My primary research focuses on determine the mechanisms of the interaction of some host factors during influenza A virus (IAV) infection. I am particularly interested in the role of the adaptive mutations within the influenza A virus polymerase in conferring species-specific interactions with essential host factors. Three main factors were identified as involved in the polymerase adaptation using high-throughput genetic screen field, and I am currently working on the characterization of these factors. Also, in my research work, I explored the role of non-coding RNAs during IAV infection and I am working on the elucidation of the mechanism behind this phenomenon.
Grant Beyleveld, Daniel J. Chin, Elena Moreno Del Olmo, Jade Carter, Isabel Najera, Cristian Cillóniz, Megan L. Shaw. Nucleolar Relocalization of RBM14 by Influenza A Virus NS1 Protein. mSphere Nov 2018, 3 (6) e00549-18; doi: 10.1128/mSphereDirect.00549-18
Moreno E, Gallego I, Gregori J, Lucía-Sanz A, Soria ME, Castro V, Beach NM, Manrubia SC, Quer J, Esteban JI, Rice CM, Gómez J, Gastaminza P, Domingo E and Perales C. Internal disequilibria and phenotypic diversification during replication of hepatitis C virus in a non-coevolving cellular environment. J Virol 2017 Apr 28;91(10) e02505-16. doi: 10.1128/JVI.02505-16.
Moreno E and Perales C. Distance effects during polyprotein processing in the complementation between defective FMDV RNAs. J Gen Virol 2016. 97:1575-1583. doi: 10.1099/jgv.0.000480.
Perales C, Moreno E and Domingo E. Clonality and intracellular polyploidy in virus evolution and pathogenesis. PNAS 2015; 112(29): 8887-8892. doi:10.1073/pnas.1501715112
Moreno E, Ojosnegros S, García-Arriaza J, Escarmís C, Domingo E and Perales C. Exploration of sequence space as the basis of viral RNA genome segmentation. PNAS 2014; 111(18): 6678-6683. doi:10.1073/pnas.1323136111