Publications

Ghiraldini FG, Filipescu D, Bernstein E. (2021) Solid tumours hijack the histone variant network. Nat Rev Cancer. doi: 10.1038/s41568-020-00330-0. Full Article

Qadeer ZA, Valle-Garcia D, Hasson D, Sun Z, Cook A, Nguyen C, Soriano A, Ma A, Griffiths LM, Zeineldin M, Filipescu D, Jubierre L, Chowdhury A, Deevy O, Chen X, Finkelstein DB, Bahrami A, Stewart E, Federico S, Gallego S, Dekio F, Fowkes M, Meni D, Maris JM, Weiss WA, Roberts SS, Cheung NV, Jin J, Segura MF, Dyer MA, Bernstein E. (2019) ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures. Cancer Cell. pii: S1535-6108(19)30385-X. doi: 10.1016/j.ccell.2019.09.002. Full Article

Sun Z, Bernstein E. (2019) Histone variant macroH2A: from chromatin deposition to molecular function. Essays Biochem. 23;63(1):59-74. doi: 10.1042/EBC20180062. Full Article

Sun, Z, Filipescu, D, Andrade, J, Gaspar-Maia, A, Ueberheide, B, Bernstein, E. (2018) Transcription-associated histone pruning demarcates macroH2A chromatin domains. Nature Structural and Molecular Biology, 25, 958–970. doi: 10.1038/s41594-018-0134-5. Full Article

Strub, T, Ghiraldini, F.G.*, Carcamo, S*, Li, M, Wroblewska, A, Singh, R, Goldberg, MS, Hasson, D, Wang, Z, Gallagher, SJ, Hersey, P, Ma’ayan, A, Long, GV, Scolyer RA, Brown, B, Zheng, B, Bernstein, E. (2018) SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signaling. Nature Communications, 9:3440. doi: 10.1038/s41467-018-05966-z. Full Article

Fontanals-Cirera B, Hasson D, Vardabasso C, Di Micco R, Agrawal P, Chowdhury A, Gantz M, de Pablos-Aragoneses A, Morgenstern A, Wu P, Filipescu D, Valle-Garcia D, Darvishian F, Roe JS, Davies MA, Vakoc CR, Hernando E, Bernstein E. Mol Cell. (2017) Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene. Molecular Cell, 68(4):731-744.e9. doi: 10.1016/j.molcel.2017.11.004. Full Article

Chung C.-Y., Sun, Z., Mullokandov, G., , Bosch, A., Qadeer, Z. A., Cihan, E., , Rapp, Z., Parsons, R., Aguirre-Ghiso J.A.,  Farias, E.F., Brown, B.D., Gaspar-Maia, A., and Bernstein, E.. Cbx8 acts non-canonically with Wdr5 to promote mammary tumorigenesis. (2016) Cell Reports. 16(2):472-486. doi: 10.1016/j.celrep.2016.06.002. Full Article

Valle-Garcia D, Qadeer ZA, McHugh D, Ghiraldini FG, Chowdhury AH, Hasson D, Dyer MA, Recillas-Targa F, Bernstein E. (2016) ATRX binds to atypical chromatin domains at the 3’ exons of ZNF genes to preserve H3K9me3 enrichment. Epigenetics. doi: 10.1080/15592294.2016.1169351. Full Article

Vardabasso, C., Gaspar-Maia, A., Hasson, D., Pünzeler, S., Valle-Garcia, D., Straub, T., Keilhauer, E.C. Strub, T., Panda, T., Chung, C-Y., Dong, J., Segura, M.F., Fontanals-Cirera, B., Verma, A., Mann, M., Hernando, E., Hake, S.B., Bernstein, E. (2015) Histone variant H2A.Z.2 mediates proliferation and drug sensitivity of malignant melanoma. Molecular Cell, 59:75-88. Full Article

Highlighted in: Cancer Discovery ‘Research Watch’ June 18, 2015 | doi: 10.1158/2159-8290.CD-RW2015-112 and Nature Reviews Cancer 15, 456 (July 2015) | doi:10.1038/nrc3996.

