Publications

Publications

Publications

2025

  • Zhang, K., Wang X., Wei T., Li Z., Zhu J., Chen, Y.W. (2025) Impact of Socioeconomic Status on Non-metastatic Papillary Thyroid Carcinoma with Delayed Surgery. Accepted: Frontiers in Public Health.
  • Zhang, K., Lei J., Su A., Wei T., Li Z., Chen, Y. W. (2025) Stratified impact of therapies on anaplastic thyroid cancer outcomes in the pre-gene-targeted therapy era. Accepted: Annals of Surgical Oncology. 
  • Thiruppathy M., Teubner L., Roberts R. R., Lasser M. C., Moscatello A., Chen Y.W., Hochstim C., Ruffins S., Sarkar A., Tassey J., Evseenko D., Lozito T. P., Willsey H. R., Gillis A., Crump G. (2025) Repurposing of gill gene regulatory program for outer ear evolution. Accepted: Nature.
  • Pinezich M.R., O’Neill J.D., Guenthart B.A., Kim J., Ma S.P., Vila O.F. Chen Y.W., Hozain A.E., Fawad M., Cunningham K., Wobma H.M., Hassel J.V., Snoeck H-W., Bacchetta M., Vunjak-Novakovic G. (2025) Theranostic methodology for ex vivo donor lung rehabilitation. Accepted: Med.
  • Khateeb J., Liang J., Li Y., Thanabalasingam T., Khang Julie, Jerkic M., Pellecchia G., Thiruv B., Chen Y.W., Rotstein O., Slutsky A.S., Zhang H. (2025) Optimized gene transduction in human lung organois: A high-efficiency method for advanced research applications. Accepted: Communications Biology.

2024

  • Genden EM, Chen YW. Tracheal transplantation: lessons learned that may apply to lung transplantation. Curr Opin Organ Transplant. 2024 Dec 1;29(6):407-411. doi: 10.1097/MOT.0000000000001180. Epub 2024 Oct 9. PMID: 39422597.
  • Aubert O, Miyake Y, Amonkar GM, Dinwoodie OM, Varisco BM, Marotta M, Zhao C, Wagner R, Chen YW, Moscatello A, Tiozzo C, Varelas X, Lerou PH, Peiro JL, Keijzer R, Ai X. Fetal Tracheal Occlusion Corelates with Normalized YAP Expression and Alveolar Epithelial Differentiation in CDH. Am J Respir Cell Mol Biol. 2024 Dec 11. doi: 10.1165/rcmb.2024-0323OC. Epub ahead of print. PMID: 39661950.
  • Patel AR, Garg A, Rosberger HT, Kowdle S, Reis RA, Frere JJ, Januska MN, Dawodu G, Valencia E, Yang MC, Stevens CS, Rao VN, Haas GD, Chen YW, Lee B, Lim JK. Alveolar macrophages are early targets of mumps virus. Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2410954121. doi: 10.1073/pnas.2410954121. Epub 2024 Dec 19. PMID: 39700136; PMCID: PMC11670124.
  • Saito-Diaz K, Dietrich P, Saini T, Rashid MM, Wu HF, Ishan M, Sun X, Bedillion S, Patel AJ, Prudden AR, Wzientek CG, Knight TN, Chen YW, Boons GJ, Chen S, Studer L, Tiemeyer M, Xu B, Dragatsis I, Liu HX, Zeltner N. Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration. Sci Transl Med. 2024 Nov 20;16(774):eadq2418. doi: 10.1126/scitranslmed.adq2418. Epub 2024 Nov 20. PMID: 39565876.
  • Liu Z, Liu Y, Yu Z, Tan C, Pek N, O’Donnell A, Wu A, Glass I, Winlaw DS, Guo M, Spence JR, Chen YW, Yutzey KE, Miao Y, Gu M. APOE-NOTCH axis governs elastogenesis during human cardiac valve remodeling. Nat Cardiovasc Res. 2024 Aug;3(8):933-950. doi: 10.1038/s44161-024-00510-3. Epub 2024 Jul 24. PMID: 39196035.
  • Zhang K, Wang X, Wei T, Li Z, Zhu J, Chen YW. Well-defined survival outcome disparity across age cutoffs at 45 and 60 for medullary thyroid carcinoma: a long-term retrospective cohort study of 3601 patients. Front Endocrinol (Lausanne). 2024 Jun 14;15:1393904. doi: 10.3389/fendo.2024.1393904. PMID: 38948527; PMCID: PMC11211583.
  • Zhang K, Wang X, Wei T, Li Z, Zhu J, Chen YW. Radioactive iodine therapy improves overall survival outcome in oncocytic carcinoma of the thyroid by reducing death risks from noncancer causes: A competing risk analysis of 4641 patients. Head Neck. 2024 Oct;46(10):2550-2568. doi: 10.1002/hed.27758. Epub 2024 Apr 4. PMID: 38572629.
  • Zhang K, Wang X, Wei T, Li Z, Zhu J, Chen YW. Comparative study between poorly differentiated thyroid cancer and anaplastic thyroid cancer: real-world pathological distribution, death attribution, and prognostic factor estimation. Front Endocrinol (Lausanne). 2024 Mar 13;15:1347362. doi: 10.3389/fendo.2024.1347362. PMID: 38544687; PMCID: PMC10965691.
  • Wu HF, Saito-Diaz K, Huang CW, McAlpine JL, Seo DE, Magruder DS, Ishan M, Bergeron HC, Delaney WH, Santori FR, Krishnaswamy S, Hart GW, Chen YW, Hogan RJ, Liu HX, Ivanova NB, Zeltner N. Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development. Cell Stem Cell. 2024 May 2;31(5):734-753.e8. doi: 10.1016/j.stem.2024.03.011. Epub 2024 Apr 11. PMID: 38608707; PMCID: PMC11069445.
  • Laitman BM, Charytonowicz D, Zhu AJ, Lynch K, Varelas EA, Burton M, Andreou C, Kore P, Kirke DN, Chen YW, Beaumont KG, Sebra R, Genden EM, Courey MS. High-Resolution Profiling of Human Vocal Fold Cellular Landscapes With Single-Nuclei RNA Sequencing. Laryngoscope. 2024 Jul;134(7):3193-3200. doi: 10.1002/lary.31334. Epub 2024 Feb 28. PMID: 38415934.

