2026 Publications

 

Song, X.; Wu, Q.; Chen, L.; Inuzuka, H.; Zhong, Y.; Qi, Y.; Lin, Y.; Kabir, M.; Xiong, Y.*; Wei, W.*; Jin, J.* “Discovery of New OTUB1 Covalent Ligands via Structure-Activity Relationship Studies for Targeted Protein Stabilization” , Journal of Medicinal Chemistry, 2026 May 4;. doi: https://doi.org/10.1021/acs.jmedchem.5c03327

Luo, K.; Xue, Z.; Qin, L.; Wang, Z.; Gao, P.; Xie, L.; Su, Y.; Chen, X.; Kaniskan, H. Ü.*; Wen, H.*; Jin, J.* “Discovery of a Highly Potent and Selective ENL Degrader” Journal of Medicinal Chemistry , 2026 Apr 23;. doi: 10.1021/acs.jmedchem.6c00386 doi:https//doi.org/10.1021/acs.jmedchem.6c00386.PMID: 42025203

Gao, P.; Zhong, Y.; Luo, K.; Jin, J.* “Bridged PROTAC, DNA-based PROTAC and hydrophobic tag technologies for targeted protein degradation” Advanced Drug Delivery Reviews , 2026, 232, 115819. PMID: 41707939  doi:
https://doi.org/10.1016/j.addr.2026.115819.

Chen, H.; Dutta, R. P.; Li, Z.; Zhong, Y.; Ma, A.; Park, K. S.; Kottur, J.; Park, A.; Babault, N.; Wang, K.; Wang, D.; Xiong, Y.; Kaniskan, H. Ü.; Luo, M.; Parekh, S.; Jin, J.*, “Discovery of a Potent, Selective, and In Vivo Efficacious Covalent Inhibitor for Lysine Methyltransferase SETD8”, Journal of Medicinal Chemistry, 2026, 69(4), 4255-4269. doi:
https://doi.org/10.1021/acs.jmedchem.5c02958PMID: 41693203

Yim, H.; Song, X.; Zhong, Y.; Hu, J.; Xiong, Y.; Jin, J.*, “Discovery of KRAS-G12D degraders via exploration of various E3 ligases”, European Journal of Medicinal Chemistry, 2026, 307, 118635. PMID:41679196 , doi: https://doi.org/10.1016/j.ejmech.2026.118635

Xia, Z.; Yang, X.; Samovich, S. N.; Tyurina, Y. Y.; Tyurin, V. A.; Kon, N.; Zhang, J.; Jiang, X.; Stockwell, B. R.; Jin, J.; Bayir, H.; Kagan, V. E.; Gu, W.*, “A GPX1–OSBPL8 Axis Mediates Noncanonical In Vivo Ferroptosis and Cancer Growth Suppression”, Cell , 2026, Feb 19, doi:https://doi.org/10.1016/j.cell.2026.01.009 PMCID: PMC12927606.

Gelles, J. D.; Chen, Y.; Luna-Vargas, M. P. A.; Viacava Follis, A.; Al Noman, M. A.; Kabir, M.; Bayiokos, S. G.; Mohammed, J. N.; Sebastian, T. M.; Pham, N. D.; Shi, Y.; Jin, J.; Kriwacki, R. W.; Chipuk, J. E.*, “A gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function”, Nature Communications , 2026, Feb 25. DOI: 10.1016/j.cell.2026.01.009 https://doi.org/10.1016/j.cell.2026.01.009

Wang, Y.; Xiong, Y.; Liu, S.; Bao, L.; Qiu, X.; Korboukh, I.; Song, X.; Toffessi Tcheuyap, V.; Wu, S.; Chen, M.; Brugarolas, J.; Jin, J.; Wang, Y.; Luo, W.*, “HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer”, Cell Reports Medicine, 2026, Feb 18, 102630. doi:
10.1016/j.xcrm.2026.102630. https://doi.org/10.1016/j.xcrm.2026.102630

Yi, Y.; Li, Y.; Wang, R.; Yu, X.; Liu, Q.; Yum, C.; Zhang, Y.; Qiao, Y.; Szczepanski, A.; Wu, S.; Li, Q.; Fazli, L.; Shen, J.; Wang, X.; Li, X.; Mu, P.; Schaeffer, E. M.; Hundley, H. A.; Niu, H.; Chinnaiyan, A. M.; Wang, L.; Shi, J.; Jin, J.; Dong, X.; Zhao, W.; Chen, K.; Cao, Q.*, “A dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR”, Nature Communications, 2026,  PMID: 41882000

Yi, Y.; Fry, J.; Yum, C.; Wang, R.; Wu, S.; Narayan, S.; Liu, Q.; Zhang, X.; Oo, H. Z.; Xie, N.; Li, Y.; Gao, X.; Yu, X.; Hu, X.; Li, Q.; Keseroglu, K.; Özbudak, E. M.; Abdulkadir, S. A.; Chen, K.; Jin, J.; Zhao, J. C.; Dong, X.; Arango, D.; Yang, R.; Cao, Q.*, “EZH2 crosstalk with RNA methylation promotes prostate cancer progression through modulation of the m6A autoregulation pathway” Journal of Clinical Investigation, 2026, 136(2). doi: 10.1172/JCI195840. https://doi.org/10.1172/JCI195840 PMCID: PMC12807473. PMID: 41252201

 

Posted on: May 26, 2026