2014-2022
Matsuda M, Chu CW, Sokol SY. Lmo7 recruits myosin II heavy chain to regulate actomyosin contractility and apical domain size in Xenopus ectoderm. Development. 2022 May 15;149(10). doi: 10.1242/dev.200236. Epub 2022 May 16. PubMed PMID: 35451459; PubMed Central PMCID: PMC9188752.
Chuykin I, Sokol SY. Analysis of Planar Cell Polarity Complexes by Proximity Biotinylation in Xenopus Embryos. Methods Mol Biol. 2022;2438:97-106. doi: 10.1007/978-1-0716-2035-9_6. PubMed PMID: 35147937.
Ossipova O, Mancini P, Sokol SY. Imaging Planar Cell Polarity Proteins in Xenopus Neuroectoderm. Methods Mol Biol. 2022;2438:147-161. doi: 10.1007/978-1-0716-2035-9_10. PubMed PMID: 35147941.
Chuykin I, Itoh K, Kim K, Sokol SY. Frizzled3 inhibits Vangl2-Prickle3 association to establish planar cell polarity in the vertebrate neural plate. J Cell Sci. 2021 Dec 15;134(24). doi: 10.1242/jcs.258864. Epub 2021 Dec 15. PubMed PMID: 34806749; PubMed Central PMCID: PMC8729781.
Reis AH, Xiang B, Ossipova O, Itoh K, Sokol SY. Identification of the centrosomal maturation factor SSX2IP as a Wtip-binding partner by targeted proximity biotinylation. PLoS One. 2021;16(10):e0259068. doi: 10.1371/journal.pone.0259068. eCollection 2021. PubMed PMID: 34710136; PubMed Central PMCID: PMC8553094.
Ossipova O, Sokol SY. Cryosectioning and Immunostaining of Xenopus Embryonic Tissues. Cold Spring Harb Protoc. 2021 Sep 1;2021(9). doi: 10.1101/pdb.prot107151. PubMed PMID: 34244349; PubMed Central PMCID: PMC8527664.
Mancini P, Ossipova O, Sokol SY. The dorsal blastopore lip is a source of signals inducing planar cell polarity in the Xenopus neural plate. Biol Open. 2021 Jul 15;10(7). doi: 10.1242/bio.058761. Epub 2021 Jul 19. PubMed PMID: 34259326; PubMed Central PMCID: PMC8325942.
Reis AH, Sokol SY. Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification. Sci Rep. 2021 Jun 28;11(1):13433. doi: 10.1038/s41598-021-92824-6. PubMed PMID: 34183732; PubMed Central PMCID: PMC8239024.
Itoh K, Ossipova O, Sokol SY. Pinhead antagonizes Admp to promote notochord formation. iScience. 2021 Jun 25;24(6):102520. doi: 10.1016/j.isci.2021.102520. eCollection 2021 Jun 25. PubMed PMID: 34142034; PubMed Central PMCID: PMC8188501.
Torban E, Sokol SY. Planar cell polarity pathway in kidney development, function and disease. Nat Rev Nephrol. 2021 Jun;17(6):369-385. doi: 10.1038/s41581-021-00395-6. Epub 2021 Feb 5. Review. PubMed PMID: 33547419; PubMed Central PMCID: PMC8967065.
Matsuda M, Sokol SY. Xenopus neural tube closure: A vertebrate model linking planar cell polarity to actomyosin contractions. Curr Top Dev Biol. 2021;145:41-60. doi: 10.1016/bs.ctdb.2021.04.001. Epub 2021 May 4. Review. PubMed PMID: 34074535.
Sokol SY. Preface. Curr Top Dev Biol. 2021;145:xi-xiii. doi: 10.1016/S0070-2153(21)00065-X. PubMed PMID: 34074538.
Ossipova O, Itoh K, Radu A, Ezan J, Sokol SY. Pinhead signaling regulates mesoderm heterogeneity via the FGF receptor-dependent pathway. Development. 2020 Sep 11;147(17). doi: 10.1242/dev.188094. PubMed PMID: 32859582; PubMed Central PMCID: PMC7502591.
