2022 Publications

 

Augmentation of humoral and cellular immune responses after third-dose SARS-CoV-2 vaccination and viral neutralization in myeloma patients.Aleman A, Van Oekelen O, Upadhyaya B, Beach K, Kogan Zajdman A, Alshammary H, Serebryakova K, Agte S, Kappes K, Gleason CR, Srivastava K; PVI/MM/Seronet Study Group, Almo S, Cordon-Cardo C, Krammer F, Merad M, Jagannath S, Wajnberg A, Simon V, Parekh S.Cancer Cell. 2022 Apr 6:S1535-6108(22)00147-7. doi: 10.1016/j.ccell.2022.03.013. Online ahead of print.PMID: 35390296

Detection of Velogenic Avian Paramyxoviruses in Rock Doves in New York City, New York.Francisco I, Bailey S, Bautista T, Diallo D, Gonzalez J, Gonzalez J, Kirkpatrick Roubidoux E, Kehinde Ajayi P, Albrecht RA, McMahon R, Krammer F, Marizzi C.Microbiol Spectr. 2022 Mar 31:e0206121. doi: 10.1128/spectrum.02061-21. Online ahead of print.PMID: 35357204

mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions.Kaplonek P, Cizmeci D, Fischinger S, Collier AR, Suscovich T, Linde C, Broge T, Mann C, Amanat F, Dayal D, Rhee J, de St Aubin M, Nilles EJ, Musk ER, Menon AS, Saphire EO, Krammer F, Lauffenburger DA, Barouch DH, Alter G.Sci Transl Med. 2022 Mar 29:eabm2311. doi: 10.1126/scitranslmed.abm2311. Online ahead of print.PMID: 35348368

Safety and immunogenicity of an inactivated recombinant Newcastle disease virus vaccine expressing SARS-CoV-2 spike: Interim results of a randomised, placebo-controlled, phase 1 trial.Pitisuttithum P, Luvira V, Lawpoolsri S, Muangnoicharoen S, Kamolratanakul S, Sivakorn C, Narakorn P, Surichan S, Prangpratanporn S, Puksuriwong S, Lamola S, Mercer LD, Raghunandan R, Sun W, Liu Y, Carreño JM, Scharf R, Phumratanaprapin W, Amanat F, Gagnon L, Hsieh CL, Kaweepornpoj R, Khan S, Lal M, McCroskery S, McLellan J, Mena I, Meseck M, Phonrat B, Sabmee Y, Singchareon R, Slamanig S, Suthepakul N, Tcheou J, Thantamnu N, Theerasurakarn S, Tran S, Vilasmongkolchai T, White JA, Bhardwaj N, Garcia-Sastre A, Palese P, Krammer F, Poopipatpol K, Wirachwong P, Hjorth R, Innis BL.EClinicalMedicine. 2022 Mar 8;45:101323. doi: 10.1016/j.eclinm.2022.101323. eCollection 2022 Mar.PMID: 35284808

The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization.Karger AB, Brien JD, Christen JM, Dhakal S, Kemp TJ, Klein SL, Pinto LA, Premkumar L, Roback JD, Binder RA, Boehme KW, Boppana S, Cordon-Cardo C, Crawford JM, Daiss JL, Dupuis AP, Espino AM, Firpo-Betancourt A, Forconi C, Forrest JC, Girardin RC, Granger DA, Granger SW, Haddad NS, Heaney CD, Hunt DT, Kennedy JL, King CL, Krammer F, Kruczynski K, LaBaer J, Lee FE, Lee WT, Liu SL, Lozanski G, Lucas T, Mendu DR, Moormann AM, Murugan V, Okoye NC, Pantoja P, Payne AF, Park J, Pinninti S, Pinto AK, Pisanic N, Qiu J, Sariol CA, Simon V, Song L, Steffen TL, Stone ET, Styer LM, Suthar MS, Thomas SN, Thyagarajan B, Wajnberg A, Yates JL, Sobhani K.medRxiv. 2022 Mar 14:2022.02.27.22271399. doi: 10.1101/2022.02.27.22271399. Preprint.PMID: 35262095

The negative effect of pre-existing immunity on influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history.Moritzky SA, Richards KA, Glover MA, Krammer F, Chaves FA, Topham DJ, Branche A, Nayak JL, Sant AJ.

Sustained Antibody-Dependent NK Cell Functions in Mild COVID-19 Outpatients During Convalescence. Fuentes-Villalobos F, Garrido JL, Medina MA, Zambrano N, Ross N, Bravo F, Gaete-Argel A, Oyarzún-Arrau A, Amanat F, Soto-Rifo R, Valiente-Echeverría F, Ocampo R, Esveile C, Ferreira L, Cabrera J, Torres V, Rioseco ML, Riquelme R, Barría S, Alvarez R, Pinos Y, Krammer F, Calvo M, Barria MI; COVID-19 South Chile Group.Front Immunol. 2022 Feb 7;13:796481. doi: 10.3389/fimmu.2022.796481. eCollection 2022.PMID: 35197972

Safety and immunogenicity of a live recombinant Newcastle disease virus-based COVID-19 vaccine (Patria) administered via the intramuscular or intranasal route: Interim results of a non-randomized open label phase I trial in Mexico.Ponce-de-León S, Torres M, Soto-Ramírez LE, José Calva J, Santillán-Doherty P, Carranza-Salazar DE, Carreño JM, Carranza C, Juárez E, Carreto-Binaghi LE, Ramírez-Martínez L, la Rosa GP, Vigueras-Moreno R, Ortiz-Stern A, López-Vidal Y, Macías AE, Torres-Flores J, Rojas-Martínez O, Suárez-Martínez A, Peralta-Sánchez G, Kawabata H, González-Domínguez I, Martínez-Guevara JL, Sun W, Sarfati-Mizrahi D, Soto-Priante E, Chagoya-Cortés HE, López-Macías C, Castro-Peralta F, Palese P, García-Sastre A, Krammer F, Lozano-Dubernard B.medRxiv. 2022 Feb 9:2022.02.08.22270676. doi: 10.1101/2022.02.08.22270676. Preprint.PMID: 35169806

Modeling SARS-CoV-2: Comparative Pathology in Rhesus Macaque and Golden Syrian Hamster Models.Choudhary S, Kanevsky I, Yildiz S, Sellers RS, Swanson KA, Franks T, Rathnasinghe R, Munoz-Moreno R, Jangra S, Gonzalez O, Meade P, Coskran T, Qian J, Lanz TA, Johnson JG, Tierney CA, Smith JD, Tompkins K, Illenberger A, Corts P, Ciolino T, Dormitzer PR, Dick EJ Jr, Shivanna V, Hall-Ursone S, Cole J, Kaushal D, Fontenot JA, Martinez-Romero C, McMahon M, Krammer F, Schotsaert M, García-Sastre A.Toxicol Pathol. 2022 Feb 5:1926233211072767. doi: 10.1177/01926233211072767. Online ahead of print.PMID: 35128980

Impacts of rapid mass vaccination against SARS-CoV2 in an early variant of concern hotspot.Paetzold J, Kimpel J, Bates K, Hummer M, Krammer F, von Laer D, Winner H.Nat Commun. 2022 Feb 1;13(1):612. doi: 10.1038/s41467-022-28233-8.PMID: 35105889

mRNA-1273 vaccine-induced antibodies maintain Fc effector functions across SARS-CoV-2 variants of concern.Kaplonek P, Fischinger S, Cizmeci D, Bartsch YC, Kang J, Burke JS, Shin SA, Dayal D, Martin P, Mann C, Amanat F, Julg B, Nilles EJ, Musk ER, Menon AS, Krammer F, Saphire EO, Andrea Carfi, Alter G.Immunity. 2022 Feb 8;55(2):355-365.e4. doi: 10.1016/j.immuni.2022.01.001. Epub 2022 Jan 6.PMID: 35090580

Broadly neutralizing antibodies target a haemagglutinin anchor epitope. Guthmiller JJ, Han J, Utset HA, Li L, Lan LY, Henry C, Stamper CT, McMahon M, O’Dell G, Fernández-Quintero ML, Freyn AW, Amanat F, Stovicek O, Gentles L, Richey ST, de la Peña AT, Rosado V, Dugan HL, Zheng NY, Tepora ME, Bitar DJ, Changrob S, Strohmeier S, Huang M, García-Sastre A, Liedl KR, Bloom JD, Nachbagauer R, Palese P, Krammer F, Coughlan L, Ward AB, Wilson PC.Nature. 2022 Feb;602(7896):314-320. doi: 10.1038/s41586-021-04356-8. Epub 2021 Dec 23.PMID: 34942633

SARS-CoV-2 breakthrough infections in vaccinated individuals: measurement, causes and impact. Lipsitch M, Krammer F, Regev-Yochay G, Lustig Y, Balicer RD.Nat Rev Immunol. 2022 Jan;22(1):57-65. doi: 10.1038/s41577-021-00662-4. Epub 2021 Dec 7.PMID: 34876702

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains.Ying B, Whitener B, VanBlargan LA, Hassan AO, Shrihari S, Liang CY, Karl CE, Mackin S, Chen RE, Kafai NM, Wilks SH, Smith DJ, Carreño JM, Singh G, Krammer F, Carfi A, Elbashir SM, Edwards DK, Thackray LB, Diamond MS.Sci Transl Med. 2022 Feb 2;14(630):eabm3302. doi: 10.1126/scitranslmed.abm3302. Epub 2022 Feb 2.PMID: 34846168

2021 Publications

 

Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron.Carreño JM, Alshammary H, Tcheou J, Singh G, Raskin A, Kawabata H, Sominsky L, Clark J, Adelsberg DC, Bielak D, Gonzalez-Reiche AS, Dambrauskas N, Vigdorovich V; PSP/PARIS Study Group, Srivastava K, Sather DN, Sordillo EM, Bajic G, van Bakel H, Simon V, Krammer F.Nature. 2021 Dec 31. doi: 10.1038/s41586-022-04399-5. Online ahead of print.PMID: 35016197

Vaccination with SARS-CoV-2 variants of concern protects mice from challenge with wild-type virusAmanat F, Strohmeier S, Meade PS, Dambrauskas N, Mühlemann B, Smith DJ, Vigdorovich V, Sather DN, Coughlan L, Krammer F.PLoS Biol. 2021 Dec 16;19(12):e3001384. doi: 10.1371/journal.pbio.3001384. eCollection 2021 Dec.PMID: 34914685

Host predictors of broadly cross-reactive antibodies against SARS-CoV-2 variants of concern differ between infection and vaccination. Tang L, Cherry S, Tuomanen EI, Roubidoux EK, Lin CY, Allison KJ, Gowen A, Freiden P, Allen EK, Su Y, Gaur AH, Estepp JH, McGargill MA, Krammer F, Thomas PG, Schultz-Cherry S, Wolf J; St. Jude Investigative Team.Clin Infect Dis. 2021 Dec 10:ciab996. doi: 10.1093/cid/ciab996. Online ahead of print.PMID: 34891165

Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA. Oh JE, Song E, Moriyama M, Wong P, Zhang S, Jiang R, Strohmeier S, Kleinstein SH, Krammer F, Iwasaki A.Sci Immunol. 2021 Dec 10;6(66):eabj5129. doi: 10.1126/sciimmunol.abj5129. Epub 2021 Dec 10.PMID: 34890255

