Publications

Full publication list can be found here.

Select Publications:

Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis. Kiss M., Mindur J., Yates A., Lee D., Fullar J., Anzai A., Poller W., Christie K., Iwamoto Y., Roudko V., Downey J., Chan C., Huynh P., Janssen H., Ntranos A., Hoffmann J., Jacob W., Goswami S., Singh S., Leppert D., Kuhle J., Kim-Schulze S., Nahrendorf M., Kleinstiver B., Probert F., Roussos P., Swirski F., McAlpine C. Immunity, 2023. (56)1-13.

Sleep calibrates atherosclerotic cardiovascular disease. Cohen O, Shah N, McAlpine C. Nature Cardiovascular Research, 2022, 1, 1104-1106

Sleep exerts lasting effects on hematopoietic stem cell function and diversity. McAlpine C, Kiss M, Zuraikat F, Cheek D, Schiroli G, Amatullah H, Huynh P, Bhatti M, Wong LP, Yates A, Poller W, Mindur J, Chan C, Janssen H, Downey J, Singh S, Sadreyev R, Nahrendorf M, Jeffrey K, Scadden D, Naxerova K, St-Onge MP, Swirski FK. Journal of Experimental Medicine, 2022, 219(11)1-16

Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease.McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK. Nature. 2021 Jul;595(7869):701-706. doi: 10.1038/s41586-021-03734-6. Epub 2021 Jul 14.PMID: 34262178

Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis. Heyde A*, Rohde D*, McAlpine CS*, Zhang S, Hoyer FF, Gerold JM, Cheek D, Iwamoto Y, Schloss MJ, Vandoorne K, Iborra-Egea O, Muñoz-Guijosa C, Bayes-Genis A, Reiter JG, Craig M, Swirski FK, Nahrendorf M, Nowak MA, Naxerova K. Cell. 2021 Mar 4;184(5):1348-1361.e22. doi: 10.1016/j.cell.2021.01.049. Epub 2021 Feb 25.PMID: 3363612 *equal contribution

Sleep modulates haematopoiesis and protects against atherosclerosis. McAlpine CS, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT, Mindur JE, Kahles F, Poller WC, Frodermann V, Fenn AM, Gregory AF, Halle L, Iwamoto Y, Hoyer FF, Binder CJ, Libby P, Tafti M, Scammell TE, Nahrendorf M, Swirski FK. Nature. 2019 Feb;566(7744):383-387. doi: 10.1038/s41586-019-0948-2. Epub 2019 Feb 13. PMID: 30760925

Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells. Frodermann V, Rohde D, Courties G, Severe N, Schloss MJ, Amatullah H, McAlpine CS, Cremer S, Hoyer FF, Ji F, van Koeverden ID, Herisson F, Honold L, Masson GS, Zhang S, Grune J, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Lee IH, Gustafsson K, Pasterkamp G, de Jager SCA, Sadreyev RI, MacFadyen J, Libby P, Ridker P, Scadden DT, Naxerova K, Jeffrey KL, Swirski FK, Nahrendorf M. Nat Med. 2019 Nov;25(11):1761-1771. doi: 10.1038/s41591-019-0633-x. Epub 2019 Nov 7.PMID: 31700184

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease. He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK.Nature. 2019 Feb;566(7742):115-119. doi: 10.1038/s41586-018-0849-9. Epub 2019 Jan 30. PMID: 30700910

Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis. Anzai A, Mindur JE, Halle L, Sano S, Choi JL, He S, McAlpine CS, Chan CT, Kahles F, Valet C, Fenn AM, Nairz M, Rattik S, Iwamoto Y, Fairweather D, Walsh K, Libby P, Nahrendorf M, Swirski FK.J Exp Med. 2019 Feb 4;216(2):369-383. doi: 10.1084/jem.20180722. Epub 2019 Jan 22.PMID: 30670465

The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes. Anzai A, Choi JL, He S, Fenn AM, Nairz M, Rattik S, McAlpine CS, Mindur JE, Chan CT, Iwamoto Y, Tricot B, Wojtkiewicz GR, Weissleder R, Libby P, Nahrendorf M, Stone JR, Becher B, Swirski FK.J Exp Med. 2017 Nov 6;214(11):3293-3310. doi: 10.1084/jem.20170689. Epub 2017 Oct 4.PMID: 2897863

Circadian Influence on Metabolism and Inflammation in Atherosclerosis. McAlpine CS, Swirski FK.Circ Res. 2016 Jun 24;119(1):131-41. doi: 10.1161/CIRCRESAHA.116.308034.PMID: 27340272

Deletion of Myeloid GSK3α Attenuates Atherosclerosis and Promotes an M2 Macrophage Phenotype. McAlpine CS, Huang A, Emdin A, Banko NS, Beriault DR, Shi Y, Werstuck GH.Arterioscler Thromb Vasc Biol. 2015 May;35(5):1113-22. doi: 10.1161/ATVBAHA.115.305438. Epub 2015 Mar 12.PMID: 25767272