Reis AH, Sokol SY. Rspo2 antagonizes FGF signaling during vertebrate mesoderm formation and patterning. Development. 2020 May 27;147(10). doi: 10.1242/dev.189324. PubMed PMID: 32366679; PubMed Central PMCID: PMC7272350.
Itoh K, Reis AH, Hayhurst A, Sokol SY. Isolation of nanobodies against Xenopus embryonic antigens using immune and non-immune phage display libraries. PLoS One. 2019;14(5):e0216083. doi: 10.1371/journal.pone.0216083. eCollection 2019. PubMed PMID: 31048885; PubMed Central PMCID: PMC6497274.
Chuykin I, Ossipova O, Sokol SY. Par3 interacts with Prickle3 to generate apical PCP complexes in the vertebrate neural plate. Elife. 2018 Sep 26;7. doi: 10.7554/eLife.37881. PubMed PMID: 30256191; PubMed Central PMCID: PMC6175575.
Ossipova O, Kerney R, Saint-Jeannet JP, Sokol SY. Regulation of neural crest development by the formin family protein Daam1. Genesis. 2018 Jun;56(6-7):e23108. doi: 10.1002/dvg.23108. Epub 2018 Apr 19. PubMed PMID: 29673042; PubMed Central PMCID: PMC6105563.
Chu CW, Xiang B, Ossipova O, Ioannou A, Sokol SY. The Ajuba family protein Wtip regulates actomyosin contractility during vertebrate neural tube closure. J Cell Sci. 2018 May 16;131(10). doi: 10.1242/jcs.213884. PubMed PMID: 29661847; PubMed Central PMCID: PMC6031329.
Sokol SY. At the Crossroads between Cell Polarity and Adhesion in Neocortical Development. Dev Cell. 2017 Jun 5;41(5):453-454. doi: 10.1016/j.devcel.2017.05.017. PubMed PMID: 28586640.
Chu CW, Sokol SY. Wnt proteins can direct planar cell polarity in vertebrate ectoderm. Elife. 2016 Sep 23;5. doi: 10.7554/eLife.16463. PubMed PMID: 27658614; PubMed Central PMCID: PMC5055393.
Chu CW, Ossipova O, Ioannou A, Sokol SY. Prickle3 synergizes with Wtip to regulate basal body organization and cilia growth. Sci Rep. 2016 Apr 11;6:24104. doi: 10.1038/srep24104. PubMed PMID: 27062996; PubMed Central PMCID: PMC4827067.
Gaston-Massuet C, McCabe MJ et al. Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E548-57. doi: 10.1073/pnas.1503346113. Epub 2016 Jan 13. PubMed PMID: 26764381; PubMed Central PMCID: PMC4747739.
Sokol SY. Mechanotransduction During Vertebrate Neurulation. Curr Top Dev Biol. 2016;117:359-76. doi: 10.1016/bs.ctdb.2015.11.036. Epub 2016 Jan 23. Review. PubMed PMID: 26969989.
Ossipova O, Chu CW, Fillatre J, Brott BK, Itoh K, Sokol SY. The involvement of PCP proteins in radial cell intercalations during Xenopus embryonic development. Dev Biol. 2015 Dec 15;408(2):316-27. doi: 10.1016/j.ydbio.2015.06.013. Epub 2015 Jun 14. PubMed PMID: 26079437; PubMed Central PMCID: PMC4810801.
Sokol SY. Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development. Semin Cell Dev Biol. 2015 Jun;42:78-85. doi: 10.1016/j.semcdb.2015.05.002. Epub 2015 May 15. Review. PubMed PMID: 25986055; PubMed Central PMCID: PMC4562884.
Ossipova O, Kim K, Sokol SY. Planar polarization of Vangl2 in the vertebrate neural plate is controlled by Wnt and Myosin II signaling. Biol Open. 2015 Apr 24;4(6):722-30. doi: 10.1242/bio.201511676. PubMed PMID: 25910938; PubMed Central PMCID: PMC4467192.