SARS-CoV-2 breakthrough infections in vaccinated individuals: measurement, causes and impact.Lipsitch M, Krammer F, Regev-Yochay G, Lustig Y, Balicer RD.Nat Rev Immunol. 2021 Dec 7:1-9. doi: 10.1038/s41577-021-00662-4. Online ahead of print.PMID: 34876702

Safety and Immunogenicity Analysis of a Newcastle Disease Virus (NDV-HXP-S) Expressing the Spike Protein of SARS-CoV-2 in Sprague Dawley Rats.Tcheou J, Raskin A, Singh G, Kawabata H, Bielak D, Sun W, González-Domínguez I, Sather DN, García-Sastre A, Palese P, Krammer F, Carreño JM.Front Immunol. 2021 Nov 18;12:791764. doi: 10.3389/fimmu.2021.791764. eCollection 2021.PMID: 34868082

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses. Alameh MG, Tombácz I, Bettini E, Lederer K, Sittplangkoon C, Wilmore JR, Gaudette BT, Soliman OY, Pine M, Hicks P, Manzoni TB, Knox JJ, Johnson JL, Laczkó D, Muramatsu H, Davis B, Meng W, Rosenfeld AM, Strohmeier S, Lin PJC, Mui BL, Tam YK, Karikó K, Jacquet A, Krammer F, Bates P, Cancro MP, Weissman D, Luning Prak ET, Allman D, Locci M, Pardi N.Immunity. 2021 Nov 4;54(12):2877-2892.e7. doi: 10.1016/j.immuni.2021.11.001. Online ahead of print.PMID: 34852217

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains. Ying B, Whitener B, VanBlargan LA, Hassan AO, Shrihari S, Liang CY, Karl CE, Mackin S, Chen RE, Kafai NM, Wilks SH, Smith DJ, Carreño JM, Singh G, Krammer F, Carfi A, Elbashir SM, Edwards DK, Thackray LB, Diamond MS.

A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model. Strohmeier S, Amanat F, Zhu X, McMahon M, Deming ME, Pasetti MF, Neuzil KM, Wilson IA, Krammer F.mBio. 2021 Nov 23:e0224121. doi: 10.1128/mBio.02241-21. Online ahead of print.PMID: 34809451

SARS-CoV-2 during pregnancy and associated outcomes: Results from an ongoing prospective cohort. Molenaar NM, Rommel AS, de Witte L, Dolan SM, Lieb W, Ibroci E, Ohrn S, Lynch J, Capuano C, Stadlbauer D, Krammer F, Zapata LB, Brody RI, Pop VJ, Jessel RH, Sperling RS, Afzal O, Gigase F, Missall R, Janevic T, Stone J, Howell EA, Bergink V.Paediatr Perinat Epidemiol. 2021 Nov 21. doi: 10.1111/ppe.12812. Online ahead of print.PMID: 34806193

Synthetic vaccine affords full protection to mice against lethal challenge of influenza B virus of both genetic lineages. Gravel C, Muralidharan A, Duran A, Zetner A, Pfeifle A, Zhang W, Hashem A, Tamming L, Farnsworth A, Loemba H, Chen W, Krammer F, Safronetz D, Cao J, Wang L, Sauve S, Rosu-Myles M, Van Domselaar G, Li X.iScience. 2021 Oct 21;24(11):103328. doi: 10.1016/j.isci.2021.103328. eCollection 2021 Nov 19.PMID: 34805790

Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination. Wild K, Smits M, Killmer S, Strohmeier S, Neumann-Haefelin C, Bengsch B, Krammer F, Schwemmle M, Hofmann M, Thimme R, Zoldan K, Boettler T.Nat Commun. 2021 Nov 18;12(1):6720. doi: 10.1038/s41467-021-27064-3.PMID: 34795301

Cross-Neutralization of Emerging SARS-CoV-2 Variants of Concern by Antibodies Targeting Distinct Epitopes on Spike. Changrob S, Fu Y, Guthmiller JJ, Halfmann PJ, Li L, Stamper CT, Dugan HL, Accola M, Rehrauer W, Zheng NY, Huang M, Wang J, Erickson SA, Utset HA, Graves HM, Amanat F, Sather DN, Krammer F, Kawaoka Y, Wilson PC.mBio. 2021 Nov 16:e0297521. doi: 10.1128/mBio.02975-21. Online ahead of print.PMID: 34781736

A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses. Sun W, Liu Y, Amanat F, González-Domínguez I, McCroskery S, Slamanig S, Coughlan L, Rosado V, Lemus N, Jangra S, Rathnasinghe R, Schotsaert M, Martinez JL, Sano K, Mena I, Innis BL, Wirachwong P, Thai DH, Oliveira RDN, Scharf R, Hjorth R, Raghunandan R, Krammer F, García-Sastre A, Palese P.

Variable cellular responses to SARS-CoV-2 in fully vaccinated patients with multiple myeloma. Aleman A, Upadhyaya B, Tuballes K, Kappes K, Gleason CR, Beach K, Agte S, Srivastava K; PVI/Seronet Study Group, Van Oekelen O, Barcessat V, Bhardwaj N, Kim-Schulze S, Gnjatic S, Brown B, Cordon-Cardo C, Krammer F, Merad M, Jagannath S, Wajnberg A, Simon V, Parekh S.

Immunity elicited by natural infection or Ad26.COV2.S vaccination protects hamsters against SARS-CoV-2 variants of concern. Tostanoski LH, Yu J, Mercado NB, McMahan K, Jacob-Dolan C, Martinot AJ, Piedra-Mora C, Anioke T, Chang A, Giffin VM, Hope DL, Wan H, Bondzie EA, Mahrokhian SH, Wrijil LM, Bauer K, Pessaint L, Porto M, Piegols J, Faudree A, Spence B, Kar S, Amanat F, Krammer F, Andersen H, Lewis MG, Wegmann F, Zahn R, Schuitemaker H, Barouch DH.

An Assessment of Serological Assays for SARS-CoV-2 as Surrogates for Authentic Virus Neutralization. Wohlgemuth N, Whitt K, Cherry S, Kirkpatrick Roubidoux E, Lin CY, Allison KJ, Gowen A, Freiden P, Allen EK; St. Jude Investigative Team,, Gaur AH, Estepp JH, Tang L, Mori T, Hijano DR, Hakim H, McGargill MA, Krammer F, Whitt MA, Wolf J, Thomas PG, Schultz-Cherry S.

Longitudinal humoral antibody response to SARS-CoV-2 infection among healthcare workers in a New York City hospital. Menon V, Shariff MA, Perez Gutierrez V, Carreño JM, Yu B, Jawed M, Gossai M, Valdez E, Pillai A, Venugopal U, Kasubhai M, Dimitrov V, Krammer F.

Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus. Arunkumar GA, Bhavsar D, Li T, Strohmeier S, Chromikova V, Amanat F, Bunyatov M, Wilson PC, Ellebedy AH, Boons GJ, Simon V, de Vries RP, Krammer F.

Evidence for retained spike-binding and neutralizing activity against emerging SARS-CoV-2 variants in serum of COVID-19 mRNA vaccine recipients. Carreño JM, Alshammary H, Singh G, Raskin A, Amanat F, Amoako A, Gonzalez-Reiche AS, van de Guchte A, Study Group P, Srivastava K, Sordillo EM, Sather DN, van Bakel H, Krammer F, Simon V.

Human anti-neuraminidase antibodies reduce airborne transmission of clinical influenza virus isolates in the guinea pig model. Tan J, O’Dell G, Hernandez MM, Sordillo EM, Kahn Z, Kriti D, van Bakel H, Ellebedy AH, Wilson PC, Simon V, Krammer F, McMahon M.

Mosaic Hemagglutinin-Based Whole Inactivated Virus Vaccines Induce Broad Protection Against Influenza B Virus Challenge in Mice . Liu Y, Strohmeier S, González-Domínguez I, Tan J, Simon V, Krammer F, García-Sastre A, Palese P, Sun W.Front Immunol. 2021 Sep 16;12:746447. doi: 10.3389/fimmu.2021.746447. eCollection 2021.PMID: 34603333

Safety and Immunogenicity of an Inactivated Recombinant Newcastle Disease Virus Vaccine Expressing SARS-CoV-2 Spike: Interim Results of a Randomised, Placebo-Controlled, Phase 1/2 Trial. Pitisuttithum P, Luvira V, Lawpoolsri S, Muangnoicharoen S, Kamolratanakul S, Sivakorn C, Narakorn P, Surichan S, Prangpratanporn S, Puksuriwong S, Lamola S, Mercer LD, Raghunandan R, Sun W, Liu Y, Carreño JM, Scharf R, Phumratanaprapin W, Amanat F, Gagnon L, Hsieh CL, Kaweepornpoj R, Khan S, Lal M, McCroskery S, McLellan J, Mena I, Meseck M, Phonrat B, Sabmee Y, Singchareon R, Slamanig S, Suthepakul N, Tcheou J, Thantamnu N, Theerasurakarn S, Tran S, Vilasmongkolchai T, White JA, Garcia-Sastre A, Palese P, Krammer F, Poopipatpol K, Wirachwong P, Hjorth R, Innis BL.medRxiv. 2021 Sep 22:2021.09.17.21263758. doi: 10.1101/2021.09.17.21263758. Preprint.PMID: 34580673

Safety and Immunogenicity of a Newcastle Disease Virus Vector-Based SARS-CoV-2 Vaccine Candidate, AVX/COVID-12-HEXAPRO (Patria), in Pigs. Lara-Puente JH, Carreño JM, Sun W, Suárez-Martínez A, Ramírez-Martínez L, Quezada-Monroy F, Paz-De la Rosa G, Vigueras-Moreno R, Singh G, Rojas-Martínez O, Chagoya-Cortés HE, Sarfati-Mizrahi D, Soto-Priante E, López-Macías C, Krammer F, Castro-Peralta F, Palese P, García-Sastre A, Lozano-Dubernard B.mBio. 2021 Sep 21:e0190821. doi: 10.1128/mBio.01908-21. Online ahead of print.PMID: 34544278

Subtle immunological differences in mRNA-1273 and BNT162b2 COVID-19 vaccine induced Fc-functional profiles. Kaplonek P, Cizmeci D, Fischinger S, Collier AR, Suscovich T, Linde C, Broge T, Mann C, Amanat F, Dayal D, Rhee J, de St Aubin M, Nilles EJ, Musk ER, Menon AS, Saphire EO, Krammer F, Lauffenburger DA, Barouch DH, Alter G.bioRxiv. 2021 Aug 31:2021.08.31.458247. doi: 10.1101/2021.08.31.458247. Preprint.PMID: 34494026

Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination. Gorman MJ, Patel N, Guebre-Xabier M, Zhu AL, Atyeo C, Pullen KM, Loos C, Goez-Gazi Y, Carrion R Jr, Tian JH, Yuan D, Bowman KA, Zhou B, Maciejewski S, McGrath ME, Logue J, Frieman MB, Montefiori D, Mann C, Schendel S, Amanat F, Krammer F, Saphire EO, Lauffenburger D, Greene AM, Portnoff AD, Massare MJ, Ellingsworth L, Glenn G, Smith G, Alter G.Cell Rep Med. 2021 Aug 31:100405. doi: 10.1016/j.xcrm.2021.100405. Online ahead of print.PMID: 34485950

