Projects and Grants

R01HL130423        Kovacic/Ishikawa (PIs)
01/25/2016 – 12/31/2020 (NCE from 1/1/21)
Awarding Body: NIH/NHLBI
Toward Therapeutic Manipulation of Endothelial to Mesenchymal Transition
This proposal seeks to leverage several novel discoveries made by our team to define the core biologic mechanisms of EndMT in atherosclerosis and cardiovascular disease, to understand how we can manipulate EndMT to promote healing after vascular grafting procedures, and ultimately to develop novel therapeutic strategies for cardiovascular disease.
Role: Principal Investigator (MPI with Dr. Kiyo Ishikawa)

R01HL135093        Kovacic/Fish (PIs)
01/20/2017 – 12/31/2020 (NCE from 1/1/21)
Awarding Body: NIH/NHLBI
Therapeutic Mechanisms of Cardiac Progenitors in Ischemic Cardiomyopathy
We will examine the roles cardiac progenitor cells (CPCs) in heart failure as a foundation for understanding their endogenous regenerative potential. Our program uses innovative delivery vectors and state of the art genomics technologies to examine CPC biology, reparative potential and impacts after myocardial function.
Role: Principal Investigator (MPI with Dr. Kenneth M. Fish)

R01HL148167-01A1        Kovacic/Kadian-Dodov (PIs)
05/15/2020 – 04/30/2024
Awarding Body: NIH/NHLBI
Understanding the Molecular Mechanisms of Fibromuscular Dysplasia
Fibromuscular dysplasia (FMD), a poorly understood disease that predominantly affects women, can result in serious consequences including stroke, myocardial infarction, and death. Although it was first reported in 1938 and with a prevalence of up to 5% in females, there is no specific treatment and very little is known about its cause. Through our DEFINE-FMD study we have identified a specific network of genes that appears important for causing FMD – here we will dissect the functional roles of this gene network, to make the first meaningful biologic inroads on this disease.
Role: Principal Investigator (MPI with Dr. Kadian-Dodov)

R01HL139865        Do (PI)
02/01/2018 – 01/31/2022
Awarding Body: NIH/NHLBI
Resolving causal influences among correlated risk biomarkers for coronary artery disease
This proposal aims to utilize genetic analysis to infer causal relationships between cardiometabolic traits, metabolites and clinical phenotypes for subclinical coronary artery disease outcomes.
Role: Co-Investigator

R01HL143221        Shah (PI)
07/15/2018 – 05/31/2023
Awarding Body: NIH/NHLBI
Imaging the Atherosclerosis Cascade in Sleep Apnea
Our study will non-invasively quantify the entire atherosclerosis cascade including endothelial dysfunction, vascular stiffness, vascular inflammation, plaque composition and total plaque burden in patients with sleep apnea using state-of-the-art vascular imaging. Our study will provide significant mechanistic insight regarding the role sleep apnea plays in the progression of atherosclerosis and regarding the anti-atherosclerotic actions of continuous positive airway pressure therapy. Our study will identify patients at high risk for progression of atherosclerosis and those who have the greatest anti-atherosclerotic actions of sleep apnea treatment.
Role: Co-Investigator