Kim K, Ossipova O, Sokol SY. Neural crest specification by inhibition of the ROCK/Myosin II pathway. Stem Cells. 2015 Mar;33(3):674-85. doi: 10.1002/stem.1877. PubMed PMID: 25346532; PubMed Central PMCID: PMC4428345.
Itoh K, Sokol SY. Early Development of Epidermis and Neural Tissue.. In: Moody SA, editor. Principles of Developmental Genetics` Second Edition ed. San Diego, California: Elsevier, Academic Press; 2015. Chapter 11. 189-201p.
Ossipova O, Chuykin I, Chu CW, Sokol SY. Vangl2 cooperates with Rab11 and Myosin V to regulate apical constriction during vertebrate gastrulation. Development. 2015 Jan 1;142(1):99-107. doi: 10.1242/dev.111161. Epub 2014 Dec 5. PubMed PMID: 25480917; PubMed Central PMCID: PMC4299144.
Itoh K, Sokol SY. Expression cloning of camelid nanobodies specific for Xenopus embryonic antigens. PLoS One. 2014;9(10):e107521. doi: 10.1371/journal.pone.0107521. eCollection 2014. PubMed PMID: 25285446; PubMed Central PMCID: PMC4186775.
Itoh K, Ossipova O, Sokol SY. GEF-H1 functions in apical constriction and cell intercalations and is essential for vertebrate neural tube closure. J Cell Sci. 2014 Jun 1;127(Pt 11):2542-53. doi: 10.1242/jcs.146811. Epub 2014 Mar 28. PubMed PMID: 24681784; PubMed Central PMCID: PMC4038946.
Ossipova O, Kim K, Lake BB, Itoh K, Ioannou A, Sokol SY. Role of Rab11 in planar cell polarity and apical constriction during vertebrate neural tube closure. Nat Commun. 2014 May 13;5:3734. doi: 10.1038/ncomms4734. PubMed PMID: 24818582; PubMed Central PMCID: PMC4097039.
2007-2013
Zylkiewicz E, Sokol SY, Hoppler S. Wnt signaling in Early Vertebrate Development: From Fertilization to Gastrulation.. In: Hoppler S, Moon RT, editors. Wnt signaling in Development and Disease Hoboken, New Jersey: Wiley Blackwell; 2014. 253-266p.
Chu CW, Gerstenzang E, Ossipova O, Sokol SY. Lulu regulates Shroom-induced apical constriction during neural tube closure. PLoS One. 2013;8(11):e81854. doi: 10.1371/journal.pone.0081854. eCollection 2013. PubMed PMID: 24282618; PubMed Central PMCID: PMC3839891.
Hikasa H, Sokol SY. Wnt signaling in vertebrate axis specification. Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a007955. doi: 10.1101/cshperspect.a007955. Review. PubMed PMID: 22914799; PubMed Central PMCID: PMC3579404.
Kim K, Lake BB, Haremaki T, Weinstein DC, Sokol SY. Rab11 regulates planar polarity and migratory behavior of multiciliated cells in Xenopus embryonic epidermis. Dev Dyn. 2012 Sep;241(9):1385-95. doi: 10.1002/dvdy.23826. Epub 2012 Jul 16. PubMed PMID: 22778024; PubMed Central PMCID: PMC4009926.
Kalinichenko SV, Itoh K, Korobko EV, Sokol SY, Buchman VL, Korobko IV. Identification of Nedd4 E3 ubiquitin ligase as a binding partner and regulator of MAK-V protein kinase. PLoS One. 2012;7(6):e39505. doi: 10.1371/journal.pone.0039505. Epub 2012 Jun 20. PubMed PMID: 22745772; PubMed Central PMCID: PMC3379983.
Hong JY, Park JI, Lee M, Muñoz WA, Miller RK, Ji H, Gu D, Ezan J, Sokol SY, McCrea PD. Down’s-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway. J Cell Sci. 2012 Feb 1;125(Pt 3):561-9. doi: 10.1242/jcs.086173. PubMed PMID: 22389395; PubMed Central PMCID: PMC3367828.
