Publications

For a complete list of publications, please click here.

BELOW ARE SELECTED PUBLICATIONS FROM 2017 ONWARDS

Publications: 2021

Semsarian C, Ingles J, Ross SB, Dunwoodie SL, Bagnall RD, Kovacic JC. Precision Medicine in Cardiovascular Disease: Genetics and Impact on Phenotypes: JACC Focus Seminar 1/5. J Am Coll Cardiol. 2021; 77(20): 2517-2530.

Miller CL, Kontorovich AR, Hao K, Ma L, Iyegbe C, Björkegren JLM, Kovacic JC. Precision Medicine Approaches to Vascular Disease: JACC Focus Seminar 2/5. J Am Coll Cardiol. 2021; 77(20): 2531-2550.

Fatkin D, Calkins H, Elliott P, James CA, Peters S, Kovacic JC. Contemporary and Future Approaches to Precision Medicine in Inherited Cardiomyopathies: JACC Focus Seminar 3/5. J Am Coll Cardiol. 2021; 77(20): 2551-2572.

Giudicessi JR, Ackerman MJ, Fatkin D, Kovacic JC. Precision Medicine Approaches to Cardiac Arrhythmias: JACC Focus Seminar 4/5. J Am Coll Cardiol. 2021; 77(20): 2573-2591.

Priori SG, Mazzanti A, Santiago DJ, Kukavica D, Trancuccio A, Kovacic JC. Precision Medicine in Catecholaminergic Polymorphic Ventricular Tachycardia: JACC Focus Seminar 5/5. J Am Coll Cardiol. 2021; 77(20): 2592-2612.

Hartman RJG, Owsiany K, Ma L, Koplev S, Hao K, Slenders L, Civelek M, Mokry M, Kovacic JC, Pasterkamp G, Owens G, Björkegren JLM, den Ruijter HM. Sex-Stratified Gene Regulatory Networks Reveal Female Key-Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching. Circulation. 2021; 143(7): 713-726.

Monteiro JP, Rodor J, Caudrillier A, Scanlon JP, Spiroski AM, Dudnakova T, Pflüger-Müller B, Shmakova A, von Kriegsheim A, Deng L, Taylor RS, Wilson-Kanamori JR, Chen SH, Stewart K, Thomson A, Mitić T, McClure JD, Iyinikkel J, Hadoke PW, Denby L, Bradshaw AC, Caruso P, Morrell NW, Kovacic JC, Ulitsky I, Henderson NC, Caporali A, Leisegang MS, Brandes RP, Baker AH. MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease. Circ Res. 2021; 128: 1173–1190.

Persu A, Dobrowolski P, Gornik HL, Olin JW, Adlam D, Azizi M, Boutouyrie P, Bruno RM, Boulanger M, Demoulin JB, Ganesh SK, Guzik T, Januszewicz M, Kovacic JC, Kruk M, Leeuw P, Loeys B, Pappaccogli M, Perik M, Touzé E, Van der Niepen P, Van Twist DJL, Warchoł-Celińska E, Prejbisz A, Januszewicz A. Current progress in clinical, molecular, and genetic aspects of adult fibromuscular dysplasia. Cardiovasc Res. 2021 Mar 19:cvab086. doi: 10.1093/cvr/cvab086. Online ahead of print.

Publications: 2020

Ma L, Chandel N, Ermel R, Sukhavasi K, Hao K, Ruusalepp A, Björkegren JLM, Kovacic JC. Multiple independent mechanisms link gene polymorphisms in the region of ZEB2 with risk of coronary artery disease. Atherosclerosis. 2020; 311: 20-29.

Olin JW,* Di Narzo AF,* d’Escamard V,* Kadian-Dodov D,* Cheng H, Georges A, King A, Thomas A, Barwari T, Michelis KC, Bouchareb R, Bander E, Anyanwu A, Stelzer P, Filsoufi F, Florman S, Civelek M, Debette S, Jeunemaitre X, Björkegren JLM, Mayr M, Bouatia-Naji N, Hao K, Kovacic JC. A Plasma Proteogenomic Signature for Fibromuscular Dysplasia. Cardiovasc Res. 2020; 116(1): 63-77. *Equal contribution.