2023

  • Onodera Y, Liang J, Li Y, Griffin B, Thanabalasingam T, Lu C, Zhu J, Liu M, Moraes T, Zheng W, Khateeb J, Khang J, Huang Y, Jerkic M, Nakane M, Baker A, Orser B, Chen YW, Wirnsberger G, Penninger JM, Rotstein OD, Slutsky AS, Li Y, Mubareka S, Zhang H. Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern. iScience. 2023 Jul 25;26(8):107470. doi: 10.1016/j.isci.2023.107470. PMID: 37609639; PMCID: PMC10440513.
  • Yang MC, Rea-Moreno MG, Chen YW. Breathing-induced forces influence lung cell fate. Cell Stem Cell. 2023 May 4;30(5):507-508. doi: 10.1016/j.stem.2023.04.004. PMID: 37146577.
  • Matkovic Leko I, Schneider RT, Thimraj TA, Schrode N, Beitler D, Liu HY, Beaumont K, Chen YW*, Snoeck HW*. A distal lung organoid model to study interstitial lung disease, viral infection and human lung development. Nat Protoc. 2023 Jul;18(7):2283-2312. doi: 10.1038/s41596-023-00827-6. Epub 2023 May 10. PMID: 37165073; PMCID: PMC11486529.
  • Zhao N, Ho JSY, Meng F, Zheng S, Kurland AP, Tian L, Rea-Moreno M, Song X, Seo JS, Kaniskan HÜ, Te Velthuis AJW, Tortorella D, Chen YW, Johnson JR, Jin J, Marazzi I. Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics. Cell Host Microbe. 2023 Jul 12;31(7):1154-1169.e10. doi: 10.1016/j.chom.2023.05.030. Epub 2023 Jun 5. PMID: 37339625; PMCID: PMC10528416.
  • Xu A, Liu M, Huang MF, Zhang Y, Hu R, Gingold JA, Liu Y, Zhu D, Chien CS, Wang WC, Liao Z, Yuan F, Hsu CW, Tu J, Yu Y, Rosen T, Xiong F, Jia P, Yang YP, Bazer DA, Chen YW, Li W, Huff CD, Zhu JJ, Aguilo F, Chiou SH, Boles NC, Lai CC, Hung MC, Zhao Z, Van Nostrand EL, Zhao R, Lee DF. Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation. Nat Commun. 2023 Mar 27;14(1):1694. doi: 10.1038/s41467-023-37398-9. PMID: 36973285; PMCID: PMC10042811.
  • Bian F, Lan YW, Zhao S, Deng Z, Shukla S, Acharya A, Donovan J, Le T, Milewski D, Bacchetta M, Hozain AE, Tipograf Y, Chen YW, Xu Y, Shi D, Kalinichenko VV, Kalin TV. Lung endothelial cells regulate pulmonary fibrosis through FOXF1/R-Ras signaling. Nat Commun. 2023 May 4;14(1):2560. doi: 10.1038/s41467-023-38177-2. PMID: 37137915; PMCID: PMC10156846.