Lee HS, Sokol SY, Moody SA, Daar IO. Using 32-cell stage Xenopus embryos to probe PCP signaling. Methods Mol Biol. 2012;839:91-104. doi: 10.1007/978-1-61779-510-7_8. PubMed PMID: 22218895; PubMed Central PMCID: PMC4461027.
Ossipova O, Sokol SY. Neural crest specification by noncanonical Wnt signaling and PAR-1. Development. 2011 Dec;138(24):5441-50. doi: 10.1242/dev.067280. PubMed PMID: 22110058; PubMed Central PMCID: PMC3222216.
Sokol SY. Maintaining embryonic stem cell pluripotency with Wnt signaling. Development. 2011 Oct;138(20):4341-50. doi: 10.1242/dev.066209. Epub 2011 Sep 8. Review. PubMed PMID: 21903672; PubMed Central PMCID: PMC3177306.
Yasunaga T, Itoh K, Sokol SY. Regulation of basal body and ciliary functions by Diversin. Mech Dev. 2011 Sep-Dec;128(7-10):376-86. doi: 10.1016/j.mod.2011.07.004. Epub 2011 Aug 6. PubMed PMID: 21843637; PubMed Central PMCID: PMC3223263.
Sokol SY. Wnt signaling through T-cell factor phosphorylation. Cell Res. 2011 Jul;21(7):1002-12. doi: 10.1038/cr.2011.86. Epub 2011 May 24. Review. PubMed PMID: 21606952; PubMed Central PMCID: PMC3193496.
Itoh K, Sokol SY. Polarized translocation of fluorescent proteins in Xenopus ectoderm in response to Wnt signaling. J Vis Exp. 2011 May 26;(51). doi: 10.3791/2700. PubMed PMID: 21654626; PubMed Central PMCID: PMC3197113.
Hikasa H, Sokol SY. Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2. J Biol Chem. 2011 Apr 8;286(14):12093-100. doi: 10.1074/jbc.M110.185280. Epub 2011 Feb 1. PubMed PMID: 21285352; PubMed Central PMCID: PMC3069413.
Hikasa H, Ezan J, Itoh K, Li X, Klymkowsky MW, Sokol SY. Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification. Dev Cell. 2010 Oct 19;19(4):521-32. doi: 10.1016/j.devcel.2010.09.005. PubMed PMID: 20951344; PubMed Central PMCID: PMC2963175.
Ossipova O, Sokol SY. Cell polarity, Notch signaling and neurogenesis. Cell Cycle. 2010 Jan 1;9(1):1-2. doi: 10.4161/cc.9.1.10357. Epub 2010 Jan 19. PubMed PMID: 20016263.
Alexandrova EM, Sokol SY. Xenopus axin-related protein: a link between its centrosomal localization and function in the Wnt/beta-catenin pathway. Dev Dyn. 2010 Jan;239(1):261-70. doi: 10.1002/dvdy.22125. PubMed PMID: 19842147.
Choi SC, Sokol SY. The involvement of lethal giant larvae and Wnt signaling in bottle cell formation in Xenopus embryos. Dev Biol. 2009 Dec 1;336(1):68-75. doi: 10.1016/j.ydbio.2009.09.033. Epub 2009 Sep 25. PubMed PMID: 19782678; PubMed Central PMCID: PMC2801549.
Itoh K, Jenny A, Mlodzik M, Sokol SY. Centrosomal localization of Diversin and its relevance to Wnt signaling. J Cell Sci. 2009 Oct 15;122(Pt 20):3791-8. doi: 10.1242/jcs.057067. Epub 2009 Sep 29. PubMed PMID: 19789178; PubMed Central PMCID: PMC2758808.
Ossipova O, Ezan J, Sokol SY. PAR-1 phosphorylates Mind bomb to promote vertebrate neurogenesis. Dev Cell. 2009 Aug;17(2):222-33. doi: 10.1016/j.devcel.2009.06.010. PubMed PMID: 19686683; PubMed Central PMCID: PMC2849776.
