2021
System-level Disease-driven Immune Signatures in Patients with Diffuse Large B-Cell Lymphoma.
Tschan-Plessl, A., Ask, E.H., Gjerdingen, T.J., Sætersmoen, M.L., Hoel, H.J., Wiiger, M.T., Olweus, J., Wahlin, B.E., Horowitz, A., Holte, H., Kolstad, A., Malmberg, K-J. Med. 2021. In Press.
MiDAS – Meaningful Immunogenetic Data at Scale.
Migdal, M., Ruan, DF, Forrest, WF, Horowitz, A, Hammer, C. PLoS Comp Biol. 2021. In Press.
The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice.
Shreeve N, Depierreux D, Hawkes D, Traherne JA, Sovio U, Huhn O, Jayaraman J, Horowitz A, Ghadially H, Perry JRB, Moffett A, Sled JG, Sharkey AM, Colucci F. Immunity. 2021. In press.
Bacillus Calmette-Guerin (BCG): Its fight against pathogens and cancer.
Sfakianos JP, Salome B, Daza J, Farkas A, Bhardwaj N, Horowitz A. Urol Oncol. 2021 Feb;39(2):121-129. Review.
Myeloid Cell-associated Resistance to PD-1/PD-L1 Blockade in Urothelial Cancer Revealed Through Bulk and Single-cell RNA Sequencing.
Wang L, Sfakianos JP, Beaumont KG, Akturk G, Horowitz A, Sebra RP, Farkas AM, Gnjatic S, Hake A, Izadmehr S, Wiklund P, Oh WK, Szabo PM, Wind-Rotolo M, Unsal-Kacmaz K, Yao X, Schadt E, Sharma P, Bhardwaj N, Zhu J, Galsky MD. Clin Cancer Res. 2021 Apr 9. In Press.
_____________________________________________________________________________________________________________________________________________________________________________________________________________________
2020
Immunology of COVID-19: Current State of the Science.
Vabret N, Britton GJ, Gruber C, Hegde S, Kim J, Kuksin M, Levantovsky R, Malle L, Moreira A, Park MD, Pia L, Risson E, Saffern M, Salomé B, Esai Selvan M, Spindler MP, Tan J, van der Heide V, Gregory JK, Alexandropoulos K, Bhardwaj N, Brown BD, Greenbaum B, Gümüş ZH, Homann D, Horowitz A, Kamphorst AO, Curotto de Lafaille MA, Mehandru S, Merad M, Samstein RM; Sinai Immunology Review Project. Immunity. 2020 Jun 16;52(6):910-941. Review.
Landscape of natural killer cell activity in head and neck squamous cell carcinoma.
Charap AJ, Enokida T, Brody R, Sfakianos J, Miles B, Bhardwaj N, Horowitz A. J Immunother Cancer. 2020 Dec;8(2):e001523. Review.
Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy.
Huhn O, Ivarsson MA, Gardner L, Hollinshead M, Stinchcombe JC, Chen P, Shreeve N, Chazara O, Farrell LE, Theorell J, Ghadially H, Parham P, Griffiths G, Horowitz A, Moffett A, Sharkey AM, Colucci F. Nat Commun. 2020 Jan 20;11(1):381.
Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing.
Smith SL, Kennedy PR, Stacey KB, Worboys JD, Yarwood A, Seo S, Solloa EH, Mistretta B, Chatterjee SS, Gunaratne P, Allette K, Wang YC, Smith ML, Sebra R, Mace EM, Horowitz A, Thomson W, Martin P, Eyre S, Davis DM. Blood Adv. 2020 Apr 14;4(7):1388-1406.
_____________________________________________________________________________________________________________________________________________________________________________________________________________________
2019
Fibroblast Growth Factor Receptor 3 Alterations and Response to PD-1/PD-L1 Blockade in Patients with Metastatic Urothelial Cancer.
Wang L, Gong Y, Saci A, Szabo PM, Martini A, Necchi A, Siefker-Radtke A, Pal S, Plimack ER, Sfakianos JP, Bhardwaj N, Horowitz A, Farkas AM, Mulholland D, Fischer BS, Oh WK, Sharma P, Zhu J, Galsky MD.Eur Urol. 2019 Nov;76(5):599-603.
Monalizumab: inhibiting the novel immune checkpoint NKG2A.
van Hall T, André P, Horowitz A, Ruan DF, Borst L, Zerbib R, Narni-Mancinelli E, van der Burg SH, Vivier E. J Immunother Cancer. 2019 Oct 17;7(1):263. Review.
CD56 as a marker of an ILC1-like population with NK cell properties that is functionally impaired in AML
Salomé B, Gomez-Cadena A, Loyon R, Suffiotti M, Salvestrini V, Wyss T, Vanoni G, Ruan DF, Rossi M, Tozzo A, Tentorio P, Bruni E, Riether C, Jacobsen EM, Jandus P, Conrad C, Hoenig M, Schulz A, Michaud K, Della Porta MG, Salvatore S, Ho PC, Gfeller D, Ochsenbein A, Mavilio D, Curti A, Marcenaro E, Steinle A, Horowitz A, Romero P, Trabanelli S, Jandus C. Blood Adv. 2019. Nov 26;3(22):3674-3687.
