Caregiving for a dementia patient is associated with increased risk of psychological and physical health problems. Our laboratory is investigating whether Mindfulness Based Stress Reduction (MBSR) training improves the psychological resilience of non-professional caregivers of Alzheimer’s disease (AD) patients. Our ongoing studies are identifying predictive biomarkers whose expression is associated with the likelihood of caregivers to benefit from MBSR, and biomarkers whose expression is associated with MBSR psychological benefits. Our studies are providing the much needed information into the mechanisms of health benefits of MBSR and a basis for developing a personalized medicine approach for applying MBSR for promoting psychological and cognitive resilience in caregivers of dementia patients.