Antigen modifications improve nucleoside-modified mRNA-based influenza virus vaccines in mice. Freyn AW, Pine M, Rosado VC, Benz M, Muramatsu H, Beattie M, Tam YK, Krammer F, Palese P, Nachbagauer R, McMahon M, Pardi N.Mol Ther Methods Clin Dev. 2021 Jun 12;22:84-95. doi: 10.1016/j.omtm.2021.06.003. eCollection 2021 Sep 10.PMID: 34485597

Influenza A viruses balance ER stress with host protein synthesis shutoff. Mazel-Sanchez B, Iwaszkiewicz J, Bonifacio JPP, Silva F, Niu C, Strohmeier S, Eletto D, Krammer F, Tan G, Zoete V, Hale BG, Schmolke M.Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2024681118. doi: 10.1073/pnas.2024681118.PMID: 34479996

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains. Ying B, Whitener B, VanBlargan LA, Hassan AO, Shrihari S, Liang CY, Karl CE, Mackin S, Chen RE, Kafai NM, Wilks SH, Smith DJ, Carreño JM, Singh G, Krammer F, Carfi A, Elbashir S, Edwards DK, Thackray LB, Diamond MS.bioRxiv. 2021 Aug 26:2021.08.25.457693. doi: 10.1101/2021.08.25.457693. Preprint.PMID: 34462745

Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity. Zhang W, Chua B, Selva K, Kedzierski L, Ashhurst T, Haycroft E, Shoffner S, Hensen L, Boyd D, James F, Mouhtouris E, Kwong J, Chua K, Drewett G, Copaescu A, Dobson J, Rowntree L, Habel J, Allen L, Koay HF, Neil J, Gartner M, Lee C, Andersson P, Seemann T, Sherry N, Amanat F, Krammer F, Londrigan S, Wakim L, King N, Godfrey D, Mackay L, Thomas P, Nicholson S, Arnold K, Chung A, Holmes N, Smibert O, Trubiano J, Gordon C, Nguyen T, Kedzierska K.Res Sq. 2021 Aug 26:rs.3.rs-802084. doi: 10.21203/rs.3.rs-802084/v1. Preprint.PMID: 34462740

The Human Antibody Response to the Influenza Virus Neuraminidase Following Infection or Vaccination. Rajendran M, Krammer F, McMahon M.Vaccines (Basel). 2021 Aug 2;9(8):846. doi: 10.3390/vaccines9080846.PMID: 34451971

Household level SARS-CoV-2 sero-epidemiology in a high prevalence group of adults and children-implications for community infection control. Werzberger A, Carreño JM, Team SS, Polinger A, Krammer F, Zachariah P.Am J Infect Control. 2021 Aug 20:S0196-6553(21)00549-6. doi: 10.1016/j.ajic.2021.08.015. Online ahead of print.PMID: 34425179

FcRn-Targeted Mucosal Vaccination against Influenza Virus Infection. Ochsner SP, Li W, Rajendrakumar AM, Palaniyandi S, Acharya G, Liu X, Wang G,Krammer F, Shi M, Tuo W, Pauza CD, Zhu X.J Immunol. 2021 Sep 1;207(5):1310-1321. doi: 10.4049/jimmunol.2100297. Epub 2021 Aug 11.PMID: 34380652

Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study.IMPACC Manuscript Writing Team; IMPACC Network Steering Committee.Sci Immunol. 2021 Aug 10;6(62):eabf3733. doi: 10.1126/sciimmunol.abf3733.PMID: 34376480

Novel TLR4 adjuvant elicits protection against homologous and heterologous Influenza A infection. Haupt RE, Harberts EM, Kitz RJ, Strohmeier S, Krammer F, Ernst RK, Frieman MB.Vaccine. 2021 Aug 23;39(36):5205-5213. doi: 10.1016/j.vaccine.2021.06.085. Epub 2021 Aug 3.PMID: 34362603

Administration of Multivalent Influenza Virus Recombinant Hemagglutinin Vaccine in Combination-Adjuvant Elicits Broad Reactivity Beyond the Vaccine Components. Hernandez-Davies JE, Felgner J, Strohmeier S, Pone EJ, Jain A, Jan S, Nakajima R, Jasinskas A, Strahsburger E, Krammer F, Felgner PL, Davies DH.Front Immunol. 2021 Jul 14;12:692151. doi: 10.3389/fimmu.2021.692151. eCollection 2021.PMID: 34335601

Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models. van Doremalen N, Purushotham JN, Schulz JE, Holbrook MG, Bushmaker T, Carmody A, Port JR, Yinda CK, Okumura A, Saturday G, Amanat F, Krammer F, Hanley PW, Smith BJ, Lovaglio J, Anzick SL, Barbian K, Martens C, Gilbert SC, Lambe T, Munster VJ.Sci Transl Med. 2021 Jul 27:eabh0755. doi: 10.1126/scitranslmed.abh0755. Online ahead of print.PMID: 34315826

Cross neutralization of emerging SARS-CoV-2 variants of concern by antibodies targeting distinct epitopes on spike.Wilson P, Changrob S, Fu Y, Guthmiller J, Halfmann P, Li L, Stamper C, Dugan H, Accola M, Rehrauer W, Zheng NY, Huang M, Wang J, Erickson S, Utset H, Graves H, Amanat F, Sather DN, Krammer F, Kawaoka Y.Res Sq. 2021 Jul 19:rs.3.rs-678247. doi: 10.21203/rs.3.rs-678247/v1. Preprint.PMID: 34312615

Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial.Rouphael NG, Lai L, Tandon S, McCullough MP, Kong Y, Kabbani S, Natrajan MS, Xu Y, Zhu Y, Wang D, O’Shea J, Sherman A, Yu T, Henry S, McAllister D, Stadlbauer D, Khurana S, Golding H, Krammer F, Mulligan MJ, Prausnitz MR.NPJ Vaccines. 2021 Jul 14;6(1):89. doi: 10.1038/s41541-021-00353-0.PMID: 34262052

Highly variable SARS-CoV-2 spike antibody responses to two doses of COVID-19 RNA vaccination in patients with multiple myeloma. Van Oekelen O, Gleason CR, Agte S, Srivastava K, Beach KF, Aleman A, Kappes K; PVI/Seronet team, Mouhieddine TH, Wang B, Chari A, Cordon-Cardo C, Krammer F, Jagannath S, Simon V, Wajnberg A, Parekh S.Cancer Cell. 2021 Jun 29:S1535-6108(21)00336-6. doi: 10.1016/j.ccell.2021.06.014. Online ahead of print.PMID: 34242572

A correlate of protection for SARS-CoV-2 vaccines is urgently needed. Krammer F.Nat Med. 2021 Jul 8. doi: 10.1038/s41591-021-01432-4. Online ahead of print.PMID: 34239135

SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2. Amanat F, Thapa M, Lei T, Ahmed SMS, Adelsberg DC, Carreño JM, Strohmeier S, Schmitz AJ, Zafar S, Zhou JQ, Rijnink W, Alshammary H, Borcherding N, Reiche AG, Srivastava K, Sordillo EM, van Bakel H; Personalized Virology Initiative, Turner JS, Bajic G, Simon V, Ellebedy AH, Krammer F.Cell. 2021 Jun 8:S0092-8674(21)00706-6. doi: 10.1016/j.cell.2021.06.005. Online ahead of print.PMID: 34192529

SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses.Turner JS, O’Halloran JA, Kalaidina E, Kim W, Schmitz AJ, Zhou JQ, Lei T, Thapa M, Chen RE, Case JB, Amanat F, Rauseo AM, Haile A, Xie X, Klebert MK, Suessen T, Middleton WD, Shi PY, Krammer F, Teefey SA, Diamond MS, Presti RM, Ellebedy AH.Nature. 2021 Jun 28. doi: 10.1038/s41586-021-03738-2. Online ahead of print.PMID: 34182569

Limited intestinal inflammation despite diarrhea, fecal viral RNA and SARS-CoV-2-specific IgA in patients with acute COVID-19.Britton GJ, Chen-Liaw A, Cossarini F, Livanos AE, Spindler MP, Plitt T, Eggers J, Mogno I, Gonzalez-Reiche AS, Siu S, Tankelevich M, Grinspan LT, Dixon RE, Jha D, van de Guchte A, Khan Z, Martinez-Delgado G, Amanat F, Hoagland DA, tenOever BR, Dubinsky MC, Merad M, van Bakel H, Krammer F, Bongers G, Mehandru S, Faith JJ.Sci Rep. 2021 Jun 25;11(1):13308. doi: 10.1038/s41598-021-92740-9.PMID: 34172783

Immunological imprinting of the antibody response in COVID-19 patients.Aydillo T, Rombauts A, Stadlbauer D, Aslam S, Abelenda-Alonso G, Escalera A, Amanat F, Jiang K, Krammer F, Carratala J, García-Sastre A.Nat Commun. 2021 Jun 18;12(1):3781. doi: 10.1038/s41467-021-23977-1.PMID: 34145263

Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans. Alter G, Yu J, Liu J, Chandrashekar A, Borducchi EN, Tostanoski LH, McMahan K, Jacob-Dolan C, Martinez DR, Chang A, Anioke T, Lifton M, Nkolola J, Stephenson KE, Atyeo C, Shin S, Fields P, Kaplan I, Robins H, Amanat F, Krammer F, Baric RS, Le Gars M, Sadoff J, de Groot AM, Heerwegh D, Struyf F, Douoguih M, van Hoof J, Schuitemaker H, Barouch DH.Nature. 2021 Jun 9. doi: 10.1038/s41586-021-03681-2. Online ahead of print.PMID: 3410752

SARS-CoV-2 vaccines for all but a single dose for COVID-19 survivors. Frieman M, Harris AD, Herati RS, Krammer F, Mantovani A, Rescigno M, Sajadi MM, Simon V.EBioMedicine. 2021 May 25;68:103401. doi: 10.1016/j.ebiom.2021.103401. Online ahead of print.PMID: 34051441

Long-lasting neutralizing antibody responses in SARS-CoV-2 seropositive individuals are robustly boosted by immunization with the CoronaVac and BNT162b2 vaccines.Muena NA, García-Salum T, Pardo-Roa C, Serrano EF, Levican J, Avendaño MJ, Almonacid LI, Valenzuela G, Poblete E, Strohmeier S, Salinas E, Haslwanter D, Dieterle ME, Jangra RK, Chandran K, González C, Riquelme A, Krammer F, Tischler ND, Medina RA.medRxiv. 2021 May 18:2021.05.17.21257197. doi: 10.1101/2021.05.17.21257197. Preprint.PMID: 34031662

Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets.Dugan HL, Stamper CT, Li L, Changrob S, Asby NW, Halfmann PJ, Zheng NY, Huang M, Shaw DG, Cobb MS, Erickson SA, Guthmiller JJ, Stovicek O, Wang J, Winkler ES, Madariaga ML, Shanmugarajah K, Jansen MO, Amanat F, Stewart I, Utset HA, Huang J, Nelson CA, Dai YN, Hall PD, Jedrzejczak RP, Joachimiak A, Krammer F, Diamond MS, Fremont DH, Kawaoka Y, Wilson PC.Immunity. 2021 May 6:S1074-7613(21)00198-9. doi: 10.1016/j.immuni.2021.05.001. Online ahead of print.PMID: 34022127