Santini MP, Malide D, Hoffman G, Pandey G, D’Escamard V, Nomura-Kitabayashi A, Rovira I, Kataoka H,  Ochando J, Harvey RP, Finkel T, Kovacic JC. Tissue-resident PDGFRαprogenitor cells contribute to fibrosis versus healing in a context- and spatiotemporally-dependent manner. Cell Rep. 2020; 30(2): 555-570.e7.

del Monte-Nieto G, Fischer JW, Gorski DJ, Harvey RP, Kovacic JC. Basic Biology of Extracellular Matrix in the Cardiovascular System, Part 1/4: JACC Focus Seminar. J Am Coll Cardiol. 2020; 75(17): 2169-2188.

Barallobre-Barreiro J, Loeys B, Mayr M, Rienks M, Verstraeten A, Kovacic JC. Extracellular Matrix in Vascular Disease, Part 2/4: JACC Focus Seminar. J Am Coll Cardiol. 2020; 75(17): 2189-2203.

Díez J, González A, Kovacic JC. Myocardial Interstitial Fibrosis in Nonischemic Heart Disease, Part 3/4: JACC Focus Seminar. J Am Coll Cardiol. 2020; 75(17): 2204-2218.

Frangogiannis NG and Kovacic JC. Extracellular Matrix in Ischemic Heart Disease, Part 4/4: JACC Focus Seminar. J Am Coll Cardiol. 2020; 75(17): 2219-2235.

Tang GHL, Lerakis S, Kini A, Khan JM, Kovacic JC. 4-Dimensional Transesophageal Echocardiographic Guidance During TAVR With BASILICA. JACC Cardiovasc Imaging. 2020; 13(7): 1601-1614

Georges A, Albuisson J, Berrandou T, Dupré D, Lorthioir A, D’Escamard V, Di Narzo AF, Kadian-Dodov D, Olin JW, Warchol-Celinska E, Prejbisz A, Januszewicz A, Bruneval P, Baranowska AA, Webb TR, Hamby SE, Samani NJ, Adlam D, Fendrikova-Mahlay N, Hazen S, Wang Y, Yang ML, Hunker K, Combaret N, Motreff P, Chédid A, Fiquet B, Plouin PF, Mousseaux E, Azarine A, Amar L, Azizi M, Gornik HL, Ganesh SK, Kovacic JC, Jeunemaitre X, Bouatia-Naji N. Rare loss-of-function mutations of PTGIR are enriched in Fibromuscular Dysplasia. Cardiovasc Res. 2020; 117(4): 1154–1165.

Fernandez-Jimenez R, Jaslow R, Bansilal S, Diaz-Munoz R, Fatterpekar M, Santana M, Clarke-Littman A, Latina J, Soto AV, Hill CA, Al-Kazaz M, Samtani R, Vedanthan R, Giannarelli C, Kovacic JC, Bagiella E, Kasarskis A, Fayad ZA, Fuster V. Different Lifestyle Interventions in Adults from Underserved Communities: The FAMILIA Trial. J Am Coll Cardiol. 2020; 75(1): 42-56.

Hulshoff MS, del Monte-Nieto G, Kovacic JC, Krenning G. Non-coding RNA in Endothelial-to-Mesenchymal Transition. Cardiovasc Res. 2019; 115(12): 1716–1731.

Publications: 2019

Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G, Baker A. Endothelial to Mesenchymal Transition in Cardiovascular Disease. J Am Coll Cardiol. 2019; 73(2): 190-209.

