2014-2025
Itoh, K., Ossipova, O., Sokol S.Y. (2025). Myocardin-related transcription factor regulates actomyosin contractility and apical junction remodeling during vertebrate neural tube closure. Development 152, dev.204681. PMID: 37808688; PMCID: PMC10557707.
Matsuda M. and Sokol, S.Y. (2025) Prickle2 regulates apical junction remodeling and tissue fluidity during vertebrate neurulation. J. Cell. Biol. 224 (4): e202407025. doi: 10.1101/2024.07.02.601771. PMID: 39005435; PMCID: PMC11245016.
Chuykin, I. and Sokol, S.Y. (2025). FGF receptor modulates planar cell polarity in the neuroectoderm via Vangl2 tyrosine phosphorylation”, Nat. Commun. 16: 7219. PMID: 40764316, PMCID: PMC12326008.
Chu, C.-W., Velayudhan, S. S., Schauser, J. H., Krishnakumar, S., Yang, S. Y., Itoh, K., Alfandari, D., Trusina, A., Sokol, S. Y. (2025). Mechanical cues polarize ADIP protein complexes to control vertebrate morphogenesis and wound healing. Curr. Biol., 35, 3315-3326.e4.
Velayudhan, S. S., Chu, C.-W., Itoh, K., Sokol, S. Y. (2025). Mechanosensitive localization of Diversin highlights its function in vertebrate morphogenesis and planar cell polarity, Biol. Open 14, bio062128. PMID: 40719643; PMCID: PMC12381922.
Matsuda M., Rozman, J., Ostvar S., Kasza, K.E., Sokol, S.Y. (2023). Mechanical control of neural plate folding by apical domain alteration. Nat. Commun. 14: 8475. PMID: 36798359; PMCID: PMC9934705.
Matsuda M, Chu CW, Sokol SY. Lmo7 recruits myosin II heavy chain to regulate actomyosin contractility and apical domain size in Xenopus ectoderm. Development. 2022 May 15;149(10). doi: 10.1242/dev.200236. Epub 2022 May 16. PubMed PMID: 35451459; PubMed Central PMCID: PMC9188752.
Chuykin I, Sokol SY. Analysis of Planar Cell Polarity Complexes by Proximity Biotinylation in Xenopus Embryos. Methods Mol Biol. 2022;2438:97-106. doi: 10.1007/978-1-0716-2035-9_6. PubMed PMID: 35147937.
Ossipova O, Mancini P, Sokol SY. Imaging Planar Cell Polarity Proteins in Xenopus Neuroectoderm. Methods Mol Biol. 2022;2438:147-161. doi: 10.1007/978-1-0716-2035-9_10. PubMed PMID: 35147941.
Chuykin I, Itoh K, Kim K, Sokol SY. Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate. J Cell Sci. 2021 Dec 15;134(24). doi: 10.1242/jcs.258864. Epub 2021 Dec 15. PubMed PMID: 34806749; PubMed Central PMCID: PMC8729781.
Reis AH, Xiang B, Ossipova O, Itoh K, Sokol SY. Identification of the centrosomal maturation factor SSX2IP as a Wtip-binding partner by targeted proximity biotinylation. PLoS One. 2021;16(10):e0259068. doi: 10.1371/journal.pone.0259068. eCollection 2021. PubMed PMID: 34710136; PubMed Central PMCID: PMC8553094.
Ossipova O, Sokol SY. Cryosectioning and Immunostaining of Xenopus Embryonic Tissues. Cold Spring Harb Protoc. 2021 Sep 1;2021(9). doi: 10.1101/pdb.prot107151. PubMed PMID: 34244349; PubMed Central PMCID: PMC8527664.
Mancini P, Ossipova O, Sokol SY. The dorsal blastopore lip is a source of signals inducing planar cell polarity in the Xenopus neural plate. Biol Open. 2021 Jul 15;10(7). doi: 10.1242/bio.058761. Epub 2021 Jul 19. PubMed PMID: 34259326; PubMed Central PMCID: PMC8325942.
