neck.
- Zhang, K., Wei T., Zhu J., Li Z., Chen, Y.W. (2024) Comparative study between poorly differentiated thyroid cancer and anaplastic thyroid cancer: real-world pathological distribution, death attribution, and prognostic factor estimation. Accepted: Front. Endocrinol.
- Wu H.F., Saito-Diaz K., Huang C.W., McAlpine J.L., Seo D.E., Santori F.R., Ishan M., Bergeron H., Delaney W.H., Hart G.W., Chen, Y.W., Hogan R.J., Liu H.X., Ivanova N.B., Zeltner N. (2024) Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development. Accepted: Cell Stem Cell.
- Laitman B.M., Charytonowicz D., Zhu A.J., Lynch K., Varelas E.A., Burton M., Andreou C., Kore P., Kirke D.N., Chen Y.W., Beaumont K., Sebra R., Genden E.M., Courey M.S. (2024) High resolution profiling of human vocal fold cellular landscapes with single-nuclei RNA sequencing. Laryngoscope, https://doi.org/10.1002/lary.31334.
2023
- Yu, O., Liang, A., Li, A., Griffin, B., Thanabalasingam, T., Lu, C., Zhu, J., Liu, M., Moraes, T., Baker, A., Chen, Y.W., Wirnsberger, G., Penninger, J., Rotstein, O., Li, Y., Mubareka, S., Slutsky, A., Zhang, H. (2023) Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern: iScience, 26(8): 107470. doi: 10.1016/j.isci.2023.107470.
- Yang M-C, Rea-Moreno MG, Chen Y-W. Breathing-induced forces influence lung cell fate. Cell Stem Cell. (2023);30(5):507-8. doi: https://doi.org/10.1016/j.stem.2023.04.004.
- Matkovic Leko I, Schneider RT, Thimraj TA, Schrode N, Beitler D, Liu H-Y, Beaumont K, Chen Y-W, Snoeck H-W. A distal lung organoid model to study interstitial lung disease, viral infection and human lung development. Nature Protocols. (2023). doi: 10.1038/s41596-023-00827-6.
- Zhao N, Ho JSY, Meng F, Zheng S, Kurland AP, Tian L, Rea-Moreno M, Song X, Seo J-S, Kaniskan HÜ, te Velthuis AJW, Tortorella D, Chen Y-W, Johnson JR, Jin J, Marazzi I. Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics. Cell Host & Microbe. (2023). doi: https://doi.org/10.1016/j.chom.2023.05.030.
- Xu A, Liu M, Huang MF, Zhang Y, Hu R, Gingold JA, Liu Y, Zhu D, Chien CS, Wang WC, Liao Z, Yuan F, Hsu CW, Tu J, Yu Y, Rosen T, Xiong F, Jia P, Yang YP, Bazer DA, Chen YW, Li W, Huff CD, Zhu JJ, Aguilo F, Chiou SH, Boles NC, Lai CC, Hung MC, Zhao Z, Van Nostrand EL, Zhao R, Lee DF. Rewired m(6)A epitranscriptomic networks link mutant p53 to neoplastic transformation. Nat Commun. (2023);14(1):1694. Epub 2023/03/28. doi: 10.1038/s41467-023-37398-9.
- Bian F, Lan YW, Zhao S, Deng Z, Shukla S, Acharya A, Donovan J, Le T, Milewski D, Bacchetta M, Hozain AE, Tipograf Y, Chen YW, Xu Y, Shi D, Kalinichenko VV, Kalin TV. Lung endothelial cells regulate pulmonary fibrosis through FOXF1/R-Ras signaling. Nat Commun. (2023);14(1):2560. Epub 2023/05/04. doi: 10.1038/s41467-023-38177-2.
2022
- Zhang, K., Su A., Wang X., Wei T., Li Z., Zhu J., Chen, Y.W. (2022) Prognostic nomogram and competing risk analysis of death for primary thyroid lymphoma: a long-term survival study of 1638 patients. Ann. Surg. Open, 3(4):p e226, December 2022. | DOI: 10.1097/AS9.0000000000000226
- Du, W., Wang, J., Kuo, T., Wang, L., McKimpson, W.M., Son, J., Watanabe, H., Kitamoto, T., Lee, Y., Creusot, R.J., Ratner, L.E., McCune, K., Chen, Y.W., Grubbs, B.H., Thornton, M.E., Fan, J., Sultana, N., Diaz, B.S., Balasubramanian, I., Gao, N., Belvedere, S., Accili, D. (2022) Triple Notch/TGFb/FOXO1 blockade converts multiple intestinal sub-lineage into b-like cells and lowers glycemia in diabetic animals. JCI. 2022;132(24):e162720. https://doi.org/10.1172/JCI162720.