_____________________________________________________________________________________________________________________________________________________________________________________________________________________
2018
Anti-α4b7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals.
Uzzan, M., Tokuyama M, Rosenstein AK, Tomescu C, SahBandar IN, Ko HM, Leyre L, Chokola A, Kaplan-Lewis E, Rodriguez G, Seki A, Corley MJ, Aberg J, La Porte A, Park EY, Ueno H, Oikonomou I, Doron I, Iliev ID, Chen BK, Lui J, Schacker TW, Furtado GC, Lira SA, Colombel JF, Horowitz A, Lim JK, Chomont N, Rahman AH, Montaner LJ, Ndhlovu LC, Mehandru S. Sci Transl Med. 2018. 10, eaau4711.
Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.
Ramsuran V, Naranbhai V, Horowitz A, Qi Y, Martin MP, Yuki Y, Gao X, Walker-Sperling V, Del Prete GQ, Schneider DK, Lifson JD, Fellay J, Deeks SG, Martin JN, Goedert JJ, Wolinsky SM, Michael NL, Kirk GD, Buchbinder S, Haas D, Ndung’u T, Goulder P, Parham P, Walker BD, Carlson JM, Carrington M. Science. 2018 Jan 5;359(6371):86-90.
_____________________________________________________________________________________________________________________________________________________________________________________________________________________
2017
The Intergenic Recombinant HLA-B*46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands
Hilton HG, McMurtrey CP, Han AS, Djaoud Z, Guethlein LA, Blokhuis JH, Pugh JL, Goyos A, Horowitz, A, Buchli R, Jackson KW, Bardet W, Bushnell DA, Robinson PJ, Mendoza JL, Birnbaum ME, Nielsen M, Garcia KC, Hildebrand WH, Parham P. The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands. Cell Rep. 2017 May 16;19(7):1394-1405.
Two alternative strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and γδ T cells
Djaoud Z, Guethlein LA, Horowitz A, Azzi T, Nemat-Gorgani N, Olive D, Nadal D, Norman PJ, Münz C, Parham P. Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and γδ T cells. J Exp Med. 2017 214(6):1827-1841.
2016
Class I HLA haplotypes form two schools that educate NK cells in different ways
Horowitz A, Djaoud Z, Nemat-Gorgani N, Blokhuis J, Hilton HG, Béziat V, Malmberg KJ, Norman PJ, Guethlein LA, Parham P. Class I HLA haplotypes form two schools that educate NK cells in different ways. Sci Immunol. 2016 1(3):eaag1672.
2015
Regulation of Adaptive NK Cells and CD8 T Cells by HLA-C Correlates with Allogeneic Hematopoietic Cell Transplantation and with Cytomegalovirus Reactivation.
Horowitz A, Guethlein LA, Nemat-Gorgani N, Norman PJ, Cooley S, Miller JS, Parham P. Regulation of Adaptive NK Cells and CD8 T Cells by HLA-C Correlates with Allogeneic Hematopoietic Cell Transplantation and with Cytomegalovirus Reactivation. J Immunol. 2015 195(9):4524-36.
A Distinctive Cytoplasmic Tail Contributes to Low Surface Expression and Intracellular Retention of the Patr-AL MHC Class I Molecule.
Goyos A, Guethlein LA, Horowitz A, Hilton HG, Gleimer M, Brodsky FM, Parham P. A Distinctive Cytoplasmic Tail Contributes to Low Surface Expression and Intracellular Retention of the Patr-AL MHC Class I Molecule. J Immunol. 2015 195(8):3725-36.
Adaptive Natural Killer Cell and Killer Cell Immunoglobulin-Like Receptor-Expressing T Cell Responses are Induced by Cytomegalovirus and Are Associated with Protection against Cytomegalovirus Reactivation after Allogeneic Donor Hematopoietic Cell Transplantation.
Davis ZB, Cooley SA, Cichocki F, Felices M, Wangen R, Luo X, DeFor TE, Bryceson YT, Diamond DJ, Brunstein C, Blazar BR, Wagner JE, Weisdorf DJ, Horowitz A, Guethlein LA, Parham P, Verneris MR, Miller JS. Adaptive Natural Killer Cell and Killer Cell Immunoglobulin-Like Receptor-Expressing T Cell Responses are Induced by Cytomegalovirus and Are Associated with Protection against Cytomegalovirus Reactivation after Allogeneic Donor Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2015 21(9):1653-62.
2014
Coordinated regulation of NK receptor expression in the maturing human immune system.
Strauss-Albee DM, Horowitz A, Parham P, Blish CA. Coordinated regulation of NK receptor expression in the maturing human immune system. J Immunol. 2014 193(10):4871-9.
2013
Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry.