Reis AH, Sokol SY. Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification. Sci Rep. 2021 Jun 28;11(1):13433. doi: 10.1038/s41598-021-92824-6. PubMed PMID: 34183732; PubMed Central PMCID: PMC8239024.
Itoh K, Ossipova O, Sokol SY. Pinhead antagonizes Admp to promote notochord formation. iScience. 2021 Jun 25;24(6):102520. doi: 10.1016/j.isci.2021.102520. eCollection 2021 Jun 25. PubMed PMID: 34142034; PubMed Central PMCID: PMC8188501.
Torban E, Sokol SY. Planar cell polarity pathway in kidney development, function and disease. Nat Rev Nephrol. 2021 Jun;17(6):369-385. doi: 10.1038/s41581-021-00395-6. Epub 2021 Feb 5. Review. PubMed PMID: 33547419; PubMed Central PMCID: PMC8967065.
Matsuda M, Sokol SY. Xenopus neural tube closure: A vertebrate model linking planar cell polarity to actomyosin contractions. Curr Top Dev Biol. 2021;145:41-60. doi: 10.1016/bs.ctdb.2021.04.001. Epub 2021 May 4. Review. PubMed PMID: 34074535.
Sokol SY. Preface. Curr Top Dev Biol. 2021;145:xi-xiii. doi: 10.1016/S0070-2153(21)00065-X. PubMed PMID: 34074538.
Ossipova O, Itoh K, Radu A, Ezan J, Sokol SY. Pinhead signaling regulates mesoderm heterogeneity via the FGF receptor-dependent pathway. Development. 2020 Sep 11;147(17). doi: 10.1242/dev.188094. PubMed PMID: 32859582; PubMed Central PMCID: PMC7502591.
Reis AH, Sokol SY. Rspo2 antagonizes FGF signaling during vertebrate mesoderm formation and patterning. Development. 2020 May 27;147(10). doi: 10.1242/dev.189324. PubMed PMID: 32366679; PubMed Central PMCID: PMC7272350.
Itoh K, Reis AH, Hayhurst A, Sokol SY. Isolation of nanobodies against Xenopus embryonic antigens using immune and non-immune phage display libraries. PLoS One. 2019;14(5):e0216083. doi: 10.1371/journal.pone.0216083. eCollection 2019. PubMed PMID: 31048885; PubMed Central PMCID: PMC6497274.
Chuykin I, Ossipova O, Sokol SY. Par3 interacts with Prickle3 to generate apical PCP complexes in the vertebrate neural plate. Elife. 2018 Sep 26;7. doi: 10.7554/eLife.37881. PubMed PMID: 30256191; PubMed Central PMCID: PMC6175575.
Ossipova O, Kerney R, Saint-Jeannet JP, Sokol SY. Regulation of neural crest development by the formin family protein Daam1. Genesis. 2018 Jun;56(6-7):e23108. doi: 10.1002/dvg.23108. Epub 2018 Apr 19. PubMed PMID: 29673042; PubMed Central PMCID: PMC6105563.
Chu CW, Xiang B, Ossipova O, Ioannou A, Sokol SY. The Ajuba family protein Wtip regulates actomyosin contractility during vertebrate neural tube closure. J Cell Sci. 2018 May 16;131(10). doi: 10.1242/jcs.213884. PubMed PMID: 29661847; PubMed Central PMCID: PMC6031329.
Sokol SY. At the Crossroads between Cell Polarity and Adhesion in Neocortical Development. Dev Cell. 2017 Jun 5;41(5):453-454. doi: 10.1016/j.devcel.2017.05.017. PubMed PMID: 28586640.
Chu CW, Sokol SY. Wnt proteins can direct planar cell polarity in vertebrate ectoderm. Elife. 2016 Sep 23;5. doi: 10.7554/eLife.16463. PubMed PMID: 27658614; PubMed Central PMCID: PMC5055393.
