The following is a list of projects being conducted in the Liver Research Laboratory of Dr. Scott Friedman:

• Characterization of cell specific gene expression, and cell-cell interactions in mouse models of non-alcoholic steatohepatitis (NASH) and human liver disease.

            Investigator: Shuang Wang, PhD

 

• Epigenetic regulation of stellate cell biology:

           Investigator: Shuang Wang, PhD

 

• Bioinformatics-based identification of novel pro-fibrogenic signaling pathways and druggable targets in hepatic stellate cells.

            Investigator: Shuang Wang, PhD

 

• Antifibrotic activity of clinical candidates for treatment of liver disease in cultured stellate cells, precision cut liver slices and animal models.

            Investigators: Dipankar Bhattacharya, MS

 

• Novel tools to interrogate and manipulate stellate cell function in culture and in vivo.

            Investigators:  Shuang Wang, PhD and Kenneth Li

 

• Identification, interactions and targeting of stellate cell surface molecules.

            Investigators:  James Carter, Vignesh Rajasekaran, Nicholas Venturini

 

• Novel hepatic stellate cell depletion models to elucidate mechanisms of NASH and liver cancer.

            Investigators: Chittampalli Yashaswini, James Carter