Lake BB, Sokol SY. Strabismus regulates asymmetric cell divisions and cell fate determination in the mouse brain. J Cell Biol. 2009 Apr 6;185(1):59-66. doi: 10.1083/jcb.200807073. Epub 2009 Mar 30. PubMed PMID: 19332887; PubMed Central PMCID: PMC2700512.
Chia IV, Kim MJ, Itoh K, Sokol SY, Costantini F. Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis. Genetics. 2009 Apr;181(4):1359-68. doi: 10.1534/genetics.109.101055. Epub 2009 Feb 9. PubMed PMID: 19204372; PubMed Central PMCID: PMC2666505.
Pan W, Choi SC, Wang H, Qin Y, Volpicelli-Daley L, Swan L, Lucast L, Khoo C, Zhang X, Li L, Abrams CS, Sokol SY, Wu D. Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Science. 2008 Sep 5;321(5894):1350-3. doi: 10.1126/science.1160741. PubMed PMID: 18772438; PubMed Central PMCID: PMC2532521.
Ossipova O, Tabler J, Green JB, Sokol SY. PAR1 specifies ciliated cells in vertebrate ectoderm downstream of aPKC. Development. 2007 Dec;134(23):4297-306. doi: 10.1242/dev.009282. PubMed PMID: 17993468; PubMed Central PMCID: PMC2170474.
Sokol SY, Wharton KA Jr. WNTers in La Jolla. Development. 2007 Oct;134(19):3393-9. doi: 10.1242/dev.008169. PubMed PMID: 17827178.
Sokol S, editor. Advances in Developmental Biology. v. 17 San Diego, CA: Elsevier Press; 2007.
Itoh K, Sokol SY. Early development of epidermis and neural tissue.. In: Moody SA, editor. Principles of Developmental Genetics San Diego, CA: Elsevier Press; 2007. 241-258.p.
Dollar G, Sokol SY. Wnt signaling and cell polarity.. In: Sokol SY, editor. Advances in Developmental Biology. v. 17 San Diego, California: Elsevier Press; 2007. 61-94p.
Park JI, Ji H, Jun S, Gu D, Hikasa H, Li L, Sokol SY, McCrea PD. Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals. Dev Cell. 2006 Nov;11(5):683-95. doi: 10.1016/j.devcel.2006.09.022. PubMed PMID: 17084360.
2000-2006
Kibardin A, Ossipova O, Sokol SY. Metastasis-associated kinase modulates Wnt signaling to regulate brain patterning and morphogenesis. Development. 2006 Aug;133(15):2845-54. doi: 10.1242/dev.02445. Epub 2006 Jun 21. PubMed PMID: 16790480; PubMed Central PMCID: PMC4428341.
Hunter NL, Hikasa H, Dymecki SM, Sokol SY. Vertebrate homologues of Frodo are dynamically expressed during embryonic development in tissues undergoing extensive morphogenetic movements. Dev Dyn. 2006 Jan;235(1):279-84. doi: 10.1002/dvdy.20609. PubMed PMID: 16278878.
Dollar GL, Weber U, Mlodzik M, Sokol SY. Regulation of Lethal giant larvae by Dishevelled. Nature. 2005 Oct 27;437(7063):1376-80. doi: 10.1038/nature04116. PubMed PMID: 16251968.
Brott BK, Sokol SY. Frodo proteins: modulators of Wnt signaling in vertebrate development. Differentiation. 2005 Sep;73(7):323-9. doi: 10.1111/j.1432-0436.2005.00032.x. Review. PubMed PMID: 16219036.
Itoh K, Lisovsky M, Hikasa H, Sokol SY. Reorganization of actin cytoskeleton by FRIED, a Frizzled-8 associated protein tyrosine phosphatase. Dev Dyn. 2005 Sep;234(1):90-101. doi: 10.1002/dvdy.20526. PubMed PMID: 16086323.