CD8⁺ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity.Nguyen THO, Rowntree LC, Petersen J, Chua BY, Hensen L, Kedzierski L, van de Sandt CE, Chaurasia P, Tan HX, Habel JR, Zhang W, Allen LF, Earnest L, Mak KY, Juno JA, Wragg K, Mordant FL, Amanat F, Krammer F, Mifsud NA, Doolan DL, Flanagan KL, Sonda S, Kaur J, Wakim LM, Westall GP, James F, Mouhtouris E, Gordon CL, Holmes NE, Smibert OC, Trubiano JA, Cheng AC, Harcourt P, Clifton P, Crawford JC, Thomas PG, Wheatley AK, Kent SJ, Rossjohn J, Torresi J, Kedzierska K.Immunity. 2021 May 11;54(5):1066-1082.e5. doi: 10.1016/j.immuni.2021.04.009. Epub 2021 Apr 15.PMID: 33951417

Refocusing the Immune Response to Selected Epitopes on a Zika Virus Protein Antigen by Nanopatterning.Castro A, Carreño JM, Duehr J, Krammer F, Kane RS.Adv Healthc Mater. 2021 Apr 30:e2002140. doi: 10.1002/adhm.202002140. Online ahead of print.PMID: 33929789

Introduction of Cysteines in the Stalk Domain of Recombinant Influenza Virus N1 Neuraminidase Enhances Protein Stability and Immunogenicity in Mice.Strohmeier S, Carreño JM, Brito RN, Krammer F.Vaccines (Basel). 2021 Apr 19;9(4):404. doi: 10.3390/vaccines9040404.PMID: 33921722

Attack rates amongst household members of outpatients with confirmed COVID-19 in Bergen, Norway: A case-ascertained study.Kuwelker K, Zhou F, Blomberg B, Lartey S, Brokstad KA, Trieu MC, Bansal A, Madsen A, Krammer F, Mohn KG, Tøndel C, Linchausen DW, Cox RJ, Langeland N; Bergen COVID-19 research group.Lancet Reg Health Eur. 2021 Apr;3:100014. doi: 10.1016/j.lanepe.2020.100014. Epub 2021 Mar 31.PMID: 33871470

SARS-CoV-2 seropositivity and subsequent infection risk in healthy young adults: a prospective cohort study.Letizia AG, Ge Y, Vangeti S, Goforth C, Weir DL, Kuzmina NA, Balinsky CA, Chen HW, Ewing D, Soares-Schanoski A, George MC, Graham WD, Jones F, Bharaj P, Lizewski RA, Lizewski SE, Marayag J, Marjanovic N, Miller CM, Mofsowitz S, Nair VD, Nunez E, Parent DM, Porter CK, Santa Ana E, Schilling M, Stadlbauer D, Sugiharto VA, Termini M, Sun P, Tracy RP, Krammer F, Bukreyev A, Ramos I, Sealfon SC.Lancet Respir Med. 2021 Apr 15:S2213-2600(21)00158-2. doi: 10.1016/S2213-2600(21)00158-2. Online ahead of print.PMID: 33865504

SARS-CoV-2 spike E484K mutation reduces antibody neutralisation.Jangra S, Ye C, Rathnasinghe R, Stadlbauer D; Personalized Virology Initiative study group, Krammer F, Simon V, Martinez-Sobrido L, García-Sastre A, Schotsaert M.Lancet Microbe. 2021 Apr 7. doi: 10.1016/S2666-5247(21)00068-9. Online ahead of print.PMID: 33846703

Correlates of protection from SARS-CoV-2 infection.Krammer F.Lancet. 2021 Apr 17;397(10283):1421-1423. doi: 10.1016/S0140-6736(21)00782-0. Epub 2021 Apr 9.PMID: 33844964

Differential T cell reactivity to endemic coronaviruses and SARS-CoV-2 in community and health care workers.da Silva Antunes R, Pallikkuth S, Williams E, Esther DY, Mateus J, Quiambao L, Wang E, Rawlings SA, Stadlbauer D, Jiang K, Amanat F, Arnold D, Andrews D, Fuego I, Dan JM, Grifoni A, Weiskopf D, Krammer F, Crotty S, Hoffer ME, Pahwa SG, Sette A.J Infect Dis. 2021 Apr 2:jiab176. doi: 10.1093/infdis/jiab176. Online ahead of print.PMID: 33822097

Persistently high antibody responses after AS03-adjuvanted H1N1pdm09 vaccine: Dissecting the HA specific antibody response.Madsen A, Jul-Larsen Å, Trieu MC, Krammer F, Cox RJ.NPJ Vaccines. 2021 Apr 1;6(1):45. doi: 10.1038/s41541-021-00308-5.PMID: 33795694

Systems serology detects functionally distinct coronavirus antibody features in children and elderly.Selva KJ, van de Sandt CE, Lemke MM, Lee CY, Shoffner SK, Chua BY, Davis SK, Nguyen THO, Rowntree LC, Hensen L, Koutsakos M, Wong CY, Mordant F, Jackson DC, Flanagan KL, Crowe J, Tosif S, Neeland MR, Sutton P, Licciardi PV, Crawford NW, Cheng AC, Doolan DL, Amanat F, Krammer F, Chappell K, Modhiran N, Watterson D, Young P, Lee WS, Wines BD, Mark Hogarth P, Esterbauer R, Kelly HG, Tan HX, Juno JA, Wheatley AK, Kent SJ, Arnold KB, Kedzierska K, Chung AW.Nat Commun. 2021 Apr 1;12(1):2037. doi: 10.1038/s41467-021-22236-7.PMID: 33795692

A public vaccine-induced human antibody protects against SARS-CoV-2 and emerging variants.Schmitz AJ, Turner JS, Liu Z, Aziati ID, Chen RE, Joshi A, Bricker TL, Darling TL, Adelsberg DC, Alsoussi WB, Case JB, Lei T, Thapa M, Amanat F, O’Halloran JA, Shi PY, Presti RM, Krammer F, Bajic G, Whelan SPJ, Diamond MS, Boon ACM, Ellebedy AH.bioRxiv. 2021 Mar 24:2021.03.24.436864. doi: 10.1101/2021.03.24.436864. Preprint.PMID: 33791696

Inhibition of HECT E3 ligases as potential therapy for COVID-19.Novelli G, Liu J, Biancolella M, Alonzi T, Novelli A, Patten JJ, Cocciadiferro D, Agolini E, Colona VL, Rizzacasa B, Giannini R, Bigio B, Goletti D, Capobianchi MR, Grelli S, Mann J, McKee TD, Cheng K, Amanat F, Krammer F, Guarracino A, Pepe G, Tomino C, Tandjaoui-Lambiotte Y, Uzunhan Y, Tubiana S, Ghosn J; COVID Human Genetic Effort; French COVID Cohort Study Group; CoV-Contact Cohort, Notarangelo LD, Su HC, Abel L, Cobat A, Elhanan G, Grzymski JJ, Latini A, Sidhu SS, Jain S, Davey RA, Casanova JL, Wei W, Pandolfi PP.Cell Death Dis. 2021 Mar 24;12(4):310. doi: 10.1038/s41419-021-03513-1.PMID: 33762578

The plasmablast response to SARS-CoV-2 mRNA vaccination is dominated by non-neutralizing antibodies that target both the NTD and the RBD.Amanat F, Thapa M, Lei T, Ahmed SMS, Adelsberg DC, Carreno JM, Strohmeier S, Schmitz AJ, Zafar S, Zhou JQ, Rijnink W, Alshammary H, Borcherding N, Reiche AG, Srivastava K, Sordillo EM, van Bakel H; Personalized Virology Initiative, Turner JS, Bajic G, Simon V, Ellebedy AH, Krammer F.medRxiv. 2021 Mar 9:2021.03.07.21253098. doi: 10.1101/2021.03.07.21253098. Preprint.PMID: 33758878

AS03-adjuvanted H7N9 inactivated split virion vaccines induce cross-reactive and protective responses in ferrets.Stadlbauer D, Waal L, Beaulieu E, Strohmeier S, Kroeze EJBV, Boutet P, Osterhaus ADME, Krammer F, Innis BL, Nachbagauer R, Stittelaar KJ, Mallett CP.NPJ Vaccines. 2021 Mar 19;6(1):40. doi: 10.1038/s41541-021-00299-3.PMID: 33742000

Integrated immune dynamics define correlates of COVID-19 severity and antibody responses.Koutsakos M, Rowntree LC, Hensen L, Chua BY, van de Sandt CE, Habel JR, Zhang W, Jia X, Kedzierski L, Ashhurst TM, Putri GH, Marsh-Wakefield F, Read MN, Edwards DN, Clemens EB, Wong CY, Mordant FL, Juno JA, Amanat F, Audsley J, Holmes NE, Gordon CL, Smibert OC, Trubiano JA, Hughes CM, Catton M, Denholm JT, Tong SYC, Doolan DL, Kotsimbos TC, Jackson DC, Krammer F, Godfrey DI, Chung AW, King NJC, Lewin SR, Wheatley AK, Kent SJ, Subbarao K, McMahon J, Thevarajan I, Nguyen THO, Cheng AC, Kedzierska K.Cell Rep Med. 2021 Mar 16;2(3):100208. doi: 10.1016/j.xcrm.2021.100208. Epub 2021 Feb 5.PMID: 33564749

The first 12 months of COVID-19: a timeline of immunological insights.Carvalho T, Krammer F, Iwasaki A.Nat Rev Immunol. 2021 Apr;21(4):245-256. doi: 10.1038/s41577-021-00522-1. Epub 2021 Mar 15.PMID: 33723416

Antibody Responses in Seropositive Persons after a Single Dose of SARS-CoV-2 mRNA Vaccine.Krammer F, Srivastava K, Alshammary H, Amoako AA, Awawda MH, Beach KF, Bermúdez-González MC, Bielak DA, Carreño JM, Chernet RL, Eaker LQ, Ferreri ED, Floda DL, Gleason CR, Hamburger JZ, Jiang K, Kleiner G, Jurczyszak D, Matthews JC, Mendez WA, Nabeel I, Mulder LCF, Raskin AJ, Russo KT, Salimbangon AT, Saksena M, Shin AS, Singh G, Sominsky LA, Stadlbauer D, Wajnberg A, Simon V.N Engl J Med. 2021 Apr 8;384(14):1372-1374. doi: 10.1056/NEJMc2101667. Epub 2021 Mar 10.PMID: 33691060

The E484K mutation in the SARS-CoV-2 spike protein reduces but does not abolish neutralizing activity of human convalescent and post-vaccination sera.Jangra S, Ye C, Rathnasinghe R, Stadlbauer D, Krammer F, Simon V, Martinez-Sobrido L, Garcia-Sastre A, Schotsaert M.medRxiv. 2021 Jan 29:2021.01.26.21250543. doi: 10.1101/2021.01.26.21250543. Preprint.PMID: 33532796

Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features.Rowntree LC, Chua BY, Nicholson S, Koutsakos M, Hensen L, Douros C, Selva K, Mordant FL, Wong CY, Habel JR, Zhang W, Jia X, Allen L, Doolan DL, Jackson DC, Wheatley AK, Kent SJ, Amanat F, Krammer F, Subbarao K, Cheng AC, Chung AW, Catton M, Nguyen TH, van de Sandt CE, Kedzierska K.Clin Transl Immunology. 2021 Feb 28;10(3):e1258. doi: 10.1002/cti2.1258. eCollection 2021.PMID: 33680466

SARS-CoV-2 Infection Risk Among Active Duty Military Members Deployed to a Field Hospital – New York City, April 2020.Clifton GT, Pati R, Krammer F, Laing ED, Broder CC, Mendu DR, Simons MP, Chen HW, Sugiharto VA, Kang AD, Stadlbauer D, Pratt KP, Bandera BC, Fritz DK, Millar EV, Burgess TH, Chung KK.MMWR Morb Mortal Wkly Rep. 2021 Mar 5;70(9):308-311. doi: 10.15585/mmwr.mm7009a3.PMID: 33661864

Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse Model.Amanat F, Strohmeier S, Rathnasinghe R, Schotsaert M, Coughlan L, García-Sastre A, Krammer F.mBio. 2021 Mar 2;12(2):e02648-20. doi: 10.1128/mBio.02648-20.PMID: 33653892

Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination.Alter G, Gorman M, Patel N, Guebre-Xabier M, Zhu A, Atyeo C, Pullen K, Loos C, Goez-Gazi Y, Carrion R, Tian JH, Yuan D, Bowman K, Zhou B, Maciejewski S, McGrath M, Logue J, Frieman M, Montefiori D, Schendel S, Saphire EO, Lauffenburger D, Greene A, Portnoff A, Massare M, Ellingsworth L, Glenn G, Smith G, Mann C, Amanat F, Krammer F.Res Sq. 2021 Feb 15:rs.3.rs-200342. doi: 10.21203/rs.3.rs-200342/v1. Preprint.PMID: 33619473

Immunological memory to SARS-CoV-2 assessed for up to eight months after infection.Dan JM, Mateus J, Kato Y, Hastie KM, Yu ED, Faliti CE, Grifoni A, Ramirez SI, Haupt S, Frazier A, Nakao C, Rayaprolu V, Rawlings SA, Peters B, Krammer F, Simon V, Saphire EO, Smith DM, Weiskopf D, Sette A, Crotty S.bioRxiv. 2020 Dec 18:2020.11.15.383323. doi: 10.1101/2020.11.15.383323. Preprint.PMID: 33442687

Quantifying Absolute Neutralization Titers against SARS-CoV-2 by a Standardized Virus Neutralization Assay Allows for Cross-Cohort Comparisons of COVID-19 Sera.Oguntuyo KY, Stevens CS, Hung CT, Ikegame S, Acklin JA, Kowdle SS, Carmichael JC, Chiu HP, Azarm KD, Haas GD, Amanat F, Klingler J, Baine I, Arinsburg S, Bandres JC, Siddiquey MNA, Schilke RM, Woolard MD, Zhang H; COVIDAR Argentina Consortium, Duty AJ, Kraus TA, Moran TM, Tortorella D, Lim JK, Gamarnik AV, Hioe CE, Zolla-Pazner S, Ivanov SS, Kamil JP, Krammer F, Lee B.mBio. 2021 Feb 16;12(1):e02492-20. doi: 10.1128/mBio.02492-20.PMID: 33593976

Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model.Roubidoux EK, Carreño JM, McMahon M, Jiang K, van Bakel H, Wilson P, Krammer F.mBio. 2021 Feb 16;12(1):e03617-20. doi: 10.1128/mBio.03617-20.PMID: 33593972

Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase.Kirkpatrick Roubidoux E, McMahon M, Carreño JM, Capuano C, Jiang K, Simon V, van Bakel H, Wilson P, Krammer F.mSphere. 2021 Feb 10;6(1):e00958-20. doi: 10.1128/mSphere.00958-20.PMID: 33568453

Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 in nonhuman primates following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination.Gorman MJ, Patel N, Guebre-Xabier M, Zhu A, Atyeo C, Pullen KM, Loos C, Goez-Gazi Y, Carrion R, Tian JH, Yaun D, Bowman K, Zhou B, Maciejewski S, McGrath ME, Logue J, Frieman MB, Montefiori D, Mann C, Schendel S, Amanat F, Krammer F, Saphire EO, Lauffenburger D, Greene AM, Portnoff AD, Massare MJ, Ellingsworth L, Glenn G, Smith G, Alter G.bioRxiv. 2021 Feb 5:2021.02.05.429759. doi: 10.1101/2021.02.05.429759. Preprint.PMID: 33564763

The N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized by convalescent and post-vaccination human sera.Rathnasinghe R, Jangra S, Cupic A, Martínez-Romero C, Mulder LCF, Kehrer T, Yildiz S, Choi A, Mena I, De Vrieze J, Aslam S, Stadlbauer D, Meekins DA, McDowell CD, Balaraman V, Richt JA, De Geest BG, Miorin L, Krammer F, Simon V, García-Sastre A, Schotsaert M.medRxiv. 2021 Jan 20:2021.01.19.21249592. doi: 10.1101/2021.01.19.21249592. Preprint.PMID: 33501468

A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity. Matsuda K, Migueles SA, Huang J, Bolkhovitinov L, Stuccio S, Griesman T, Pullano AA, Kang BH, Ishida E, Zimmerman M, Kashyap N, Martins KM, Stadlbauer D, Pederson J, Patamawenu A, Wright N, Shofner T, Evans S, Liang CJ, Candia J, Biancotto A, Fantoni G, Poole A, Smith J, Alexander J, Gurwith M, Krammer F, Connors M.J Clin Invest. 2021 Mar 1;131(5):e140794. doi: 10.1172/JCI140794.PMID: 33529172

Pandemic Vaccines: How Are We Going to Be Better Prepared Next Time? Krammer F.Med (N Y). 2020 Dec 18;1(1):28-32. doi: 10.1016/j.medj.2020.11.004. Epub 2020 Dec 5.PMID: 33521752

Longitudinal SARS-CoV-2 seroconversion and functional heterogeneity in a pediatric dialysis unit.Canas JJ, Starr MC, Hooks J, Arregui S, Wilson AC, Carroll AE, Saxena V, Amanat F, Krammer F, Fill J, Schade A, Chambers A, Schneider J, Schwaderer AL, Hains DS.Kidney Int. 2021 Feb;99(2):484-486. doi: 10.1016/j.kint.2020.11.014.PMID: 33509357

A 10-Minute “Mix and Read” Antibody Assay for SARS-CoV-2.Rusanen J, Kareinen L, Levanov L, Mero S, Pakkanen SH, Kantele A, Amanat F, Krammer F, Hedman K, Vapalahti O, Hepojoki J.Viruses. 2021 Jan 20;13(2):143. doi: 10.3390/v13020143.PMID: 33498157

Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers.da Silva Antunes R, Pallikkuth S, Williams E, Yu ED, Mateus J, Quiambao L, Wang E, Rawlings SA, Stadlbauer D, Jiang K, Amanat F, Arnold D, Andrews D, Fuego I, Dan JM, Grifoni A, Weiskopf D, Krammer F, Crotty S, Hoffer ME, Pahwa SG, Sette A.medRxiv. 2021 Jan 15:2021.01.12.21249683. doi: 10.1101/2021.01.12.21249683. Preprint.PMID: 33469594

SARS-CoV-2 vaccination for patients with inflammatory bowel diseases: recommendations from an international consensus meeting.Siegel CA, Melmed GY, McGovern DP, Rai V, Krammer F, Rubin DT, Abreu MT, Dubinsky MC; International Organization for the Study of Inflammatory Bowel Disease (IOIBD); International Organization for the Study of Inflammatory Bowel Diseases (IOIBD).Gut. 2021 Apr;70(4):635-640. doi: 10.1136/gutjnl-2020-324000. Epub 2021 Jan 20.PMID: 33472895

SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike.Guthmiller JJ, Stovicek O, Wang J, Changrob S, Li L, Halfmann P, Zheng NY, Utset H, Stamper CT, Dugan HL, Miller WD, Huang M, Dai YN, Nelson CA, Hall PD, Jansen M, Shanmugarajah K, Donington JS, Krammer F, Fremont DH, Joachimiak A, Kawaoka Y, Tesic V, Madariaga ML, Wilson PC.mBio. 2021 Jan 19;12(1):e02940-20. doi: 10.1128/mBio.02940-20.PMID: 33468695

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine*.Jangra S, De Vrieze J, Choi A, Rathnasinghe R, Laghlali G, Uvyn A, Van Herck S, Nuhn L, Deswarte K, Zhong Z, Sanders NN, Lienenklaus S, David SA, Strohmeier S, Amanat F, Krammer F, Hammad H, Lambrecht BN, Coughlan L, García-Sastre A, De Geest BG, Schotsaert M.Angew Chem Int Ed Engl. 2021 Apr 19;60(17):9467-9473. doi: 10.1002/anie.202015362. Epub 2021 Mar 11.PMID: 33464672

Chimeric Hemagglutinin-Based Live-Attenuated Vaccines Confer Durable Protective Immunity against Influenza A Viruses in a Preclinical Ferret Model.Liu WC, Nachbagauer R, Stadlbauer D, Strohmeier S, Solórzano A, Berlanda-Scorza F, Innis BL, García-Sastre A, Palese P, Krammer F, Albrecht RA.Vaccines (Basel). 2021 Jan 11;9(1):40. doi: 10.3390/vaccines9010040.PMID: 33440898

Heterologous viral protein interactions within licensed seasonal influenza virus vaccines.Koroleva M, Batarse F, Moritzky S, Henry C, Chaves F, Wilson P, Krammer F, Richards K, Sant AJ.NPJ Vaccines. 2020 Jan 10;5(1):3. doi: 10.1038/s41541-019-0153-1.PMID: 33420089

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.Dan JM, Mateus J, Kato Y, Hastie KM, Yu ED, Faliti CE, Grifoni A, Ramirez SI, Haupt S, Frazier A, Nakao C, Rayaprolu V, Rawlings SA, Peters B, Krammer F, Simon V, Saphire EO, Smith DM, Weiskopf D, Sette A, Crotty S.Science. 2021 Feb 5;371(6529):eabf4063. doi: 10.1126/science.abf4063. Epub 2021 Jan 6.PMID: 33408181

 

2020 Publications

 

A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective Inactivated SARS-CoV-2 Vaccine.Sun W, McCroskery S, Liu WC, Leist SR, Liu Y, Albrecht RA, Slamanig S, Oliva J, Amanat F, Schäfer A, Dinnon KH 3rd, Innis BL, García-Sastre A, Krammer F, Baric RS, Palese P.Vaccines (Basel). 2020 Dec 17;8(4):771. doi: 10.3390/vaccines8040771.PMID: 33348607