Horowitz A, Strauss-Albee DM, Leipold M, Kubo J, Nemat-Gorgani N, Dogan OC, Dekker CL, Mackey S, Maecker H, Swan GE, Davis MM, Norman PJ, Guethlein LA, Desai M, Parham P, Blish CA. Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry. Sci Transl Med. 2013 5(208):208ra145.
Activation of human NK cells by Plasmodium-infected red blood cells
Horowitz A, Riley EM. Activation of human NK cells by Plasmodium-infected red blood cells. Methods Mol Biol. 2013 923:447-64.
2012
Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine.
Horowitz A, Hafalla JC, King E, Lusingu J, Dekker D, Leach A, Moris P, Cohen J, Vekemans J, Villafana T, Corran PH, Bejon P, Drakeley CJ, von Seidlein L, Riley EM. Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine. J Immunol. 2012 May 15;188(10):5054-62.
Activation of natural killer cells during microbial infections.
Horowitz A, Stegmann KA, Riley EM. Activation of natural killer cells during microbial infections. Front Immunol. 2012 2:88.
2011
Systemic effector and regulatory immune responses to chlamydial antigens in trachomatous trichiasis.
Gall A, Horowitz A, Joof H, Natividad A, Tetteh K, Riley E, Bailey RL, Mabey DC, Holland MJ. Systemic effector and regulatory immune responses to chlamydial antigens in trachomatous trichiasis. Front Microbiol. 2011 2:10.
A distinct subset of human NK cells expressing HLA-DR expand in response to IL-2 and can aid immune responses to BCG.
Evans JH, Horowitz A, Mehrabi M, Wise EL, Pease JE, Riley EM, Davis DM. A distinct subset of human NK cells expressing HLA-DR expand in response to IL-2 and can aid immune responses to BCG. Eur J Immunol. 2011 41(7):1924-33.
2010
NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination.
Horowitz A, Behrens RH, Okell L, Fooks AR, Riley EM. NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination. J Immunol. 2010 Sep 1;185(5):2808-18.
Cross-talk between T cells and NK cells generates rapid effector responses to Plasmodium falciparum-infected erythrocytes
Horowitz A, Newman KC, Evans JH, Korbel DS, Davis DM, Riley EM. Cross-talk between T cells and NK cells generates rapid effector responses to Plasmodium falciparum-infected erythrocytes. J Immunol. 2010 184(11):6043-52.
2009
Killer Ig-like receptor (KIR) genotype predicts the capacity of human KIR-positive CD56dim NK cells to respond to pathogen-associated signals.
Korbel DS, Norman PJ, Newman KC, Horowitz A, Gendzekhadze K, Parham P, Riley EM. Killer Ig-like receptor (KIR) genotype predicts the capacity of human KIR-positive CD56dim NK cells to respond to pathogen-associated signals. J Immunol. 2009 182(10):6426-34.
Use of immobilized HLA-A2:Ig dimeric proteins to determine the level of epitope-specific, HLA-restricted CD8(+) T-cell response.
Horowitz A, Li X, Poles MA, Tsuji M. Use of immobilized HLA-A2:Ig dimeric proteins to determine the level of epitope-specific, HLA-restricted CD8(+) T-cell response. Scand J Immunol. 2009 Nov;70(5):415-22.
2007
Function of NKT cells, potential anti-HIV effector cells, are improved by beginning HAART during acute HIV-1 infection.
Vasan S, Poles MA, Horowitz A, Siladji EE, Markowitz M, Tsuji M. Function of NKT cells, potential anti-HIV effector cells, are improved by beginning HAART during acute HIV-1 infection. Int Immunol. 2007 Aug;19(8):943-51.
2005
Infection with multidrug resistant, dual-tropic HIV-1 and rapid progression to AIDS: a case report.
Markowitz M, Mohri H, Mehandru S, Shet A, Berry L, Kalyanaraman R, Kim A, Chung C, Jean-Pierre P, Horowitz A, La Mar M, Wrin T, Parkin N, Poles M, Petropoulos C, Mullen M, Boden D, Ho DD. Infection with multidrug resistant, dual-tropic HIV-1 and rapid progression to AIDS: a case report. Lancet. 2005 365(9464):1031-8.
Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells.
Wu D, Xing GW, Poles MA, Horowitz A, Kinjo Y, Sullivan B, Bodmer-Narkevitch V, Plettenburg O, Kronenberg M, Tsuji M, Ho DD, Wong CH. Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells. Proc Natl Acad Sci U S A. 2005 102(5):1351-6.
Synthesis and human NKT cell stimulating properties of 3-O-sulfo-alpha/beta-galactosylceramides.
Xing GW, Wu D, Poles MA, Horowitz A, Tsuji M, Ho DD, Wong CH. Synthesis and human NKT cell stimulating properties of 3-O-sulfo-alpha/beta-galactosylceramides. Bioorg Med Chem. 2005 Apr 15;13(8):2907-16.
2004
Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract.
Mehandru S, Poles MA, Tenner-Racz K, Horowitz A, Hurley A, Hogan C, Boden D, Racz P, Markowitz M. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med. 2004 200(6):761-70.