Gornik HL, Persu A, Adlam D, Aparicio LS, Azizi M, Boulanger M, Bruno RM, De Leeuw P, Fendrikova-Mahlaya N, Froehlich J, Ganesh SK, Gray BH, Jamison C, Januszewicz A, Jeunemaitre X, Kadian-Dodov D, Kim ESH, Kovacic JC, Mace P, Morganti A, Sharma A, Southerland AM, Touze E, Van Der Niepen P, Wang J, Weinberg I, Wilson S, Olin JW, Plouin PF, on behalf of the Working Group ‘Hypertension and the Kidney’ of the European Society of Hypertension (ESH) and the Society for Vascular Medicine (SVM). First International Consensus on the Diagnosis and Management of Fibromuscular Dysplasia. Joint Publication, Vascular Medicine and Jnl of Hypertension 2019, 37:229–252.

Kalkman DN, Aquino M, Claessen BE, Baber U, Guedeney P, Sorrentino S, Vogel B, de Winter RJ, Sweeny J, Kovacic JC, Shah S, Vijay P, Barman N, Kini A, Sharma S, Dangas GD, Mehran R. Residual inflammatory risk and the impact on clinical outcomes in patients after percutaneous coronary interventions. Eur Heart J. 2018; 39(46): 4101-4108.

Adlam D, Olson TM, Combaret N, Kovacic JC, Iismaa SE, Al-Hussaini A, O’Byrne MM, Bouajila S, Georges A, Mishra K, Braund PS, d’Escamard V, Huang S, Magaritis M, Nelson CP, de Andrade M, Kadian-Dodov D, Welch CA,  Mazurkiewiczh S, Jeunemaitre X, DISCO Consortium, Wong CMY, Giannoulatou E, Sweeting M, Muller D, Wood A, McGrath-Cadell L, Fatkin D, Dunwoodie SL, Harvey R, Holloway C, Empana JP, Jouven X, CARDIoGRAMPlusC4D, Olin JW, Gulati R, Tweet MS, Hayes SN, Samani NJ, Graham RM, Motreff P, Bouatia-Naji N. Association of the PHACTR1/EDN1Genetic Locus With Spontaneous Coronary Artery Dissection. J Am Coll Cardiol. 2019; 73(1): 58-66.

Robson P, Trivieri MG, Karakatsanis N, Padilla M, Abgral R, Dweck M, Kovacic JC, Fayad Z. Correction of Respiratory and Cardiac Motion in Cardiac PET/MR Using MR-Based Motion Modeling. Phys Med Biol. 2018; 63(22): 225011.

Peng S, Deyssenroth MA, Di Narzo AF, Cheng H, Zhang Z, Lambertini L, Rusualepp A, Kovacic JC, Bjorkegren JLM, Marsit C, Chen J, Hao K. Genetic Regulation of the Placental Transcriptome Underlies Birth Weight and Risk of Childhood Obesity. PLoS Genetics. 2018; 14(12): e1007799.

Publications: 2018

Michelis KC, Nomura-Kitabayashi A, Lecce L, Franzén O, Koplev S, Xu Y, Santini MP, D’Escamard V, Lee JTL, Fuster V, Hajjar R, Reddy R, Chikwe J, Stelzer P, Filsoufi F, Stewart A, Anyanwu A, Björkegren JLM, Kovacic JC. CD90 Identifies adventitial mesenchymal progenitor cells in adult human medium- and large-sized arteries. Stem Cell Reports. 2018; 11: 242-57.

Dweck MR, Abgral R, Trivieri MG, Robson PM, Karakatsanis N, Mani V, Palmisano A, Miller M, Lala A, Chang HL, Sanz J, Contreras J, Narula J, Fuster V, Padilla M, Fayad ZA, Kovacic JC. Hybrid MR/PET Imaging with FDG to Diagnose Active Cardiac Sarcoidosis. JACC Cardiovasc Imaging. 2018; 11: 94–107.

Nomura-Kitabayashi A, Kovacic JC. Mouse Model of Wire Injury-Induced Vascular Remodeling. Methods Mol Biol. 2018; 1816: 253-268.

