CPTAC-PGDAC at Mount Sinai
The aims of our PGDAC are to: 1) derive biological and clinically relevant information from the CPTAC proteogenomic(PG) data, 2) develop new computational/software/web tools for analyzing CPTAC data and for visualizing/interpreting our analysis results, and 3) identify protein biomarkers and drug targets for further investigation by targeted proteomics assays.
CPTAC Flagship Papers
We have led and/or contributed to the following research on cancer proteogenomics:
A proteogenomic portrait of lung squamous cell carcinoma
Proteogenomic and metabolomic characterization of human glioblastoma
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
Proteogenomic Characterization of Endometrial Carcinoma
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma
A proteogenomic portrait of lung squamous cell carcinoma
Satpathy et al. Cell. Aug 2021. PMID: 34358469
Proteogenomic and metabolomic characterization of human glioblastoma
Wang et al. Cancer Cell. Apr 2021. PMID: 33577785
Read the full text at Cancer Cell
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
Huang et al. Cancer Cell. Mar 2021. PMID: 33417831
Read the full text at Cancer Cell
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer
Petralia et al. Cell. Dec 2020. PMID: 33242424
You can explore the pediatric brain tumor data with interactive heatmap with our ProTrack web tool at http://pbt.cptac-data-view.org/
Related reading:
Proteogenomic analysis provides new insights into pediatric brain tumors
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
Gillette et al. Cell. July 2020. PMID: 32649874
Proteogenomic Characterization of Endometrial Carcinoma
Dou et al. Cell. Feb 2020. PMID: 32059776
Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma
Clark et al. Cell. Oct 2019. PMID: 31675502
You can explore the ccRCC cohort data with interactive heatmap with our ProTrack web tool at http://ccrcc.cptac-data-view.org/
Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma
Gao et al. Cell. Oct 2019. PMID: 31585088
