Enhancing the protection of influenza virus vaccines with BECC TLR4 adjuvant in aged mice. Haupt R, Baracco L, Harberts EM, Loganathan M, Kerstetter LJ, Krammer F, Coughlan L, Ernst RK, Frieman MB.Sci Rep. 2023 Jan 13;13(1):715. doi: 10.1038/s41598-023-27965-x.PMID: 36639569 Free PMC article. 

Antigenic Landscape Analysis of Individuals Vaccinated with a Universal Influenza Virus Vaccine Candidate Reveals Induction of Cross-Subtype Immunity. Meade P, Strohmeier S, Bermúdez-González MC, García-Sastre A, Palese P, Simon V, Krammer F.J Virol. 2023 Jan 31;97(1):e0107022. doi: 10.1128/jvi.01070-22. Epub 2022 Dec 19.PMID: 36533948 Free PMC article. Clinical Trial. 

The Negative Effect of Preexisting Immunity on Influenza Vaccine Responses Transcends the Impact of Vaccine Formulation Type and Vaccination History. Moritzky SA, Richards KA, Glover MA, Krammer F, Chaves FA, Topham DJ, Branche A, Nayak JL, Sant AJ.J Infect Dis. 2023 Feb 1;227(3):381-390. doi: 10.1093/infdis/jiac068.PMID: 35199825 Free PMC article. 

Evaluation of immunological responses to third COVID-19 vaccine among people treated with sphingosine receptor-1 modulators and anti-CD20 therapy. Katz Sand I, Gnjatic S, Krammer F, Tuballes K, Carreño JM, Satyanarayan S, Filomena S, Staker E, Tcheou J, Miller A, Fabian M, Safi N, Nichols J, Patel J, Krieger S, Tankou S, Horng S, Klineova S, Beck E, Merad M, Lublin F.Mult Scler Relat Disord. 2023 Feb;70:104486. doi: 10.1016/j.msard.2022.104486. Epub 2022 Dec 28.PMID: 36628884 Free PMC article.

Predictors for reactogenicity and humoral immunity to SARS-CoV-2 following infection and mRNA vaccination: A regularized, mixed-effects modelling approach. Williams EC, Kizhner A, Stark VS, Nawab A, Muniz DD, Echeverri Tribin F, Carreño JM, Bielak D, Singh G, Hoffer ME, Krammer F, Pallikkuth S, Pahwa S.Front Immunol. 2023 Feb 9;14:971277. doi: 10.3389/fimmu.2023.971277. eCollection 2023.PMID: 36845120 Free PMC article. 

Generation of a high yield vaccine backbone for influenza B virus in embryonated chicken eggs. Aslam S, Rajendran M, Kriti D, Kurland A, Johnson J, van Bakel H, Krammer F, García-Sastre A, Ayllon J.NPJ Vaccines. 2023 Feb 10;8(1):12. doi: 10.1038/s41541-023-00603-3.PMID: 36765053 Free PMC article.  

An inactivated NDV-HXP-S COVID-19 vaccine elicits a higher proportion of neutralizing antibodies in humans than mRNA vaccination. Carreño JM, Raskin A, Singh G, Tcheou J, Kawabata H, Gleason C, Srivastava K, Vigdorovich V, Dambrauskas N, Gupta SL, González Domínguez I, Martinez JL, Slamanig S, Sather DN, Raghunandan R, Wirachwong P, Muangnoicharoen S, Pitisuttithum P, Wrammert J, Suthar MS, Sun W, Palese P, García-Sastre A, Simon V, Krammer F.Sci Transl Med. 2023 Feb 15;15(683):eabo2847. doi: 10.1126/scitranslmed.abo2847. Epub 2023 Feb 15.PMID: 36791207 Free article. 

A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins. Chonira V, Kwon YD, Gorman J, Case JB, Ku Z, Simeon R, Casner RG, Harris DR, Olia AS, Stephens T, Shapiro L, Bender MF, Boyd H, Teng IT, Tsybovsky Y, Krammer F, Zhang N, Diamond MS, Kwong PD, An Z, Chen Z.Nat Chem Biol. 2023 Mar;19(3):284-291. doi: 10.1038/s41589-022-01193-2. Epub 2022 Nov 21.PMID: 36411391 

Viral immunity: Basic mechanisms and therapeutic applications-a Keystone Symposia report. Cable J, Balachandran S, Daley-Bauer LP, Rustagi A, Antony F, Frere JJ, Strampe J, Kedzierska K, Cannon JL, McGargill MA, Weiskopf D, Mettelman RC, Niessl J, Thomas PG, Briney B, Valkenburg SA, Bloom JD, Bjorkman PJ, Iketani S, Rappazzo CG, Crooks CM, Crofts KF, Pöhlmann S, Krammer F, Sant AJ, Nabel GJ, Schultz-Cherry S.Ann N Y Acad Sci. 2023 Mar;1521(1):32-45. doi: 10.1111/nyas.14960. Epub 2023 Jan 30.PMID: 36718537 

A research and development (R&D) roadmap for broadly protective coronavirus vaccines: A pandemic preparedness strategy. Moore KA, Leighton T, Ostrowsky JT, Anderson CJ, Danila RN, Ulrich AK, Lackritz EM, Mehr AJ, Baric RS, Baylor NW, Gellin BG, Gordon JL, Krammer F, Perlman S, Rees HV, Saville M, Weller CL, Osterholm MT; Coronavirus Vaccines R&D Roadmap Taskforce.Vaccine. 2023 Mar 24;41(13):2101-2112. doi: 10.1016/j.vaccine.2023.02.032. Epub 2023 Feb 21.PMID: 36870874 Free PMC article. Review. 