Williams JW, Giannarelli C, Rahman A, Randolph GJ, Kovacic JC. Macrophage Biology, Classification, and Phenotype in Cardiovascular Disease. JACC Macrophage in CVD Series (Part 1). J Am Coll Cardiol. 2018; 72: 2166-2180.

Moore KJ, Koplev S, Fisher EA, Tabas I, Björkegren JLM, Doran AC, Kovacic JC. Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis. JACC Macrophage in CVD Series (Part 2). J Am Coll Cardiol. 2018; 72: 2181-2197.

Fayad ZA, Swirski FK, Calcagno C, Robbins CS, Mulder W, Kovacic JC. Monocyte and Macrophage Dynamics in the Cardiovascular System. JACC Macrophage in CVD Series (Part 3). J Am Coll Cardiol. 2018; 72: 2198-2212.

Lavine KJ, Pinto AR, Epelman S, Kopecky BJ, Clemente-Casares X, Godwin J, Rosenthal N, Kovacic JC. The Macrophage in Cardiac Homeostasis and Disease. JACC Macrophage in CVD Series (Part 4). J Am Coll Cardiol. 2018; 72: 2213-2230.

Watanabe S, Fish K, Kovacic JC, Bikou B, Leonardson L, Nomoto K, Aguero J, Kapur NK, Hajjar RJ, Ishikawa K. LV Unloading using an Impella CP Improves Coronary Flow and Infarct Zone Perfusion in Ischemic Heart Failure. J Am Heart Assoc. 2018; 7(6): pii: e006462.

Publications: 2017

Sack MN, Fyhrquist FY, Saijonmaa OJ, Fuster V, Kovacic JC. Basic Biology of Oxidative Stress and the Cardiovascular System. J Am Coll Cardiol. 2017; 70(2): 196-211.

Münzel T, Camici GC, Maack C, Bonetti NR, Fuster V, Kovacic JC. Impact of oxidative stress on the heart and vasculature. J Am Coll Cardiol. 2017; 70(2): 212-229.

Niemann B, Rohrbach S, Miller MR, Newby DE, Fuster V, Kovacic JC. Oxidative stress and cardiovascular risk factors: obesity, diabetes, smoking and pollution. J Am Coll Cardiol. 2017; 70(2): 230-251.

Krishnamoorthy P, Vengrenyuk Y, Ueda H, Yoshimura T, Pena J, Motoyama S, Baber U, Hasan C, Kesanakurthy S, Sweeny JM, Sharma SK, Narula J, Kovacic JC, Kini AS. Three Dimensional Volumetric Assessment of Coronary Artery Calcification in Patients with stable Coronary Artery Disease by OCT. EuroIntervention. 2017; 13(3): 312-319.

Johnson KW, Shameer K, Glicksberg BS, Readhead B, Sengupta PP, Björkegren JLM, Kovacic JC, Dudley JT. Enabling Precision Cardiology through Disease Networks and Systems Pharmacotherapy. JACC Basic to Translational Science. 2017; 2(3): 311-327.

Robson PM, Dweck MR, Trivieri MG, Abgral R, Karakatsanis NA, Contreras J, Gidwani U, Narula JP, Fuster V, Kovacic JC, Fayad ZA. Coronary Artery PET/MR Imaging: Feasibility, Limitations, and Solutions. JACC Cardiovasc Imaging. 2017; 10(10 Pt A): 1103-1112.

Bansilal S, Vedanthan R, Kovacic JC, Soto AV, Latina J, Björkegren JLM, Jaslow R, Santana M, Sartori S, Giannarelli C, Mani V, Hajjar R, Schadt E, Kasarskis A, Fayad ZA, Fuster V. Rationale and Design of Family-Based Approach in a Minority Community Integrating Systems-Biology for Promotion of Health (FAMILIA). Am Heart J. 2017; 187: 170-81.