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Welcome to the SOKOL laboratory

Department of Cell, Developmental and Regenerative Biology

Icahn School of Medicine at Mount Sinai

 

Signaling mechanisms regulating cell fate and morphogenesis in the vertebrate embryo  

Our past experiments revealed an essential function for the Wnt pathway in vertebrate axis determination and uncovered equally important roles in morphogenesis (Sokol et al., 1991; Sokol, 1996). We also studied cross-talk of apical-basal and planar cell polarity (PCP) proteins in various models (Dollar et al., 2005; Lake and Sokol, 2009; Chuykin et al., 2018, Chuykin et al., 2021). Using new technologies based on proximity biotinylation and live imaging, we investigate how different spatially localized signaling pathways modulate actomyosin dynamics and vesicular trafficking during apical constriction and related morphogenetic processes (Itoh et al., 2021; Reis et al., 2021; Matsuda et al., 2022).

 

We would like to learn how embryonic cells and tissues sense and respond to mechanical forces during morphogenesis. Mechanotransduction is a process, by which a mechanical cue is sensed by a molecular component of the cell, converted to a biochemical signal and used to affect various biological processes, from cell migration to cell lineage specification.  Our group continues to investigate how changes in planar cell polarity (PCP) alter collective cell movements in vertebrates including neural tube closure (Ossipova et al., 2014; Ossipova et al., 2015a,b).

 

 

 

 

Contact us or inquire about research opportunities by writing to sergei.sokol@mssm.edu