- Zhang, K., Su, A., Wang, X., Zhao, W., He, L., Wei, T., Li, Z., Zhu, J., Chen, Y.W. (2022) Non-linear correlation between tumor size and survival outcomes for parathyroid carcinoma: a SEER population-based cohort study. Front. Endocrinol., 13:882579. Doi: 10.3389/fendo.2022.882579.
- Li, C., Peinado, N., Smith, SM., Zhou, J., Gao, F., Kohbodi, G., Zhou, B.,Thronton, M., Grubbs, BH., Lee, MK., Bellusci, S., Borok, Z., Chen, Y.W., Minoo, P. (2022) Wnt5a promotes AT1 and repressess AT2 lineage specific gene expression in a cell-context-dependent manner. Stem Cells, https://doi.org/10.1093/stmcls/sxac031.
- Lian, Q., Zhang, K., Zhang, Z., Duan, F., Guo, L., Luo, W., Mok, B., Thakur, A., Ke, X., Motallebnejad, P., Nicolaescu, V., Chen, J., Ma, C., Zhou, X., Han, S., Han, T., Zhang, W., Tan, A., Zhang, T., Wang, X., Xu, D., Xiang, J., Xu, A., Liao, C., Huang, F.P., Chen, Y.W., Na, J., Randall, G., Tse, H.F., Chen, Z., Chen, Y., Chen J. (2021) Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model. Nat. Commu. 2022.13: 2028. DOI: 10.1038/s41467-022-29731-5
2021
- Chen, H.Y., Huang, C., Tian, L., Huang, X., Zhang, C., Llewellyn, G., Rogers, G., Chen, Y.W., Cannon, P. (2021) Cytoplasmic tail truncation of SARS-CoV-2 spike protein enhances of speudotyped vectors but masks the effect of the D614G mutation. Virol. JVI00966-21R2.
- Rodrigues Toste de Carvalho, A. L., Liu, H.Y., Chen, Y.W., Moscona, A., Porotto, M., Snoeck, H.W. (2021) The in vitro multi-lineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D. Protoc, 16, 1802-1829.
2020
- Lu, T., Gao, J., Garcia, I., Chen, H., Castaldi, A., Chen, Y.W. (2020). Human pluripotent stem cell‐derived lung organoids: Potential applications in development and disease modeling. WIREs Developmental Biology, DOI: 10.1002/wdev.399.
- Hozain A., O’Neill J.D., Pinezhich, M., Tipograf, Y., Donocoff R., Cunningham, K., Tumen A., Fung K., Utika R., Simpson M., Reimer J., Ruiz E., Queen D., Stokes J., Caldwell N., Talackine J., Chen, Y.W., Romanov A., Marboe C., Griesmer A., Guenthart, B., Vunjak-Novakovic G., & Bacchetta, M. (2020) Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs. Med. 26, 1102-1113.
- Thakur, A., Chen, Y.W., Chen H. (2020). The mini-player with large functions: extracellular vesicles in stem cell communication, cancer and therapeutics. Protein Cell, DOI: 1007/s13238-021-00863-6.
- Climent, M., Viggiani, G., Chen, Y.W., Castaldi, A. (2020). MicroRNA and ROS crosstalk in cardiac and pulmonary diseases. J. Mol. Sci., 21(12), 4370. https://doi.org/10.3390/ijms21124370
- Wanger D.E., Ikonomou L., Gilpin S.E., Magin C.M., Cruz F., Greaney A., Magnusson M.M., Chen, Y.W., Davis B., Vanuytsel K., Enes S.R., Krasnodembskaya A., Lehmann M., Westergren-Thorsson G., Stegmayr J., Alfasadi H.N., Hoffman E.T., Weiss D.J., Ryan (Firth) A.L. (2020). Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019. ERJ Open Res., 16;6(4):00123-2020. DOI: 10.1183/23120541.00123-2020.
2019
- Strikoudis, A., Cieslak, A., Loffredo, L., Chen, Y.W., Patel, N., Saqi, A., Lederer, D., & Snoeck, H.W. (2019) Modeling of fibrotic lung disease using 3D organoids derived from human pluripotent stem cells. Cell Reports, 27(12), 3709-3723.