Chu CW, Ossipova O, Ioannou A, Sokol SY. Prickle3 synergizes with Wtip to regulate basal body organization and cilia growth. Sci Rep. 2016 Apr 11;6:24104. doi: 10.1038/srep24104. PubMed PMID: 27062996; PubMed Central PMCID: PMC4827067.
Gaston-Massuet C, McCabe MJ et al. Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E548-57. doi: 10.1073/pnas.1503346113. Epub 2016 Jan 13. PubMed PMID: 26764381; PubMed Central PMCID: PMC4747739.
Sokol SY. Mechanotransduction During Vertebrate Neurulation. Curr Top Dev Biol. 2016;117:359-76. doi: 10.1016/bs.ctdb.2015.11.036. Epub 2016 Jan 23. Review. PubMed PMID: 26969989.
Ossipova O, Chu CW, Fillatre J, Brott BK, Itoh K, Sokol SY. The involvement of PCP proteins in radial cell intercalations during Xenopus embryonic development. Dev Biol. 2015 Dec 15;408(2):316-27. doi: 10.1016/j.ydbio.2015.06.013. Epub 2015 Jun 14. PubMed PMID: 26079437; PubMed Central PMCID: PMC4810801.
Sokol SY. Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development. Semin Cell Dev Biol. 2015 Jun;42:78-85. doi: 10.1016/j.semcdb.2015.05.002. Epub 2015 May 15. Review. PubMed PMID: 25986055; PubMed Central PMCID: PMC4562884.
Ossipova O, Kim K, Sokol SY. Planar polarization of Vangl2 in the vertebrate neural plate is controlled by Wnt and Myosin II signaling. Biol Open. 2015 Apr 24;4(6):722-30. doi: 10.1242/bio.201511676. PubMed PMID: 25910938; PubMed Central PMCID: PMC4467192.
Kim K, Ossipova O, Sokol SY. Neural crest specification by inhibition of the ROCK/Myosin II pathway. Stem Cells. 2015 Mar;33(3):674-85. doi: 10.1002/stem.1877. PubMed PMID: 25346532; PubMed Central PMCID: PMC4428345.
Itoh K, Sokol SY. Early Development of Epidermis and Neural Tissue.. In: Moody SA, editor. Principles of Developmental Genetics` Second Edition ed. San Diego, California: Elsevier, Academic Press; 2015. Chapter 11. 189-201p.
Ossipova O, Chuykin I, Chu CW, Sokol SY. Vangl2 cooperates with Rab11 and Myosin V to regulate apical constriction during vertebrate gastrulation. Development. 2015 Jan 1;142(1):99-107. doi: 10.1242/dev.111161. Epub 2014 Dec 5. PubMed PMID: 25480917; PubMed Central PMCID: PMC4299144.
Itoh K, Sokol SY. Expression cloning of camelid nanobodies specific for Xenopus embryonic antigens. PLoS One. 2014;9(10):e107521. doi: 10.1371/journal.pone.0107521. eCollection 2014. PubMed PMID: 25285446; PubMed Central PMCID: PMC4186775.
Itoh K, Ossipova O, Sokol SY. GEF-H1 functions in apical constriction and cell intercalations and is essential for vertebrate neural tube closure. J Cell Sci. 2014 Jun 1;127(Pt 11):2542-53. doi: 10.1242/jcs.146811. Epub 2014 Mar 28. PubMed PMID: 24681784; PubMed Central PMCID: PMC4038946.
Ossipova O, Kim K, Lake BB, Itoh K, Ioannou A, Sokol SY. Role of Rab11 in planar cell polarity and apical constriction during vertebrate neural tube closure. Nat Commun. 2014 May 13;5:3734. doi: 10.1038/ncomms4734. PubMed PMID: 24818582; PubMed Central PMCID: PMC4097039.
