Teresa Aydillo-Gomez, Ph.D.







Research Interests
My long-term goal is to identify immunological mechanisms triggered by natural influenza infection in humans to elucidate correlates of protection that will predict clinical outcomes and robust immune responses. We will apply this knowledge to predict protective immunity before vaccination for successful development of broadly cross-reactive influenza vaccines. For this we propose using an ongoing clinically characterized cohort to precisely characterize influenza immunity and correlates of immune protection, specifically by identifying those resulting from vaccination versus virus infection.


Notable Publications

Karakus U, Thamamongood T, Ciminski K, Ran W, Günther SC, Pohl MO, Eletto D, Jeney C, Hoffmann D, Reiche S, Schinköthe J, Ulrich R, Wiener J, Hayes MGB, Chang MW, Hunziker A, Yángüez E, Aydillo T, Krammer F, Oderbolz J, Meier M, Oxenius A, Halenius A, Zimmer G, Benner C, Hale BG, García-Sastre A, Beer M, Schwemmle M, Stertz S. MHC class II proteins mediate cross-species entry of bat influenza viruses. Nature. 2019 Mar;567(7746):109-112. doi: 10.1038/s41586-019-0955-3.

Aydillo T, Ayllon J, Pavlisin A, Martinez-Romero C, Tripathi S, Mena I, Moreira-Soto A, Vicente-Santos A, Corrales-Aguilar E, Schwemmle M and García-Sastre A. Specific mutations in the PB2 protein of influenza A virus compensate for the lack of efficient IFN antagonism of the NS1 protein of bat influenza A-like viruses. J Virol. 2018. Mar 14;92(7). pii: e02021-17. doi: 10.1128/JVI.02021-17.

Cordero E, Roca-Oporto C, Bulnes-Ramos A, Aydillo T, et al. Two doses of inactivated influenza vaccine improve immune response in solid organ transplant recipients. Results of TRANSGRIPE1-2, a randomised, controlled clinical trial. Clin Infect Dis. 2017 Apr 1;64(7):829-838. doi: 10.1093/cid/ciw855.

Aydillo T, Pérez-Romero P, Perez-Ordoñez A, et al. Reduced Incidence of Pneumonia in Influenza Vaccinated Solid Organ Transplant Recipients with Influenza Disease. Clin Microbiol Infect. 2012 Dec;18(12):E533-40.

Aydillo T, Cordero E, Perez-Ordoñez A, et al. Deficient Long-term Response to Pandemic Vaccine Results in an Insufficient Antibody Response to Seasonal Influenza Vaccination in SOT-Recipients. Transplantation 2012; Apr 27;93(8):847-54.