- Porotto, M., Ferren, M., Chen, Y. W., Siu, Y., Makhsous, N., Rima, B., Briese, T., Greninger, A. L., Snoeck, H. W., & Moscona, A. (2019). Authentic Modeling of Human Respiratory Virus Infection in Human Pluripotent Stem Cell-Derived Lung Organoids. mBio, 10(3), e00723-00719. doi:10.1128/mBio.00723-19
- Guenthart, B. A., Chen, Y. W., & Bacchetta, M. (2019). New insights and therapeutic targets: Lung injury and disease. J Thorac Cardiovasc Surg, 157(1), 416-420. doi:10.1016/j.jtcvs.2018.09.026
2018
- Zhang, Y., Yang, Y., Jiang, M., Huang, S. X., Zhang, W., Al Alam, D., Danopoulos, S., Mori, M., Chen, Y. W., Balasubramanian, R., Chuva de Sousa Lopes, S. M., Serra, C., Bialecka, M., Kim, E., Lin, S., Toste de Carvalho, A. L. R., Riccio, P. N., Cardoso, W. V., Zhang, X., Snoeck, H. W., & Que, J. (2018). 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling. Cell Stem Cell, 23(4), 516-529 e515. doi:10.1016/j.stem.2018.08.009
- Rodrigues Toste de Carvalho, A. L., Strikoudis, A., Liu, H.-Y., Chen, Y.-W., Dantas, T. J., Vallee, R. B., Correia-Pinto, J., & Snoeck, H.-W. (2018). Glycogen synthase kinase 3 induces multilineage maturation of human pluripotent stem cell-derived lung progenitors in 3D culture. Development, dev.171652. doi:10.1242/dev.171652
2017
- Chen, Y. W., Huang, S. X., de Carvalho, A., Ho, S. H., Islam, M. N., Volpi, S., Notarangelo, L. D., Ciancanelli, M., Casanova, J. L., Bhattacharya, J., Liang, A. F., Palermo, L. M., Porotto, M., Moscona, A., & Snoeck, H. W. (2017). A three-dimensional model of human lung development and disease from pluripotent stem cells. Nat Cell Biol, 19(5), 542-549. doi:10.1038/ncb3510
- Dorrello, N. V., Guenthart, B. A., O’Neill, J. D., Kim, J., Cunningham, K., Chen, Y. W., Biscotti, M., Swayne, T., Wobma, H. M., Huang, S. X. L., Snoeck, H. W., Bacchetta, M., & Vunjak-Novakovic, G. (2017). Functional vascularized lung grafts for lung bioengineering. Sci Adv, 3(8), e1700521. doi:10.1126/sciadv.1700521
- O’Neill, J. D., Guenthart, B. A., Kim, J., Chicotka, S., Queen, D., Fung, K., Marboe, C., Romanov, A., Huang, S. X. L., Chen, Y.-W., Snoeck, H.-W., Bacchetta, M., & Vunjak-Novakovic, G. (2017). Cross-circulation for extracorporeal support and recovery of the lung. Nature Biomedical Engineering, 1, 0037. doi:10.1038/s41551-017-0037.
- Chen, Y.-W., Ahmed, A., & Snoeck, H.-W. (2017). Generation of three-dimensional lung bud organoid and its derived branching colonies. Protocol Exchange. doi:https://doi.org/10.1038/protex.2017.027
2016
- Chen, Y. W., Yin, S., Lai, Y. J., Johnson, M. D., & Lin, C. Y. (2016). Plasminogen-Dependent Matriptase Activation Accelerates Plasmin Generation by Differentiating Primary Human Keratinocytes. J Invest Dermatol, 136(6), 1210-1218. doi:10.1016/j.jid.2016.01.029
2015
- Huang, S. X., Green, M. D., de Carvalho, A. T., Mumau, M., Chen, Y. W., D’Souza, S. L., & Snoeck, H. W. (2015). The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc, 10(3), 413-425. doi:10.1038/nprot.2015.023
2014
- Wu, B. Y., Lee, S. P., Hsiao, H. C., Chiu, H., Chen, C. Y., Yeo, Y. H., Lee, H. S., Chen, Y. W., Kaul, M., Kataoka, H., Johnson, M. D., Wang, J. K., & Lin, C. Y. (2014). Matriptase expression and zymogen activation in human pilosebaceous unit. J Histochem Cytochem, 62(1), 50-59. doi:10.1369/0022155413505599
- Huang, S. X., Islam, M. N., O’Neill, J., Hu, Z., Yang, Y. G., Chen, Y. W., Mumau, M., Green, M. D., Vunjak-Novakovic, G., Bhattacharya, J., & Snoeck, H. W. (2014). Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol, 32(1), 84-91. doi:10.1038/nbt.2754
- Chen, Y. W., Wang, J. K., Chou, F. P., Wu, B. Y., Hsiao, H. C., Chiu, H., Xu, Z., Baksh, A. N. H., Shi, G., Kaul, M., Barndt, R., Shanmugam, V. K., Johnson, M. D., & Lin, C. Y. (2014). Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytes. J Invest Dermatol, 134(2), 405-414. doi:10.1038/jid.2013.320
2013