Ku M, Sokol SY, Wu J, Tussie-Luna MI, Roy AL, Hata A. Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors. Mol Cell Biol. 2005 Aug;25(16):7144-57. doi: 10.1128/MCB.25.16.7144-7157.2005. PubMed PMID: 16055724; PubMed Central PMCID: PMC1190264.
Ossipova O, Dhawan S, Sokol S, Green JB. Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development. Dev Cell. 2005 Jun;8(6):829-41. doi: 10.1016/j.devcel.2005.04.011. PubMed PMID: 15935773.
Brott BK, Sokol SY. A vertebrate homolog of the cell cycle regulator Dbf4 is an inhibitor of Wnt signaling required for heart development. Dev Cell. 2005 May;8(5):703-15. doi: 10.1016/j.devcel.2005.02.012. PubMed PMID: 15866161.
Itoh K, Brott BK, Bae GU, Ratcliffe MJ, Sokol SY. Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling. J Biol. 2005;4(1):3. doi: 10.1186/jbiol20. Epub 2005 Feb 15. PubMed PMID: 15720724; PubMed Central PMCID: PMC551520.
Hikasa H, Sokol SY. The involvement of Frodo in TCF-dependent signaling and neural tissue development. Development. 2004 Oct;131(19):4725-34. doi: 10.1242/dev.01369. Epub 2004 Aug 25. PubMed PMID: 15329348.
Gillhouse M, Wagner Nyholm M, Hikasa H, Sokol SY, Grinblat Y. Two Frodo/Dapper homologs are expressed in the developing brain and mesoderm of zebrafish. Dev Dyn. 2004 Jul;230(3):403-9. doi: 10.1002/dvdy.20060. PubMed PMID: 15188426.
Weber JR, Sokol SY. Identification of a phylogenetically conserved activin-responsive enhancer in the Zic3 gene. Mech Dev. 2003 Aug;120(8):955-64. doi: 10.1016/s0925-4773(03)00082-0. PubMed PMID: 12963115.
Brott BK, Sokol SY. Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. Mol Cell Biol. 2002 Sep;22(17):6100-10. doi: 10.1128/MCB.22.17.6100-6110.2002. PubMed PMID: 12167704; PubMed Central PMCID: PMC133995.
Gloy J, Hikasa H, Sokol SY. Frodo interacts with Dishevelled to transduce Wnt signals. Nat Cell Biol. 2002 May;4(5):351-7. doi: 10.1038/ncb784. PubMed PMID: 11941372.
Lisovsky M, Itoh K, Sokol SY. Frizzled receptors activate a novel JNK-dependent pathway that may lead to apoptosis. Curr Biol. 2002 Jan 8;12(1):53-8. doi: 10.1016/s0960-9822(01)00628-5. PubMed PMID: 11790303.
Sokol SY, Li Z, Sacks DB. The effect of IQGAP1 on Xenopus embryonic ectoderm requires Cdc42. J Biol Chem. 2001 Dec 21;276(51):48425-30. doi: 10.1074/jbc.M107975200. Epub 2001 Oct 2. PubMed PMID: 11584017.
Ratcliffe MJ, Itoh K, Sokol SY. A positive role for the PP2A catalytic subunit in Wnt signal transduction. J Biol Chem. 2000 Nov 17;275(46):35680-3. doi: 10.1074/jbc.C000639200. PubMed PMID: 11007767.
Broun M, Sokol S, Bode HR. Cngsc, a homologue of goosecoid, participates in the patterning of the head, and is expressed in the organizer region of Hydra. Development. 1999 Dec;126(23):5245-54. doi: 10.1242/dev.126.23.5245. PubMed PMID: 10556050.
1990-2000
Selected papers 1990-1995
Sokol S., Wong G.G., Melton D.A. (1990). A mouse macrophage factor induces head structures and organizes a body axis in Xenopus. Science 249, 561-564.
Sokol, S., and Melton, D.A. (1991).Pre-existent pattern in Xenopus animal pole cells revealed by induction with activin. Nature 351, 409-411.
Sokol, S. , Christian J., Moon, R.T., and D.A. Melton (1991). Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell 67, 741-752. Sokol, S., and Melton, D.A. (1992). Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus . Dev. Biol. 154 , 348-355.