2022

  • Zhang K, Peng X, Wei T, Li Z, Zhu J, Chen YW. Prognostic Nomogram and Competing Risk Analysis of Death for Primary Thyroid Lymphoma: A Long-term Survival Study of 1638 Patients. Ann Surg Open. 2022 Nov 29;3(4):e226. doi: 10.1097/AS9.0000000000000226. PMID: 36590887; PMCID: PMC9780050.
  • Du W, Wang J, Kuo T, Wang L, McKimpson WM, Son J, Watanabe H, Kitamoto T, Lee Y, Creusot RJ, Ratner LE, McCune K, Chen YW, Grubbs BH, Thornton ME, Fan J, Sultana N, Diaz BS, Balasubramanian I, Gao N, Belvedere S, Accili D. Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals. J Clin Invest. 2022 Dec 15;132(24):e162720. doi: 10.1172/JCI162720. PMID: 36282594; PMCID: PMC9754100.
  • Zhang K, Su A, Wang X, Zhao W, He L, Wei T, Li Z, Zhu J, Chen YW. Non-Linear Correlation Between Tumor Size and Survival Outcomes for Parathyroid Carcinoma: A SEER Population-Based Cohort Study. Front Endocrinol (Lausanne). 2022 Jul 1;13:882579. doi: 10.3389/fendo.2022.882579. PMID: 35846299; PMCID: PMC9285012.
  • Li C, Peinado N, Smith SM, Zhou J, Gao F, Kohbodi G, Zhou B, Thornton ME, Grubbs BH, Lee MK, Bellusci S, Borok Z, Chen YW, Minoo P. Wnt5a Promotes AT1 and Represses AT2 Lineage-Specific Gene Expression in a Cell-Context-Dependent Manner. Stem Cells. 2022 Jul 27;40(7):691-703. doi: 10.1093/stmcls/sxac031. PMID: 35429397; PMCID: PMC9332903.
  • Lian Q, Zhang K, Zhang Z, Duan F, Guo L, Luo W, Mok BW, Thakur A, Ke X, Motallebnejad P, Nicolaescu V, Chen J, Ma CY, Zhou X, Han S, Han T, Zhang W, Tan AY, Zhang T, Wang X, Xu D, Xiang J, Xu A, Liao C, Huang FP, Chen YW, Na J, Randall G, Tse HF, Chen Z, Chen Y, Chen HJ. Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model. Nat Commun. 2022 Apr 19;13(1):2028. doi: 10.1038/s41467-022-29731-5. PMID: 35440562; PMCID: PMC9018716.
  • Thakur A, Ke X, Chen YW, Motallebnejad P, Zhang K, Lian Q, Chen HJ. The mini player with diverse functions: extracellular vesicles in cell biology, disease, and therapeutics. Protein Cell. 2022 Sep;13(9):631-654. doi: 10.1007/s13238-021-00863-6. Epub 2021 Aug 10. PMID: 34374936; PMCID: PMC9233731.

2021

  • Tian L, Gao J, Garcia IM, Chen HJ, Castaldi A, Chen YW. Human pluripotent stem cell-derived lung organoids: Potential applications in development and disease modeling. Wiley Interdiscip Rev Dev Biol. 2021 Nov;10(6):e399. doi: 10.1002/wdev.399. Epub 2020 Nov 3. PMID: 33145915.
  • Chen HY, Huang C, Tian L, Huang X, Zhang C, Llewellyn GN, Rogers GL, Andresen K, O’Gorman MRG, Chen YW, Cannon PM. Cytoplasmic Tail Truncation of SARS-CoV-2 Spike Protein Enhances Titer of Pseudotyped Vectors but Masks the Effect of the D614G Mutation. J Virol. 2021 Oct 27;95(22):e0096621. doi: 10.1128/JVI.00966-21. Epub 2021 Sep 8. PMID: 34495700; PMCID: PMC8549521.
  • Rodrigues Toste de Carvalho AL, Liu HY, Chen YW, Porotto M, Moscona A, Snoeck HW. The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D. Nat Protoc. 2021 Apr;16(4):1802-1829. doi: 10.1038/s41596-020-00476-z. Epub 2021 Mar 1. PMID: 33649566; PMCID: PMC9460941.

