Publications

Lu, S. X.; De Neef, E.;  Thomas, J. D.;  Sabio, E.;  Rousseau, B.; Gigoux, M.;  Knorr, D. A.;  Greenbaum, B.;  Elhanati, Y.; Hogg, S. J.;  Chow, A.;  Ghosh, A.; Xie, A.;  Zamarin, D.;  Cui, D.; Erickson, C.;  Singer, M.;  Cho, H.; Wang, E.;  Lu, B.;  Durham, B. H.;  Shah, H.; Chowell, D.;  Gabel, A. M.;  Shen, Y.; Liu, J.;  Jin, J.;  Rhodes, M. C.;  Taylor, R. E.;  Molina, H.; Wolchok, J. D.;  Merghoub, T.;  Diaz, L. A.; Abdel-Wahab, O.*; Bradley, R. K.* Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell 2021, 184, In Press, DOI: 10.1016/j.cell.2021.05.038.

Dale, B.; Cheng, M.; Park, K.-S.; Kaniskan, H. Ü.; Xiong, Y.*; Jin, J*. Advancing targeted protein degradation for cancer therapy. Nature Reviews Cancer 2021, in press, DOI: 10.1038/s41568-021-00365-x.

Li, J.; Galbo, P. M., Jr.; Gong, W.; Storey, A. J.; Tsai, Y. H.; Yu, X.; Ahn, J. H.;Guo, Y.; Mackintosh, S. G.; Edmondson, R. D.; Byrum, S. D.; Farrar, J. E.; He, S.; Cai, L.; Jin, J.; Tackett, A. J.; Zheng, D.; Wang, G. G.* ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism. Nat. Commun. 2021, 12, 1045. PMID: 33594072, PMCID: PMC7886901.

Wu, X.; Yang, X.; Xiong, Y.; Li, R.; Ito, T.; Ahmed, T. A.; Karoulia, Z.; Adamopoulos, C.; Wang, H.; Wang, L.; Xie, L.; Liu, J.; Ueberheide, B.; Aaronson, S. A.; Chen, X.; Buchanan, S. G.; Sellers, W.R.; Jin, J.; Poulikakos, P. I.* Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders. Nature Cancer 2021, 2, 429-443.

Bhat, K. P.Ümit Kaniskan, H. Jin, J.*; Gozani, O.* Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat. Rev. Drug Discov. 2021, 20, 265-286. PMID: 33469207, PMCID: PMC8035146.

Wang, M.;  Li, A.;  Sekiya, M.; Beckmann, N. D.;  Quan, X.;  Schrode, N.; Fernando, M. B.;  Yu, A.;  Zhu, L.; Cao, J.;  Lyu, L.;  Horgusluoglu, E.;  Wang, Q.; Guo, L.;  Wang, Y. S.;  Neff, R.; Song, W. M.;  Wang, E.;  Shen, Q.; Zhou, X.;  Ming, C.;  Ho, S. M.; Vatansever, S.;  Kaniskan, H. U.;  Jin, J.;  Zhou, M. M.; Ando, K.;  Ho, L.;  Slesinger, P. A.;  Yue, Z.; Zhu, J.;  Katsel, P.;  Gandy, S.; Ehrlich, M. E.;  Fossati, V.;  Noggle, S.; Cai, D.;  Haroutunian, V.;  Iijima, K. M.;  Schadt, E.; Brennand, K. J.; Zhang, B.* Transformative network modeling of multi-omics data reveals detailed circuits, key regulators, and potential therapeutics for alzheimer’s disease. Neuron 2020, 109, 257-272. PMID: 33238137, PMCID: PMC7855384.

Clarke, T. L.; Tang, R.; Chakraborty, D.; Rechem, C. V.; Ji, F.; Mishra, S.; Ma, A.; Kaniskan, H. U.; Jin, J.; Lawrence, M. S.; Sadreyev, R. I.; and Whetstine, J. R.* Histone Lysine Methylation Dynamics Control EGFR DNA Copy Number Amplification. Cancer Discovery 2020, 10, 306-325. PMID: 31776131PMCID: PMC7271978.