Sokol, S. (1993). Mesoderm formation in Xenopus ectodermal explants overexpressing Xwnt8: Evidence for a cooperating signal reaching animal pole by gastrulation. Development 118 , 1335-1342.
Itoh, K., and Sokol, S. (1994). Heparan sulfate proteoglycans are required for mesoderm formation in Xenopus embryos. Development 120, 2703-2711.
Sokol, S. (1994). The pregastrula establishment of gene expression pattern in Xenopus embryos: requirements for local cell interactions and for protein synthesis. Dev. Biol. 166, 782-788.
Itoh, K., Tang, T.L., Neel, B.G., and Sokol, S. (1995). Specific modulation of ectodermal cell fates in Xenopus embryos by glycogen synthase kinase. Development 121, 3979-3988.
Tang, T.L., Freeman, R.M., O’Reilly, A.M., Neel, B.G., and Sokol, S. (1995). The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. Cell 80, 473-483.
Sokol, S., and Itoh, K. (1995). The role of proteoglycans in Xenopus gastrulation. In: Proceedings of the Workshop ‘Interplay of genetic and physical processes in the development of biological form’, ed. Beysens, D., Les Houches Series, World Scientific, Singapore, pp.106-113.
Sokol, S., Klingensmith, J., Perrimon, N., and Itoh, K. (1995). Dorsalizing and neuralizing activities of Xdsh, a maternally expressed Xenopus homolog of dishevelled. Development 121 (6), 1637-1647. Dominguez, I., Itoh, K., and Sokol, S. (1995).
1996-1998
Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos. Proc. Natl. Acad. Sci. USA 92 , 8498-8502.Sokol, S. (1996).
Analysis of Dishevelled signaling pathways during Xenopus development. Curr. Biol. 6, 1456-1467.
Itoh K. and S. Sokol. (1997). Graded amounts ofXenopus dishevelled specify discrete anteroposterior cell fates in prospective ectoderm. Mech. Dev. 61, 113-125. Fan, M. J., Sokol S.Y. (1997).
A role for Siamois in Spemann organizer formation. Development 124, 2581-2589. Landesman, Y. and S. Sokol (1997).
Xwnt-2b is a novel axis-inducing Xenopus Wnt, which is expressed in embryonic brain. Mech.Dev. 63, 199-209.
Fan, M. J., Gruning, W., Walz, G., and Sokol, S. (1998). Wnt signaling and transcriptional control of Siamois in Xenopus embryos. Proc. Natl. Acad. Sci. 95, 5626-5631.
Itoh, K., Krupnik, V. and S.Y. Sokol (1998). Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin. Curr.Biol. 8, 591-594.
Sokol, S.Y., and K. Itoh (1998). A network of cell interactions mediated by Frizzled is essential for gastrulation and anteroposterior axis determination in Xenopus embryos. In: “Dynamical networks in Physics and Biology”, Editions de Physique- Springer Verlag, 227-236.
Xu, Q., D’Amore, P. A. and S. Y. Sokol (1998). Functional and biochemical interactions of Wnts with FrzA, a secreted Wnt antagonist. Development Nov 9; 125(Pt 23), 4767-4776.
Kim, E., Arnould, T., Fan, M. J., Gruning, W., Sokol, S. Y., Drummond, I., and Walz, G. (1999). Polycystin modulates Wnt signaling. J Biol Chem. 274, 4947-53.
Itoh, K., Jacob, J. and Sokol, S.Y. (1998). A role for Xenopus Frizzled 8 in dorsal development. Mech. Dev. 74, 145-157 Cngsc, a homologue of goosecoid, participates in the patterning of the head, and is expressed in the organizer region of Hydra. Development. 126(23), 5245-54.
Itoh, K., Antipova, A., Ratcliffe, M.J., Sokol, S.Y. (2000). Interaction of dishevelled and Xenopus axin-related protein is required for Wnt signal transduction. Mol. Cell. Biol. 20, 2228-2238.
