Adaptive immune responses to tumor antigens


Jenna studies mutation-derived tumor antigens (MTA), and MTA-specific T lymphocytes, with the hope of better understanding the interaction between malignant cells and the host immune system. We employ multiple high-throughput techniques such as exome and transcript sequencing, as well as single-cell mass cytometry to understand the phenotype, function, trafficking as well signal transduction and transcriptional and epigenetic regulation of tumor-antigen specific T cells, including MTA-specific T cells. Ultimately, the knowledge gained in the course of our studies will facilitate the safe and effective use of the current class of cancer immune therapies, and aid in the design of more effective next generation immune therapies.