MacroH2A function in development & disease

In recent years there has been a growing appreciation for the importance of histone variants.

Melanoma chromatin dynamics

Cutaneous melanoma is a highly aggressive skin cancer and one of the most challenging cancers in its therapeutic management.

Polycomb proteins in stem cells & disease

We have a long-standing interest in the mammalian Cbx family members (Cbx2, 4, 6, 7 and 8), which are homologs of the single Drosophila Polycomb (Pc) protein.