Our work focuses on human NK cells and T cells and their functional roles in cancer, microbial infections, transplantation, and in autoimmunity. Our analyses are designed to identify specific subsets of NK cells and T cells with enhanced immunotherapeutic potential as well as to identify pathways regulating NK cell and T cell function that can be perturbed for therapeutic benefit. To achieve this goal, our lab uses mass cytometry (CyTOF^TM), imaging mass cytometry, single cell RNA sequencing, and Olink Proteomics^TM along with genomic data to study NK cells and T cells with ultra-resolution.

Currently, the lab has studies focused on bladder cancer, kidney cancer, head and neck cancer, kidney transplantation, and Type 1 diabetes.

Our approach combines:

1. epidemiologic analyses of HLA and KIR alleles in genomic studies of cancers, immunotherapy, transplantation and Type 1 Diabetes;
2. Ex-vivo phenotyping and in-vitro mechanistic studies using high-resolution transcriptomic and proteomic analyses (CyTOF^TM, imaging mass cytometry, single-cell RNAseq, spatial-sequencing, and Olink proteomics^TM)

We invite you to scroll through our Projects Page for more details on our current studies.