Nagai, Y.; Miyakawa, N.; Takuwa, H.; Hori, Y.; Oyama, K.; Ji, B.; Takahashi, M.; Huang, X. P.; Slocum, S. T.; DiBerto, J. F.; Xiong, Y.; Urushihata, T.; Hirabayashi, T.; Fujimoto, A.; Mimura, K.; English, J. G.; Liu, J.; Inoue, K. I.; Kumata, K.; Seki, C.; Ono, M.; Shimojo, M.; Zhang, M. R.; Tomita, Y.; Nakahara, J.; Suhara, T.; Takada, M.; Higuchi, M.; Jin, J.; Roth, B. L.; Minamimoto, T. Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys. Nat Neurosci. 2020, 23, 1157-1167PMID: 32632286, PMCID: In progress.

Kato, S.; Weng, Q. Y.; Insco, M. L.; Chen, K. Y.; Muralidhar, S.; Pozniak, J.; Diaz, J.; Drier, Y.; Nguyen, N.; Lo, J. A.; van Rooijen, E.; Kemeny, L. V.; Zhan, Y.; Feng, Y.; Silkworth, W.; Powell, C. T.; Liau, B. B.; Xiong, Y.; Jin, J.; Newton-Bishop, J.; Zon, L. I.; Bernstein, B. E.; Fisher, D. E.* Gain-of-function genetic alterations of G9a drive oncogenesis. Cancer discovery 2020, 10, 7, 980-997. PMID: 32269030, PMCID: PMC7334057.

Li, T.; Li, X.; Zamani, A.; Wang, W.; Lee, C –N.; Li, M.; Luo, G.; Eiler, E.; Sun, H.; Ghosh, S.; Jin, J.; Murali, R.; Ruan, Q.; Shi, W.; & Chen. Y. H.* c-Rel is a myeloid checkpoint for cancer immunotherapy. Nature Cancer2020, 1, 507-517. PMID: 33458695, PMCID: PMC7808269.

Liu, J.; Chen, H.; Ma, L.; He, Z.; Wang, D.; Liu, Y.; Lin, Q.; Zhang, T.; Gray, N.; Kaniskan, H. U.; Jin, J.*; Wei, W.*Light-induced control of protein destruction by opto-PROTAC. Sci. Adv., 2020, 6, eaay5154PMID: 32128407, PMCID: PMC7034987.

Ma, A.; Stratikopoulos, E.; Park, K –S.; Wei, J.; Martin, T. C.; Yang, X.; Schwarz, M.; Leshchenko, V.; Rialdi, A.; Dale, B.; Lagana, A.; Guccione, E.; Parekh, S.; Parsons, R.* and Jin, J.* Discovery of a first-in-class EZH2 selective degrader. Nature Chemical Biology 2020,16, 214–222.PMID: 31730343, PMCID: PMC6982609.

Chiarella, A. M.; Butler, K. V.; Gryder, B. E.; Lu, D.; Wang, T. A.; Yu, X.; Pomella, S.; Khan, J.; Jin, J.*; Hathaway, N. A.* Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Nature Biotechnology 2020, 38, 50–55. PMID: 31712774, PMCID: PMC6954327.

Qadeer, Z. A.; Valle-Garcia, D.; Hasson, D.; Sun, Z.; Cook, A.; Nguyen, C.; Soriano, A.; Ma, A.; Griffiths, L. M.; Zeineldin, M.; Filipescu, D.; Jubierre, L.; Chowdhury, A.; Deevy, O.; Chen, X.; Finkelstein, D. B.; Bahrami, A.; Stewart, E.; Federico, S.; Gallego, S.; Dekio, F.; Fowkes, M.; Meni, D.; Maris, J. M.; Weiss, W. A.; Roberts, S. S.; Cheung, N. V.; Jin, J.; Segura, M. F.; Dyer, M. A.; Bernstein, E. ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures. Cancer Cell 2019, 36, 1–16. PMID: 31631027, PMCID: PMC6851493.