Ratcliffe MJ, Itoh K, Sokol SY. (2000). A positive role for the PP2A catalytic subunit in Wnt signal transduction. J. Biol. Chem. 275(46), 35680-3. Sokol, S. Y. (2000).
A role for Wnts in morphogenesis and tissue polarity. Nat. Cell Biol. 2(7), E124-5. Semenov MV, Tamai K, Brott BK, Kuhl M, Sokol S, He X.(2001).
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol. 11, 951-61. Sokol, S. Y. , Li, Z., and Sacks D. (2001). The effect of IQGAP1 on Xenopus embryonic ectoderm requires Cdc42. J Biol Chem. , Oct 2 . 2002 Brott, B. and Sokol S. Y. (2002).
Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. Mol Cell Biol., 22, 6100-10. Lisovsky, M., Itoh, K., and Sokol S. Y. (2002).
Frizzled receptors activate a novel JNK-dependent pathway that may lead to apoptosis. Curr Biol., 12(1), 53-8. Gloy, J., and Sokol S. Y. (2002).
Frodo interacts with Dishevelled to transduce Wnt signals. Nat Cell Biol, 4, 351-7. Hanai, J., Karumanchi, S. A. Gloy, J., Ramchandran, R., Kale, S., Jha, V., Sukhatme, V. P., and Sokol, S. Y. (2002).
Endostatin is a potential inhibitor of Wnt signaling. J Cell Biol. 2002 , 158, 529-39. 2003.
Weber J.R., Sokol S.Y. (2003). Identification of a phylogenetically conserved activin-responsive enhancer in the Zic3 gene. Mech. Dev.(in press). 2004.
Gillhouse M, Wagner Nyholm M, Hikasa H, Sokol SY, Grinblat Y. (2004). Two Frodo/Dapper homologs are expressed in the developing brain and mesoderm of zebrafish. Dev Dyn. 230:403-9. Hikasa, H. and Sokol, S. Y. (2004).
The involvement of Frodo in TCF-dependent signaling and neural tissue development. Development 131, 4725-34. 2005 Itoh, K., Brott, B. K., Bae, G., Ratcliffe, M. R., and Sokol, S. Y. (2005).
Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling. J. Biol. 4, 3. Brott, B. K., and Sokol, S. Y. (2005).
A vertebrate homologue of the cell cycle regulator Dbf4 is a Wnt inhibitor required for heart development. Dev. Cell 8, 703-715. Itoh K., Lisovsky M., Hikasa H., and Sokol S. Y. (2005).
Reorganization of actin cytoskeleton by FRIED, a Frizzled-8 associated protein tyrosine phosphatase. Dev Dyn. 234:90-101. Ku M., Sokol S. Y., Wu J., Tussie-Luna M. I., Roy A. L., Hata A. (2005).
Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors. Mol Cell Biol. 25:7144-57. Ossipova O, Dhawan S, Sokol S, Green JB. (2005).
Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development. Dev. Cell 8:829-41. Brott, B. K., and Sokol, S. Y. (2005).
Frodo proteins: novel regulators of signaling pathways in vertebrate embryos. Differentiation 73:323-329. Dollar, G., Weber, U., Mlodzik, M., and Sokol, S. Y. (2005).
Regulation of Lethal giant larvae by Dishevelled. Nature 437:1376-1389. 2006 Park J.I., Ji H., Jun S., Gu D., Hikasa H., Li L, Sokol S. Y., McCrea P. D. (2006).
Frodo links Dishevelled to the p120-catenin/ Kaiso pathway: distinct catenin sub-families promote Wnt signals. Dev. Cell 11, 683. Hunter, N. L., Hikasa, H., Dymecki, S. M, and Sokol, S. Y. (2006).
Vertebrate homologues of Frodo are dynamically expressed in tissues undergoing extensive morphogenetic movements. Dev. Dyn. 235: 279-284. Kibardin, A., Ossipova, O., and Sokol, S. Y. (2006).
Sergei Y Sokol, PhD
sergei.sokol@mssm.edu
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