Duarte, L.F., Young, A.R.J., Wang, Z., Wu, H-A., Panda, T., Kou, Y., Kapoor, A., Hasson, D., Mills, N.R., Ma’ayan, A., Narita, M., Bernstein, E. (2014) Histone H3.3 and its proteolytically processed form drive a cellular senescence program. Nature Communications 5:5210 doi: 10.1038/ncomms6210. Full Article

Highlighted in: Cancer Research, Highlights from Recent Cancer Literature (December 15, 2014) 74:7159-7160

Qadeer, Z.A.*, Harcharik, S.*, Valle-Garcia, D., Chen, C., Birge, M.B., Vardabasso, C., Duarte, L.F., Bernstein, E. (2014) Decreased expression of the chromatin remodeler ATRX associates with melanoma progression. Journal of Investigative Dermatology 134:1768-72. Full Article

Wu, H.-A., Balsbaugh, J.L., Chandler, H., Georgilis, A., Zullow, H., Shabanowitz, J., Hunt, D.F., Gil, J., Peters, G., Bernstein, E. (2013) MAP Kinase Signaling Mediates Phosphorylation of Polycomb Ortholog Cbx7. Journal of Biological Chemistry 288:36398-36408. Full Article

Gaspar-Maia, A., Qadeer, Z.A., Ratnakumar, K., Hasson, D., Leu N.A., Leroy, G., Liu, S., Costanzi, C., Schaniel, C., Lemischka, I.R., Garcia, B.A., Pehrson, J.R., Bernstein, E. (2013) macroH2A histone variants act as a barrier upon reprogramming towards pluripotency. Nature Communications 4:1565 doi: 10.1038/ncomms2582. Full Article

Chicas, A.*, Kapoor, A.*, Wang, X.*, Aksoy, O., Evertts, A.G., Zhang, M.Q., Garcia, B.A., Bernstein, E.**, and Lowe, S.W.**. (2012) H3K4 demethylation by Jarid1a and Jarid1b contributes to RB-driven gene silencing during cellular senescence. Proc Natl Acad Sci USA, 109: 8971-8976. Full Article

Ratnakumar, K., Duarte, L.F., LeRoy, G., Hasson, D., Smeets, D., Vardabasso, C., Bönisch, C., Zeng, T., Xiang, B., Zhang, D.Y., Li, H., Wang, X., Hake, S.B., Schermelleh, L., Garcia, B.A. and Bernstein, E. (2012) ATRX-mediated chromatin association of histone variant macroH2A1 regulates alpha globin expression. Genes & Development 26: 433-438. Full Article

O’Loghlen A., Muñoz-Cabello, A.M. Gaspar-Maia, A., Wu, H-A., Banito, A., Kunowska, N. Racek, T., Pemberton, H.N., Beolchi, P., Lavial, F., Masui, O., Vermeulen, M., Carroll, T., Graumann, J., Heard, E., Dillon, N., Azuara, V., Snijders, A.P., Peters, G., Bernstein, E., and Gil, J. (2012) MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation. Cell Stem Cell 10, 33-46. Full Article

Ang, Y-S., Tsai, S-Y., Lee, D-F., Monk, J., Su, J., Ratnakumar, K., Ding, J., Ge, Y., Darr, H., Chang, B., Wang, J., Rendl, M., Bernstein, E.*, Schaniel, C.*, and Lemischka, I.R.  (2011) Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell 145, 183-197. Full Article

Kapoor, A., Goldberg, M.S., Cumberland L.K.*, Ratnakumar, K.*, Segura, M.F., Emanuel, P.O., Menendez, S., Vardabasso, C., LeRoy, G., Vidal, C., Polsky, D., Osman, I. , Garcia, B.A., Hernando, E., and Bernstein, E. (2010) The histone variant macroH2A suppresses melanoma progression through regulation of CDK8.  Nature 468: 1105-1109. Full Article

Highlighted in: Nature Reviews Cancer  11, 81 (February 2011) | doi:10.1038/nrc3014