H1 Hemagglutinin Priming Provides Long-Lasting Heterosubtypic Immunity against H5N1 Challenge in the Mouse Model.Carreño JM, Strohmeier S, Kirkpatrick Roubidoux E, Hai R, Palese P, Krammer F.mBio. 2020 Dec 15;11(6):e02090-20. doi: 10.1128/mBio.02090-20.PMID: 33323511

Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans.Dugan HL, Guthmiller JJ, Arevalo P, Huang M, Chen YQ, Neu KE, Henry C, Zheng NY, Lan LY, Tepora ME, Stovicek O, Bitar D, Palm AE, Stamper CT, Changrob S, Utset HA, Coughlan L, Krammer F, Cobey S, Wilson PC.Sci Transl Med. 2020 Dec 9;12(573):eabd3601. doi: 10.1126/scitranslmed.abd3601.PMID: 33298562

SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation.Lederer K, Castaño D, Gómez Atria D, Oguin TH 3rd, Wang S, Manzoni TB, Muramatsu H, Hogan MJ, Amanat F, Cherubin P, Lundgreen KA, Tam YK, Fan SHY, Eisenlohr LC, Maillard I, Weissman D, Bates P, Krammer F, Sempowski GD, Pardi N, Locci M.Immunity. 2020 Dec 15;53(6):1281-1295.e5. doi: 10.1016/j.immuni.2020.11.009. Epub 2020 Nov 21.PMID: 33296685

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial.Nachbagauer R, Feser J, Naficy A, Bernstein DI, Guptill J, Walter EB, Berlanda-Scorza F,Stadlbauer D, Wilson PC, Aydillo T, Behzadi MA, Bhavsar D, Bliss C, Capuano C, Carreño JM, Chromikova V, Claeys C, Coughlan L, Freyn AW, Gast C, Javier A, Jiang K, Mariottini C, McMahon M, McNeal M, Solórzano A, Strohmeier S, Sun W, Van der Wielen M, Innis BL, García-Sastre A, Palese P, Krammer F.Nat Med. 2021 Jan;27(1):106-114. doi: 10.1038/s41591-020-1118-7. Epub 2020 Dec 7.PMID: 33288923

Real-Time Investigation of a Large Nosocomial Influenza A Outbreak Informed by Genomic Epidemiology.Javaid W, Ehni J, Gonzalez-Reiche AS, Carreño JM, Hirsch E, Tan J, Khan Z, Kriti D, Ly T, Kranitzky B, Barnett B, Cera F, Prespa L, Moss M, Albrecht RA, Mustafa A, Herbison I, Hernandez MM, Pak TR, Alshammary H, Sebra R, Smith M, Krammer F, Gitman MR, Sordillo EM, Simon V, van Bakel H.Clin Infect Dis. 2020 Nov 30:ciaa1781. doi: 10.1093/cid/ciaa1781. Online ahead of print.PMID: 33252647

SARS-CoV-2-Specific Neutralizing Antibody Responses in Norwegian Health Care Workers After the First Wave of COVID-19 Pandemic: A Prospective Cohort Study.Trieu MC, Bansal A, Madsen A, Zhou F, Sævik M, Vahokoski J, Brokstad KA, Krammer F, Tøndel C, Mohn KGI, Blomberg B, Langeland N, Cox RJ; Bergen COVID-19 Research Group.J Infect Dis. 2021 Feb 24;223(4):589-599. doi: 10.1093/infdis/jiaa737.PMID: 33247924

Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as a live virus vaccine candidate.Sun W, Leist SR, McCroskery S, Liu Y, Slamanig S, Oliva J, Amanat F, Schäfer A, Dinnon KH 3rd, García-Sastre A, Krammer F, Baric RS, Palese P.EBioMedicine. 2020 Dec;62:103132. doi: 10.1016/j.ebiom.2020.103132. Epub 2020 Nov 21.PMID: 33232870

Assessment of Seroconversion to SARS-CoV-2 in a Cohort of Pediatric Kidney Transplant Recipients.Nailescu C, Khalid M, Wilson AC, Amanat F, Arregui S, Canas J, Hooks J, Krammer F, Schwaderer AL, Hains DS.Front Pediatr. 2020 Oct 30;8:601327. doi: 10.3389/fped.2020.601327. eCollection 2020.PMID: 33194930

Development and Assessment of a Pooled Serum as Candidate Standard to Measure Influenza A Virus Group 1 Hemagglutinin Stalk-Reactive Antibodies.Carreño JM, McDonald JU, Hurst T, Rigsby P, Atkinson E, Charles L, Nachbagauer R, Behzadi MA, Strohmeier S, Coughlan L, Aydillo T, Brandenburg B, García-Sastre A, Kaszas K, Levine MZ, Manenti A, McDermott AB, Montomoli E, Muchene L, Narpala SR, Perera RAPM, Salisch NC, Valkenburg SA, Zhou F, Engelhardt OG, Krammer F.Vaccines (Basel). 2020 Nov 9;8(4):666. doi: 10.3390/vaccines8040666.PMID: 33182279

Repeated cross-sectional sero-monitoring of SARS-CoV-2 in New York City.Stadlbauer D, Tan J, Jiang K, Hernandez MM, Fabre S, Amanat F, Teo C, Arunkumar GA, McMahon M, Capuano C, Twyman K, Jhang J, Nowak MD, Simon V, Sordillo EM, van Bakel H, Krammer F.Nature. 2021 Feb;590(7844):146-150. doi: 10.1038/s41586-020-2912-6. Epub 2020 Nov 3.PMID: 33142304

Robust and Specific Secretory IgA Against SARS-CoV-2 Detected in Human Milk.Fox A, Marino J, Amanat F, Krammer F, Hahn-Holbrook J, Zolla-Pazner S, Powell RL.iScience. 2020 Nov 20;23(11):101735. doi: 10.1016/j.isci.2020.101735. Epub 2020 Oct 26.PMID: 33134887

Transfusion reactions associated with COVID-19 convalescent plasma therapy for SARS-CoV-2 Nguyen FT, van den Akker T, Lally K, Lam H, Lenskaya V, Liu STH, Bouvier NM, Aberg JA, Rodriguez D, Krammer F, Strauss D, Shaz BH, Rudon L, Galdon P, Jhang JS, Arinsburg SA, Baine I; Mount Sinai Health System Convalescent Plasma Team.Transfusion. 2021 Jan;61(1):78-93. doi: 10.1111/trf.16177. Epub 2020 Nov 20.PMID: 33125158

Robust neutralizing antibodies to SARS-CoV-2 infection persist for months.Wajnberg A, Amanat F, Firpo A, Altman DR, Bailey MJ, Mansour M, McMahon M, Meade P, Mendu DR, Muellers K, Stadlbauer D, Stone K, Strohmeier S, Simon V, Aberg J, Reich DL, Krammer F, Cordon-Cardo C.Science. 2020 Dec 4;370(6521):1227-1230. doi: 10.1126/science.abd7728. Epub 2020 Oct 28.PMID: 33115920

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Modified Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine.

Neutralizing Antibody Responses in COVID-19 Convalescent Sera. Lee WT, Girardin RC, Dupuis AP, Kulas KE, Payne AF, Wong SJ, Arinsburg S, Nguyen FT, Mendu DR, Firpo-Betancourt A, Jhang J, Wajnberg A, Krammer F, Cordon-Cardo C, Amler S, Montecalvo M, Hutton B, Taylor J, McDonough KA.

Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses. Guthmiller JJ, Lan LY, Fernández-Quintero ML, Han J, Utset HA, Bitar DJ, Hamel NJ, Stovicek O, Li L, Tepora M, Henry C, Neu KE, Dugan HL, Borowska MT, Chen YQ, Liu STH, Stamper CT, Zheng NY, Huang M, Palm AE, García-Sastre A, Nachbagauer R, Palese P, Coughlan L, Krammer F, Ward AB, Liedl KR, Wilson PC.

In Utero Vertical Transmission of Coronavirus Disease 2019 in a Severely Ill 29-week Preterm Infant. Gupta A, Malhotra Y, Patil U, Muradas AR, Lee WT, Krammer F, Amanat F, Clare CA, Vinod S, Ghaly E.

COVID-19: Staging of a New Disease. Cordon-Cardo C, Pujadas E, Wajnberg A, Sebra R, Patel G, Firpo-Betancourt A, Fowkes M, Sordillo E, Paniz-Mondolfi A, Gregory J, Krammer F, Simon V, Isola L, Soon-Shiong P, Aberg JA, Fuster V, Reich DL.

Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection. Rathnasinghe R, Strohmeier S, Amanat F, Gillespie VL, Krammer F, García-Sastre A, Coughlan L, Schotsaert M, Uccellini MB.

Scientific consensus on the COVID-19 pandemic: we need to act now. Alwan NA, Burgess RA, Ashworth S, Beale R, Bhadelia N, Bogaert D, Dowd J, Eckerle I, Goldman LR, Greenhalgh T, Gurdasani D, Hamdy A, Hanage WP, Hodcroft EB, Hyde Z, Kellam P, Kelly-Irving M, Krammer F, Lipsitch M, McNally A, McKee M, Nouri A, Pimenta D, Priesemann V, Rutter H, Silver J, Sridhar D, Swanton C, Walensky RP, Yamey G, Ziauddeen H.

Humoral response and PCR positivity in patients with COVID-19 in the New York City region, USA: an observational study. Wajnberg A, Mansour M, Leven E, Bouvier NM, Patel G, Firpo-Betancourt A, Mendu R, Jhang J, Arinsburg S, Gitman M, Houldsworth J, Sordillo E, Paniz-Mondolfi A, Baine I, Simon V, Aberg J, Krammer F, Reich D, Cordon-Cardo C.

Introduction of two prolines and removal of the polybasic cleavage site leads to optimal efficacy of a recombinant spike based SARS-CoV-2 vaccine in the mouse model. Amanat F, Strohmeier S, Rathnasinghe R, Schotsaert M, Coughlan L, García-Sastre A, Krammer F. 2020 Sep 17. PMID: 32995785

Distinct B cell subsets give rise to antigen-specific antibody responses against SARS-CoV-2. Wilson P, Stamper C, Dugan H, Li L, Asby N, Halfmann P, Guthmiller J, Zheng NY, Huang M, Stovicek O, Wang J, Madariaga ML, Shanmugarajah K, Jansen M, Amanat F, Stewart I, Changrob S, Utset H, Huang J, Nelson C, Dai YN, Hall P, Jedrzejczak R, Joachimiak A, Krammer F, Fremont D, Kawaoka Y. 2020 Sep 25. PMID: 32995763

Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C). Gruber CN, Patel RS, Trachtman R, Lepow L, Amanat F, Krammer F, Wilson KM, Onel K, Geanon D, Tuballes K, Patel M, Mouskas K, O’Donnell T, Merritt E, Simons NW, Barcessat V, Del Valle DM, Udondem S, Kang G, Gangadharan S, Ofori-Amanfo G, Laserson U, Rahman A, Kim-Schulze S, Charney AW, Gnjatic S, Gelb BD, Merad M, Bogunovic D. 2020 Sep 14. PMID: 32991843

Human Antibodies Targeting Influenza B Virus Neuraminidase Active Site Are Broadly Protective. Madsen A, Dai YN, McMahon M, Schmitz AJ, Turner JS, Tan J, Lei T, Alsoussi WB, Strohmeier S, Amor M, Mohammed BM, Mudd PA, Simon V, Cox RJ, Fremont DH, Krammer F, Ellebedy AH. 2020 Sep 22. PMID: 32976769