Fong, J. Y.; Pignata, L.; Goy, P. A.; Kawabata, K. C.; Lee, S. C.; Koh, C. M.; Musiani, D.; Massignani, E.; Kotini, A. G.; Penson, A.; Wun, C. M.; Shen, Y.; Schwarz, M.; Low, D. H.; Rialdi, A.; Ki, M.; Wollmann, H.; Mzoughi, S.; Gay, F.; Thompson, C.; Hart, T.; Barbash, O.; Luciani, G. M.; Szewczyk, M. M.; Wouters, B. J.; Delwel, R.; Papapetrou, E. P.; Barsyte-Lovejoy, D.; Arrowsmith, C. H.; Minden, M. D.; Jin, J.; Melnick, A.; Bonaldi, T.; Abdel-Wahab, O.*; Guccione, E.* Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation. Cancer Cell 2019, 36, 194-209. e9. PMID: 31408619, PMCID: in progress.

Lima-Fernandes, E.; Murison, A.; Medina, T.S.; Wang, Y.; Ma, A.; Leung, C.; Luciani, G. M.; Haynes, J.; Pollett, A.; Zeller, C.; Duan, S.; Kreso, A.; Barsyte-Lovejoy, D.; Wouters, B. G.; Jin, J.; De Carvalho, D. D.; Lupien, M.; Arrowsmith, C. H.*; O’Brien, C. A.* Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells. Nat. Commun. 2019, 10(1), 1436. PMID: 30926792, PMCID : PMC6441108.

Scheer, S.; Ackloo, S.; Medina, T. S.; Schapira, M.; Li, F.; Ward, J. A.; Lewis, A. M.; Northrop, J. P.; Richardson, P. L.; Kaniskan, H. Ü.; Shen, Y.; Liu, J.; Smil, D.; McLeod, D.; Zepeda-Velazquez, C. A.; Luo, M.; Jin, J.; Barsyte-Lovejoy, D.; Huber, K. V. M.; De Carvalho, D. D.; Vedadi, M.; Zaph, C.; Brown, P. J.; Arrowsmith, C. H.  A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat. Commun. 2019, 10, 19. PMID:30604761, PMCID:PMC6318333.

Ren, Z.; Ahn, J. H.; Liu, H.; Tsai, Y. H.; Bhanu, N. V.; Koss, B.; Allison, D. F.; Ma, A.; Storey, A. J.; Wang, P.; Mackintosh, S. G.; Edmondson, R. D.; Groen, R. W. J.; Martens, A. C.; Garcia, B. A.; Tackett, A. J.; Jin, J.; Cai, L.; Zheng, D.; Wang, G. G. PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation. Blood Blood 2019, 134 (14): 1176–1189. PMID: 31383640. PMCID: PMC6776795.

Zhu, Y.; He, X.; Lin, Y. C.; Dong, H.; Zhang, L.; Chen, X.; Wang, Z.; Shen, Y.; Li, M.; Wang, H.; Sun, J.; Nguyen, L. X.; Zhang, H.; Jiang, W.; Yang, Y.; Chen, J.; Müschen, M.; Chen, C. W.; Konopleva, M. Y.; Sun, W.; Jin, J.; Carlesso, N.; Marcucci, G.; Luo, Y.; Li, L. Targeting PRMT1-Mediated FLT3 Methylation Disrupts Maintenance of MLL- rearranged Acute Lymphoblastic Leukemia. Blood 2019, 134 (15): 1257–1268. PMID: 31395602. PMCID: PMC6788006.