2007-2013
Chu CW, Gerstenzang E, Ossipova O, Sokol SY. Lulu regulates Shroom-induced apical constriction during neural tube closure. PLoS One. 2013;8(11):e81854. doi: 10.1371/journal.pone.0081854. eCollection 2013. PubMed PMID: 24282618; PubMed Central PMCID: PMC3839891.
Hikasa H, Sokol SY. Wnt signaling in vertebrate axis specification. Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a007955. doi: 10.1101/cshperspect.a007955. Review. PubMed PMID: 22914799; PubMed Central PMCID: PMC3579404.
Kim K, Lake BB, Haremaki T, Weinstein DC, Sokol SY. Rab11 regulates planar polarity and migratory behavior of multiciliated cells in Xenopus embryonic epidermis. Dev Dyn. 2012 Sep;241(9):1385-95. doi: 10.1002/dvdy.23826. Epub 2012 Jul 16. PubMed PMID: 22778024; PubMed Central PMCID: PMC4009926.
Kalinichenko SV, Itoh K, Korobko EV, Sokol SY, Buchman VL, Korobko IV. Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase. PLoS One. 2012;7(6):e39505. doi: 10.1371/journal.pone.0039505. Epub 2012 Jun 20. PubMed PMID: 22745772; PubMed Central PMCID: PMC3379983.
Hong JY, Park JI, Lee M, Muñoz WA, Miller RK, Ji H, Gu D, Ezan J, Sokol SY, McCrea PD. Down’s-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway. J Cell Sci. 2012 Feb 1;125(Pt 3):561-9. doi: 10.1242/jcs.086173. PubMed PMID: 22389395; PubMed Central PMCID: PMC3367828.
Lee HS, Sokol SY, Moody SA, Daar IO. Using 32-cell stage Xenopus embryos to probe PCP signaling. Methods Mol Biol. 2012;839:91-104. doi: 10.1007/978-1-61779-510-7_8. PubMed PMID: 22218895; PubMed Central PMCID: PMC4461027.
Ossipova O, Sokol SY. Neural crest specification by noncanonical Wnt signaling and PAR-1. Development. 2011 Dec;138(24):5441-50. doi: 10.1242/dev.067280. PubMed PMID: 22110058; PubMed Central PMCID: PMC3222216.
Sokol SY. Maintaining embryonic stem cell pluripotency with Wnt signaling. Development. 2011 Oct;138(20):4341-50. doi: 10.1242/dev.066209. Epub 2011 Sep 8. Review. PubMed PMID: 21903672; PubMed Central PMCID: PMC3177306.
Yasunaga T, Itoh K, Sokol SY. Regulation of basal body and ciliary functions by Diversin. Mech Dev. 2011 Sep-Dec;128(7-10):376-86. doi: 10.1016/j.mod.2011.07.004. Epub 2011 Aug 6. PubMed PMID: 21843637; PubMed Central PMCID: PMC3223263.
Sokol SY. Wnt signaling through T-cell factor phosphorylation. Cell Res. 2011 Jul;21(7):1002-12. doi: 10.1038/cr.2011.86. Epub 2011 May 24. Review. PubMed PMID: 21606952; PubMed Central PMCID: PMC3193496.
Itoh K, Sokol SY. Polarized translocation of fluorescent proteins in Xenopus ectoderm in response to Wnt signaling. J Vis Exp. 2011 May 26;(51). doi: 10.3791/2700. PubMed PMID: 21654626; PubMed Central PMCID: PMC3197113.
Hikasa H, Sokol SY. Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2. J Biol Chem. 2011 Apr 8;286(14):12093-100. doi: 10.1074/jbc.M110.185280. Epub 2011 Feb 1. PubMed PMID: 21285352; PubMed Central PMCID: PMC3069413.
Hikasa H, Ezan J, Itoh K, Li X, Klymkowsky MW, Sokol SY. Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification. Dev Cell. 2010 Oct 19;19(4):521-32. doi: 10.1016/j.devcel.2010.09.005. PubMed PMID: 20951344; PubMed Central PMCID: PMC2963175.
