Projects and Grants

R01HL148167-01A1        Kovacic/Kadian-Dodov (PIs)
05/15/2020 – 04/30/2024
Awarding Body: NIH/NHLBI
Understanding the Molecular Mechanisms of Fibromuscular Dysplasia
Fibromuscular dysplasia (FMD), a poorly understood disease that predominantly affects women, can result in serious consequences including stroke, myocardial infarction, and death. Although it was first reported in 1938 and with a prevalence of up to 5% in females, there is no specific treatment and very little is known about its cause. Through our DEFINE-FMD study we have identified a specific network of genes that appears important for causing FMD – here we will dissect the functional roles of this gene network, to make the first meaningful biologic inroads on this disease.
Role: Principal Investigator (MPI with Dr. Kadian-Dodov)

R01HL143221        Shah (PI)
07/15/2018 – 05/31/2023
Awarding Body: NIH/NHLBI
Imaging the Atherosclerosis Cascade in Sleep Apnea
Our study will non-invasively quantify the entire atherosclerosis cascade including endothelial dysfunction, vascular stiffness, vascular inflammation, plaque composition and total plaque burden in patients with sleep apnea using state-of-the-art vascular imaging. Our study will provide significant mechanistic insight regarding the role sleep apnea plays in the progression of atherosclerosis and regarding the anti-atherosclerotic actions of continuous positive airway pressure therapy. Our study will identify patients at high risk for progression of atherosclerosis and those who have the greatest anti-atherosclerotic actions of sleep apnea treatment.
Role: Co-Investigator