2020

  • Hozain AE, O’Neill JD, Pinezich MR, Tipograf Y, Donocoff R, Cunningham KM, Tumen A, Fung K, Ukita R, Simpson MT, Reimer JA, Ruiz EC, Queen D, Stokes JW, Cardwell NL, Talackine J, Kim J, Snoeck HW, Chen YW, Romanov A, Marboe CC, Griesemer AD, Guenthart BA, Bacchetta M, Vunjak-Novakovic G. Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs. Nat Med. 2020 Jul;26(7):1102-1113. doi: 10.1038/s41591-020-0971-8. Epub 2020 Jul 13. PMID: 32661401; PMCID: PMC9990469.
  • Climent M, Viggiani G, Chen YW, Coulis G, Castaldi A. MicroRNA and ROS Crosstalk in Cardiac and Pulmonary Diseases. Int J Mol Sci. 2020 Jun 19;21(12):4370. doi: 10.3390/ijms21124370. PMID: 32575472; PMCID: PMC7352701.
  • Wagner DE, Ikonomou L, Gilpin SE, Magin CM, Cruz F, Greaney A, Magnusson M, Chen YW, Davis B, Vanuytsel K, Rolandsson Enes S, Krasnodembskaya A, Lehmann M, Westergren-Thorsson G, Stegmayr J, Alsafadi HN, Hoffman ET, Weiss DJ, Ryan AL. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019. ERJ Open Res. 2020 Oct 19;6(4):00123-2020. doi: 10.1183/23120541.00123-2020. PMID: 33123557; PMCID: PMC7569162.

2019

  • Strikoudis A, Cieślak A, Loffredo L, Chen YW, Patel N, Saqi A, Lederer DJ, Snoeck HW. Modeling of Fibrotic Lung Disease Using 3D Organoids Derived from Human Pluripotent Stem Cells. Cell Rep. 2019 Jun 18;27(12):3709-3723.e5. doi: 10.1016/j.celrep.2019.05.077. PMID: 31216486; PMCID: PMC6594401.
  • Porotto M, Ferren M, Chen YW, Siu Y, Makhsous N, Rima B, Briese T, Greninger AL, Snoeck HW, Moscona A. Authentic Modeling of Human Respiratory Virus Infection in Human Pluripotent Stem Cell-Derived Lung Organoids. mBio. 2019 May 7;10(3):e00723-19. doi: 10.1128/mBio.00723-19. PMID: 31064833; PMCID: PMC6509192.
  • Guenthart BA, Chen YW, Bacchetta M. New insights and therapeutic targets: Lung injury and disease. J Thorac Cardiovasc Surg. 2019 Jan;157(1):416-420. doi: 10.1016/j.jtcvs.2018.09.026. Epub 2018 Oct 6. PMID: 30557958.
  • de Carvalho ALRT, Strikoudis A, Liu HY, Chen YW, Dantas TJ, Vallee RB, Correia-Pinto J, Snoeck HW. Glycogen synthase kinase 3 induces multilineage maturation of human pluripotent stem cell-derived lung progenitors in 3D culture. Development. 2019 Jan 22;146(2):dev171652. doi: 10.1242/dev.171652. PMID: 30578291; PMCID: PMC6361135.

2018

  • Zhang Y, Yang Y, Jiang M, Huang SX, Zhang W, Al Alam D, Danopoulos S, Mori M, Chen YW, Balasubramanian R, Chuva de Sousa Lopes SM, Serra C, Bialecka M, Kim E, Lin S, Toste de Carvalho ALR, Riccio PN, Cardoso WV, Zhang X, Snoeck HW, Que J. 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling. Cell Stem Cell. 2018 Oct 4;23(4):516-529.e5. doi: 10.1016/j.stem.2018.08.009. Epub 2018 Sep 20. PMID: 30244870; PMCID: PMC6282026.