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, Korniotis S, Karpf L, Philippot Q, Chbihi M, Bonnet-Madin L, Dorgham K, Smith N, Schneider WM, Razooky BS, Hoffmann HH, Michailidis E, Moens L, Han JE, Lorenzo L, Bizien L, Meade P, Neehus AL, Ugurbil AC, Corneau A, Kerner G, Zhang P, Rapaport F, Seeleuthner Y, Manry J, Masson C, Schmitt Y, Schlüter A, Le Voyer T, Khan T, Li J, Fellay J, Roussel L, Shahrooei M, Alosaimi MF, Mansouri D, Al-Saud H, Al-Mulla F, Almourfi F, Al-Muhsen SZ, Alsohime F, Al Turki S, Hasanato R, van de Beek D, Biondi A, Bettini LR, D’Angio M, Bonfanti P, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Oler AJ, Tompkins MF, Alba C, Vandernoot I, Goffard JC, Smits G, Migeotte I, Haerynck F, Soler-Palacin P, Martin-Nalda A, Colobran R, Morange PE, Keles S, Çölkesen F, Ozcelik T, Yasar KK, Senoglu S, Karabela ŞN, Gallego CR, Novelli G, Hraiech S, Tandjaoui-Lambiotte Y, Duval X, Laouénan C; COVID-STORM Clinicians; COVID Clinicians; Imagine COVID Group; French COVID Cohort Study Group; CoV-Contact Cohort; Amsterdam UMC Covid-19; Biobank; COVID Human Genetic Effort; NIAID-USUHS; TAGC COVID Immunity Group, Snow AL, Dalgard CL, Milner J, Vinh DC, Mogensen TH, Marr N, Spaan AN, Boisson B, Boisson-Dupuis S, Bustamante J, Puel A, Ciancanelli M, Meyts I, Maniatis T, Soumelis V, Amara A, Nussenzweig M, García-Sastre A, Krammer F, Pujol A, Duffy D, Lifton R, Zhang SY, Gorochov G, Béziat V, Jouanguy E, Sancho-Shimizu V, Rice CM, Abel L, Notarangelo LD, Cobat A, Su HC, Casanova JL. 2020 Sep 24. PMID: 32972995

SARS-CoV-2 vaccines in development. Krammer F. 2020 Sep 23. PMID: 32967006

Dengue and Zika virus infections are enhanced by live attenuated dengue vaccine but not by recombinant DSV4 vaccine candidate in mouse models. Shukla R, Beesetti H, Brown JA, Ahuja R, Ramasamy V, Shanmugam RK, Poddar A, Batra G, Krammer F, Lim JK, Kale S, Lal AA, Swaminathan S, Khanna N. 2020 Sep 15. PMID: 32949997

Correctly folded – but not necessarily functional – influenza virus neuraminidase is required to induce protective antibody responses in mice. McMahon M, Strohmeier S, Rajendran M, Capuano C, Ellebedy AH, Wilson PC, Krammer F. 2020 Sep 15. PMID: 32943267

SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike. Guthmiller JJ, Stovicek O, Wang J, Changrob S, Li L, Halfmann P, Zheng NY, Utset H, Stamper CT, Dugan HL, Miller WD, Huang M, Dai YN, Nelson CA, Hall PD, Jansen M, Shanmugarajah K, Donington JS, Krammer F, Fremont D, Joachimiak A, Kawaoka Y, Tesic V, Madariaga ML, Wilson PC. 2020 Sep 13. PMID: 32935099

Convalescent plasma treatment of severe COVID-19: a propensity score-matched control study. Liu STH, Lin HM, Baine I, Wajnberg A, Gumprecht JP, Rahman F, Rodriguez D, Tandon P, Bassily-Marcus A, Bander J, Sanky C, Dupper A, Zheng A, Nguyen FT, Amanat F, Stadlbauer D, Altman DR, Chen BK, Krammer F, Mendu DR, Firpo-Betancourt A, Levin MA, Bagiella E, Casadevall A, Cordon-Cardo C, Jhang JS, Arinsburg SA, Reich DL, Aberg JA, Bouvier NM. 2020 Sep 15. PMID: 32934372

SARS-CoV-2-specific IgA and limited inflammatory cytokines are present in the stool of select patients with acute COVID-19. Britton GJ, Chen-Liaw A, Cossarini F, Livanos AE, Spindler MP, Plitt T, Eggers J, Mogno I, Gonzalez-Reiche A, Siu S, Tankelevich M, Grinspan L, Dixon RE, Jha D, Martinez-Delgado G, Amanat F, Hoagland DA, tenOever B, Dubinsky MC, Merad M, van Bakel H, Krammer F, Bongers G, Mehandru S, Faith JJ. 2020 Sep 5. PMID: 32909002

Characterization of novel cross-reactive influenza B virus hemagglutinin head specific antibodies that lack hemagglutinin inhibition activity. Kirkpatrick E, Henry C, McMahon M, Jiang K, Strohmeier S, van Bakel H, Wilson PC, Krammer F. 2020 Sep 9. PMID: 32907980

Serological identification of SARS-CoV-2 infections among children visiting a hospital during the initial Seattle outbreak. Dingens AS, Crawford KHD, Adler A, Steele SL, Lacombe K, Eguia R, Amanat F, Walls AC, Wolf CR, Murphy M, Pettie D, Carter L, Qin X, King NP, Veesler D, Krammer F, Dickerson JA, Chu HY, Englund JA, Bloom JD. 2020 Sep 1. PMID: 32873791

Human germinal centres engage memory and naive B cells after influenza vaccination. Turner JS, Zhou JQ, Han J, Schmitz AJ, Rizk AA, Alsoussi WB, Lei T, Amor M, McIntire KM, Meade P, Strohmeier S, Brent RI, Richey ST, Haile A, Yang YR, Klebert MK, Suessen T, Teefey S, Presti RM, Krammer F, Kleinstein SH, Ward AB, Ellebedy AH. 2020 Aug 31. PMID: 32866963

A High Through-Put Assay For Circulating Antibodies Directed Against The S Protein Of Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2). Weiss S, Klingler J, Hioe C, Amanat F, Baine I, Arinsburg S, Kojic EM, Stoever J, Liu STH, Jurczyszak D, Bermudez-Gonzalez M, Simon V, Krammer F, Zolla-Pazner S. 2020 Aug 29. PMID: 32860510

Quantifying absolute neutralization titers against SARS-CoV-2 by a standardized virus neutralization assay allows for cross-cohort comparisons of COVID-19 sera. Oguntuyo KY, Stevens CS, Hung CT, Ikegame S, Acklin JA, Kowdle SS, Carmichael JC, Chiu HP, Azarm KD, Haas GD, Amanat F, Klingler J, Baine I, Arinsburg S, Bandres JC, Siddiquey MN, Schilke RM, Woolard MD, Zhang H, Duty AJ, Kraus TA, Moran TM, Tortorella D, Lim JK, Gamarnik AV, Hioe CE, Zolla-Pazner S, Ivanov SS, Kamil JP, Krammer F, Lee B. 2020 Aug 15. PMID: 32817961

Anti-SARS-CoV-2 Spike Antibodies are Stable in Convalescent Plasma when Stored at 4° Celsius for at Least 6 Weeks. Stadlbauer D, Baine I, Amanat F, Jiang K, Lally K, Krammer F, Jhang JS, Arinsburg SA. 2020 Aug 14. PMID: 32798271

A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice. Laczkó D, Hogan MJ, Toulmin SA, Hicks P, Lederer K, Gaudette BT, Castaño D, Amanat F, Muramatsu H, Oguin TH 3rd, Ojha A, Zhang L, Mu Z, Parks R, Manzoni TB, Roper B, Strohmeier S, Tombácz I, Arwood L, Nachbagauer R, Karikó K, Greenhouse J, Pessaint L, Porto M, Putman-Taylor T, Strasbaugh A, Campbell TA, Lin PJC, Tam YK, Sempowski GD, Farzan M, Choe H, Saunders KO, Haynes BF, Andersen H, Eisenlohr LC, Weissman D, Krammer F, Bates P, Allman D, Locci M, Pardi N. 2020 Jul 30. PMID: 32783919

A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine. Sun W, McCroskery S, Liu WC, Leist SR, Liu Y, Albrecht RA, Slamanig S, Oliva J, Amanat F, Schaefer A, Dinnon KH, Innis BL, Garcia-Sastre A, Krammer F, Baric RS, Palese P. 2020 Jul 31. PMID: 32766572

Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as vaccine candidate. Sun W, Leist SR, McCroskery S, Liu Y, Slamanig S, Oliva J, Amanat F, Schaefer A, Dinnon K, Garcia-Sastre A, Krammer F, Baric RS, Palese P. 2020 Jul 26. PMID: 32743571

Surveillance of European Domestic Pig Populations Identifies an Emerging Reservoir of Potentially Zoonotic Swine Influenza A Viruses. Henritzi D, Petric PP, Lewis NS, Graaf A, Pessia A, Starick E, Breithaupt A, Strebelow G, Luttermann C, Parker LMK, Schröder C, Hammerschmidt B, Herrler G, Beilage EG, Stadlbauer D, Simon V, Krammer F, Wacheck S, Pesch S, Schwemmle M, Beer M, Harder TC. 2020 Jul 23. PMID: 32721380

An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses. Hong JP, Reynoso GV, Andhey PS, Swain A, Turner JS, Boon ACM, Krammer F, Ellebedy AH, Zanini F, Artyomov M, Hickman HD, Diamond MS. 2020 Jun 23.  PMID: 32699843

Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C). Gruber C, Patel R, Trachman R, Lepow L, Amanat F,Krammer F, Wilson KM, Onel K, Geanon D, Tuballes K, Patel M, Mouskas K, Simons N, Barcessat V, Del Valle D, Udondem S, Kang G, Gangadharan S, Ofori-Amanfo G, Rahman A, Kim-Schulze S, Charney A, Gnjatic S, Gelb B, Merad M, Bogunovic D. 2020 Jul 6. PMID: 32676612

Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection. Rathnasinghe R, Strohmeier S, Amanat F, Gillespie VL, Krammer F, García-Sastre A, Coughlan L, Schotsaert M, Uccellini M. 2020 Jul 6. PMID: 32676603

Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans. Ellebedy AH, Nachbagauer R, Jackson KJL, Dai YN, Han J, Alsoussi WB, Davis CW, Stadlbauer D, Rouphael N, Chromikova V, McCausland M, Chang CY, Cortese M, Bower M, Chennareddy C, Schmitz AJ, Zarnitsyna VI, Lai L, Rajabhathor A, Kazemian C, Antia R, Mulligan MJ, Ward AB, Fremont DH, Boyd SD, Pulendran B, Krammer F, Ahmed R. 2020 Jul 13. PMID: 32661157

Monoclonal Antibody Therapy Protects Pharmacologically Immunosuppressed Mice from Lethal Infection with Influenza B Virus. Marathe BM, Asthagiri Arunkumar G, Vogel P, Pascua PNQ, Jones J, Webby RJ, Krammer F, Govorkova EA. 2020 Jul 6. PMID: 32631823

