Associate Researcher
sadaf.aslam@mssm.edu
Research Interests
My research focuses on developing an optimized backbone for influenza B virus for vaccine production. We are working on generating a backbone that can be used in combination with any influenza B hemagglutinin and neuraminidase to give high yields in eggs for vaccine production. I am also working on studying how influenza A virus NS1 protein interacts with phosphoinositide 3-kinase.
Notable Publications
- Asthagiri Arunkumar, G., Ioannou, A., Wohlbold, T. J., Meade, P., Aslam, S., Amanat, F., Ayllón, J., García-Sastre, A., Krammer, F. (2019). Broadly Cross-Reactive, Nonneutralizing Antibodies against Influenza B Virus Hemagglutinin Demonstrate Effector Function-Dependent Protection against Lethal Viral Challenge in Mice. Journal of virology, 93(6), e01696-18. doi:10.1128/JVI.01696-18
- Muñoz-Moreno, R., Martínez-Romer, C., Blanco-Melo, D., Forst, C.V., Nachbagauer, R., Benitez, A. A., Mena, I., Aslam, S., Balasubramaniam, V., Lee, I., Panis, M., Ayllón, J., Sachs, D., Parks, M.S., Krammer, F., Tenoever, B. R., García-Sastre, A. (2019). Viral fitness landscapes in diverse host species reveal multiple evolutionary lines for the NS1 gene of influenza A viruses. Cell Reports, 29(12):3997-4009.e5. doi: 10.1016/j.celrep.2019.11.070.
- Chromikova, V., Tan, J., Aslam, S., Rajabhathor, A., Ayllón, J., García-Sastre, A., Salaun, B., Nachbagauer, R., Krammer, F. (2019). Activity of serum antibody in a hemagglutinin stalk based ADCC reporter assay correlates well with activity in a CD107a-based degranulation assay. (Accepted in Vaccines)