2017

  • Chen YW, Huang SX, de Carvalho ALRT, Ho SH, Islam MN, Volpi S, Notarangelo LD, Ciancanelli M, Casanova JL, Bhattacharya J, Liang AF, Palermo LM, Porotto M, Moscona A, Snoeck HW. A three-dimensional model of human lung development and disease from pluripotent stem cells. Nat Cell Biol. 2017 May;19(5):542-549. doi: 10.1038/ncb3510. Epub 2017 Apr 24. PMID: 28436965; PMCID: PMC5777163.
  • Dorrello NV, Guenthart BA, O’Neill JD, Kim J, Cunningham K, Chen YW, Biscotti M, Swayne T, Wobma HM, Huang SXL, Snoeck HW, Bacchetta M, Vunjak-Novakovic G. Functional vascularized lung grafts for lung bioengineering. Sci Adv. 2017 Aug 30;3(8):e1700521. doi: 10.1126/sciadv.1700521. PMID: 28875163; PMCID: PMC5576878.
  • O’Neill, J. D., Guenthart, B. A., Kim, J., Chicotka, S., Queen, D., Fung, K., Marboe, C., Romanov, A., Huang, S. X. L., Chen, Y.-W., Snoeck, H.-W., Bacchetta, M., & Vunjak-Novakovic, G. (2017). Cross-circulation for extracorporeal support and recovery of the lung. Nature Biomedical Engineering, 1, 0037. doi:10.1038/s41551-017-0037.
  • Chen, Y.-W., Ahmed, A., & Snoeck, H.-W. (2017). Generation of three-dimensional lung bud organoid and its derived branching colonies. Protocol Exchange. doi:https://doi.org/10.1038/protex.2017.027

2016

  • Chen YW, Yin S, Lai YJ, Johnson MD, Lin CY. Plasminogen-Dependent Matriptase Activation Accelerates Plasmin Generation by Differentiating Primary Human Keratinocytes. J Invest Dermatol. 2016 Jun;136(6):1210-1218. doi: 10.1016/j.jid.2016.01.029. Epub 2016 Feb 9. PMID: 26872599.

2015

  • Huang SX, Green MD, de Carvalho AT, Mumau M, Chen YW, D’Souza SL, Snoeck HW. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc. 2015 Mar;10(3):413-25. doi: 10.1038/nprot.2015.023. Epub 2015 Feb 5. PMID: 25654758; PMCID: PMC4654940.

2014

  • Wu BY, Lee SP, Hsiao HC, Chiu H, Chen CY, Yeo YH, Lee HS, Chen YW, Kaul M, Kataoka H, Johnson MD, Wang JK, Lin CY. Matriptase expression and zymogen activation in human pilosebaceous unit. J Histochem Cytochem. 2014 Jan;62(1):50-9. doi: 10.1369/0022155413505599. Epub 2013 Sep 4. PMID: 24004857; PMCID: PMC3873802.
  • Huang SX, Islam MN, O’Neill J, Hu Z, Yang YG, Chen YW, Mumau M, Green MD, Vunjak-Novakovic G, Bhattacharya J, Snoeck HW. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol. 2014 Jan;32(1):84-91. doi: 10.1038/nbt.2754. Epub 2013 Dec 1. PMID: 24291815; PMCID: PMC4101921.
  • Chen YW, Wang JK, Chou FP, Wu BY, Hsiao HC, Chiu H, Xu Z, Baksh ANH, Shi G, Kaul M, Barndt R, Shanmugam VK, Johnson MD, Lin CY. Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytes. J Invest Dermatol. 2014 Feb;134(2):405-414. doi: 10.1038/jid.2013.320. Epub 2013 Jul 26. PMID: 23900022; PMCID: PMC3925676.

2013

  • Chou FP, Chen YW, Zhao XF, Xu-Monette ZY, Young KH, Gartenhaus RB, Wang JK, Kataoka H, Zuo AH, Barndt RJ, Johnson M, Lin CY. Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas. Am J Pathol. 2013 Oct;183(4):1306-17. doi: 10.1016/j.ajpath.2013.06.024. PMID: 24070417; PMCID: PMC3791685.
  • Chen YW, Xu Z, Baksh AN, Wang JK, Chen CY, Swanson R, Olson ST, Kataoka H, Johnson MD, Lin CY. Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes. PLoS One. 2013 May 13;8(5):e62826. doi: 10.1371/journal.pone.0062826. PMID: 23675430; PMCID: PMC3652837.