A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection. Alsoussi WB, Turner JS, Case JB, Zhao H, Schmitz AJ, Zhou JQ, Chen RE, Lei T, Rizk AA, McIntire KM, Winkler ES, Fox JM, Kafai NM, Thackray LB, Hassan AO, Amanat F, Krammer F, Watson CT, Kleinstein SH, Fremont DH, Diamond MS, Ellebedy AH. 2020 Jun 26. PMID: 32591393

An In Vitro Microneutralization Assay for SARS-CoV-2 Serology and Drug Screening. Amanat F, White KM, Miorin L, Strohmeier S, McMahon M, Meade P, Liu WC, Albrecht RA, Simon V, Martinez-Sobrido L, Moran T, García-Sastre A, Krammer F. 2020 Sep. PMID: 32585083

Non-sterilizing, Infection-Permissive Vaccination With Inactivated Influenza Virus Vaccine Reshapes Subsequent Virus Infection-Induced Protective Heterosubtypic Immunity From Cellular to Humoral Cross-Reactive Immune Responses. Choi A, Ibañez LI, Strohmeier S, Krammer F, García-Sastre A, Schotsaert M. 2020 Jun 9. PMID: 32582220

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development. Imai M, Iwatsuki-Horimoto K, Hatta M, Loeber S, Halfmann PJ, Nakajima N, Watanabe T, Ujie M, Takahashi K, Ito M, Yamada S, Fan S, Chiba S, Kuroda M, Guan L, Takada K, Armbrust T, Balogh A, Furusawa Y, Okuda M, Ueki H, Yasuhara A, Sakai-Tagawa Y, Lopes TJS, Kiso M, Yamayoshi S, Kinoshita N, Ohmagari N, Hattori SI, Takeda M, Mitsuya H, Krammer F, Suzuki T, Kawaoka Y. 2020 Jul 14. PMID: 32571934

Seroconversion in household members of COVID-19 outpatients. Cox RJ, Brokstad KA, Krammer F, Langeland N; Bergen COVID-19 Research Group. 2020 Jun 15. PMID: 32553187

A High Through-put Assay for Circulating Antibodies Directed against the S Protein of Severe Acute Respiratory Syndrome Corona virus 2. Weiss S, Klingler J, Hioe C, Amanat F, Baine I, Kojic EM, Stoever J, Liu S, Jurczyszak D, Bermudez-Gonzalez M, Simon V, Krammer F, Zolla-Pazner S. 2020 Apr 17. PMID: 32511609

Seroprevalence of SARS-CoV-2 among children visiting a hospital during the initial Seattle outbreak. Dingens AS, Crawford KH, Adler A, Steele SL, Lacombe K, Eguia R, Amanat F, Walls AC, Wolf CR, Murphy M, Pettie D, Carter L, Qin X, King NP, Veesler D, Krammer F, Chu HY, Englund JA, Bloom JD. 2020 May 28. PMID: 32511483

Symptomatic SARS-CoV-2 infections display specific IgG Fc structures. Chakraborty S, Edwards K, Buzzanco AS, Memoli MJ, Sherwood R, Mallajosyula V, Xie MM, Gonzalez J, Buffone C, Kathale N, Providenza S, Jagannathan P, Andrews JR, Blish CA, Krammer F, Dugan H, Wilson PC, Pham TD, Boyd SD, Zhang S, Taubenberger JK, Morales T, Schapiro JM, Parsonnet J, Wang TT. 2020 May 18. PMID: 32511463

A serological assay to detect SARS-CoV-2 seroconversion in humans. Amanat F, Stadlbauer D, Strohmeier S, Nguyen THO, Chromikova V, McMahon M, Jiang K, Asthagiri Arunkumar G, Jurczyszak D, Polanco J, Bermudez-Gonzalez M, Kleiner G, Aydillo T, Miorin L, Fierer D, Amarilis Lugo L, Milunka Kojic E, Stoever J, Liu STH, Cunningham-Rundles C, Felgner PL, Moran T, Garcia-Sastre A, Caplivski D, Cheng A, Kedzierska K, Vapalahti O, Hepojoki JM, Simon V, Krammer F. 2020 Apr 16. PMID: 32511441

Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals. Zheng A, Sun W, Xiong X, Freyn AW, Peukes J, Stromeier S, Nachbagauer R, Briggs JAG, Krammer F, Palese P. 2020 Jun 3. PMID: 32493826

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans With COVID-19 Disease and Unexposed Individuals. Grifoni A, Weiskopf D, Ramirez SI, Mateus J, Dan JM, Moderbacher CR, Rawlings SA, Sutherland A, Premkumar L, Jadi RS, Marrama D, de Silva AM, Frazier A, Carlin AF, Greenbaum JA, Peters B, Krammer F, Smith DM, Crotty S, Sette A. 2020 May 20. PMID: 32473127

Introductions and Early Spread of SARS-CoV-2 in the New York City Area. Gonzalez-Reiche AS, Hernandez MM, Sullivan MJ, Ciferri B, Alshammary H, Obla A, Fabre S, Kleiner G, Polanco J, Khan Z, Alburquerque B, van de Guchte A, Dutta J, Francoeur N, Melo BS, Oussenko I, Deikus G, Soto J, Sridhar SH, Wang YC, Twyman K, Kasarskis A, Altman DR, Smith M, Sebra R, Aberg J, Krammer F, García-Sastre A, Luksza M, Patel G, Paniz-Mondolfi A, Gitman M, Sordillo EM, Simon V, van Bakel H. 2020 May 29. PMID: 32471856

Serology Assays to Manage COVID-19. Krammer F, Simon V. 2020 Jun 5. PMID: 32414781

Asymptomatic Seroconversion of Immunoglobulins to SARS-CoV-2 in a Pediatric Dialysis Unit. Hains DS, Schwaderer AL, Carroll AE, Starr MC, Wilson AC, Amanat F, Krammer F. 2020 May 14. PMID: 32407440

A Serological Assay to Detect SARS-CoV-2 Seroconversion in Humans. Amanat F, Stadlbauer D, Strohmeier S, Nguyen THO, Chromikova V, McMahon M, Jiang K, Arunkumar GA, Jurczyszak D, Polanco J, Bermudez-Gonzalez M, Kleiner G, Aydillo T, Miorin L, Fierer DS, Lugo LA, Kojic EM, Stoever J, Liu STH, Cunningham-Rundles C, Felgner PL, Moran T, García-Sastre A, Caplivski D, Cheng AC, Kedzierska K, Vapalahti O, Hepojoki JM, Simon V, Krammer F. 2020 May 12. PMID: 32398876

Antibody Responses to Influenza A(H1N1)pdm Infection. Wraith S, Nachbagauer R, Balmaseda A, Stadlbauer D, Ojeda S, Rajabhathor A, Lopez R, Guglia AF, Sanchez N, Amanat F, Gresh L, Kuan G, Krammer F, Gordon A. 2020 Jun 2. PMID: 32389495

A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice. Freyn AW, Ramos da Silva J, Rosado VC, Bliss CM, Pine M, Mui BL, Tam YK, Madden TD, de Souza Ferreira LC, Weissman D, Krammer F, Coughlan L, Palese P, Pardi N, Nachbagauer R. 2020 Apr 19. PMID: 32359470

Zika Virus Envelope Nanoparticle Antibodies Protect Mice Without Risk of Disease Enhancement. Shukla R, Shanmugam RK, Ramasamy V, Arora U, Batra G, Acklin JA, Krammer F, Lim JK, Swaminathan S, Khanna N. 2020 Apr. PMID: 32305868

SARS-CoV-2 Seroconversion in Humans: A Detailed Protocol for a Serological Assay, Antigen Production, and Test Setup. Stadlbauer D, Amanat F, Chromikova V, Jiang K, Strohmeier S, Arunkumar GA, Tan J, Bhavsar D, Capuano C, Kirkpatrick E, Meade P, Brito RN, Teo C, McMahon M, Simon V, Krammer F. 2020 Jun. PMID: 32302069

SARS-CoV-2 Vaccines: Status Report. Amanat F, Krammer F. 2020 Apr 14. PMID: 32259480

Neutralizing Monoclonal Antibodies Against the Gn and the Gc of the Andes Virus Glycoprotein Spike Complex Protect From Virus Challenge in a Preclinical Hamster Model. Duehr J, McMahon M, Williamson B, Amanat F, Durbin A, Hawman DW, Noack D, Uhl S, Tan GS, Feldmann H, Krammer F. 2020 Mar 24. PMID: 32209676

High-complexity extracellular barcoding using a viral hemagglutinin. Mullokandov G, Vijayakumar G, Leon P, Henry C, Wilson PC, Krammer F, Palese P, Brown BD. 2020 Feb 11. PMID: 31988118

Influenza Virus Infection Induces a Narrow Antibody Response in Children but a Broad Recall Response in Adults. Meade P, Kuan G, Strohmeier S, Maier HE, Amanat F, Balmaseda A, Ito K, Kirkpatrick E, Javier A, Gresh L, Nachbagauer R, Gordon A, Krammer F. 2020 Jan 21. PMID:31964741

Activity of human serum antibodies in an influenza virus hemagglutinin stalk-based ADCC reporter assay correlates with activity in a CD107a degranulation assay. Chromikova V, Tan J, Aslam S, Rajabhathor A, Bermudez-Gonzalez M, Ayllon J, Simon V, García-Sastre A, Salaun B, Nachbagauer R, Krammer F. 2020 Jan 17. PMID:31959425

 

2019 Publications

 

Viral Fitness Landscapes in Diverse Host Species Reveal Multiple Evolutionary Lines for the NS1 Gene of Influenza A Viruses. Muñoz-Moreno R, Martínez-Romero C, Blanco-Melo D, Forst CV, Nachbagauer R, Benitez AA, Mena I, Aslam S, Balasubramaniam V, Lee I, Panis M, Ayllón J, Sachs D, Park MS, Krammer F, tenOever BR, García-Sastre A. 2019 Dec 17. PMID:31851929

Pandemic influenza virus vaccines boost hemagglutinin stalk-specific antibody responses in primed adult and pediatric cohorts. Nachbagauer R, Salaun B, Stadlbauer D, Behzadi MA, Friel D, Rajabhathor A, Choi A, Albrecht RA, Debois M, García-Sastre A, Rouxel RN, Sun W, Palese P, Mallett CP, Innis BL, Krammer F, Claeys C. 2019 Dec 6. PMID:31839997

Meeting report and review: Immunological assays and correlates of protection for next-generation influenza vaccines. Krammer F, Weir JP, Engelhardt O, Katz JM, Cox RJ. 2019 Dec 13. PMID:31837382

Monoclonal antibodies with neutralizing activity and Fc-effector functions against the Machupo virus glycoprotein. Amanat F, Duehr J, Huang C, Paessler S, Tan G, Krammer F. 2019 Dec 4. PMID:31801871

Broadly protective human antibodies that target the active site of influenza virus neuraminidase. Stadlbauer D, Zhu X, McMahon M, Turner JS, Wohlbold TJ, Schmitz AJ, Strohmeier S, Yu W, Nachbagauer R, Mudd PA, Wilson IA, Ellebedy AH, Krammer F. 2019 Oct 25. PMID:31649200