He, X.; Zhu, Y.; Lin, Y. -C.; Li, M.; Du, J.; Dong, H.; Sun, D. J.; Zhu, L.; Wang, H.; Ding, Z.; Zhang, Lei.; Zhang, Lianjun.; Zhao, D.; Wang, Z.; Wu, H.; Zhang, H.; Jiang, W.; Xu, Y.; Jin, J.; Shen, Y.; Perry, J.; Zhao, X.; Zhang, B.; Liu, S.; Xue, S. -L.; Shen, B.; Chen, C. -W.; Chen, J.; Khaled, S.; Kuo, Y. -H.; Marcucci, G.; Luo, Y.; Li, L. PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ Acute Myeloid Leukemia. Blood 2019, 134 (6): 548–560. PMID: 31217189, PMCID: PMC6688430.

Zhao, N.; Sebastiano, V.; Moshkina, N.; Mena, N.; Hultquist, J.; Jimenez-Morales, D.; Ma, Y.; Rialdi, A.; Albrecht, R.; Fenouil, R.; Sánchez-Aparicio, M. T.; Ayllon, J.; Ravisankar, S.; Haddad, B.; Ho, J. S. Y.; Low, D.; Jin, J.; Yurchenko, V.; Prinjha, R. K.; Tarakhovsky, A.; Squatrito, M.; Pinto, D.; Allette, K.; Byun, M.; Smith, M. L.; Sebra, R.; Guccione, E.; Tumpey, T.; Krogan, N.; Greenbaum, B.; van Bakel, H.; García-Sastre, A.; Marazzi, I.* Influenza virus infection causes global RNAPII termination defects. Nature Structural & Molecular Biology 2018, 25, 885-893. PMID: 30177761,  PMCID: in progress.

McCorvy, J. D.*; Wacker, D.; Wang, S.; Agegnehu, B.; Liu, J.; Lansu, K.; Tribo, A. R.; Olsen, R. H. J.; Che, T.; Jin, J.; Roth, B. L.* Structural determinants of 5-HT2B receptor activation and biased agonism. Nature Structural & Molecular Biology 2018, 25, 787-796. PMID: 30127358,  PMCID: PMC6237183.

McCorvy, J. D.; Butler, K. V.; Kelly, B.; Rechsteiner, K.; Karpiak, J.; Betz, R. M.; Kormos, B. L.; Shoichet, B. K.; Dror, R. O.*; Jin, J.*; Roth, B. L.* Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs. Nature Chemical Biology 2018, 14, 126-134. PMID: 29227473, PMCID: PMC5771956.

Veschi, V.; Liu, Z.; Voss, T. C.; Ozbun, L.; Gryder, B.; Yan, C.; Hu, Y.; Ma, A.; Jin, J.; Mazur, S. J.; Lam, N.; Souza, B. K.; Giannini, G.; Hager, G. L.; Arrowsmith, C. H.; Khan, J.; Appella, E.; Thiele, C. J.* Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma. Cancer Cell 2017, 31, 50-63. PMID: 28073004  PMCID: PMC5233415.

Kim, Y.; Lee, H.-M.; Xiong, Y.; Sciaky, N.; Hulbert, S. W.; Cao, X.; Everitt, J. I.; Jin, J.; Roth, B. L.*; Jiang, Y.-h.* Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome. Nat. Med. 2017, 23, 213-222. PMID: 28024084  PMCID: PMC5589073.

Lansu, K.; Karpiak, J.; Liu, J.; Huang, X.-P.; McCorvy, J. D.; Kroeze, W. K.; Che, T.; Nagase, H.; Carroll, F. I.; Jin, J.; Shoichet, B. K.; Roth, B. L.* In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat. Chem. Biol. 2017, 13, 529-536. PMID: 28288109  PMCID: PMC5391270.

Huang, Q.; He, S.; Tian, Y.; Gu, Y.; Chen, P.; Li, C.; Huang, J.; Liu, Y.; Yu, H.; Jin, M.; Hu, S.; Tong, Q.; Ma, A.; Jin, J.; Hexner, E.; Fung, H.; Reshef, R.; Zhang, Y.*; Zhang, Y.* Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice. Blood 2017, . PMID:28246193  PMCID: PMC5437825