Study of efficacy and longevity of immune response to third and fourth doses of COVID-19 vaccines in patients with cancer: A single arm clinical trial. Thakkar A, Pradhan K, Duva B, Carreno JM, Sahu S, Thiruthuvanathan V, Campbell S, Gallego S, Bhagat TD, Rivera J, Choudhary G, Olea R, Sabalza M, Shapiro LC, Lee M, Quinn R, Mantzaris I, Chu E, Will B, Pirofski LA, Krammer F, Verma A, Halmos B.Elife. 2023 Mar 28;12:e83694. doi: 10.7554/eLife.83694.PMID: 36975207 Free PMC article. Clinical Trial.

Immunity to Seasonal Coronavirus Spike Proteins Does Not Protect from SARS-CoV-2 Challenge in a Mouse Model but Has No Detrimental Effect on Protection Mediated by COVID-19 mRNA Vaccination. Amanat F, Clark J, Carreño JM, Strohmeier S, Yellin T, Meade PS, Bhavsar D, Muramatsu H, Sun W, Coughlan L, Pardi N, Krammer F.J Virol. 2023 Mar 30;97(3):e0166422. doi: 10.1128/jvi.01664-22. Epub 2023 Feb 13.PMID: 36779758 Free PMC article. 

Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations. Habel JR, Chua BY, Kedzierski L, Selva KJ, Damelang T, Haycroft ER, Nguyen TH, Koay HF, Nicholson S, McQuilten HA, Jia X, Allen LF, Hensen L, Zhang W, van de Sandt CE, Neil JA, Pragastis K, Lau JS, Jumarang J, Allen EK, Amanant F, Krammer F, Wragg KM, Juno JA, Wheatley AK, Tan HX, Pell G, Walker S, Audsley J, Reynaldi A, Thevarajan I, Denholm JT, Subbarao K, Davenport MP, Hogarth PM, Godfrey DI, Cheng AC, Tong SY, Bond K, Williamson DA, McMahon JH, Thomas PG, Pannaraj PS, James F, Holmes NE, Smibert OC, Trubiano JA, Gordon CL, Chung AW, Whitehead CL, Kent SJ, Lappas M, Rowntree LC, Kedzierska K.JCI Insight. 2023 Apr 10;8(7):e167157. doi: 10.1172/jci.insight.167157.PMID: 37036008 Free PMC article. 

Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody against antigenically distinct Omicron subvariants. Changrob S, Halfmann PJ, Liu H, Torres JL, McGrath JJC, Ozorowski G, Li L, Wilbanks GD, Kuroda M, Maemura T, Huang M, Zheng NY, Turner HL, Erickson SA, Fu Y, Yasuhara A, Singh G, Monahan B, Mauldin J, Srivastava K, Simon V, Krammer F, Sather DN, Ward AB, Wilson IA, Kawaoka Y, Wilson PC.J Clin Invest. 2023 Apr 17;133(8):e166844. doi: 10.1172/JCI166844.PMID: 36862518 Free PMC article. 

Robust SARS-CoV-2 T cell responses with common TCRαβ motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells. Nguyen THO, Rowntree LC, Allen LF, Chua BY, Kedzierski L, Lim C, Lasica M, Tennakoon GS, Saunders NR, Crane M, Chee L, Seymour JF, Anderson MA, Whitechurch A, Clemens EB, Zhang W, Chang SY, Habel JR, Jia X, McQuilten HA, Minervina AA, Pogorelyy MV, Chaurasia P, Petersen J, Menon T, Hensen L, Neil JA, Mordant FL, Tan HX, Cabug AF, Wheatley AK, Kent SJ, Subbarao K, Karapanagiotidis T, Huang H, Vo LK, Cain NL, Nicholson S, Krammer F, Gibney G, James F, Trevillyan JM, Trubiano JA, Mitchell J, Christensen B, Bond KA, Williamson DA, Rossjohn J, Crawford JC, Thomas PG, Thursky KA, Slavin MA, Tam CS, Teh BW, Kedzierska K.Cell Rep Med. 2023 Apr 18;4(4):101017. doi: 10.1016/j.xcrm.2023.101017. Epub 2023 Mar 27.PMID: 37030296 Free PMC article. 

Nanovaccines Displaying the Influenza Virus Hemagglutinin in an Inverted Orientation Elicit an Enhanced Stalk-Directed Antibody Response. Frey SJ, Carreño JM, Bielak D, Arsiwala A, Altomare CG, Varner C, Rosen-Cheriyan T, Bajic G, Krammer F, Kane RS.Adv Healthc Mater. 2023 May;12(13):e2202729. doi: 10.1002/adhm.202202729. Epub 2023 Feb 3.PMID: 36689343 

We need to keep an eye on avian influenza. Krammer F, Schultz-Cherry S.Nat Rev Immunol. 2023 May;23(5):267-268. doi: 10.1038/s41577-023-00868-8.PMID: 36944755 Free PMC article.

Poor Prognosis for Puumala Virus Infections Predicted by Lymphopenia and Dyspnea. Hatzl S, Posch F, Linhofer M, Aberle S, Zollner-Schwetz I, Krammer F, Krause R.Emerg Infect Dis. 2023 May;29(5):1038-1041. doi: 10.3201/eid2905.221625.PMID: 37081597 Free PMC article.