Ossipova O, Sokol SY. Cell polarity, Notch signaling and neurogenesis. Cell Cycle. 2010 Jan 1;9(1):1-2. doi: 10.4161/cc.9.1.10357. Epub 2010 Jan 19. PubMed PMID: 20016263.
Alexandrova EM, Sokol SY. Xenopus axin-related protein: a link between its centrosomal localization and function in the Wnt/beta-catenin pathway. Dev Dyn. 2010 Jan;239(1):261-70. doi: 10.1002/dvdy.22125. PubMed PMID: 19842147.
Choi SC, Sokol SY. The involvement of lethal giant larvae and Wnt signaling in bottle cell formation in Xenopus embryos. Dev Biol. 2009 Dec 1;336(1):68-75. doi: 10.1016/j.ydbio.2009.09.033. Epub 2009 Sep 25. PubMed PMID: 19782678; PubMed Central PMCID: PMC2801549.
Itoh K, Jenny A, Mlodzik M, Sokol SY. Centrosomal localization of Diversin and its relevance to Wnt signaling. J Cell Sci. 2009 Oct 15;122(Pt 20):3791-8. doi: 10.1242/jcs.057067. Epub 2009 Sep 29. PubMed PMID: 19789178; PubMed Central PMCID: PMC2758808.
Ossipova O, Ezan J, Sokol SY. PAR-1 phosphorylates Mind bomb to promote vertebrate neurogenesis. Dev Cell. 2009 Aug;17(2):222-33. doi: 10.1016/j.devcel.2009.06.010. PubMed PMID: 19686683; PubMed Central PMCID: PMC2849776.
Lake BB, Sokol SY. Strabismus regulates asymmetric cell divisions and cell fate determination in the mouse brain. J Cell Biol. 2009 Apr 6;185(1):59-66. doi: 10.1083/jcb.200807073. Epub 2009 Mar 30. PubMed PMID: 19332887; PubMed Central PMCID: PMC2700512.
Chia IV, Kim MJ, Itoh K, Sokol SY, Costantini F. Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis. Genetics. 2009 Apr;181(4):1359-68. doi: 10.1534/genetics.109.101055. Epub 2009 Feb 9. PubMed PMID: 19204372; PubMed Central PMCID: PMC2666505.
Pan W, Choi SC, Wang H, Qin Y, Volpicelli-Daley L, Swan L, Lucast L, Khoo C, Zhang X, Li L, Abrams CS, Sokol SY, Wu D. Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Science. 2008 Sep 5;321(5894):1350-3. doi: 10.1126/science.1160741. PubMed PMID: 18772438; PubMed Central PMCID: PMC2532521.
Ossipova O, Tabler J, Green JB, Sokol SY. PAR1 specifies ciliated cells in vertebrate ectoderm downstream of aPKC. Development. 2007 Dec;134(23):4297-306. doi: 10.1242/dev.009282. PubMed PMID: 17993468; PubMed Central PMCID: PMC2170474.
Sokol SY, Wharton KA Jr. WNTers in La Jolla. Development. 2007 Oct;134(19):3393-9. doi: 10.1242/dev.008169. PubMed PMID: 17827178.
Sokol S, editor. Advances in Developmental Biology. v. 17 San Diego, CA: Elsevier Press; 2007.
Itoh K, Sokol SY. Early development of epidermis and neural tissue.. In: Moody SA, editor. Principles of Developmental Genetics San Diego, CA: Elsevier Press; 2007. 241-258.p.
Dollar G, Sokol SY. Wnt signaling and cell polarity.. In: Sokol SY, editor. Advances in Developmental Biology. v. 17 San Diego, California: Elsevier Press; 2007. 61-94p.
Park JI, Ji H, Jun S, Gu D, Hikasa H, Li L, Sokol SY, McCrea PD. Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals. Dev Cell. 2006 Nov;11(5):683-95. doi: 10.1016/j.devcel.2006.09.022. PubMed PMID: 17084360.