Representative Publications from Over 300 Peer-Reviewed Manuscripts


Westfall S, Pasinetti GM. The gut microbiota links dietary polyphenols with management of psychiatric mood disorders. Frontiers in Neuroscience, (2019). DOI: 10.3389/fnins.2019.01196

Yamasaki TR, Ono K, Ho L, Pasinetti GM. Gut Microbiome-Modified Polyphenolic Compounds Inhibit alpha- synuclein Seeding and Spreading in alpha-synucleinopathies. Frontiers in Neurosciences, (2020).  DOI: 10.3389/fnins.2020.00398

Helmer DA, Van Doren W, Litke D, Tseng C, Ho L, Osinubi O, Pasinetti GM. Safety, tolerability and efficacy of dietary supplementation with Concord grape juice in Gulf War Veterans with Gulf War Illness: a phase I/IIA, randomized, double-blind, placebo-controlled trial. International Journal of Environmental Research and Public Health, (2020). DOI: 10.3390/ijerph17103546

Sebastian-Valverde M, Wu H, Rahim M, Sanchez R, Kumar K, De Vita RJ, Pasinetti GM. Discovery and characterization of small molecule inhibitors of NLRP3 and NLRC4 inflammasomes. Journal Biological Chemistry, (2021). DOI: 10.1016/j.jbc.2021.100597

Smith C, Trageser KJ, Frolinger T, Sebastian-Valverde M, Iqbal U, Zeng E, Herman FJ, Pasinetti GM. Anxiolytic Effects of NLRP3 Inflammasome Inhibition in a Model of Chronic Sleep Deprivation. Translational Psychiatry, (2020). DOI: 10.1038/s41398-020-01189-3.

Westfall S, Caracci F, Estill M, Frolinger T, Shen L, Pasinetti GM. Chronic Stress-Induced Depression and Anxiety Modulated by Gut-Brain-Axis Immunity. Frontiers in Immunology, 2021. DOI: 10.3389/fimmu.2021.670500

Westfall S, Carracci F, Estill M, Zhao D, Wu Q, Shen L, Simon J, Pasinetti GM. Optimization of Probiotic Therapeutics using Machine Learning in an Artificial Human Gastrointestinal Tract. Nature Scientific Reports, (2020). DOI: 10.1038/s41598-020-79947-y

Rahim M, Thatipamula S, Pasinetti GM, and Hossain MA.  Neuronal pentraxin 1 promotes hypoxic-ischemic neuronal injury by impairing mitochondrial biogenesis via interactions with active Bax[6A7] and mitochondrial hexokinase II. ASN Neuro, (2021). DOI: 10.1177/17590914211012888.

Westfall S, Caracci F, Zhao D, Wu Q, Frolinger T, Simon J, Pasinetti GM. Microbiota metabolites modulate the regulatory T to T helper 17 (Treg/Th17) imbalance promoting resilience to stress-induced psychological impairment. Brain Behavior and Immunity, (2020). DOI: 10.1016/j.bbi.2020.10.013.

Westfall S, Caracci F, Estill M, Frolinger T, Shen L, Pasinetti GM. Chronic Stress-Induced Depression and Anxiety Modulated by Gut-Brain-Axis Immunity. Frontiers in Immunology, (2021). DOI: 10.3389/fimmu.2021.670500

Trageser KJ, Sebastian M, Naughton SX, Pasinetti GM. The Innate Immune System and Inflammatory Priming: Linking Mood Disorders and Gulf War Illness. Frontiers in Psychiatry, (2020). DOI: 10.3389/fpsyt.2020.00704

Naughton SX, Raval U, Pasinetti GM. The Viral Hypothesis in Alzheimer’s Disease: Insight toward Novel Biomarkers. Journal of Personalized Medicine, 2020. DOI: 10.3390/jpm10030074.

Wang J, Hodes G, Zhang H, Zhang S, Zhao W, Golden S, Bi W, Menard C, Kana V, Leboef M, Tiano S, Esteban-Fernandez A, Xie M, Bregman D, Ho L, Dixon R, Merad M, Han MH, Russo S, Pasinetti GM. Targeting inflammation and synaptic plasticity promotes resilience against stress disorder and depression. Nature Communications,9, 477 (2018). DOI: 10.1038/s41467-017-02794-5

Varghese M, Santa-Maria I, Ho L, Yemul S, Dubner L, Chudasma A, Ward L, Księżak-Reding H, Pasinetti GM. Extracellular Tau Paired Helical Filaments Differentially Affect Tau Pathogenic Mechanisms in Mitotic and Post-Mitotic Cells: Implications in Mechanisms of Tau Propagation in the Brain. J Alzheimers Dis PMID: 27567821 (2016).

Ho L, Cheng H, Wang J, Simon J, Wu Q, Zhao D, Carry E, Ferruzzi M, Faith J, Valcarcel B, Hao K, Pasinetti GM. A comprehensive database and analysis framework to incorporate multiscale data types and enable integrated analysis of bioactive polyphenols. Molecular Pharmaceutics PMID: 28665131 (2017).

Blaze J, Wang J, Ho L, Mendelev N, Haghighi F, Pasinetti GM. Polyphenolic compounds alter stress-induced patterns of global DNA methylation in brain and blood. Molecular Nutrition and Food Research, (2018.)

Frolinger T, Sharma A, De Boer S, Bell A, Sims S, Pasinetti GM. Role of polyphenols in kinase complex mammalian target of rapamycin complex 1 (mTORC1)-dependent protein translation as novel mechanisms in promoting resilience against sleep deprivation-induced cognitive impairment. FASEB: (2018) DOI:10.1096/fj.201800030R

Ward L and Pasinetti GM. Recommendations for Development of Botanical Polyphenols as “Natural Drugs” for Promotion of Resilience Against Stress-Induced Depression and Cognitive Impairment. NeuroMol Med PMID: 26402120 (2016).