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Garcia-Sastre Lab Notable Publications:

Grant A, Ponia S, Tripathi S, Balasubramaniam V, Miorin L, Sourisseau M, Schwarz M, Sánchez-Seco M, Evans M, Best S, García-Sastre A. Zika virus targets human STAT2 to inhibit type I interferon signaling. Cell Host & Microbe 2016; 19: 882-890.

Tripathi S, Pohl M, Zhou Y, Rodriguez-Frandsen A, Wang G, Stein D, Moulton H, DeJesus P, Che J, Mulder L, Yángüez E, Andenmatten D, Pache L, Manicassamy B, Albrecht R, Gonzalez M, Nguyen Q, Brass A, Elledge S, White M, Shapira S, Hacohen N, Karlas A, Meyer T, Shales M, Gatorano A, Johnson J, Jang G, Johnson T, Verschueren E, Sanders D, Krogan N, Shaw M, König R, Stertz S, García-Sastre A. Meta- and orthogonal integration of influenza ‘OMICs’ data reveals UBR4 as a critical regulator of M2 ion channel membrane trafficking. Cell Host & Microbe 2015; 18: 723-735.

Cuadrado-Castano S, Ayllon J, Mansour M, de la Iglesia-Vicente J, Jordan S, Tripathi S, García-Sastre A, Villar E. Enhancement of the pro-apoptotic properties of Newcastle disease virus promotes tumor remission in syngeneic murine cancer models. Mol. Cancer Ther. 2015; 14(5): 1247-1258.

Laurent-Rolle M, Morrison J, Rajsbaum R, Macleod J, Pisanelli G, Pham A, Ayllon J, Miorin L, Martinez C, tenOever B, García-Sastre A. The interferon signaling antagonist function of yellow fever virus NS5 protein is activated by Type I interferon. Cell Host and Microbe 2014; 16: 314-327.

Rajsbaum R, Versteeg G, Schmid S, Maestre A, Belicha-Villanueva A, Martínez-Romero C, Patel J, Morrison J, Pisanelli G, Miorin L, Laurent-Rolle M, Moulton H, Stein D, Fernandez-Sesma A, tenOever B, García-Sastre A. Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response. Immunity 2014; 40: 880-895.

Versteeg G, Rajsbaum R, Sánchez-Aparicio M, Maestre A, Valdiviezo J, Shi M, Inn K, Fernandez-Sesma A, Jung J, García-Sastre A. The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors. Immunity 2013; 38: 384-398.

Langlois R, Albrecht R, Kimble B, Sutton T, Shapiro J, Finch C, Angel M, Chua M, Gonzalez-Reiche A, Xu K, Perez D, García-Sastre A. MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies. Nat. Biotech. 2013; 31: 844-847.

Medina R, Stertz S, Manicassamy B, Zimmermann P, Sun X, Albrecht R, Uusi-Kerttula H, Zagordi O, Belshe R, Frey S, Eggink D, Tumpey T, García-Sastre A. Glycosylations in the globular head of the hemagglutinin protein modulate the virulence and antigenic properties of the H1N1 influenza viruses. Sci. Trans. Med. 2013; 5: 187ra70.

Baum A, Sachidanandam R, García-Sastre A. Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing. Proc. Natl. Acad. Sci. (USA) 2010; 107: 16303-16308.

Ashour J, Morrison J, Laurent-Rolle M, Belicha-Villanueva A, Plumlee C, Bernal-Rubio D, Williams K, Harris E, Fernandez-Sesma A, Schindler C, García-Sastre A. Mouse STAT2 restricts early dengue virus replication. Cell Host and Microbe 2010; 8: 410-421.

Vigil A, Martinez O, Chua M, García-Sastre A. Recombinant Newcastle disease virus as a vaccine vector for cancer therapy. Mol. Ther. 2008; 16: 1883-1890.

Tumpey T, Maines T, Van Hoeven N, Glaser L, Solórzano A, Pappas C, Cox N, Swayne D, Palese P, Katz J, García-Sastre A. A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission. Science 2007; 315: 655-659.

Tumpey T, Basler C, Aguilar P, Zeng H, Solorzano A, Swayne D, Cox N, Katz J, Taubenberger J, Palese P, García-Sastre A. Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 2005; 310: 77-80.

Nakaya Y, Nakaya T, Park M, Cros J, Imanishi J, Palese P, García-Sastre A. Induction of cellular immune responses to SIV gag by two recombinant negative-strand RNA virus vectors. J. Virol. 2004; 78: 9366 9375.

Fodor E, Devenish L, Engelhardt O, Palese P, Brownlee G, García-Sastre A. Rescue of influenza A virus from recombinant DNA. J. Virol. 1999; 73: 9679-9682.

García-Sastre A, Egorov A, Matassov D, Brandt S, Levy D, Durbin J, Palese P, Muster T. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology 1998; 252: 324-330.