2012

  • Xu H, Xu Z, Tseng IC, Chou FP, Chen YW, Wang JK, Johnson MD, Kataoka H, Lin CY. Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1. Am J Physiol Cell Physiol. 2012 Jan 15;302(2):C453-62. doi: 10.1152/ajpcell.00344.2011. Epub 2011 Oct 26. PMID: 22031598; PMCID: PMC3328841.
  • Chiu YJ, Huang TH, Chiu CS, Lu TC, Chen YW, Peng WH, Chen CY. Analgesic and Antiinflammatory Activities of the Aqueous Extract from Plectranthus amboinicus (Lour.) Spreng. Both In Vitro and In Vivo. Evid Based Complement Alternat Med. 2012;2012:508137. doi: 10.1155/2012/508137. Epub 2011 Sep 11. PMID: 21915187; PMCID: PMC3170901.
  • Chen, Ya-Wen et al. “The Transmembrane Serine Protease Matriptase: Implications for Cellular Biology and Human Diseases.” Journal of Medical Sciences 32 (2012): 97-108. DOI:10.6136/JMS.2012.32(3).097

2011

  • Xu Z, Chen YW, Battu A, Wilder P, Weber D, Yu W, Mackerell AD, Chen LM, Chai KX, Johnson MD, Lin CY. Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade. J Med Chem. 2011 Nov 10;54(21):7567-78. doi: 10.1021/jm200920s. Epub 2011 Oct 12. PMID: 21966950; PMCID: PMC3214968.
  • Chou FP, Xu H, Lee MS, Chen YW, Richards OX, Swanson R, Olson ST, Johnson MD, Lin CY. Matriptase is inhibited by extravascular antithrombin in epithelial cells but not in most carcinoma cells. Am J Physiol Cell Physiol. 2011 Nov;301(5):C1093-103. doi: 10.1152/ajpcell.00122.2011. Epub 2011 Jul 27. PMID: 21795523; PMCID: PMC3213911.
  • Chen CJ, Wu BY, Tsao PI, Chen CY, Wu MH, Chan YL, Lee HS, Johnson MD, Eckert RL, Chen YW, Chou F, Wang JK, Lin CY. Increased matriptase zymogen activation in inflammatory skin disorders. Am J Physiol Cell Physiol. 2011 Mar;300(3):C406-15. doi: 10.1152/ajpcell.00403.2010. Epub 2010 Dec 1. PMID: 21123732; PMCID: PMC3063967.

2010

  • Jiang H, Jans R, Xu W, Rorke EA, Lin CY, Chen YW, Fang S, Zhong Y, Eckert RL. Type I transglutaminase accumulation in the endoplasmic reticulum may be an underlying cause of autosomal recessive congenital ichthyosis. J Biol Chem. 2010 Oct 8;285(41):31634-46. doi: 10.1074/jbc.M110.128645. Epub 2010 Jul 27. PMID: 20663883; PMCID: PMC2951236.
  • Chen YW, Wang JK, Chou FP, Chen CY, Rorke EA, Chen LM, Chai KX, Eckert RL, Johnson MD, Lin CY. Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation. J Biol Chem. 2010 Oct 8;285(41):31755-62. doi: 10.1074/jbc.M110.150367. Epub 2010 Aug 9. PMID: 20696767; PMCID: PMC2951247.
  • Chen YW, Lee MS, Lucht A, Chou FP, Huang W, Havighurst TC, Kim K, Wang JK, Antalis TM, Johnson MD, Lin CY. TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells. Am J Pathol. 2010 Jun;176(6):2986-96. doi: 10.2353/ajpath.2010.090665. Epub 2010 Apr 9. PMID: 20382709; PMCID: PMC2877858.

2009

  • Wang JK, Lee MS, Tseng IC, Chou FP, Chen YW, Fulton A, Lee HS, Chen CJ, Johnson MD, Lin CY. Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition. Am J Physiol Cell Physiol. 2009 Aug;297(2):C459-70. doi: 10.1152/ajpcell.00201.2009. Epub 2009 Jun 17. PMID: 19535514; PMCID: PMC2724094.

2008

  • Lin CY, Tseng IC, Chou FP, Su SF, Chen YW, Johnson MD, Dickson RB. Zymogen activation, inhibition, and ectodomain shedding of matriptase. Front Biosci. 2008 Jan 1;13:621-35. doi: 10.2741/2707. PMID: 17981575.

Book Chapters

  • Lu T., Zheng C., Rea M., Chen, Y.W. Lung organoids: a new pathway into lung regeneration and repair. Stem Cell Biology and Regenerative Medicine, https://doi.org/10.1007/978-3-030-93056-1_2.
  • Lin CY., Chen YW., Xu ZH., Johnson MD. MS. 681|Matriptase. Handbook of Proteolytic Enzymes (Third edition). https://doi.org/10.1016/B978-0-12-382219-2.00649-9.
  • Rea M., John, T., Chen, Y.W., Ryan A.L. Lung organoid models. 3D Lung Models for Regenerating Lung Tissue, 2022 pages 73-89.

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