- Chou, F. P., Chen, Y. W., Zhao, X. F., Xu-Monette, Z. Y., Young, K. H., Gartenhaus, R. B., Wang, J. K., Kataoka, H., Zuo, A. H., Barndt, R. J., Johnson, M., & Lin, C. Y. (2013). Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas. Am J Pathol, 183(4), 1306-1317. doi:10.1016/j.ajpath.2013.06.024
- Chen, Y. W., Xu, Z., Baksh, A. N., Wang, J. K., Chen, C. Y., Swanson, R., Olson, S. T., Kataoka, H., Johnson, M. D., & Lin, C. Y. (2013). Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes. PLoS One, 8(5), e62826. doi:10.1371/journal.pone.0062826
2012
- Xu, H., Xu, Z., Tseng, I. C., Chou, F. P., Chen, Y. W., Wang, J. K., Johnson, M. D., Kataoka, H., & Lin, C. Y. (2012). Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1. Am J Physiol Cell Physiol, 302(2), C453-462. doi:10.1152/ajpcell.00344.2011
- Chiu, Y. J., Huang, T. H., Chiu, C. S., Lu, T. C., Chen, Y. W., Peng, W. H., & Chen, C. Y. (2012). Analgesic and Antiinflammatory Activities of the Aqueous Extract from Plectranthus amboinicus (Lour.) Spreng. Both In Vitro and In Vivo. Evid Based Complement Alternat Med, 2012, 508137. doi:10.1155/2012/508137
- Chen, Y. W., Eckert, R. L., Johnson, M., & Lin, C. Y. (2012). The transmembrane serine protease matriptase: implications for cellular biology and human diseases. J Med Sci. 32, 97-108. DOI:10.6136/JMS.2012.32(3).097
2011
- Xu, Z., Chen, Y. W., Battu, A., Wilder, P., Weber, D., Yu, W., Mackerell, A. D., Chen, L. M., Chai, K. X., Johnson, M. D., & Lin, C. Y. (2011). Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade. J Med Chem, 54(21), 7567-7578. doi:10.1021/jm200920s
- Chou, F. P., Xu, H., Lee, M. S., Chen, Y. W., Richards, O. X., Swanson, R., Olson, S. T., Johnson, M. D., & Lin, C. Y. (2011). Matriptase is inhibited by extravascular antithrombin in epithelial cells but not in most carcinoma cells. Am J Physiol Cell Physiol, 301(5), C1093-1103. doi:10.1152/ajpcell.00122.2011
- Chen, C. J., Wu, B. Y., Tsao, P. I., Chen, C. Y., Wu, M. H., Chan, Y. L., Lee, H. S., Johnson, M. D., Eckert, R. L., Chen, Y. W., Chou, F., Wang, J. K., & Lin, C. Y. (2011). Increased matriptase zymogen activation in inflammatory skin disorders. Am J Physiol Cell Physiol, 300(3), C406-415. doi:10.1152/ajpcell.00403.2010
2010
- Jiang, H., Jans, R., Xu, W., Rorke, E. A., Lin, C. Y., Chen, Y. W., Fang, S., Zhong, Y., & Eckert, R. L. (2010). Type I transglutaminase accumulation in the endoplasmic reticulum may be an underlying cause of autosomal recessive congenital ichthyosis. J Biol Chem, 285(41), 31634-31646. doi:10.1074/jbc.M110.128645
- Chen, Y. W., Wang, J. K., Chou, F. P., Chen, C. Y., Rorke, E. A., Chen, L. M., Chai, K. X., Eckert, R. L., Johnson, M. D., & Lin, C. Y. (2010). Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation. J Biol Chem, 285(41), 31755-31762. doi:10.1074/jbc.M110.150367
- Chen, Y. W., Lee, M. S., Lucht, A., Chou, F. P., Huang, W., Havighurst, T. C., Kim, K., Wang, J. K., Antalis, T. M., Johnson, M. D., & Lin, C. Y. (2010). TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells. Am J Pathol, 176(6), 2986-2996. doi:10.2353/ajpath.2010.090665
2009
- Wang, J. K., Lee, M. S., Tseng, I. C., Chou, F. P., Chen, Y. W., Fulton, A., Lee, H. S., Chen, C. J., Johnson, M. D., & Lin, C. Y. (2009). Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition. Am J Physiol Cell Physiol, 297(2), C459-470. doi:10.1152/ajpcell.00201.2009
2008
- Lin, C. Y., Tseng, I. C., Chou, F. P., Su, S. F., Chen, Y. W., Johnson, M. D., & Dickson, R. B. (2008). Zymogen activation, inhibition, and ectodomain shedding of matriptase. Front Biosci, 13, 621-635.
Book Chapters
- Lu T., Zheng C., Rea M., Chen, Y.W. Lung organoids: a new pathway into lung regeneration and repair. Stem Cell Biology and Regenerative Medicine, https://doi.org/10.1007/978-3-030-93056-1_2.
- Lin CY., Chen YW., Xu ZH., Johnson MD. MS. 681|Matriptase. Handbook of Proteolytic Enzymes (Third edition). https://doi.org/10.1016/B978-0-12-382219-2.00649-9.