A1. Highlighted publications:

  1. Dominguez-Sola D*, Kung J, Holmes AB, Wells VA, Mo T, Basso K, Dalla-Favera R*. FOXO1 instructs the germinal center dark zone program. Immunity 2015, 43(6):1064-74.
    Journal cover (December 2015) Oftentimes, genes targeted by structural rearrangements or mutations in B cell non-Hodgkin lymphomas play essential roles for the normal biology of the B cell of origin. In this article we described a role for FOXO1 – a gene mutated in a fraction of aggressive germinal center-derived B cell non-Hodgkin lymphomas –, in the control of germinal center zonal polarity. We provided evidence indicating that FOXO1 regulates a gene program defining the dark zone cell fate, and that this program is essential for normal germinal center homeostasis and function. These findings suggest that altered control of germinal center zonal polarity or of dark zone cell programs, might mechanistically contribute to the pathogenesis of B cell non-Hodgkin lymphomas. You can read a commentary article by Jason G. Cyster  here:
  2. Dominguez-Sola D*, Victora GD*, Ying CY, Phan RT, Saito M, Nussenzweig MC, Dalla-Favera R. The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry. Nat Immunol 2012, 13(11): 1083-91.
    Previews by Shaffer & Staudt, Nat immunol 2012; 13(11) & O. Leavy, Nat Rev Immunol, 2012; 12(11), 741.
    In this article we described how MYC plays an essential role in the initiation and normal homeostasis of the germinal center reaction. As discussed in the article, the MYC+ germinal center B cell subset could be closely related to the cell of origin of some lymphomas. See also the commentary by Shaffer and Staudt:
  3. Victora GD*, Dominguez-Sola D*, Holmes AB, Deroubaix S, Dalla-Favera R, Nussenzweig MC. Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas. Blood. 2012; 120(11): 2240 8. Commentary by David Tarlinton in Blood 2012; 120: 2158-9.
  4. Dominguez-Sola D*, Ying CY*, Grandori C, Ruggiero L, Chen B, Li M, Galloway DA, Gu W, Gautier J, Dalla-Favera R. Non-transcriptional control of DNA replication by c-Myc. Nature 2007; 448 (7152): 445-451.
    This article describes a novel role for Myc in the control of DNA replication initiation. This biological activity occurs in absence of transcription, which is remarkable given the prominent role of Myc as a transcription factor. Moreover, deregulation of this activity is linked to the generation of replication stress, which might be important for MYC dependent oncogenesis. See also the commentary by Lefobsky and Walter:

A2. Additional publications:

  1. Ersching J, Efeyan A, Mesin L, Jacobsen JT, Pasqual G, Grabiner BC, Dominguez-Sola D, Sabatini DM, Victora GD. Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase. Immunity 2017; 46(6): 1045-1058. PMID: 28636954
  2. Dominguez-Sola D, Cattoretti G. Analysis of the Germinal Center Reaction in Tissue Sections. Methods Mol Biol 2017; 1623: 1-20. PMID: 28589343
  3. Schneider C, Kon N, Amadori L, Shen Q, Schwartz FH, Tischler B, Bossennec M, Dominguez-Sola D, Bhagat G, Gu W, Basso K, Dalla-Favera R. FBXO11 inactivation leads to abnormal germinal center formation and lymphoproliferative diseases. Blood 2016, 128(5): 660-6
  4. Zhang J, Dominguez-Sola D, Hussein S, Lee JE, Holmes AB, Bansal M, Vlasevska S, Mo T, Tang H, Basso K, Ge K, Dalla-Favera R, Pasqualucci L. Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis. Nat Med 2015; 21(10):1190-8.
  5. Ying CY, Dominguez-Sola D, Fabi M, Lorenz IC, Hussein S, Bansal M, Califano A, Pasqualucci L, Basso K, Dalla-Favera R. MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma. Nat Immunol 2013; 14(10): 1084-1092.
  6. Srinivasan SV, Dominguez-Sola D, Wang LC, Hyrien O, Gautier J. Cdc45 is a critical effector of Myc-dependent DNA replication stress. Cell Reports 2013, 3: 1-11.
  7. Challa-Malladi M, Lieu YK, Califano O, Holmes AB, Bhagat G, Murty VV, Dominguez-Sola D, Pasqualucci L, Dalla-Favera R. Combined genetic inactivation of 2-Microgobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma. Cancer Cell. 2011, 20(6):728-40. (PMID: 22137796)
  8. Rossi D, Deaglio S, Dominguez-Sola D, Rasi S, Vaisitti T, Agostinelli C, Spina V, Bruscaggin A, Monti S, Cerri M, Cresta S, Fangazio M, Arcaini L, Lucioni M, Marasca R, Thieblemont C, Capello D, Facchetti F, Kwee I, Pileri SA, Foà R, Bertoni F, Dalla-Favera R, Pasqualucci L, Gaidano G. Alteration of BIRC3 and multiple other NF-B pathway genes in splenic marginal zone lymphoma. Blood 2001; 118(18):4930-4.
  9. Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, Kasper LH, Lerach S, Tang H, Ma J, Rossi D, Chadburn A, Murty VV, Mullighan CG, Gaidano G, Rabadan R, Brindle PK, Dalla-Favera R. Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature 2011; 471 (7337): 189-95.
  10. Amente S, Gargano B, Varrone F, Ruggiero L, Dominguez-Sola D, Lania L, Majello B. p14ARF directly interacts with Myc through the Myc BoxII domain. Cancer Biol Ther. 2006;5(3):287-91.
  11. Barbera MJ*, Puig I*, Domínguez D*, Julien-Grille S, Guaita-Esteruelas S, Peiro S, Baulida J, Franci C, Dedhar S, Larue L, Garcia de Herreros A. Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. 2004;23(44):7345-54.
  12. Roura S, Dominguez D. Inducible expression of p120Cas1B isoform corroborates the role for p120-catenin as a positive regulator of E-cadherin function in intestinal cancer cells. Biochem Biophys Res Comun 2004; 320(2): 435-41
  13. Dominguez D, Montserrat-Sentis B, Virgos-Soler A, Guaita S, Grueso J, Porta M, Puig I, Baulida J, Franci C, Garcia de Herreros A. Phosphorylation regulates the subcellular location and activity of the Snail transcriptional repressor. Mol Cell Biol. 2003; 23(14): 5078-89.
  14. Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, De Herreros AG, Baulida J. Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem. 2002; 277(42): 39209-16.
  15. Poser I, Dominguez D, de Herreros AG, Varnai A, Buettner R, Bosserhoff AK. Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail. J Biol Chem. 2001; 276(27): 24661-6.
  16. Tan C, Costello P, Sanghera J, Dominguez D, Baulida J, de Herreros AG, Dedhar S. Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells. Oncogene. 2001; 20(1): 133-40.
  17. Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, Garcia De Herreros A. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol. 2000; 2(2): 84-9.
  18. Batlle E, Verdu J, Dominguez D, del Mont Llosas M, Diaz V, Loukili N, Paciucci R, Alameda F, de Herreros AG. Protein kinase C-alpha activity inversely modulates invasion and growth of intestinal cells. J Biol Chem. 1998; 273(24): 15091-8.

B. Review Articles and Book Chapters

  1. Dominguez-Sola D. SOX11 hold mantle cell lymphoma’s key to home. Blood 2017; 130(4): 389-391. (Commentary) (PMID: 28751356)
  2. Dominguez-Sola D, Dalla-Favera R. Burkitt Lymphoma. In: Malignant Lymphomas: Biology and Molecular Pathogenesis. Lenz G & Pasqualucci L (Eds.). Walter de Gruyter GmbH, Berlin/Boston (2016)
  3. Dominguez-Sola D, Gautier J. MYC and the Control of DNA Replication. Cold Spring Harb Perspect Med 2014. 4(6). (Review) This is a comprehensive review article providing an overview on the connection between MYC, DNA replication initiation, and cancer. Part of a bigger series on the role of MYC in cancer.
  4. Dominguez-Sola D, Dalla-Favera R. Burkitt Lymphoma: Much More than MYC. Cancer Cell, 2012. 22(2):141-2. (Preview)
  5. Dominguez-Sola D, Dalla-Favera R. PINning down the c-Myc oncoprotein. Nat Cell Biol 2004; 6(4): 288-9 (Preview)